Pirfenidone Sensitizes NCI-H460 Non-Small Cell Lung Cancer Cells to Paclitaxel and to a Combination of Paclitaxel with Carboplatin

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2021) Hyuna Sung et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Five-Year Outcomes With Pembrolizumab Versus Chemotherapy for Metastatic Non–Small-Cell Lung Cancer With PD-L1 Tumor Proportion Score ≥ 50%

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Synthesis of Novel Methyl 3-(hetero)arylthieno[3,2-b]pyridine-2-carboxylates and Antitumor Activity Evaluation: Studies In Vitro and In Ovo Grafts of Chick Chorioallantoic Membrane (CAM) with a Triple Negative Breast Cancer Cell Line

(2021) Bruna R. Silva et al.   MOLECULES

Drug Repurposing Opportunities in Pancreatic Ductal Adenocarcinoma

(2021) Rita Rebelo et al.   Pharmaceuticals

Failure of Immunotherapy—The Molecular and Immunological Origin of Immunotherapy Resistance in Lung Cancer

(2021) Justyna Błach et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Current and Future Development in Lung Cancer Diagnosis

(2021) Reem Nooreldeen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Toward personalized treatment approaches for non-small-cell lung cancer

(2021) Meina Wang et al.   NATURE MEDICINE

Molecular Mechanism of EGFR-TKI Resistance in EGFR-Mutated Non-Small Cell Lung Cancer: Application to Biological Diagnostic and Monitoring

(2021) Damien Reita et al.   Cancers

The Multi-Modal Effect of the Anti-fibrotic Drug Pirfenidone on NSCLC

(2020) Sebastian Marwitz et al.   Frontiers in Oncology

Repurposing approved drugs for cancer therapy

(2020) Catherine H Schein   BRITISH MEDICAL BULLETIN

Pirfenidone, an Anti-Fibrotic Drug, Suppresses the Growth of Human Prostate Cancer Cells by Inducing G1 Cell Cycle Arrest

(2019) Kenichiro Ishii et al.   Journal of Clinical Medicine

Synthesis of New Proteomimetic Quinazolinone Alkaloids and Evaluation of Their Neuroprotective and Antitumor Effects

(2019) Solida Long et al.   MOLECULES

Non–Small Cell Lung Cancer: Epidemiology, Screening, Diagnosis, and Treatment

(2019) Narjust Duma et al.   MAYO CLINIC PROCEEDINGS

Pirfenidone inhibits motility of NSCLC cells by interfering with the urokinase system

(2019) Matthias Krämer et al.   CELLULAR SIGNALLING

Synthesis and Evaluation of the Tumor Cell Growth Inhibitory Potential of New Putative HSP90 Inhibitors

(2018) Ana Bizarro et al.   MOLECULES

Melissa officinalis L. ethanolic extract inhibits the growth of a lung cancer cell line by interfering with the cell cycle and inducing apoptosis

(2018) D. B. Magalhães et al.   Food & Function

OUP accepted manuscript

(2018)   ANNALS OF ONCOLOGY

Pirfenidone decreases mesothelioma cell proliferation and migration via inhibition of ERK and AKT and regulates mesothelioma tumor microenvironment in vivo

(2018) Chang Li et al.   Scientific Reports

Drug repurposing: progress, challenges and recommendations

(2018) Sudeep Pushpakom et al.   NATURE REVIEWS DRUG DISCOVERY

Pirfenidone plays a biphasic role in inhibition of epithelial-mesenchymal transition in non-small cell lung cancer

(2017) Ayako Fujiwara et al.   LUNG CANCER

Pirfenidone may revert the epithelial-to-mesenchymal transition in human lung adenocarcinoma

(2017) Ryota Kurimoto et al.   Oncology Letters

Pirfenidone normalizes the tumor microenvironment to improve chemotherapy

(2017) Christiana Polydorou et al.   Oncotarget

Pirfenidone Inhibits Proliferation and Promotes Apoptosis of Hepatocellular Carcinoma Cells by Inhibiting the Wnt/β-Catenin Signaling Pathway

(2017) Wei-Jie Zou et al.   MEDICAL SCIENCE MONITOR

The anti-fibrotic agent pirfenidone synergizes with cisplatin in killing tumor cells and cancer-associated fibroblasts

(2016) Melanie Mediavilla-Varela et al.   BMC CANCER

Can you teach old drugs new tricks?

(2016) Nicola Nosengo   NATURE

Pirfenidone enhances the efficacy of combined radiation and sunitinib therapy

(2015) Seo-Hyun Choi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Lung cancer: Biology and treatment options

(2015) Hassan Lemjabbar-Alaoui et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Drug repositioning and repurposing: terminology and definitions in literature

(2015) Joris Langedijk et al.   DRUG DISCOVERY TODAY

Non-small-cell lung cancer

(2015) Cesare Gridelli et al.   Nature Reviews Disease Primers

Preoperative chemotherapy for non-small-cell lung cancer: a systematic review and meta-analysis of individual participant data

(2014)   LANCET

A Phase 3 Trial of Pirfenidone in Patients with Idiopathic Pulmonary Fibrosis

(2014) Talmadge E. King et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pirfenidone Inhibits Pancreatic Cancer Desmoplasia by Regulating Stellate Cells

(2013) S. Kozono et al.   CANCER RESEARCH

Cancer drug discovery by repurposing: teaching new tricks to old dogs

(2013) Subash C. Gupta et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Pirfenidone in idiopathic pulmonary fibrosis

(2009) H. Taniguchi et al.   EUROPEAN RESPIRATORY JOURNAL