Urinary Proteomics Identifies Cathepsin D as a Biomarker of Rapid eGFR Decline in Type 1 Diabetes

Rationale and design of the Kidney Precision Medicine Project

(2021) Ian H. de Boer et al.   KIDNEY INTERNATIONAL

Circulating Free Fatty Acid and Phospholipid Signature Predicts Early Rapid Kidney Function Decline in Patients With Type 1 Diabetes

(2021) Farsad Afshinnia et al.   DIABETES CARE

Early detection of diabetic kidney disease by urinary proteomics and subsequent intervention with spironolactone to delay progression (PRIORITY): a prospective observational study and embedded randomised placebo-controlled trial

(2020) Nete Tofte et al.   Lancet Diabetes & Endocrinology

Role of Impaired Nutrient and Oxygen Deprivation Signaling and Deficient Autophagic Flux in Diabetic CKD Development: Implications for Understanding the Effects of Sodium-Glucose Cotransporter 2-Inhibitors

(2020) Milton Packer   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Lysosomal dysfunction–induced autophagic stress in diabetic kidney disease

(2020) Hui Juan Zheng et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

A Targeted Multiomics Approach to Identify Biomarkers Associated with Rapid eGFR Decline in Type 1 Diabetes

(2020) Christine P. Limonte et al.   AMERICAN JOURNAL OF NEPHROLOGY

SARS-CoV-2 receptor networks in diabetic and COVID-19 associated kidney disease

(2020) Rajasree Menon et al.   KIDNEY INTERNATIONAL

Lack of Cathepsin D in the Renal Proximal Tubular Cells Resulted in Increased Sensitivity against Renal Ischemia/Reperfusion Injury

(2019) Chigure Suzuki et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Changes in Albuminuria But Not GFR are Associated with Early Changes in Kidney Structure in Type 2 Diabetes

(2019) Helen C. Looker et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Evaluating Glomerular Filtration Rate Slope as a Surrogate End Point for ESKD in Clinical Trials: An Individual Participant Meta-Analysis of Observational Data

(2019) Morgan E. Grams et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Lysosome restoration to activate podocyte autophagy: a new therapeutic strategy for diabetic kidney disease

(2019) Wei Jing Liu et al.   Cell Death & Disease

Are All Patients With Type 1 Diabetes Destined for Dialysis if They Live Long Enough? Probably Not

(2018) George L. Bakris et al.   DIABETES CARE

The Prognostic Value of Histopathologic Lesions in Native Kidney Biopsy Specimens: Results from the Boston Kidney Biopsy Cohort Study

(2018) Anand Srivastava et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Single-Cell Transcriptomics of a Human Kidney Allograft Biopsy Specimen Defines a Diverse Inflammatory Response

(2018) Haojia Wu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Advanced glycation end products in the pathogenesis of chronic kidney disease

(2018) Naila Rabbani et al.   KIDNEY INTERNATIONAL

A molecular morphometric approach to diabetic kidney disease can link structure to function and outcome

(2018) Viji Nair et al.   KIDNEY INTERNATIONAL

Imaging mass spectrometry reveals direct albumin fragmentation within the diabetic kidney

(2018) Kerri J. Grove et al.   KIDNEY INTERNATIONAL

Insights into Diabetic Kidney Disease Using Urinary Proteomics and Bioinformatics

(2017) Julie A.D. Van et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Urinary peptidomics analysis reveals proteases involved in diabetic nephropathy

(2017) Magdalena Krochmal et al.   Scientific Reports

High-Fat Diet–Induced Lysosomal Dysfunction and Impaired Autophagic Flux Contribute to Lipotoxicity in the Kidney

(2016) Takeshi Yamamoto et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Cathepsin D in Podocytes Is Important in the Pathogenesis of Proteinuria and CKD

(2016) K. Yamamoto-Nonaka et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Lysosomal protease cathepsin D; a new driver of apoptosis during acute kidney injury

(2016) Pasquale Cocchiaro et al.   Scientific Reports

Inhibition of lysosomal protease cathepsin D reduces renal fibrosis in murine chronic kidney disease

(2016) Christopher Fox et al.   Scientific Reports

Autophagy-Lysosome Pathway in Renal Tubular Epithelial Cells Is Disrupted by Advanced Glycation End Products in Diabetic Nephropathy

(2015) Wei Jing Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metabolomics Reveals a Key Role for Fumarate in Mediating the Effects of NADPH Oxidase 4 in Diabetic Kidney Disease

(2015) Y.-H. You et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Proteases and Protease Inhibitors of Urinary Extracellular Vesicles in Diabetic Nephropathy

(2015) Luca Musante et al.   Journal of Diabetes Research

A New Equation to Estimate Glomerular Filtration Rate

(2013) Andrew S. Levey et al.   ANNALS OF INTERNAL MEDICINE

Lysosomal enzymes are decreased in the kidney of diabetic rats

(2012) Giovani B. Peres et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The early decline in renal function in patients with type 1 diabetes and proteinuria predicts the risk of end-stage renal disease

(2012) Jan Skupien et al.   KIDNEY INTERNATIONAL

Cathepsin D is one of the major enzymes involved in intracellular degradation of AGE-modified proteins

(2010) Stefanie Grimm et al.   FREE RADICAL RESEARCH

Urinary Peptidome May Predict Renal Function Decline in Type 1 Diabetes and Microalbuminuria

(2009) M. L. Merchant et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Cathepsin D—Many functions of one aspartic protease

(2008) Petr Benes et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Human cathepsin D.

(2008) Alina Minarowska et al.   FOLIA HISTOCHEMICA ET CYTOBIOLOGICA