Instructing durable humoral immunity for COVID-19 and other vaccinable diseases

Germinal Centers

(2022) Gabriel D. Victora et al.   Annual Review of Immunology

Immune imprinting, breadth of variant recognition, and germinal center response in human SARS-CoV-2 infection and vaccination

(2022) Katharina Röltgen et al.   CELL

Germinal center responses to SARS-CoV-2 mRNA vaccines in healthy and immunocompromised individuals

(2022) Katlyn Lederer et al.   CELL

SARS-CoV-2 vaccination induces immunological T cell memory able to cross-recognize variants from Alpha to Omicron

(2022) Alison Tarke et al.   CELL

Germinal centre-driven maturation of B cell response to mRNA vaccination

(2022) Wooseob Kim et al.   NATURE

Omicron extensively but incompletely escapes Pfizer BNT162b2 neutralization

(2022) Sandile Cele et al.   NATURE

Rapid epidemic expansion of the SARS-CoV-2 Omicron variant in southern Africa

(2022) Raquel Viana et al.   NATURE

Immune correlates analysis of the mRNA-1273 COVID-19 vaccine efficacy clinical trial

(2022) Peter B. Gilbert et al.   SCIENCE

Neutralization of SARS-CoV-2 Omicron by BNT162b2 mRNA vaccine–elicited human sera

(2022) Alexander Muik et al.   SCIENCE

SARS-CoV-2 Omicron Spike recognition by plasma from individuals receiving BNT162b2 mRNA vaccination with a 16-weeks interval between doses

(2022) Debashree Chatterjee et al.   Cell Reports

Effectiveness of a Third Dose of mRNA Vaccines Against COVID-19–Associated Emergency Department and Urgent Care Encounters and Hospitalizations Among Adults During Periods of Delta and Omicron Variant Predominance — VISION Network, 10 States, August 2021–January 2022

(2022) Mark G. Thompson et al.   MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT

Intranasal COVID-19 vaccines: From bench to bed

(2022) Aqu Alu et al.   EBioMedicine

Divergent SARS CoV-2 Omicron-reactive T- and B cell responses in COVID-19 vaccine recipients

(2022) Corine H. GeurtsvanKessel et al.   Science Immunology

Large-Scale Study of Antibody Titer Decay following BNT162b2 mRNA Vaccine or SARS-CoV-2 Infection

(2022) Ariel Israel et al.   Vaccines

Imprinted SARS-CoV-2-specific memory lymphocytes define hybrid immunity

(2022) Lauren B. Rodda et al.   CELL

Efficient recall of Omicron-reactive B cell memory after a third dose of SARS-CoV-2 mRNA vaccine

(2022) Rishi R. Goel et al.   CELL

Persistence of immunogenicity after seven COVID-19 vaccines given as third dose boosters following two doses of ChAdOx1 nCov-19 or BNT162b2 in the UK: Three month analyses of the COV-BOOST trial.

(2022) Xinxue Liu et al.   JOURNAL OF INFECTION

Mechanisms of innate and adaptive immunity to the Pfizer-BioNTech BNT162b2 vaccine

(2022) Chunfeng Li et al.   NATURE IMMUNOLOGY

Pan-coronavirus vaccine pipeline takes form

(2022) Elie Dolgin   NATURE REVIEWS DRUG DISCOVERY

Interim Results of a Phase 1–2a Trial of Ad26.COV2.S Covid-19 Vaccine

(2021) Jerald Sadoff et al.   NEW ENGLAND JOURNAL OF MEDICINE

Immunological memory to SARS-CoV-2 assessed for up to 8 months after infection

(2021) Jennifer M. Dan et al.   SCIENCE

Transcriptional and Metabolic Control of Memory B Cells and Plasma Cells

(2021) Tyler J. Ripperger et al.   Annual Review of Immunology

Maturation and persistence of the anti-SARS-CoV-2 memory B cell response

(2021) Aurélien Sokal et al.   CELL

Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity

(2021) Wilfredo F. Garcia-Beltran et al.   CELL

Human neutralizing antibodies against SARS-CoV-2 require intact Fc effector functions for optimal therapeutic protection

(2021) Emma S. Winkler et al.   CELL

Presence of antibody-dependent cellular cytotoxicity (ADCC) against SARS-CoV-2 in COVID-19 plasma

(2021) For Yue Tso et al.   PLoS One

Plasma cell dynamics in the bone marrow niche

(2021) Zachary Benet et al.   Cell Reports

Infection- and vaccine-induced antibody binding and neutralization of the B.1.351 SARS-CoV-2 variant

(2021) Venkata Viswanadh Edara et al.   Cell Host & Microbe

Differential T cell reactivity to endemic coronaviruses and SARS-CoV-2 in community and health care workers

(2021) Ricardo da Silva Antunes et al.   JOURNAL OF INFECTIOUS DISEASES

Neutralizing antibody levels are highly predictive of immune protection from symptomatic SARS-CoV-2 infection

(2021) David S. Khoury et al.   NATURE MEDICINE

Safety and Efficacy of Single-Dose Ad26.COV2.S Vaccine against Covid-19

(2021) Jerald Sadoff et al.   NEW ENGLAND JOURNAL OF MEDICINE

A human coronavirus evolves antigenically to escape antibody immunity

(2021) Rachel T. Eguia et al.   PLoS Pathogens

Individuals cannot rely on COVID-19 herd immunity: Durable immunity to viral disease is limited to viruses with obligate viremic spread

(2021) Jonathan W. Yewdell   PLoS Pathogens

Distinct antibody and memory B cell responses in SARS-CoV-2 naïve and recovered individuals following mRNA vaccination

(2021) Rishi R. Goel et al.   Science Immunology

SARS-CoV-2 mRNA vaccination induces functionally diverse antibodies to NTD, RBD, and S2

(2021) Fatima Amanat et al.   CELL

Reactogenicity and immunogenicity after a late second dose or a third dose of ChAdOx1 nCoV-19 in the UK: a substudy of two randomised controlled trials (COV001 and COV002)

(2021) Amy Flaxman et al.   LANCET

Efficacy and safety of an inactivated whole-virion SARS-CoV-2 vaccine (CoronaVac): interim results of a double-blind, randomised, placebo-controlled, phase 3 trial in Turkey

(2021) Mine Durusu Tanriover et al.   LANCET

SARS-CoV-2 mRNA vaccines induce persistent human germinal centre responses

(2021) Jackson S. Turner et al.   NATURE

Naturally enhanced neutralizing breadth against SARS-CoV-2 one year after infection

(2021) Zijun Wang et al.   NATURE

Pan-Sarbecovirus Neutralizing Antibodies in BNT162b2-Immunized SARS-CoV-1 Survivors

(2021) Chee-Wah Tan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Safety and Efficacy of NVX-CoV2373 Covid-19 Vaccine

(2021) Paul T. Heath et al.   NEW ENGLAND JOURNAL OF MEDICINE

Efficacy of the mRNA-1273 SARS-CoV-2 Vaccine at Completion of Blinded Phase

(2021) Hana M. El Sahly et al.   NEW ENGLAND JOURNAL OF MEDICINE

Efficacy and breadth of adjuvanted SARS-CoV-2 receptor-binding domain nanoparticle vaccine in macaques

(2021) Hannah A. D. King et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cross-reactive CD4+ T cells enhance SARS-CoV-2 immune responses upon infection and vaccination

(2021) Lucie Loyal et al.   SCIENCE

Hybrid immunity

(2021) Shane Crotty   SCIENCE

Chimeric spike mRNA vaccines protect against Sarbecovirus challenge in mice

(2021) David R. Martinez et al.   SCIENCE

Expression of Foxp3 by T follicular helper cells in end-stage germinal centers

(2021) Johanne T. Jacobsen et al.   SCIENCE

Mapping mutations to the SARS-CoV-2 RBD that escape binding by different classes of antibodies

(2021) Allison J. Greaney et al.   Nature Communications

Adaptive immune determinants of viral clearance and protection in mouse models of SARS-CoV-2

(2021) Benjamin Israelow et al.   Science Immunology

SARS-CoV-2 variants of concern partially escape humoral but not T-cell responses in COVID-19 convalescent donors and vaccinees

(2021) Daryl Geers et al.   Science Immunology

Immunogenicity of standard and extended dosing intervals of BNT162b2 mRNA vaccine

(2021) Rebecca P. Payne et al.   CELL

Strong humoral immune responses against SARS-CoV-2 Spike after BNT162b2 mRNA vaccination with a 16-week interval between doses

(2021) Alexandra Tauzin et al.   Cell Host & Microbe

Virological and serological kinetics of SARS-CoV-2 Delta variant vaccine breakthrough infections: a multicentre cohort study

(2021) Po Ying Chia et al.   CLINICAL MICROBIOLOGY AND INFECTION

Indoleamine 2,3-dioxygenase 1 is essential for sustaining durable antibody responses

(2021) Shivana M. Lightman et al.   IMMUNITY

Lipid nanoparticles enhance the efficacy of mRNA and protein subunit vaccines by inducing robust T follicular helper cell and humoral responses

(2021) Mohamad-Gabriel Alameh et al.   IMMUNITY

Oral Vaccination Protects Against Severe Acute Respiratory Syndrome Coronavirus 2 in a Syrian Hamster Challenge Model

(2021) Susan Johnson et al.   JOURNAL OF INFECTIOUS DISEASES

Safety and immunogenicity of seven COVID-19 vaccines as a third dose (booster) following two doses of ChAdOx1 nCov-19 or BNT162b2 in the UK (COV-BOOST): a blinded, multicentre, randomised, controlled, phase 2 trial

(2021) Alasdair P S Munro et al.   LANCET

Effectiveness of a third dose of the BNT162b2 mRNA COVID-19 vaccine for preventing severe outcomes in Israel: an observational study

(2021) Noam Barda et al.   LANCET

Pre-existing polymerase-specific T cells expand in abortive seronegative SARS-CoV-2

(2021) Leo Swadling et al.   NATURE

Effectiveness of BNT162b2 Vaccine against Omicron Variant in South Africa

(2021) Shirley Collie et al.   NEW ENGLAND JOURNAL OF MEDICINE

High-affinity memory B cells induced by SARS-CoV-2 infection produce more plasmablasts and atypical memory B cells than those primed by mRNA vaccines

(2021) Kathryn A. Pape et al.   Cell Reports

Temporal dynamics of persistent germinal centers and memory B cell differentiation following respiratory virus infection

(2021) William T. Yewdell et al.   Cell Reports

A new coronavirus associated with human respiratory disease in China

(2020) Fan Wu et al.   NATURE

A pneumonia outbreak associated with a new coronavirus of probable bat origin

(2020) Peng Zhou et al.   NATURE

Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals

(2020) Alba Grifoni et al.   CELL

Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19

(2020) Mingfeng Liao et al.   NATURE MEDICINE

Presymptomatic SARS-CoV-2 Infections and Transmission in a Skilled Nursing Facility

(2020) Melissa M. Arons et al.   NEW ENGLAND JOURNAL OF MEDICINE

Two X‐linked agammaglobulinemia patients develop pneumonia as COVID‐19 manifestation but recover

(2020) Annarosa Soresina et al.   PEDIATRIC ALLERGY AND IMMUNOLOGY

Prevalence of SARS-CoV-2 in Spain (ENE-COVID): a nationwide, population-based seroepidemiological study

(2020) Marina Pollán et al.   LANCET

Rapid Decay of Anti–SARS-CoV-2 Antibodies in Persons with Mild Covid-19

(2020) F. Javier Ibarrondo et al.   NEW ENGLAND JOURNAL OF MEDICINE

Influenza vaccine–induced human bone marrow plasma cells decline within a year after vaccination

(2020) Carl W. Davis et al.   SCIENCE

Selective and cross-reactive SARS-CoV-2 T cell epitopes in unexposed humans

(2020) Jose Mateus et al.   SCIENCE

CD28 Regulates Metabolic Fitness for Long-Lived Plasma Cell Survival

(2020) Adam Utley et al.   Cell Reports

Squalene emulsion-based vaccine adjuvants stimulate CD8 T cell, but not antibody responses, through a RIPK3-dependent pathway

(2020) Eui Ho Kim et al.   eLife

Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19

(2020) Takuya Sekine et al.   CELL

Loss of Bcl-6-Expressing T Follicular Helper Cells and Germinal Centers in COVID-19

(2020) Naoki Kaneko et al.   CELL

A Single-Dose Intranasal ChAd Vaccine Protects Upper and Lower Respiratory Tracts against SARS-CoV-2

(2020) Ahmed O. Hassan et al.   CELL

Orthogonal SARS-CoV-2 Serological Assays Enable Surveillance of Low Prevalence Communities and Reveal Durable Humoral Immunity.

(2020) Tyler J. Ripperger et al.   IMMUNITY

Multifaceted Effects of Antigen Valency on B Cell Response Composition and Differentiation In Vivo

(2020) Yu Kato et al.   IMMUNITY

Affinity-Restricted Memory B Cells Dominate Recall Responses to Heterologous Flaviviruses

(2020) Rachel Wong et al.   IMMUNITY

Safety and immunogenicity of an inactivated SARS-CoV-2 vaccine, BBIBP-CorV: a randomised, double-blind, placebo-controlled, phase 1/2 trial

(2020) Shengli Xia et al.   LANCET INFECTIOUS DISEASES

Human germinal centres engage memory and naive B cells after influenza vaccination

(2020) Jackson S. Turner et al.   NATURE

Structures and distributions of SARS-CoV-2 spike proteins on intact virions

(2020) Zunlong Ke et al.   NATURE

Extrafollicular B cell responses correlate with neutralizing antibodies and morbidity in COVID-19

(2020) Matthew C. Woodruff et al.   NATURE IMMUNOLOGY

Seasonal coronavirus protective immunity is short-lasting

(2020) Arthur W. D. Edridge et al.   NATURE MEDICINE

Structural analysis of full-length SARS-CoV-2 spike protein from an advanced vaccine candidate

(2020) Sandhya Bangaru et al.   SCIENCE

Longitudinal observation and decline of neutralizing antibody responses in the three months following SARS-CoV-2 infection in humans

(2020) Jeffrey Seow et al.   Nature Microbiology

Persistence and decay of human antibody responses to the receptor binding domain of SARS-CoV-2 spike protein in COVID-19 patients

(2020) Anita S. Iyer et al.   Science Immunology

Functional SARS-CoV-2-Specific Immune Memory Persists after Mild COVID-19

(2020) Lauren B. Rodda et al.   CELL

Complete Mapping of Mutations to the SARS-CoV-2 Spike Receptor-Binding Domain that Escape Antibody Recognition

(2020) Allison J. Greaney et al.   Cell Host & Microbe

Recent endemic coronavirus infection is associated with less-severe COVID-19

(2020) Manish Sagar et al.   JOURNAL OF CLINICAL INVESTIGATION

Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK

(2020) Merryn Voysey et al.   LANCET

Correlates of protection against SARS-CoV-2 in rhesus macaques

(2020) Katherine McMahan et al.   NATURE

Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine

(2020) Lindsey R. Baden et al.   NEW ENGLAND JOURNAL OF MEDICINE

Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine

(2020) Fernando P. Polack et al.   NEW ENGLAND JOURNAL OF MEDICINE

T‐bet + memory B cells: Generation, function, and fate

(2019) James J. Knox et al.   IMMUNOLOGICAL REVIEWS

Induction of Potent Neutralizing Antibody Responses by a Designed Protein Nanoparticle Vaccine for Respiratory Syncytial Virus

(2019) Jessica Marcandalli et al.   CELL

Slow Delivery Immunization Enhances HIV Neutralizing Antibody and Germinal Center Responses via Modulation of Immunodominance

(2019) Kimberly M. Cirelli et al.   CELL

Role of Multivalency and Antigenic Threshold in Generating Protective Antibody Responses

(2019) Mark K. Slifka et al.   Frontiers in Immunology

TNF-α Contributes to Lymphoid Tissue Disorganization and Germinal Center B Cell Suppression during Intracellular Bacterial Infection

(2019) Maria Popescu et al.   JOURNAL OF IMMUNOLOGY

Measles virus infection diminishes preexisting antibodies that offer protection from other pathogens

(2019) Michael J. Mina et al.   SCIENCE

ZBTB32 restrains antibody responses to murine cytomegalovirus infections, but not other repetitive challenges

(2019) Arijita Jash et al.   Scientific Reports

Restricted Clonality and Limited Germinal Center Reentry Characterize Memory B Cell Reactivation by Boosting

(2019) Luka Mesin et al.   CELL

No strict requirement for eosinophils for bone marrow plasma cell survival

(2018) Alexandra Bortnick et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Precursor Frequency and Affinity Determine B Cell Competitive Fitness in Germinal Centers, Tested with Germline-Targeting HIV Vaccine Immunogens

(2018) Robert K. Abbott et al.   IMMUNITY

Matrix-M™ adjuvant enhances immunogenicity of both protein- and modified vaccinia virus Ankara-based influenza vaccines in mice

(2018) Sofia E. Magnusson et al.   IMMUNOLOGIC RESEARCH

Factors of the bone marrow microniche that support human plasma cell survival and immunoglobulin secretion

(2018) Doan C. Nguyen et al.   Nature Communications

Metabolic and Transcriptional Modules Independently Diversify Plasma Cell Lifespan and Function

(2018) Wing Y. Lam et al.   Cell Reports

Distinct Effector B Cells Induced by Unregulated Toll-like Receptor 7 Contribute to Pathogenic Responses in Systemic Lupus Erythematosus

(2018) Scott A. Jenks et al.   IMMUNITY

The establishment of resident memory B cells in the lung requires local antigen encounter

(2018) S. Rameeza Allie et al.   NATURE IMMUNOLOGY

Plasmodium-specific atypical memory B cells are short-lived activated B cells

(2018) Damián Pérez-Mazliah et al.   eLife

Antibody-secreting plasma cells persist for decades in human intestine

(2017) Ole J.B. Landsverk et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Priming and Activation of Inflammasome by Canarypox Virus Vector ALVAC via the cGAS/IFI16–STING–Type I IFN Pathway and AIM2 Sensor

(2017) Fengliang Liu et al.   JOURNAL OF IMMUNOLOGY

Here, There, and Anywhere? Arguments for and against the Physical Plasma Cell Survival Niche

(2017) Joel R. Wilmore et al.   JOURNAL OF IMMUNOLOGY

B Cell–Intrinsic MyD88 Signaling Promotes Initial Cell Proliferation and Differentiation To Enhance the Germinal Center Response to a Virus-like Particle

(2017) Meijie Tian et al.   JOURNAL OF IMMUNOLOGY

Malaria-induced interferon-γ drives the expansion of Tbethi atypical memory B cells

(2017) Nyamekye Obeng-Adjei et al.   PLoS Pathogens

ATP-degrading ENPP1 is required for survival (or persistence) of long-lived plasma cells

(2017) Hongsheng Wang et al.   Scientific Reports

Independent Roles of Switching and Hypermutation in the Development and Persistence of B Lymphocyte Memory

(2016) Alexander D. Gitlin et al.   IMMUNITY

Complex Antigens Drive Permissive Clonal Selection in Germinal Centers

(2016) Masayuki Kuraoka et al.   IMMUNITY

A Temporal Switch in the Germinal Center Determines Differential Output of Memory B and Plasma Cells

(2016) Florian J. Weisel et al.   IMMUNITY

Mitochondrial Pyruvate Import Promotes Long-Term Survival of Antibody-Secreting Plasma Cells

(2016) Wing Y. Lam et al.   IMMUNITY

Somatically Hypermutated Plasmodium-Specific IgM+ Memory B Cells Are Rapid, Plastic, Early Responders upon Malaria Rechallenge

(2016) Akshay T. Krishnamurty et al.   IMMUNITY

ZBTB32 Restricts the Duration of Memory B Cell Recall Responses

(2016) Arijita Jash et al.   JOURNAL OF IMMUNOLOGY

Diminished Innate Antiviral Response to Adenovirus Vectors in cGAS/STING-Deficient Mice Minimally Impacts Adaptive Immunity

(2016) Daniela Anghelina et al.   JOURNAL OF VIROLOGY

Blimp-1 controls plasma cell function through the regulation of immunoglobulin secretion and the unfolded protein response

(2016) Julie Tellier et al.   NATURE IMMUNOLOGY

Defining antigen-specific plasmablast and memory B cell subsets in human blood after viral infection or vaccination

(2016) Ali H Ellebedy et al.   NATURE IMMUNOLOGY

TFH cells progressively differentiate to regulate the germinal center response

(2016) Jason S Weinstein et al.   NATURE IMMUNOLOGY

Visualizing antibody affinity maturation in germinal centers

(2016) J. M. J. Tas et al.   SCIENCE

Long-lived antigen-induced IgM plasma cells demonstrate somatic mutations and contribute to long-term protection

(2016) Caitlin Bohannon et al.   Nature Communications

Severe Malaria Infections Impair Germinal Center Responses by Inhibiting T Follicular Helper Cell Differentiation

(2016) Victoria Ryg-Cornejo et al.   Cell Reports

Blood Stage Malaria Disrupts Humoral Immunity to the Pre-erythrocytic Stage Circumsporozoite Protein

(2016) Gladys J. Keitany et al.   Cell Reports

A unique population of IgG-expressing plasma cells lacking CD19 is enriched in human bone marrow

(2015) H. E. Mei et al.   BLOOD

Long-Lived Plasma Cells Are Contained within the CD19−CD38hiCD138+ Subset in Human Bone Marrow

(2015) Jessica L. Halliley et al.   IMMUNITY

High Preexisting Serological Antibody Levels Correlate with Diversification of the Influenza Vaccine Response

(2015) Sarah F. Andrews et al.   JOURNAL OF VIROLOGY

Immunogenicity of the RTS,S/AS01 malaria vaccine and implications for duration of vaccine efficacy: secondary analysis of data from a phase 3 randomised controlled trial

(2015) Michael T White et al.   LANCET INFECTIOUS DISEASES

Responsiveness of B cells is regulated by the hinge region of IgD

(2015) Rudolf Übelhart et al.   NATURE IMMUNOLOGY

Class-switched memory B cells remodel BCRs within secondary germinal centers

(2015) Louise J McHeyzer-Williams et al.   NATURE IMMUNOLOGY

Transcriptional profiling of mouse B cell terminal differentiation defines a signature for antibody-secreting plasma cells

(2015) Wei Shi et al.   NATURE IMMUNOLOGY

Apoptosis and antigen affinity limit effector cell differentiation of a single naive B cell

(2015) J. J. Taylor et al.   SCIENCE

Persistence of antibodies six years after booster vaccination with inactivated vaccine against Japanese encephalitis

(2015) Maria Paulke-Korinek et al.   VACCINE

Malaria-associated atypical memory B cells exhibit markedly reduced B cell receptor signaling and effector function

(2015) Silvia Portugal et al.   eLife

Static and dynamic components synergize to form a stable survival niche for bone marrow plasma cells

(2014) Sandra Zehentmeier et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Adjuvant-specific regulation of long-term antibody responses by ZBTB20

(2014) Yinan Wang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Agonists of TLR4 and 9 Are Sufficient to Activate Memory B Cells to Differentiate into Plasma Cells In Vitro but Not In Vivo

(2014) K. Richard et al.   JOURNAL OF IMMUNOLOGY

Systematic Comparison of Gene Expression between Murine Memory and Naive B Cells Demonstrates That Memory B Cells Have Unique Signaling Capabilities

(2014) M. M. Tomayko et al.   JOURNAL OF IMMUNOLOGY

IL-21-Induced Isotype Switching to IgG and IgA by Human Naive B Cells Is Differentially Regulated by IL-4

(2014) D. T. Avery et al.   JOURNAL OF IMMUNOLOGY

Lasting Antibody Responses Are Mediated by a Combination of Newly Formed and Established Bone Marrow Plasma Cells Drawn from Clonally Distinct Precursors

(2014) Irene Chernova et al.   JOURNAL OF IMMUNOLOGY

IL-6 supports the generation of human long-lived plasma cells in combination with either APRIL or stromal cell-soluble factors

(2014) M Jourdan et al.   LEUKEMIA

Clonal selection in the germinal centre by regulated proliferation and hypermutation

(2014) Alexander D. Gitlin et al.   NATURE

CD80 and PD-L2 define functionally distinct memory B cell subsets that are independent of antibody isotype

(2014) Griselda V Zuccarino-Catania et al.   NATURE IMMUNOLOGY

Identification and characterization of the constituent human serum antibodies elicited by vaccination

(2014) Jason J. Lavinder et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comparative humoral and cellular immunogenicity and safety of human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine and HPV-6/11/16/18 vaccine in healthy women aged 18–45 years: Follow-up through Month 48 in a Phase III randomized study

(2014) Mark H Einstein et al.   Human Vaccines & Immunotherapeutics

Eosinophils Are Not Required for the Induction and Maintenance of an Alloantibody Response

(2013) P. Cravedi et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Endocytosis and Recycling of Immune Complexes by Follicular Dendritic Cells Enhances B Cell Antigen Binding and Activation

(2013) Balthasar A. Heesters et al.   IMMUNITY

Germinal Center Centroblasts Transition to a Centrocyte Phenotype According to a Timed Program and Depend on the Dark Zone for Effective Selection

(2013) Oliver Bannard et al.   IMMUNITY

Repression of the Transcription Factor Bach2 Contributes to Predisposition of IgG1 Memory B Cells toward Plasma Cell Differentiation

(2013) Kohei Kometani et al.   IMMUNITY

Atypical and classical memory B cells producePlasmodium falciparumneutralizing antibodies

(2013) Matthias F. Muellenbeck et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus

(2013) Hua-Xin Liao et al.   NATURE

Mcl-1 is essential for the survival of plasma cells

(2013) Victor Peperzak et al.   NATURE IMMUNOLOGY

Four-Year Efficacy of RTS,S/AS01E and Its Interaction with Malaria Exposure

(2013) Ally Olotu et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Replicative Self-Renewal Model for Long-Lived Plasma Cells: Questioning Irreversible Cell Cycle Exit

(2013) Reuben M. Tooze   Frontiers in Immunology

B cell depletion in immune thrombocytopenia reveals splenic long-lived plasma cells

(2012) Matthieu Mahévas et al.   JOURNAL OF CLINICAL INVESTIGATION

Distinct cellular pathways select germline-encoded and somatically mutated antibodies into immunological memory

(2012) Tomohiro Kaji et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A germinal center–independent pathway generates unswitched memory B cells early in the primary response

(2012) Justin J. Taylor et al.   JOURNAL OF EXPERIMENTAL MEDICINE

In Vitro Generation of Long-lived Human Plasma Cells

(2012) M. Cocco et al.   JOURNAL OF IMMUNOLOGY

A vaccine strategy that protects against genital herpes by establishing local memory T cells

(2012) Haina Shin et al.   NATURE

Endothelial and perivascular cells maintain haematopoietic stem cells

(2012) Lei Ding et al.   NATURE

Selective Utilization of Toll-like Receptor and MyD88 Signaling in B Cells for Enhancement of the Antiviral Germinal Center Response

(2011) Baidong Hou et al.   IMMUNITY

Sustained antibody responses depend on CD28 function in bone marrow–resident plasma cells

(2011) Cheryl H. Rozanski et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Memory B cells, but not long-lived plasma cells, possess antigen specificities for viral escape mutants

(2011) Whitney E. Purtha et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A dynamic T cell–limited checkpoint regulates affinity-dependent B cell entry into the germinal center

(2011) Tanja A. Schwickert et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A Unique Role of the Cholera Toxin A1-DD Adjuvant for Long-Term Plasma and Memory B Cell Development

(2011) M. Bemark et al.   JOURNAL OF IMMUNOLOGY

Live and Inactivated Influenza Vaccines Induce Similar Humoral Responses, but Only Live Vaccines Induce Diverse T-Cell Responses in Young Children

(2011) Daniel F. Hoft et al.   JOURNAL OF INFECTIOUS DISEASES

Programming the magnitude and persistence of antibody responses with innate immunity

(2011) Sudhir Pai Kasturi et al.   NATURE

Eosinophils are required for the maintenance of plasma cells in the bone marrow

(2011) Van Trung Chu et al.   NATURE IMMUNOLOGY

IL-21 and IL-6 Are Critical for Different Aspects of B Cell Immunity and Redundantly Induce Optimal Follicular Helper CD4 T Cell (Tfh) Differentiation

(2011) Danelle Eto et al.   PLoS One

Different B Cell Populations Mediate Early and Late Memory During an Endogenous Immune Response

(2011) K. A. Pape et al.   SCIENCE

Megakaryocytes constitute a functional component of a plasma cell niche in the bone marrow

(2010) O. Winter et al.   BLOOD

Highly Efficient Reprogramming to Pluripotency and Directed Differentiation of Human Cells with Synthetic Modified mRNA

(2010) Luigi Warren et al.   Cell Stem Cell

IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responses

(2010) Michelle A. Linterman et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-21 regulates germinal center B cell differentiation and proliferation through a B cell–intrinsic mechanism

(2010) Dimitra Zotos et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Basophils Support the Survival of Plasma Cells in Mice

(2010) M. R. Gomez et al.   JOURNAL OF IMMUNOLOGY

Adenovirus Membrane Penetration Activates the NLRP3 Inflammasome

(2010) A. U. Barlan et al.   JOURNAL OF VIROLOGY

PD-1 regulates germinal center B cell survival and the formation and affinity of long-lived plasma cells

(2010) Kim L Good-Jacobson et al.   NATURE IMMUNOLOGY

Reversible Microbial Colonization of Germ-Free Mice Reveals the Dynamics of IgA Immune Responses

(2010) S. Hapfelmeier et al.   SCIENCE

The Plasmodium falciparum-Specific Human Memory B Cell Compartment Expands Gradually with Repeated Malaria Infections

(2010) Greta E. Weiss et al.   PLoS Pathogens

B-cell fate decisions following influenza virus infection

(2009) Kristina Rothaeusler et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Taking Advantage: High-Affinity B Cells in the Germinal Center Have Lower Death Rates, but Similar Rates of Division, Compared to Low-Affinity Cells

(2009) S. M. Anderson et al.   JOURNAL OF IMMUNOLOGY

Atypical Memory B Cells Are Greatly Expanded in Individuals Living in a Malaria-Endemic Area

(2009) G. E. Weiss et al.   JOURNAL OF IMMUNOLOGY

Alum Induces Innate Immune Responses through Macrophage and Mast Cell Sensors, But These Sensors Are Not Required for Alum to Act As an Adjuvant for Specific Immunity

(2009) A. S. McKee et al.   JOURNAL OF IMMUNOLOGY

Antigen Affinity Controls Rapid T-Dependent Antibody Production by Driving the Expansion Rather than the Differentiation or Extrafollicular Migration of Early Plasmablasts

(2009) T. D. Chan et al.   JOURNAL OF IMMUNOLOGY

Multiple layers of B cell memory with different effector functions

(2009) Ismail Dogan et al.   NATURE IMMUNOLOGY

Recruitment of the cytoplasmic adaptor Grb2 to surface IgG and IgE provides antigen receptor–intrinsic costimulation to class-switched B cells

(2009) Niklas Engels et al.   NATURE IMMUNOLOGY

CD93 is required for maintenance of antibody secretion and persistence of plasma cells in the bone marrow niche

(2009) S. Chevrier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

APRIL is critical for plasmablast survival in the bone marrow and poorly expressed by early-life bone marrow stromal cells

(2008) E. Belnoue et al.   BLOOD

Vaccine Adjuvants Alter TCR-Based Selection Thresholds

(2008) Laurent Malherbe et al.   IMMUNITY

Neutralizing antibodies derived from the B cells of 1918 influenza pandemic survivors

(2008) Xiaocong Yu et al.   NATURE

Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants

(2008) Stephanie C. Eisenbarth et al.   NATURE

Autoreactive IgG memory antibodies in patients with systemic lupus erythematosus arise from nonreactive and polyreactive precursors

(2008) B. Mietzner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Maintenance of the plasma cell pool is independent of memory B cells

(2008) A. Ahuja et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA