Proline Dehydrogenase/Proline Oxidase (PRODH/POX) Is Involved in the Mechanism of Metformin-Induced Apoptosis in C32 Melanoma Cell Line

Platelet-Rich Plasma Promotes the Proliferation of Human Keratinocytes via a Progression of the Cell Cycle. A Role of Prolidase

(2021) Magdalena Misiura et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Extracellular Prolidase (PEPD) Induces Anabolic Processes through EGFR, β1-integrin, and IGF-1R Signaling Pathways in an Experimental Model of Wounded Fibroblasts

(2021) Weronika Baszanowska et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Metformin prevents PFKFB3‑related aerobic glycolysis from enhancing collagen synthesis in lung fibroblasts by regulating AMPK/mTOR pathway

(2021) Ci-Jun Tang et al.   Experimental and Therapeutic Medicine

Metformin Treatment or PRODH/POX-Knock out Similarly Induces Apoptosis by Reprograming of Amino Acid Metabolism, TCA, Urea Cycle and Pentose Phosphate Pathway in MCF-7 Breast Cancer Cells

(2021) Thi Yen Ly Huynh et al.   Biomolecules

Proline Metabolism in Tumor Growth and Metastatic Progression

(2020) Cristina D'Aniello et al.   Frontiers in Oncology

Targeting the Mitochondrial Metabolic Network: A Promising Strategy in Cancer Treatment

(2020) Luca Frattaruolo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Development of an LC-MS Targeted Metabolomics Methodology to Study Proline Metabolism in Mammalian Cell Cultures

(2020) Agnieszka Klupczynska et al.   MOLECULES

Prolidase Stimulates Proliferation and Migration through Activation of the PI3K/Akt/mTOR Signaling Pathway in Human Keratinocytes

(2020) Magdalena Misiura et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Verapamil and collagenase differentially affect collagen metabolism in experimental model of Peyronie's disease

(2019) Jacek Karaszewski et al.   MOLECULAR AND CELLULAR PROBES

Metformin Suppresses Tumor Progression by Inactivating Stromal Fibroblasts in Ovarian Cancer

(2018) Sen Xu et al.   MOLECULAR CANCER THERAPEUTICS

Proline oxidase silencing induces proline-dependent pro-survival pathways in MCF-7 cells

(2018) Ilona Zareba et al.   Oncotarget

The Metabolism of Proline as Microenvironmental Stress Substrate

(2018) James M. Phang et al.   JOURNAL OF NUTRITION

Metformin: Focus on Melanoma

(2018) Emilie Jaune et al.   Frontiers in Endocrinology

Metformin is also effective on lactic acidosis-exposed melanoma cells switched to oxidative phosphorylation

(2016) Silvia Peppicelli et al.   CELL CYCLE

Metformin inhibits growth of human non-small cell lung cancer cells via liver kinase B-1-independent activation of adenosine monophosphate-activated protein kinase

(2016) QIANQIAN GUO et al.   Molecular Medicine Reports

Pharmacological Modulation of Lung Carcinogenesis in Smokers: Preclinical and Clinical Evidence

(2016) Silvio De Flora et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Repurposing metformin for cancer treatment: current clinical studies

(2016) Young Kwang Chae et al.   Oncotarget

Proline dehydrogenase 2 (PRODH2) is a hydroxyproline dehydrogenase (HYPDH) and molecular target for treating primary hyperoxaluria

(2015) Candice B. Summitt et al.   BIOCHEMICAL JOURNAL

Metformin inhibits growth of lung adenocarcinoma cells by inducing apoptosis via the mitochondria-mediated pathway

(2015) JUNLING WANG et al.   Oncology Letters

Targeting metabolic flexibility by simultaneously inhibiting respiratory complex I and lactate generation retards melanoma progression

(2015) Balkrishna Chaube et al.   Oncotarget

LKB1/AMPK/mTOR Signaling Pathway in Non-small-cell Lung Cancer

(2013) Dong Han et al.   Asian Pacific Journal of Cancer Prevention

Molecular crosstalk between apoptosis and autophagy induced by a novel 2-methoxyestradiol analogue in cervical adenocarcinoma cells

(2013) Anne E Theron et al.   Cancer Cell International

Proline dehydrogenase (oxidase), a mitochondrial tumor suppressor, and autophagy under the hypoxia microenvironment

(2012) Wei Liu et al.   Autophagy

Proline Oxidase Promotes Tumor Cell Survival in Hypoxic Tumor Microenvironments

(2012) W. Liu et al.   CANCER RESEARCH

Proline dehydrogenase is essential for proline protection against hydrogen peroxide-induced cell death

(2012) Sathish Kumar Natarajan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Glutamine-fueled mitochondrial metabolism is decoupled from glycolysis in melanoma

(2012) Fabian V. Filipp et al.   Pigment Cell & Melanoma Research

Expression in Escherichia coli of the catalytic domain of human proline oxidase

(2012) Elena Tallarita et al.   PROTEIN EXPRESSION AND PURIFICATION

The Proline Regulatory Axis and Cancer

(2012) James Ming Phang et al.   Frontiers in Oncology

In vitro and in vivo anti-melanoma action of metformin

(2011) Kristina Janjetovic et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Caveolin-1 is essential for metformin inhibitory effect on IGF1 action in non-small-cell lung cancer cells

(2011) Barbara Salani et al.   FASEB JOURNAL

Proline metabolism and cancer

(2011) James et al.   Frontiers in Bioscience-Landmark

AMP-activated protein kinase and cancer

(2009) W. Wang et al.   Acta Physiologica

Quantitative Metabolome Profiling of Colon and Stomach Cancer Microenvironment by Capillary Electrophoresis Time-of-Flight Mass Spectrometry

(2009) A. Hirayama et al.   CANCER RESEARCH

Metabolic Approaches to Treatment of Melanoma

(2009) P. Hersey et al.   CLINICAL CANCER RESEARCH

Metabolic profiling reveals key metabolic features of renal cell carcinoma

(2009) Gareth Catchpole et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Regulation and function of proline oxidase under nutrient stress

(2009) Jui Pandhare et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Berberine reduces fibronectin and collagen accumulation in rat glomerular mesangial cells cultured under high glucose condition

(2009) Weihua Liu et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

The metabolism of proline, a stress substrate, modulates carcinogenic pathways

(2008) James M. Phang et al.   AMINO ACIDS

Identification of a p53-response element in the promoter of the proline oxidase gene

(2008) Steve A. Maxwell et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

AMPK and Raptor: Matching Cell Growth to Energy Supply

(2008) D. Grahame Hardie   MOLECULAR CELL

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

(2008) Dana M. Gwinn et al.   MOLECULAR CELL

Proline oxidase, a p53-induced gene, targets COX-2/PGE2 signaling to induce apoptosis and inhibit tumor growth in colorectal cancers

(2008) Y Liu et al.   ONCOGENE

Role of hypoxia-inducible factor 1alpha in the integrity of articular cartilage in murine knee joints

(2008) Kolja Gelse et al.   ARTHRITIS RESEARCH & THERAPY