Nimbolide retards T cell lymphoma progression by altering apoptosis, glucose metabolism, pH regulation, and ROS homeostasis

Incidence and risk markers of 5-fluorouracil and capecitabine cardiotoxicity in patients with colorectal cancer

(2020) Anne Dyhl-Polk et al.   ACTA ONCOLOGICA

ROS induced p53 activation: DNA damage, redox signaling or both?

(2020) Tao Shi et al.   ANTIOXIDANTS & REDOX SIGNALING

Regulators of glucose uptake in thyroid cancer cell lines

(2020) Shabnam Heydarzadeh et al.   Cell Communication and Signaling

HKDC1 promotes the tumorigenesis and glycolysis in lung adenocarcinoma via regulating AMPK/mTOR signaling pathway

(2020) Xinyu Wang et al.   Cancer Cell International

Nimbolide induces cell death in T lymphoma cells: Implication of altered apoptosis and glucose metabolism

(2020) Pradip Kumar Jaiswara et al.   ENVIRONMENTAL TOXICOLOGY

The p53/LDHA axis negatively regulates aerobic glycolysis and tumor progression in breast cancer expressing wild-type p53

(2019) Yao Zhou et al.   CANCER SCIENCE

What is pH regulation, and why do cancer cells need it?

(2019) Pawel Swietach   CANCER AND METASTASIS REVIEWS

Nimbolide Represses the Proliferation, Migration, and Invasion of Bladder Carcinoma Cells via Chk2-Mediated G2/M Phase Cell Cycle Arrest, Altered Signaling Pathways, and Reduced Transcription Factors-Associated MMP-9 Expression

(2019) Seung-Shick Shin et al.   Evidence-based Complementary and Alternative Medicine

New Insights into Mechanisms of Cisplatin Resistance: From Tumor Cell to Microenvironment

(2019) Shang-Hung Chen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Matrine Reverses the Warburg Effect and Suppresses Colon Cancer Cell Growth via Negatively Regulating HIF-1α

(2019) Xiaoting Hong et al.   Frontiers in Pharmacology

Lactate in the Regulation of Tumor Microenvironment and Therapeutic Approaches

(2019) Karen G. de la Cruz-López et al.   Frontiers in Oncology

Lysophosphatidic acid promotes survival of T lymphoma cells by altering apoptosis and glucose metabolism

(2019) Vishal Kumar Gupta et al.   APOPTOSIS

Glucose transporters in cancer - from tumor cells to the tumor microenvironment

(2018) Pierre-Benoit Ancey et al.   FEBS Journal

Antitumor action of 3-bromopyruvate implicates reorganized tumor growth regulatory components of tumor milieu, cell cycle arrest and induction of mitochondria-dependent tumor cell death

(2018) Saveg Yadav et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Nimbolide, a neem limonoid inhibits cytoprotective autophagy to activate apoptosis via modulation of the PI3K/Akt/GSK-3β signalling pathway in oral cancer

(2018) Josephraj Sophia et al.   Cell Death & Disease

Preventive Effect of Curcumin Against Chemotherapy-Induced Side-Effects

(2018) Zhijun Liu et al.   Frontiers in Pharmacology

NK Cell Effector Functions Regulation by Modulating nTreg Cell Population During Progressive Growth of Dalton’s Lymphoma in Mice

(2017) Munendra Singh Tomar et al.   IMMUNOLOGICAL INVESTIGATIONS

Value of pH regulators in the diagnosis, prognosis and treatment of cancer

(2017) Sara Granja et al.   SEMINARS IN CANCER BIOLOGY

Resveratrol reverses the Warburg effect by targeting the pyruvate dehydrogenase complex in colon cancer cells

(2017) Elise Saunier et al.   Scientific Reports

The sweet trap in tumors: aerobic glycolysis and potential targets for therapy

(2016) Li Yu et al.   Oncotarget

Anticancer properties of nimbolide and pharmacokinetic considerations to accelerate its development

(2016) Lingzhi Wang et al.   Oncotarget

Inhibition of cancer antioxidant defense by natural compounds

(2016) Alicja Sznarkowska et al.   Oncotarget

Nimbolide inhibits pancreatic cancer growth and metastasis through ROS-mediated apoptosis and inhibition of epithelial-to-mesenchymal transition

(2016) Ramadevi Subramani et al.   Scientific Reports

Curcumin inhibits aerobic glycolysis and induces mitochondrial-mediated apoptosis through hexokinase II in human colorectal cancer cells in vitro

(2015) Ke Wang et al.   ANTI-CANCER DRUGS

Nimbolide Induces ROS-Regulated Apoptosis and Inhibits Cell Migration in Osteosarcoma

(2015) Ju-Fang Liu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Nimbolide inhibits invasion and migration, and down-regulates uPAR chemokine gene expression, in two breast cancer cell lines

(2014) P. Elumalai et al.   CELL PROLIFERATION

Chemopreventive and therapeutic effects of nimbolide in cancer: The underlying mechanisms

(2014) Lakshmi Narendra Bodduluru et al.   TOXICOLOGY IN VITRO

Nimbolide targets BCL2 and induces apoptosis in preclinical models of Waldenströms macroglobulinemia

(2014) K Chitta et al.   Blood Cancer Journal

Hexokinase 2-Mediated Warburg Effect Is Required for PTEN- and p53-Deficiency-Driven Prostate Cancer Growth

(2014) Lei Wang et al.   Cell Reports

Acidic extracellular microenvironment and cancer

(2013) Yasumasa Kato et al.   Cancer Cell International

Direct Inhibition of Retinoblastoma Phosphorylation by Nimbolide Causes Cell-Cycle Arrest and Suppresses Glioblastoma Growth

(2013) S. Karkare et al.   CLINICAL CANCER RESEARCH

Nimbolide, a Limonoid Triterpene, Inhibits Growth of Human Colorectal Cancer Xenografts by Suppressing the Proinflammatory Microenvironment

(2013) S. C. Gupta et al.   CLINICAL CANCER RESEARCH

Tumor glycolysis as a target for cancer therapy: progress and prospects

(2013) Shanmugasundaram Ganapathy-Kanniappan et al.   Molecular Cancer

Myelopoietic Efficacy of Orlistat in Murine Hosts Bearing T Cell Lymphoma: Implication in Macrophage Differentiation and Activation

(2013) Shiva Kant et al.   PLoS One

Antitumor and chemosensitizing action of dichloroacetate implicates modulation of tumor microenvironment: A role of reorganized glucose metabolism, cell survival regulation and macrophage differentiation

(2013) Ajay Kumar et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Cancer Prevention with Promising Natural Products: Mechanisms of Action and Molecular Targets

(2012) Poyil Pratheeshkumar et al.   Anti-Cancer Agents in Medicinal Chemistry

The critical role of catalase in prooxidant and antioxidant function of p53

(2012) M Y Kang et al.   CELL DEATH AND DIFFERENTIATION

Novel molecular mechanisms of antitumor action of dichloroacetate against T cell lymphoma: Implication of altered glucose metabolism, pH homeostasis and cell survival regulation

(2012) Ajay Kumar et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Progressive increase of glucose transporter-3 (GLUT-3) expression in estrogen-induced breast carcinogenesis

(2012) M. A. Kocdor et al.   Clinical & Translational Oncology

Progressive growth of a murine T cell lymphoma alters population kinetics and cell viability of macrophages in a tumor-bearing host

(2012) Pramod K. Gautam et al.   TUMOR BIOLOGY

Oxidative Stress and Antioxidant Defense

(2012) Esra Birben et al.   World Allergy Organization Journal

Regulation of Monocarboxylate Transporter MCT1 Expression by p53 Mediates Inward and Outward Lactate Fluxes in Tumors

(2011) R. Boidot et al.   CANCER RESEARCH

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiforme

(2011) Amparo Wolf et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The neem limonoids azadirachtin and nimbolide induce cell cycle arrest and mitochondria-mediated apoptosis in human cervical cancer (HeLa) cells

(2010) R. Vidya Priyadarsini et al.   FREE RADICAL RESEARCH

Reactive oxygen species in cancer

(2010) Geou-Yarh Liou et al.   FREE RADICAL RESEARCH

Tumour hypoxia induces a metabolic shift causing acidosis: a common feature in cancer

(2010) Johanna Chiche et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Phytochemicals in Cancer Prevention and Therapy: Truth or Dare?

(2010) Maria Russo et al.   Toxins

The neem limonoids azadirachtin and nimbolide inhibit cell proliferation and induce apoptosis in an animal model of oral oncogenesis

(2009) G. Harish Kumar et al.   INVESTIGATIONAL NEW DRUGS

The Warburg Effect Suppresses Oxidative Stress Induced Apoptosis in a Yeast Model for Cancer

(2009) Christoph Ruckenstuhl et al.   PLoS One

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

ROS and p53: A versatile partnership

(2008) Bin Liu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nimbolide a limonoid from Azadirachta indica inhibits proliferation and induces apoptosis of human choriocarcinoma (BeWo) cells

(2008) G. Harish Kumar et al.   INVESTIGATIONAL NEW DRUGS

5-Fluorouracil: Mechanisms of Resistance and Reversal Strategies

(2008) Ning Zhang et al.   MOLECULES

p53 regulates glucose metabolism through an IKK-NF-κB pathway and inhibits cell transformation

(2008) Keiko Kawauchi et al.   NATURE CELL BIOLOGY