Wnt/ -Catenin Signaling and AXIN1 Regulate Apoptosis Triggered by Inhibition of the Mutant Kinase BRAFV600E in Human Melanoma
出版年份 2012 全文链接
标题
Wnt/ -Catenin Signaling and AXIN1 Regulate Apoptosis Triggered by Inhibition of the Mutant Kinase BRAFV600E in Human Melanoma
作者
关键词
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出版物
Science Signaling
Volume 5, Issue 206, Pages ra3-ra3
出版商
American Association for the Advancement of Science (AAAS)
发表日期
2012-01-11
DOI
10.1126/scisignal.2002274
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Phase I/II study of GSK2118436, a selective inhibitor of oncogenic mutant BRAF kinase, in patients with metastatic melanoma and other solid tumors.
- (2017) R. Kefford et al. JOURNAL OF CLINICAL ONCOLOGY
- Pharmacodynamic Characterization of the Efficacy Signals Due to Selective BRAF Inhibition with PLX4032 in Malignant Melanoma
- (2015) William D. Tap et al. NEOPLASIA
- Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation
- (2011) Paul B. Chapman et al. NEW ENGLAND JOURNAL OF MEDICINE
- β-Catenin Signaling Increases during Melanoma Progression and Promotes Tumor Cell Survival and Chemoresistance
- (2011) Tobias Sinnberg et al. PLoS One
- Acquired Resistance to BRAF Inhibitors Mediated by a RAF Kinase Switch in Melanoma Can Be Overcome by Cotargeting MEK and IGF-1R/PI3K
- (2010) Jessie Villanueva et al. CANCER CELL
- MicroRNA-206 expression is down-regulated in estrogen receptor a-positive human breast cancer.
- (2010) N Kondo et al. CANCER RESEARCH
- Suppression of Casein Kinase 1 in Melanoma Cells Induces a Switch in -Catenin Signaling to Promote Metastasis
- (2010) T. Sinnberg et al. CANCER RESEARCH
- Transcriptional Pathway Signatures Predict MEK Addiction and Response to Selumetinib (AZD6244)
- (2010) J. R. Dry et al. CANCER RESEARCH
- Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma
- (2010) Gideon Bollag et al. NATURE
- Inhibition of Mutated, Activated BRAF in Metastatic Melanoma
- (2010) Keith T. Flaherty et al. NEW ENGLAND JOURNAL OF MEDICINE
- PLX4032, a potent inhibitor of the B-Raf V600E oncogene, selectively inhibits V600E-positive melanomas
- (2010) John T. Lee et al. Pigment Cell & Melanoma Research
- Apoptosis of human melanoma cells induced by inhibition of B-RAFV600E involves preferential splicing of bimS
- (2010) C C Jiang et al. Cell Death & Disease
- A Re-evaluation of the “Oncogenic” Nature of Wnt/β-catenin Signaling in Melanoma and Other Cancers
- (2010) Olivia M. Lucero et al. Current Oncology Reports
- Apoptosis and autophagy: BIM as a mediator of tumour cell death in response to oncogene-targeted therapeutics
- (2009) Annette S. Gillings et al. FEBS Journal
- Melanoma Prognostic Model Using Tissue Microarrays and Genetic Algorithms
- (2009) Bonnie E. Gould Rothberg et al. JOURNAL OF CLINICAL ONCOLOGY
- A Wnt Survival Guide: From Flies to Human Disease
- (2009) Andy J. Chien et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- EGF-Induced ERK Activation Promotes CK2-Mediated Disassociation of α-Catenin from β-Catenin and Transactivation of β-Catenin
- (2009) Haitao Ji et al. MOLECULAR CELL
- Activated Wnt/ss-catenin signaling in melanoma is associated with decreased proliferation in patient tumors and a murine melanoma model
- (2009) A. J. Chien et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Akt3 and Mutant V600EB-Raf Cooperate to Promote Early Melanoma Development
- (2008) M. Cheung et al. CANCER RESEARCH
- Oncogenic B-RafV600EInhibits Apoptosis and Promotes ERK-dependent Inactivation of Bad and Bim
- (2008) Clare Sheridan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Treatment of B-RAF mutant human tumor cells with a MEK inhibitor requires Bim and is enhanced by a BH3 mimetic
- (2008) Mark S. Cragg et al. JOURNAL OF CLINICAL INVESTIGATION
- Mutant B-RAF mediates resistance to anoikis via Bad and Bim
- (2008) K Boisvert-Adamo et al. ONCOGENE
- Oncogenic BRAFV600E inhibits BIM expression to promote melanoma cell survival
- (2008) Robert A. Cartlidge et al. Pigment Cell & Melanoma Research
- Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity
- (2008) J. Tsai et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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