Nimbolide induces cell death in T lymphoma cells: Implication of altered apoptosis and glucose metabolism

Cancer cells change their glucose metabolism to overcome increased ROS: One step from cancer cell to cancer stem cell?

(2019) Zahra Ghanbari Movahed et al.   BIOMEDICINE & PHARMACOTHERAPY

Lysophosphatidic acid promotes survival of T lymphoma cells by altering apoptosis and glucose metabolism

(2019) Vishal Kumar Gupta et al.   APOPTOSIS

Epoxyazadiradione suppresses breast tumor growth through mitochondrial depolarization and caspase-dependent apoptosis by targeting PI3K/Akt pathway

(2018) Dhiraj Kumar et al.   BMC CANCER

Glucose transporters in cancer - from tumor cells to the tumor microenvironment

(2018) Pierre-Benoit Ancey et al.   FEBS Journal

Apoptosis: A Target for Anticancer Therapy

(2018) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

BCL-2 as therapeutic target for hematological malignancies

(2018) Guilherme Fleury Perini et al.   Journal of Hematology & Oncology

Antitumor action of 3-bromopyruvate implicates reorganized tumor growth regulatory components of tumor milieu, cell cycle arrest and induction of mitochondria-dependent tumor cell death

(2018) Saveg Yadav et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Nimbolide, a neem limonoid inhibits cytoprotective autophagy to activate apoptosis via modulation of the PI3K/Akt/GSK-3β signalling pathway in oral cancer

(2018) Josephraj Sophia et al.   Cell Death & Disease

Cytotoxicity of nimbolide towards multidrug-resistant tumor cells and hypersensitivity via cellular metabolic modulation

(2018) Nuha Mahmoud et al.   Oncotarget

Cytotoxic action of acetate on tumor cells of thymic origin: Role of MCT-1, pH homeostasis and altered cell survival regulation

(2018) Shrish Kumar Pandey et al.   BIOCHIMIE

Epoxyazadiradione Purified from the Azadirachta indica Seed Induced Mitochondrial Apoptosis and Inhibition of NFκB Nuclear Translocation in Human Cervical Cancer Cells

(2017) G. Shilpa et al.   PHYTOTHERAPY RESEARCH

Nimbolide upregulates RECK by targeting miR-21 and HIF-1α in cell lines and in a hamster oral carcinogenesis model

(2017) Jaganathan Kowshik et al.   Scientific Reports

A comprehensive characterization of the impact of mycophenolic acid on the metabolism of Jurkat T cells

(2017) Ana A. Fernández-Ramos et al.   Scientific Reports

The Emerging Hallmarks of Cancer Metabolism

(2016) Natalya N. Pavlova et al.   Cell Metabolism

Therapeutics Role ofAzadirachta indica(Neem) and Their Active Constituents in Diseases Prevention and Treatment

(2016) Mohammad A. Alzohairy   Evidence-based Complementary and Alternative Medicine

The Role of the Reactive Oxygen Species and Oxidative Stress in the Pathomechanism of the Age-Related Ocular Diseases and Other Pathologies of the Anterior and Posterior Eye Segments in Adults

(2016) Małgorzata Nita et al.   Oxidative Medicine and Cellular Longevity

The sweet trap in tumors: aerobic glycolysis and potential targets for therapy

(2016) Li Yu et al.   Oncotarget

Anticancer properties of nimbolide and pharmacokinetic considerations to accelerate its development

(2016) Lingzhi Wang et al.   Oncotarget

Nimbolide inhibits pancreatic cancer growth and metastasis through ROS-mediated apoptosis and inhibition of epithelial-to-mesenchymal transition

(2016) Ramadevi Subramani et al.   Scientific Reports

Targeting Tumor Metabolism for Cancer Treatment: Is Pyruvate Dehydrogenase Kinases (PDKs) a Viable Anticancer Target?

(2015) Wen Zhang et al.   International Journal of Biological Sciences

Nimbolide Induces ROS-Regulated Apoptosis and Inhibits Cell Migration in Osteosarcoma

(2015) Ju-Fang Liu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Metabolic reprogramming: the emerging concept and associated therapeutic strategies

(2015) Go J. Yoshida   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Rapamycin Suppresses Tumor Growth and Alters the Metabolic Phenotype in T-Cell Lymphoma

(2015) Wasakorn Kittipongdaja et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Induction of cell cycle arrest, DNA damage, and apoptosis by nimbolide in human renal cell carcinoma cells

(2015) Yi-Hsien Hsieh et al.   TUMOR BIOLOGY

Bicarbonate transport inhibitor SITS modulates pH homeostasis triggering apoptosis of Dalton’s lymphoma: implication of novel molecular mechanisms

(2014) Shiva Kant et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Chemopreventive and therapeutic effects of nimbolide in cancer: The underlying mechanisms

(2014) Lakshmi Narendra Bodduluru et al.   TOXICOLOGY IN VITRO

Nimbolide targets BCL2 and induces apoptosis in preclinical models of Waldenströms macroglobulinemia

(2014) K Chitta et al.   Blood Cancer Journal

HIF-1-mediated metabolic reprogramming reduces ROS levels and facilitates the metastatic colonization of cancers in lungs

(2014) Tao Zhao et al.   Scientific Reports

BH4 domain of bcl-2 protein is required for its proangiogenic function under hypoxic condition

(2013) Chiara Gabellini et al.   CARCINOGENESIS

Antitumor and chemosensitizing action of dichloroacetate implicates modulation of tumor microenvironment: A role of reorganized glucose metabolism, cell survival regulation and macrophage differentiation

(2013) Ajay Kumar et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

α-Cyano-4-hydroxycinnamate induces apoptosis in Dalton’s lymphoma cells

(2012) Ajay Kumar et al.   ANTI-CANCER DRUGS

Novel molecular mechanisms of antitumor action of dichloroacetate against T cell lymphoma: Implication of altered glucose metabolism, pH homeostasis and cell survival regulation

(2012) Ajay Kumar et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Hypoxia-inducible factors and their roles in energy metabolism

(2012) Nobuhito Goda et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Novel Anti-inflammatory Activity of Epoxyazadiradione against Macrophage Migration Inhibitory Factor

(2012) Athar Alam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MDM2 Inhibitor Nutlin-3a Induces Apoptosis and Senescence in Cutaneous T-Cell Lymphoma: Role of p53

(2012) Valentina Manfé et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Induction of apoptosis in human breast cancer cells by nimbolide through extrinsic and intrinsic pathway

(2012) P. Elumalai et al.   TOXICOLOGY LETTERS

Anticancer Targets in the Glycolytic Metabolism of Tumors: A Comprehensive Review

(2011) Paolo E. Porporato et al.   Frontiers in Pharmacology

Balancing biosynthesis and bioenergetics: metabolic programs in oncogenesis

(2010) Jennifer F Barger et al.   ENDOCRINE-RELATED CANCER

The neem limonoids azadirachtin and nimbolide induce cell cycle arrest and mitochondria-mediated apoptosis in human cervical cancer (HeLa) cells

(2010) R. Vidya Priyadarsini et al.   FREE RADICAL RESEARCH

Modification of Cysteine 179 of IκBα Kinase by Nimbolide Leads to Down-regulation of NF-κB-regulated Cell Survival and Proliferative Proteins and Sensitization of Tumor Cells to Chemotherapeutic Agents

(2010) Subash C. Gupta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bcl-2 Regulates HIF-1α Protein Stabilization in Hypoxic Melanoma Cells via the Molecular Chaperone HSP90

(2010) Daniela Trisciuoglio et al.   PLoS One

HIF-1α Modulates Energy Metabolism in Cancer Cells by Inducing Over-Expression of Specific Glycolytic Isoforms

(2009) Alvaro Marin-Hernandez et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Nimbolide a limonoid from Azadirachta indica inhibits proliferation and induces apoptosis of human choriocarcinoma (BeWo) cells

(2008) G. Harish Kumar et al.   INVESTIGATIONAL NEW DRUGS

The p53 family and programmed cell death

(2008) E C Pietsch et al.   ONCOGENE