The anti-fibrotic agent pirfenidone synergizes with cisplatin in killing tumor cells and cancer-associated fibroblasts

Pirfenidone enhances the efficacy of combined radiation and sunitinib therapy

(2015) Seo-Hyun Choi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Importance of carcinoma-associated fibroblast-derived proteins in clinical oncology

(2014) Gabor Valcz et al.   JOURNAL OF CLINICAL PATHOLOGY

A Phase 3 Trial of Pirfenidone in Patients with Idiopathic Pulmonary Fibrosis

(2014) Talmadge E. King et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pharmacogenomics of Cisplatin Sensitivity in Non-small Cell Lung Cancer

(2014) Maimon C. Rose et al.   GENOMICS PROTEOMICS & BIOINFORMATICS

Cancer-Associated Fibroblasts as Another Polarized Cell Type of the Tumor Microenvironment

(2014) Martin Augsten   Frontiers in Oncology

Fibroblast-mediated drug resistance in cancer

(2013) Kim H.T. Paraiso et al.   BIOCHEMICAL PHARMACOLOGY

Antagonism of adenosine A2A receptor expressed by lung adenocarcinoma tumor cells and cancer associated fibroblasts inhibits their growth

(2013) Melanie Mediavilla-Varela et al.   CANCER BIOLOGY & THERAPY

Pirfenidone Inhibits Pancreatic Cancer Desmoplasia by Regulating Stellate Cells

(2013) S. Kozono et al.   CANCER RESEARCH

Pirfenidone attenuates IL-1β-induced COX-2 and PGE2 production in orbital fibroblasts through suppression of NF-κB activity

(2013) Youn-Hee Choi et al.   EXPERIMENTAL EYE RESEARCH

Inhibition of Pirfenidone on TGF-beta2 Induced Proliferation, Migration and Epithlial-Mesenchymal Transition of Human Lens Epithelial Cells Line SRA01/04

(2013) Yangfan Yang et al.   PLoS One

Meta-Analysis on Pharmacogenetics of Platinum-Based Chemotherapy in Non Small Cell Lung Cancer (NSCLC) Patients

(2012) Ji-Ye Yin et al.   PLoS One

Pirfenidone inhibits TGF-β1-induced over-expression of collagen type I and heat shock protein 47 in A549 cells

(2012) Keiko Hisatomi et al.   BMC Pulmonary Medicine

In Vitro Effects of Pirfenidone on Cardiac Fibroblasts: Proliferation, Myofibroblast Differentiation, Migration and Cytokine Secretion

(2011) Qiang Shi et al.   PLoS One

Pirfenidone mitigates left ventricular fibrosis and dysfunction after myocardial infarction and reduces arrhythmias

(2010) Duy T. Nguyen et al.   HEART RHYTHM

Highly variable response to cytotoxic chemotherapy in carcinoma-associated fibroblasts (CAFs) from lung and breast

(2009) Maike Sonnenberg et al.   BMC CANCER

Antifibrotic action of pirfenidone and prednisolone: Different effects on pulmonary cytokines and growth factors in bleomycin-induced murine pulmonary fibrosis

(2008) Hisashi Oku et al.   EUROPEAN JOURNAL OF PHARMACOLOGY