T‐bet + memory B cells: Generation, function, and fate

IL-21 drives expansion and plasma cell differentiation of autoreactive CD11chiT-bet+ B cells in SLE

(2018) Shu Wang et al.   Nature Communications

Transient T-bet expression functionally specifies a distinct T follicular helper subset

(2018) Difeng Fang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

T-Bet + IgM Memory Cells Generate Multi-lineage Effector B Cells

(2018) Kevin J. Kenderes et al.   Cell Reports

Distinct Effector B Cells Induced by Unregulated Toll-like Receptor 7 Contribute to Pathogenic Responses in Systemic Lupus Erythematosus

(2018) Scott A. Jenks et al.   IMMUNITY

A TLR9-dependent checkpoint governs B cell responses to DNA-containing antigens

(2017) Vishal J. Sindhava et al.   JOURNAL OF CLINICAL INVESTIGATION

B cells expressing the transcription factor T-bet drive lupus-like autoimmunity

(2017) Kira Rubtsova et al.   JOURNAL OF CLINICAL INVESTIGATION

Antibody-secreting plasma cells persist for decades in human intestine

(2017) Ole J.B. Landsverk et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Age-Associated B Cells Express a Diverse Repertoire of VHand Vκ Genes with Somatic Hypermutation

(2017) Lisa M. Russell Knode et al.   JOURNAL OF IMMUNOLOGY

Early derivation of IgM memory cells and bone marrow plasmablasts

(2017) Amber M. Papillion et al.   PLoS One

Malaria-induced interferon-γ drives the expansion of Tbethi atypical memory B cells

(2017) Nyamekye Obeng-Adjei et al.   PLoS Pathogens

T-bet-Expressing B Cells Are Positively Associated with Crohn's Disease Activity and Support Th1 Inflammation

(2016) Zhenlong Wang et al.   DNA AND CELL BIOLOGY

A Temporal Switch in the Germinal Center Determines Differential Output of Memory B and Plasma Cells

(2016) Florian J. Weisel et al.   IMMUNITY

Cutting Edge: IL-4, IL-21, and IFN-γ Interact To Govern T-bet and CD11c Expression in TLR-Activated B Cells

(2016) Martin S. Naradikian et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: B Cell–Intrinsic T-bet Expression Is Required To Control Chronic Viral Infection

(2016) Burton E. Barnett et al.   JOURNAL OF IMMUNOLOGY

Hepatitis C viraemia reversibly maintains subset of antigen-specific T-bet+ tissue-like memory B cells

(2016) L.-Y. Chang et al.   JOURNAL OF VIRAL HEPATITIS

Human memory B cells

(2016) M Seifert et al.   LEUKEMIA

Defining antigen-specific plasmablast and memory B cell subsets in human blood after viral infection or vaccination

(2016) Ali H Ellebedy et al.   NATURE IMMUNOLOGY

T Cell Production of IFNγ in Response to TLR7/IL-12 Stimulates Optimal B Cell Responses to Viruses

(2016) Kira Rubtsova et al.   PLoS One

Patients with Tuberculosis Have a Dysfunctional Circulating B-Cell Compartment, Which Normalizes following Successful Treatment

(2016) Simone A. Joosten et al.   PLoS Pathogens

A unique population of IgG-expressing plasma cells lacking CD19 is enriched in human bone marrow

(2015) H. E. Mei et al.   BLOOD

TLR7, IFNγ, and T-bet: Their roles in the development of ABCs in female-biased autoimmunity

(2015) Kira Rubtsova et al.   CELLULAR IMMUNOLOGY

Long-Lived Plasma Cells Are Contained within the CD19−CD38hiCD138+ Subset in Human Bone Marrow

(2015) Jessica L. Halliley et al.   IMMUNITY

Age-associated B cells: key mediators of both protective and autoreactive humoral responses

(2015) Martin S. Naradikian et al.   IMMUNOLOGICAL REVIEWS

The V Gene Repertoires of Classical and Atypical Memory B Cells in Malaria-Susceptible West African Children

(2015) Severin Zinöcker et al.   JOURNAL OF IMMUNOLOGY

Age-Associated B Cells: A T-bet–Dependent Effector with Roles in Protective and Pathogenic Immunity

(2015) Kira Rubtsova et al.   JOURNAL OF IMMUNOLOGY

CD11c-Expressing B Cells Are Located at the T Cell/B Cell Border in Spleen and Are Potent APCs

(2015) Anatoly V. Rubtsov et al.   JOURNAL OF IMMUNOLOGY

Tissue-Resident Memory T Cells

(2014) Jason M. Schenkel et al.   IMMUNITY

CD11c Expression Identifies a Population of Extrafollicular Antigen-Specific Splenic Plasmablasts Responsible for CD4 T-Independent Antibody Responses during Intracellular Bacterial Infection

(2014) R. Racine et al.   JOURNAL OF IMMUNOLOGY

Lasting Antibody Responses Are Mediated by a Combination of Newly Formed and Established Bone Marrow Plasma Cells Drawn from Clonally Distinct Precursors

(2014) Irene Chernova et al.   JOURNAL OF IMMUNOLOGY

CD80 and PD-L2 define functionally distinct memory B cell subsets that are independent of antibody isotype

(2014) Griselda V Zuccarino-Catania et al.   NATURE IMMUNOLOGY

CD73 Expression Is Dynamically Regulated in the Germinal Center and Bone Marrow Plasma Cells Are Diminished in Its Absence

(2014) Laura J. Conter et al.   PLoS One

In senescence, age-associated B cells secrete TNFα and inhibit survival of B-cell precursors*

(2013) Michelle Ratliff et al.   AGING CELL

Broadly Neutralizing Antiviral Antibodies

(2013) Davide Corti et al.   Annual Review of Immunology

Review of thoracic duct anatomical variations and clinical implications

(2013) K. Phang et al.   CLINICAL ANATOMY

How specific is too specific? B-cell responses to viral infections reveal the importance of breadth over depth

(2013) Nicole Baumgarth   IMMUNOLOGICAL REVIEWS

Atypical and classical memory B cells producePlasmodium falciparumneutralizing antibodies

(2013) Matthias F. Muellenbeck et al.   JOURNAL OF EXPERIMENTAL MEDICINE

T Cell-Dependent IgM Memory B Cells Generated during Bacterial Infection Are Required for IgG Responses to Antigen Challenge

(2013) J. L. Yates et al.   JOURNAL OF IMMUNOLOGY

SLE Peripheral Blood B Cell, T Cell and Myeloid Cell Transcriptomes Display Unique Profiles and Each Subset Contributes to the Interferon Signature

(2013) Amy M. Becker et al.   PLoS One

T-box transcription factor T-bet, a key player in a unique type of B-cell activation essential for effective viral clearance

(2013) Kira Rubtsova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expansion of Autoreactive Unresponsive CD21−/lowB Cells in Sjögren's Syndrome-Associated Lymphoproliferation

(2012) D. Saadoun et al.   ARTHRITIS AND RHEUMATISM

TLR7 drives accumulation of ABCs and autoantibody production in autoimmune-prone mice

(2012) Anatoly V. Rubtsov et al.   IMMUNOLOGIC RESEARCH

Divergent transcriptional programming of class-specific B cell memory by T-bet and RORα

(2012) Nathaniel S Wang et al.   NATURE IMMUNOLOGY

A B-cell subset uniquely responsive to innate stimuli accumulates in aged mice

(2011) Y. Hao et al.   BLOOD

Human memory B cells originate from three distinct germinal center-dependent and -independent maturation pathways

(2011) M. A. Berkowska et al.   BLOOD

Toll-like receptor 7 (TLR7)-driven accumulation of a novel CD11c+ B-cell population is important for the development of autoimmunity

(2011) A. V. Rubtsov et al.   BLOOD

Clonal B cells in patients with hepatitis C virus-associated mixed cryoglobulinemia contain an expanded anergic CD21low B-cell subset

(2011) E. D. Charles et al.   BLOOD

Complex regulation and function of activation-induced cytidine deaminase

(2011) Janet Stavnezer   TRENDS IN IMMUNOLOGY

Complement receptor 2/CD21- human naive B cells contain mostly autoreactive unresponsive clones

(2010) I. Isnardi et al.   BLOOD

Cutting Edge: Hierarchy of Maturity of Murine Memory B Cell Subsets

(2010) M. M. Tomayko et al.   JOURNAL OF IMMUNOLOGY

IgM Production by Bone Marrow Plasmablasts Contributes to Long-Term Protection against Intracellular Bacterial Infection

(2010) R. Racine et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: The Transcription Factor Eomesodermin Enables CD8+ T Cells To Compete for the Memory Cell Niche

(2010) A. Banerjee et al.   JOURNAL OF IMMUNOLOGY

Polyreactivity increases the apparent affinity of anti-HIV antibodies by heteroligation

(2010) Hugo Mouquet et al.   NATURE

Atypical Memory B Cells Are Greatly Expanded in Individuals Living in a Malaria-Endemic Area

(2009) G. E. Weiss et al.   JOURNAL OF IMMUNOLOGY

Circulating CD21low B cells in common variable immunodeficiency resemble tissue homing, innate-like B cells

(2009) M. Rakhmanov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Increased expression of T-bet in circulating B cells from a patient with multiple sclerosis and celiac disease

(2008) Giovanni Frisullo et al.   HUMAN IMMUNOLOGY

Evidence for HIV-associated B cell exhaustion in a dysfunctional memory B cell compartment in HIV-infected viremic individuals

(2008) Susan Moir et al.   JOURNAL OF EXPERIMENTAL MEDICINE