Sex-Differential Responses of Tumor Promotion-Associated Genes and Dysregulation of Novel Long Noncoding RNAs in Constitutive Androstane Receptor-Activated Mouse Liver

Activation of Male Liver Chromatin Accessibility and STAT5-Dependent Gene Transcription by Plasma Growth Hormone Pulses

(2017) Jeannette Connerney et al.   ENDOCRINOLOGY

Non-coding RNA in hepatocellular carcinoma: Mechanisms, biomarkers and therapeutic targets

(2017) Marcel Klingenberg et al.   JOURNAL OF HEPATOLOGY

Mouse species-specific control of hepatocarcinogenesis and metabolism by FGF19/FGF15

(2017) Mei Zhou et al.   JOURNAL OF HEPATOLOGY

Role of nuclear constitutive androstane receptor in regulation of hepatocyte proliferation and hepatocarcinogenesis

(2016) Y. A. Kazantseva et al.   BIOCHEMISTRY-MOSCOW

RNA-Seq reveals common and unique PXR- and CAR-target gene signatures in the mouse liver transcriptome

(2016) Julia Yue Cui et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Circadian Homeostasis of Liver Metabolism Suppresses Hepatocarcinogenesis

(2016) Nicole M. Kettner et al.   CANCER CELL

Insulated Neighborhoods: Structural and Functional Units of Mammalian Gene Control

(2016) Denes Hnisz et al.   CELL

Local regulation of gene expression by lncRNA promoters, transcription and splicing

(2016) Jesse M. Engreitz et al.   NATURE

CRISPRi-based genome-scale identification of functional long noncoding RNA loci in human cells

(2016) S. John Liu et al.   SCIENCE

Regulation of gene expression by CAR: an update

(2015) Kaoru Kobayashi et al.   ARCHIVES OF TOXICOLOGY

From Discovery to Function: The Expanding Roles of Long NonCoding RNAs in Physiology and Disease

(2015) Miao Sun et al.   ENDOCRINE REVIEWS

Small-molecule modulators of the constitutive androstane receptor

(2015) Milu T Cherian et al.   Expert Opinion on Drug Metabolism & Toxicology

Linking RNA biology to lncRNAs

(2015) Loyal A. Goff et al.   GENOME RESEARCH

Activating CAR and β-catenin induces uncontrolled liver growth and tumorigenesis

(2015) Bingning Dong et al.   Nature Communications

Nuclear Fractionation Reveals Thousands of Chromatin-Tethered Noncoding RNAs Adjacent to Active Genes

(2015) Michael S. Werner et al.   Cell Reports

Comparative Hi-C Reveals that CTCF Underlies Evolution of Chromosomal Domain Architecture

(2015) Matteo Vietri Rudan et al.   Cell Reports

Deciphering the roles of the constitutive androstane receptor in energy metabolism

(2014) Jiong Yan et al.   ACTA PHARMACOLOGICA SINICA

Phenobarbital Induces Cell Cycle Transcriptional Responses in Mouse Liver Humanized for Constitutive Androstane and Pregnane X Receptors

(2014) Raphaëlle Luisier et al.   TOXICOLOGICAL SCIENCES

Dose-Response Modeling of Early Molecular and Cellular Key Events in the CAR-Mediated Hepatocarcinogenesis Pathway

(2014) David R. Geter et al.   TOXICOLOGICAL SCIENCES

CAR-mediated repression of Foxo1 transcriptional activity regulates the cell cycle inhibitor p21 in mouse livers

(2014) Yuliya A. Kazantseva et al.   TOXICOLOGY

Characteristics of long non-coding RNA and its relation to hepatocellular carcinoma

(2013) J.-L. Huang et al.   CARCINOGENESIS

Sex Differences in the Circadian Variation of Cytochrome P450 Genes and Corresponding Nuclear Receptors in Mouse Liver

(2013) Yuan-Fu Lu et al.   CHRONOBIOLOGY INTERNATIONAL

Gene regulation by antisense transcription

(2013) Vicent Pelechano et al.   NATURE REVIEWS GENETICS

Xenobiotic-Induced Hepatocyte Proliferation Associated with Constitutive Active/Androstane Receptor (CAR) or Peroxisome Proliferator-Activated Receptor α (PPARα) Is Enhanced by Pregnane X Receptor (PXR) Activation in Mice

(2013) Ryota Shizu et al.   PLoS One

Estradiol induces cytochrome P450 2B6 expression at high concentrations: Implication in estrogen-mediated gene regulation in pregnancy

(2012) Kwi Hye Koh et al.   BIOCHEMICAL PHARMACOLOGY

Foxa1 and Foxa2 Are Essential for Sexual Dimorphism in Liver Cancer

(2012) Zhaoyu Li et al.   CELL

RNA Polymerase II Collision Interrupts Convergent Transcription

(2012) David J. Hobson et al.   MOLECULAR CELL

Ligand dependent hepatic gene expression profiles of nuclear receptors CAR and PXR

(2012) Hiroki Tojima et al.   TOXICOLOGY LETTERS

The nuclear receptor CAR modulates alcohol-induced liver injury

(2011) Xiaosong Chen et al.   LABORATORY INVESTIGATION

Nuclear receptor CAR (NR1I3) is essential for DDC-induced liver injury and oval cell proliferation in mouse liver

(2011) Yuichi Yamazaki et al.   LABORATORY INVESTIGATION

A function for cyclin D1 in DNA repair uncovered by protein interactome analyses in human cancers

(2011) Siwanon Jirawatnotai et al.   NATURE

Cyclin D1 multitasks

(2011) Jiri Bartek et al.   NATURE

Multi-species Analyses of Direct Activators of the Constitutive Androstane Receptor

(2011) Curtis J. Omiecinski et al.   TOXICOLOGICAL SCIENCES

Constitutive active/androstane receptor promotes hepatocarcinogenesis in a mouse model of non-alcoholic steatohepatitis

(2010) Daichi Takizawa et al.   CARCINOGENESIS

Correlation between expression of p53, p21/WAF1, and MDM2 proteins and their prognostic significance in primary hepatocellular carcinoma

(2009) Mei-Fang Zhang et al.   Journal of Translational Medicine

Sex Differences in the Expression of Hepatic Drug Metabolizing Enzymes

(2009) D. J. Waxman et al.   MOLECULAR PHARMACOLOGY

The nuclear receptor CAR (NR1I3) regulates serum triglyceride levels under conditions of metabolic stress

(2008) Jodi M. Maglich et al.   JOURNAL OF LIPID RESEARCH

Sexually dimorphic regulation and induction of P450s by the constitutive androstane receptor (CAR)

(2008) J.P. Hernandez et al.   TOXICOLOGY

Time-course comparison of xenobiotic activators of CAR and PPARα in mouse liver

(2008) Pamela K. Ross et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Role of sex steroid receptors in pathobiology of hepatocellular carcinoma

(2008) Mamta Kalra et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Xenoreceptors CAR and PXR Activation and Consequences on Lipid Metabolism, Glucose Homeostasis, and Inflammatory Response

(2007) Amélie Moreau et al.   MOLECULAR PHARMACEUTICS