Interplay Between GH-regulated, Sex-biased Liver Transcriptome and Hepatic Zonation Revealed by Single-Nucleus RNA Sequencing

Androgens increase excitatory neurogenic potential in human brain organoids

(2022) Iva Kelava et al.   NATURE

Constitutively Active STAT5b Feminizes Mouse Liver Gene Expression

(2022) Dana Lau-Corona et al.   ENDOCRINOLOGY

Regulation of Sexually Dimorphic Expression of Major Urinary Proteins

(2022) Dustin J. Penn et al.   Frontiers in Physiology

Global analysis of expression, maturation and subcellular localization of mouse liver transcriptome identifies novel sex-biased and TCPOBOP-responsive long non-coding RNAs

(2021) Christine N. Goldfarb et al.   BMC GENOMICS

Clinical impact of sexual dimorphism in non‐alcoholic fatty liver disease (NAFLD) and non‐alcoholic steatohepatitis (NASH)

(2021) Patrizia Burra et al.   LIVER INTERNATIONAL

Hepatic steatosis and steatohepatitis: a functional meta-analysis of sex-based differences in transcriptomic studies

(2021) José F. Català-Senent et al.   Biology of Sex Differences

Long Noncoding RNAs and Human Liver Disease

(2021) Johanna K. DiStefano et al.   Annual Review of Pathology-Mechanisms of Disease

Sex-dependent dynamics of metabolism in primary mouse hepatocytes

(2021) Luise Hochmuth et al.   ARCHIVES OF TOXICOLOGY

Distinct roles of androgen receptor, estrogen receptor alpha, and BCL6 in the establishment of sex-biased DNA methylation in mouse liver

(2021) Najla AlOgayil et al.   Scientific Reports

The Landscape of lncRNAs in Hepatocellular Carcinoma: A Translational Perspective

(2021) Juan Pablo Unfried et al.   Cancers

Targeting epigenetics and lncRNAs in liver disease: From mechanisms to therapeutics

(2021) Xiao-Fei Peng et al.   PHARMACOLOGICAL RESEARCH

Single-cell RNA transcriptome landscape of hepatocytes and non-parenchymal cells in healthy and NAFLD mouse liver

(2021) Qi Su et al.   iScience

The Roles and Mechanisms of lncRNAs in Liver Fibrosis

(2020) Zhi He et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Regulation of gene expression by growth hormone

(2020) Peter Rotwein   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Widespread dysregulation of long non-coding genes associated with fatty acid metabolism, cell division, and immune response gene networks in xenobiotic-exposed rat liver

(2020) Kritika Karri et al.   TOXICOLOGICAL SCIENCES

Women have Lower Risk of Nonalcoholic Fatty Liver Disease but Higher Risk of Progression vs Men: A Systematic Review and Meta-analysis

(2020) Maya Balakrishnan et al.   Clinical Gastroenterology and Hepatology

Epigenetic modifications in the GH-dependent Prlr, Hnf6, Cyp7b1, Adh1 and Cyp2a4 genes

(2020) Belen Brie et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

NAFLD and NASH in postmenopausal women: implications for diagnosis and treatment

(2020) Johanna K DiStefano   ENDOCRINOLOGY

Reporting animal research: Explanation and elaboration for the ARRIVE guidelines 2.0

(2020) Nathalie Percie du Sert et al.   PLOS BIOLOGY

Single nuclei RNA sequencing assessment of the hepatic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin

(2020) Rance Nault et al.   Cellular and Molecular Gastroenterology and Hepatology

A novel prognostic index of hepatocellular carcinoma based on immunogenomic landscape analysis

(2020) Han Xiao et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Controversies Surrounding the Origin of Hepatocytes in Adult Livers and the in Vitro Generation or Propagation of Hepatocytes

(2020) Nicole Min Qian Pek et al.   Cellular and Molecular Gastroenterology and Hepatology

STAT5 Regulation of Sex-Dependent Hepatic CpG Methylation at Distal Regulatory Elements Mapping to Sex-Biased Genes

(2020) Pengying Hao et al.   MOLECULAR AND CELLULAR BIOLOGY

The absence of hepatic glucose-6 phosphatase/ChREBP couple is incompatible with survival in mice

(2020) Fabienne Rajas et al.   Molecular Metabolism

Propagation of pericentral necrosis during acetaminophen-induced liver injury: evidence for early interhepatocyte communication and information-exchange

(2019) Ryan C Kennedy et al.   TOXICOLOGICAL SCIENCES

Cellular functions of long noncoding RNAs

(2019) Run-Wen Yao et al.   NATURE CELL BIOLOGY

Spatial heterogeneity in the mammalian liver

(2019) Shani Ben-Moshe et al.   Nature Reviews Gastroenterology & Hepatology

DoubletFinder: Doublet Detection in Single-Cell RNA Sequencing Data Using Artificial Nearest Neighbors

(2019) Christopher S. McGinnis et al.   Cell Systems

Comprehensive Integration of Single-Cell Data

(2019) Tim Stuart et al.   CELL

A human liver cell atlas reveals heterogeneity and epithelial progenitors

(2019) Nadim Aizarani et al.   NATURE

Sexual Dimorphism in Drug Metabolism and Pharmacokinetics

(2019) Askhi M. Valodara et al.   CURRENT DRUG METABOLISM

Fast, sensitive and accurate integration of single-cell data with Harmony

(2019) Ilya Korsunsky et al.   NATURE METHODS

Single-Cell Transcriptomics Uncovers Zonation of Function in the Mesenchyme during Liver Fibrosis

(2019) Ross Dobie et al.   Cell Reports

Sex-Related Differences in Pharmacokinetics and Pharmacodynamics of Frequently Prescribed Drugs: A Review of the Literature

(2019) André Farkouh et al.   ADVANCES IN THERAPY

Wnt/β-Catenin Signaling in Liver Development, Homeostasis, and Pathobiology

(2018) Jacquelyn O. Russell et al.   Annual Review of Pathology-Mechanisms of Disease

TCPOBOP-induced hepatomegaly & hepatocyte proliferation is attenuated by combined disruption of MET & EGFR signaling

(2018) Bharat Bhushan et al.   HEPATOLOGY

Establishment and analysis of a mouse model that regulates sex-related differences in liver drug metabolism

(2018) Hiromi Chikada et al.   LABORATORY INVESTIGATION

Integrating single-cell transcriptomic data across different conditions, technologies, and species

(2018) Andrew Butler et al.   NATURE BIOTECHNOLOGY

Glucagon contributes to liver zonation

(2018) Xiping Cheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High fat diet overfeeding promotes non-detrimental liver steatosis in female mice

(2018) Lino Arisqueta et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Paired-cell sequencing enables spatial gene expression mapping of liver endothelial cells

(2018) Keren Bahar Halpern et al.   NATURE BIOTECHNOLOGY

JAZF1 ameliorates age and diet-associated hepatic steatosis through SREBP-1c -dependent mechanism

(2018) Qin Wei et al.   Cell Death & Disease

Hepatic growth hormone - JAK2 - STAT5 signalling: Metabolic function, non-alcoholic fatty liver disease and hepatocellular carcinoma progression

(2018) Doris Kaltenecker et al.   CYTOKINE

Regulation of Hepatic Long Non-coding RNAs by PXR and CAR Agonists in Mouse Liver

(2018) Joseph L Dempsey et al.   DRUG METABOLISM AND DISPOSITION

Advantages of Single-Nucleus over Single-Cell RNA Sequencing of Adult Kidney: Rare Cell Types and Novel Cell States Revealed in Fibrosis

(2018) Haojia Wu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Single-cell transcriptomics of 20 mouse organs creates a Tabula Muris

(2018) et al.   NATURE

Dimensionality reduction for visualizing single-cell data using UMAP

(2018) Etienne Becht et al.   NATURE BIOTECHNOLOGY

Single-nucleus and single-cell transcriptomes compared in matched cortical cell types

(2018) Trygve E. Bakken et al.   PLoS One

Sexual dimorphism in hepatitis B and C and hepatocellular carcinoma

(2018) Nico Buettner et al.   Seminars in Immunopathology

Single cell RNA sequencing of human liver reveals distinct intrahepatic macrophage populations

(2018) Sonya A. MacParland et al.   Nature Communications

Tissue-specific pathways and networks underlying sexual dimorphism in non-alcoholic fatty liver disease

(2018) Zeyneb Kurt et al.   Biology of Sex Differences

Activation of Male Liver Chromatin Accessibility and STAT5-Dependent Gene Transcription by Plasma Growth Hormone Pulses

(2017) Jeannette Connerney et al.   ENDOCRINOLOGY

Feminization of Male Mouse Liver by Persistent Growth Hormone Stimulation: Activation of Sex-Biased Transcriptional Networks and Dynamic Changes in Chromatin States

(2017) Dana Lau-Corona et al.   MOLECULAR AND CELLULAR BIOLOGY

Single-cell spatial reconstruction reveals global division of labour in the mammalian liver

(2017) Keren Bahar Halpern et al.   NATURE

Sex-Differential Responses of Tumor Promotion-Associated Genes and Dysregulation of Novel Long Noncoding RNAs in Constitutive Androstane Receptor-Activated Mouse Liver

(2017) Nicholas J. Lodato et al.   TOXICOLOGICAL SCIENCES

The liver-enriched lnc-LFAR1 promotes liver fibrosis by activating TGFβ and Notch pathways

(2017) Kun Zhang et al.   Nature Communications

Assessment of Single Cell RNA-Seq Normalization Methods

(2017) Bo Ding et al.   G3-Genes Genomes Genetics

Metabolic zonation of the liver: The oxygen gradient revisited

(2017) Thomas Kietzmann   Redox Biology

A comparative strategy for single-nucleus and single-cell transcriptomes confirms accuracy in predicted cell-type expression from nuclear RNA

(2017) Blue B. Lake et al.   Scientific Reports

Divergent Inflammatory, Fibrogenic, and Liver Progenitor Cell Dynamics in Two Common Mouse Models of Chronic Liver Injury

(2016) Julia Köhn-Gaone et al.   AMERICAN JOURNAL OF PATHOLOGY

Dynamic zonation of liver polyploidy

(2016) Sivan Tanami et al.   CELL AND TISSUE RESEARCH

Long live the liver: immunohistochemical and stereological study of hepatocytes, liver sinusoidal endothelial cells, Kupffer cells and hepatic stellate cells of male and female rats throughout ageing

(2016) Ricardo Marcos et al.   CELL AND TISSUE RESEARCH

The growth hormone receptor

(2016) Michael J. Waters   GROWTH HORMONE & IGF RESEARCH

Stereological assessment of sexual dimorphism in the rat liver reveals differences in hepatocytes and Kupffer cells but not hepatic stellate cells

(2016) Ricardo Marcos et al.   JOURNAL OF ANATOMY

Male and female mice show significant differences in hepatic transcriptomic response to 2,3,7,8-tetrachlorodibenzo-p-dioxin

(2015) Jamie Lee et al.   BMC GENOMICS

Somatostatin Is Essential for the Sexual Dimorphism of GH Secretion, Corticosteroid-Binding Globulin Production, and Corticosterone Levels in Mice

(2015) Jessica M. Adams et al.   ENDOCRINOLOGY

Hepatic lincRNAs: high promoter conservation and dynamic, sex-dependent transcriptional regulation by growth hormone

(2015) Tisha Melia et al.   MOLECULAR AND CELLULAR BIOLOGY

Cross Talk Between GH-Regulated Transcription Factors HNF6 and CUX2 in Adult Mouse Liver

(2015) Tara L. Conforto et al.   MOLECULAR ENDOCRINOLOGY

Developmental bisphenol A (BPA) exposure leads to sex-specific modification of hepatic gene expression and epigenome at birth that may exacerbate high-fat diet-induced hepatic steatosis

(2015) Rita S. Strakovsky et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

BAG3 elevation inhibits cell proliferation via direct interaction with G6PD in hepatocellular carcinomas

(2015) De-Hui Kong et al.   Oncotarget

Analysis of long non-coding RNAs highlights tissue-specific expression patterns and epigenetic profiles in normal and psoriatic skin

(2015) Lam C Tsoi et al.   GENOME BIOLOGY

Overexpression of Jazf1 reduces body weight gain and regulates lipid metabolism in high fat diet

(2014) Woo Young Jang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inhibitory effects of long noncoding RNA MEG3 on hepatic stellate cells activation and liver fibrogenesis

(2014) Yong He et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Fatty acid elongase-5 (Elovl5) regulates hepatic triglyceride catabolism in obese C57BL/6J mice

(2014) Sasmita Tripathy et al.   JOURNAL OF LIPID RESEARCH

Liver zonation: Novel aspects of its regulation and its impact on homeostasis

(2014) Rolf Gebhardt   WORLD JOURNAL OF GASTROENTEROLOGY

Sexual dimorphisms in zonal gene expression in mouse liver

(2013) Kosuke Saito et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Shrinkage estimation of dispersion in Negative Binomial models for RNA-seq experiments with small sample size

(2013) Danni Yu et al.   BIOINFORMATICS

The Tissue-Specific lncRNA Fendrr Is an Essential Regulator of Heart and Body Wall Development in the Mouse

(2013) Phillip Grote et al.   DEVELOPMENTAL CELL

Genome-Wide Analysis of Chromatin States Reveals Distinct Mechanisms of Sex-Dependent Gene Regulation in Male and Female Mouse Liver

(2013) A. Sugathan et al.   MOLECULAR AND CELLULAR BIOLOGY

Mouse obesity network reconstruction with a variational Bayes algorithm to employ aggressive false positive control

(2012) Benjamin A Logsdon et al.   BMC BIOINFORMATICS

Foxa1 and Foxa2 Are Essential for Sexual Dimorphism in Liver Cancer

(2012) Zhaoyu Li et al.   CELL

Impact of CUX2 on the Female Mouse Liver Transcriptome: Activation of Female-Biased Genes and Repression of Male-Biased Genes

(2012) T. L. Conforto et al.   MOLECULAR AND CELLULAR BIOLOGY

Growth hormone-STAT5 regulation of growth, hepatocellular carcinoma, and liver metabolism

(2011) Myunggi Baik et al.   Annals of the New York Academy of Sciences

Dynamic, Sex-Differential STAT5 and BCL6 Binding to Sex-Biased, Growth Hormone-Regulated Genes in Adult Mouse Liver

(2011) Y. Zhang et al.   MOLECULAR AND CELLULAR BIOLOGY

RAD51 paralogs: Roles in DNA damage signalling, recombinational repair and tumorigenesis

(2011) Natsuko Suwaki et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Scopolamine Treatment and Muscarinic Receptor Subtype-3 Gene Ablation Augment Azoxymethane-Induced Murine Liver Injury

(2010) S. Khurana et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Unbiased, Genome-Wide In Vivo Mapping of Transcriptional Regulatory Elements Reveals Sex Differences in Chromatin Structure Associated with Sex-Specific Liver Gene Expression

(2010) G. Ling et al.   MOLECULAR AND CELLULAR BIOLOGY

Unravelling the evolutionary origins of X chromosome inactivation in mammals: insights from marsupials and monotremes

(2009) Janine E. Deakin et al.   CHROMOSOME RESEARCH

Sex Differences in the Expression of Hepatic Drug Metabolizing Enzymes

(2009) D. J. Waxman et al.   MOLECULAR PHARMACOLOGY

Sexually dimorphic regulation and induction of P450s by the constitutive androstane receptor (CAR)

(2008) J.P. Hernandez et al.   TOXICOLOGY

Role of sex steroid receptors in pathobiology of hepatocellular carcinoma

(2008) Mamta Kalra et al.   WORLD JOURNAL OF GASTROENTEROLOGY