Pirfenidone, an Anti-Fibrotic Drug, Suppresses the Growth of Human Prostate Cancer Cells by Inducing G1 Cell Cycle Arrest

Overview on Anticancer Drug Design and Development

(2018) Sureyya Olgen   CURRENT MEDICINAL CHEMISTRY

Recent Advances in Prostate Cancer Treatment and Drug Discovery

(2018) Ekaterina Nevedomskaya et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Interleukin-6 induces VEGF secretion from prostate cancer cells in a manner independent of androgen receptor activation

(2018) Kenichiro Ishii et al.   PROSTATE

Role of Stromal Paracrine Signals in Proliferative Diseases of the Aging Human Prostate

(2018) Kenichiro Ishii et al.   Journal of Clinical Medicine

Intracellular and extracellular TGF-β signaling in cancer: some recent topics

(2018) Kohei Miyazono et al.   Frontiers of Medicine

Additive naftopidil treatment synergizes docetaxel-induced apoptosis in human prostate cancer cells

(2017) Kenichiro Ishii et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Pirfenidone Induces G1 Arrest in Human Tenon's Fibroblasts In Vitro Involving AKT and MAPK Signaling Pathways

(2017) Xiujuan Guo et al.   JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS

p21: A Two-Faced Genome Guardian

(2017) Alexandros G. Georgakilas et al.   TRENDS IN MOLECULAR MEDICINE

Pirfenidone Inhibits Proliferation and Promotes Apoptosis of Hepatocellular Carcinoma Cells by Inhibiting the Wnt/β-Catenin Signaling Pathway

(2017) Wei-Jie Zou et al.   MEDICAL SCIENCE MONITOR

In the Shadow of Fibrosis: Innate Immune Suppression Mediated by Transforming Growth Factor-β

(2016) Belinda J. Thomas et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Nintedanib and Pirfenidone. New Antifibrotic Treatments Indicated for Idiopathic Pulmonary Fibrosis Offer Hopes and Raises Questions

(2015) Ganesh Raghu et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Pirfenidone inhibits proliferation, arrests the cell cycle, and downregulates heat shock protein-47 and collagen type I in rat hepatic stellate cells in vitro

(2015) XIAN-HONG XIANG et al.   Molecular Medicine Reports

Metastatic castration-resistant prostate cancer (CRPC): preclinical and clinical evidence for the sequential use of novel therapeutics

(2014) Deborah Mukherji et al.   CANCER AND METASTASIS REVIEWS

Effect of pirfenidone on proliferation, TGF-β-induced myofibroblast differentiation and fibrogenic activity of primary human lung fibroblasts

(2014) Enrico Conte et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Recent Advances in Drug Repositioning for the Discovery of New Anticancer Drugs

(2014) Joong Sup Shim et al.   International Journal of Biological Sciences

Effects of 14 frequently used drugs on prostate-specific antigen expression in prostate cancer LNCaP cells

(2014) KAZUHIRO IGUCHI et al.   Oncology Letters

Pirfenidone Inhibits Pancreatic Cancer Desmoplasia by Regulating Stellate Cells

(2013) S. Kozono et al.   CANCER RESEARCH

Phase III, Randomized, Placebo-Controlled Study of Docetaxel in Combination With Zibotentan in Patients With Metastatic Castration-Resistant Prostate Cancer

(2013) Karim Fizazi et al.   JOURNAL OF CLINICAL ONCOLOGY

Inhibition of Pirfenidone on TGF-beta2 Induced Proliferation, Migration and Epithlial-Mesenchymal Transition of Human Lens Epithelial Cells Line SRA01/04

(2013) Yangfan Yang et al.   PLoS One

Low Androgen Sensitivity Is Associated With Low Levels of Akt Phosphorylation in LNCaP-E9 Cells

(2012) K. Iguchi et al.   JOURNAL OF ANDROLOGY

Characterization of the low pH/low nutrient-resistant LNCaP cell subline LNCaP-F10

(2012) KAZUHIRO IGUCHI et al.   ONCOLOGY REPORTS

Role for Stromal Heterogeneity in Prostate Tumorigenesis

(2011) M. A. Kiskowski et al.   CANCER RESEARCH

Altered TGF-β Signaling in a Subpopulation of Human Stromal Cells Promotes Prostatic Carcinogenesis

(2011) Omar E. Franco et al.   CANCER RESEARCH

In Vitro Effects of Pirfenidone on Cardiac Fibroblasts: Proliferation, Myofibroblast Differentiation, Migration and Cytokine Secretion

(2011) Qiang Shi et al.   PLoS One

Associations of aspirin, nonsteroidal anti-inflammatory drug and paracetamol use with PSA-detected prostate cancer: Findings from a large, population-based, case-control study (the ProtecT study)

(2010) Ali S. Murad et al.   INTERNATIONAL JOURNAL OF CANCER

Statins reduce the androgen sensitivity and cell proliferation by decreasing the androgen receptor protein in prostate cancer cells

(2010) Akira Yokomizo et al.   PROSTATE

Evidence that androgen-independent stromal growth factor signals promote androgen-insensitive prostate cancer cell growth in vivo

(2009) Kenichiro Ishii et al.   ENDOCRINE-RELATED CANCER

Tranilast inhibits hormone refractory prostate cancer cell proliferation and suppresses transforming growth factor β1-associated osteoblastic changes

(2009) Kouji Izumi et al.   PROSTATE