ADAM10 and ADAM17 promote SARS‐CoV‐2 cell entry and spike protein‐mediated lung cell fusion

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SARS-CoV-2 and SARS-CoV spike-mediated cell-cell fusion differ in the requirements for receptor expression and proteolytic activation

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Strategies to Target ADAM17 in Disease: From Its Discovery to the iRhom Revolution

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A genome-wide CRISPR screen identifies host factors that regulate SARS-CoV-2 entry

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Drugs that inhibit TMEM16 proteins block SARS-CoV-2 spike-induced syncytia

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Drug repurposing screens reveal cell-type-specific entry pathways and FDA-approved drugs active against SARS-Cov-2

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The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade

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Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2

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SARS ‐CoV‐2 receptor ACE 2 and TMPRSS 2 are primarily expressed in bronchial transient secretory cells

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The pathogenicity of SARS-CoV-2 in hACE2 transgenic mice

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Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV

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TMPRSS2 and TMPRSS4 promote SARS-CoV-2 infection of human small intestinal enterocytes

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Distribution of ACE2, CD147, CD26 and other SARS‐CoV‐2 associated molecules in tissues and immune cells in health and in asthma, COPD, obesity, hypertension, and COVID‐19 risk factors

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Data, reagents, assays and merits of proteomics for SARS-CoV-2 research and testing

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Longitudinal analyses reveal immunological misfiring in severe COVID-19

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COVID-19 severity correlates with airway epithelium–immune cell interactions identified by single-cell analysis

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An inflammatory cytokine signature predicts COVID-19 severity and survival

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A Simplified Quantitative Real-Time PCR Assay for Monitoring SARS-CoV-2 Growth in Cell Culture

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Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes

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Spike glycoprotein and host cell determinants of SARS-CoV-2 entry and cytopathic effects

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Comparison of Four SARS-CoV-2 Neutralization Assays

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Beyond Bonferroni revisited: concerns over inflated false positive research findings in the fields of conservation genetics, biology, and medicine

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Systematic substrate identification indicates a central role for the metalloprotease ADAM10 in axon targeting and synapse function

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ADAM-family metalloproteinases in lung inflammation: potential therapeutic targets

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ADAM metalloproteases promote a developmental switch in responsiveness to the axonal repellant Sema3A

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TMPRSS2 and ADAM17 Cleave ACE2 Differentially and Only Proteolysis by TMPRSS2 Augments Entry Driven by the Severe Acute Respiratory Syndrome Coronavirus Spike Protein

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The Coxsackievirus and Adenovirus Receptor (CAR) Undergoes Ectodomain Shedding and Regulated Intramembrane Proteolysis (RIP)

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Evidence that TMPRSS2 Activates the Severe Acute Respiratory Syndrome Coronavirus Spike Protein for Membrane Fusion and Reduces Viral Control by the Humoral Immune Response

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ADAM10 is the physiologically relevant, constitutive α-secretase of the amyloid precursor protein in primary neurons

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ADAM17 is regulated by a rapid and reversible mechanism that controls access to its catalytic site

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Pharmacokinetic-Pharmacodynamic Modeling of Apratastat: A Population-Based Approach

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The Disintegrin/Metalloproteinase ADAM10 Is Essential for the Establishment of the Brain Cortex

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Ectodomain shedding of angiotensin converting enzyme 2 in human airway epithelia

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TACE antagonists blocking ACE2 shedding caused by the spike protein of SARS-CoV are candidate antiviral compounds

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Differential Downregulation of ACE2 by the Spike Proteins of Severe Acute Respiratory Syndrome Coronavirus and Human Coronavirus NL63

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ADAMs 10 and 17 Represent Differentially Regulated Components of a General Shedding Machinery for Membrane Proteins Such as Transforming Growth Factor α, L-Selectin, and Tumor Necrosis Factor α

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Human P-selectin glycoprotein ligand-1 is a functional receptor for enterovirus 71

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Modulation of TNF- -converting enzyme by the spike protein of SARS-CoV and ACE2 induces TNF-  production and facilitates viral entry

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Drug Insight: tumor necrosis factor-converting enzyme as a pharmaceutical target for rheumatoid arthritis

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