Inflammatory Links Between Hypertriglyceridemia and Atherogenesis

Genetics of hypertriglyceridemia and atherosclerosis

(2021) Praneet K. Gill et al.   CURRENT OPINION IN CARDIOLOGY

Nonclassical Monocytes (CD14dimCD16+) Are Associated With Carotid Intima-Media Thickness Progression for Men but Not Women

(2021) Matthew J. Feinstein et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Role of VLDL receptor in atherogenesis

(2021) Sadao Takahashi   CURRENT OPINION IN LIPIDOLOGY

The changing landscape of atherosclerosis

(2021) Peter Libby   NATURE

Triglyceride-rich lipoproteins and their remnants: metabolic insights, role in atherosclerotic cardiovascular disease, and emerging therapeutic strategies—a consensus statement from the European Atherosclerosis Society

(2021) Henry N Ginsberg et al.   EUROPEAN HEART JOURNAL

Triglycerides and Residual Atherosclerotic Risk

(2021) Sergio Raposeiras-Roubin et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Elevated remnant cholesterol increases the risk of peripheral artery disease, myocardial infarction, and ischaemic stroke: a cohort-based study

(2021) Benjamin Nilsson Wadström et al.   EUROPEAN HEART JOURNAL

Pemafibrate, a New Selective PPARα Modulator: Drug Concept and Its Clinical Applications for Dyslipidemia and Metabolic Diseases

(2020) Shizuya Yamashita et al.   Current Atherosclerosis Reports

Remnants of the Triglyceride-Rich Lipoproteins, Diabetes, and Cardiovascular Disease

(2020) Alan Chait et al.   DIABETES

The association between triglycerides and incident cardiovascular disease: What is “optimal”?

(2020) Tsion Aberra et al.   Journal of Clinical Lipidology

ApoB48-remnant lipoproteins are associated with increased cardiometabolic risk in adolescents

(2020) Jacqueline A. Krysa et al.   ATHEROSCLEROSIS

Triglycerides and ASCVD Risk Reduction: Recent Insights and Future Directions

(2020) Aliza Hussain et al.   Current Atherosclerosis Reports

An Allosteric Shift in CD11c Affinity Activates a Proatherogenic State in Arrested Intermediate Monocytes

(2020) Alfredo A. Hernandez et al.   JOURNAL OF IMMUNOLOGY

Time Course of LDL Cholesterol Exposure and Cardiovascular Disease Event Risk

(2020) Michael J. Domanski et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Triacylglycerol synthesis enhances macrophage inflammatory function

(2020) Angela Castoldi et al.   Nature Communications

Association of Hypertriglyceridemia with All‐Cause Mortality and Atherosclerotic Cardiovascular Events in a Low‐Risk Italian Population: The TG‐REAL Retrospective Cohort Analysis

(2020) Marcello Arca et al.   Journal of the American Heart Association

Effects of n-3 Fatty Acid Supplements in Elderly Patients after Myocardial Infarction: A Randomized Controlled Trial

(2020) Are Annesønn Kalstad et al.   CIRCULATION

Effect of High-Dose Omega-3 Fatty Acids vs Corn Oil on Major Adverse Cardiovascular Events in Patients at High Cardiovascular Risk

(2020) Stephen J. Nicholls et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Remnant Cholesterol, Not LDL Cholesterol, Is Associated With Incident Cardiovascular Disease

(2020) Olga Castañer et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Evinacumab in Patients with Refractory Hypercholesterolemia

(2020) Robert S. Rosenson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Gut intraepithelial T cells calibrate metabolism and accelerate cardiovascular disease

(2019) Shun He et al.   NATURE

N-acetyl galactosamine-conjugated antisense drug to APOC3 mRNA, triglycerides and atherogenic lipoprotein levels

(2019) Veronica J Alexander et al.   EUROPEAN HEART JOURNAL

Plasma levels of apolipoprotein E, APOE genotype, and all-cause and cause-specific mortality in 105 949 individuals from a white general population cohort

(2019) Katrine L Rasmussen et al.   EUROPEAN HEART JOURNAL

2019 ESC/EAS Guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk

(2019) François Mach et al.   EUROPEAN HEART JOURNAL

Increased apolipoprotein C3 drives cardiovascular risk in type 1 diabetes

(2019) Jenny E. Kanter et al.   JOURNAL OF CLINICAL INVESTIGATION

Association of Elevated Triglycerides With Increased Cardiovascular Risk and Direct Costs in Statin-Treated Patients

(2019) Peter P. Toth et al.   MAYO CLINIC PROCEEDINGS

Role of LpL (Lipoprotein Lipase) in Macrophage Polarization In Vitro and In Vivo

(2019) Hye Rim Chang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Clinical review on triglycerides

(2019) Ulrich Laufs et al.   EUROPEAN HEART JOURNAL

sDietary and pharmacological fatty acids and cardiovascular health

(2019) Huaizhu Wu et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Efficacy and Safety of Low-Dose Colchicine after Myocardial Infarction

(2019) Jean-Claude Tardif et al.   NEW ENGLAND JOURNAL OF MEDICINE

Apolipoprotein C3 induces inflammation and organ damage by alternative inflammasome activation

(2019) Stephen Zewinger et al.   NATURE IMMUNOLOGY

Remnant-Like Particle Cholesterol, Low-Density Lipoprotein Triglycerides, and Incident Cardiovascular Disease

(2018) Anum Saeed et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

MT4-MMP deficiency increases patrolling monocyte recruitment to early lesions and accelerates atherosclerosis

(2018) Cristina Clemente et al.   Nature Communications

Fenofibrate and Dyslipidemia: Still a Place in Therapy?

(2018) Nicola Tarantino et al.   DRUGS

Effects of n−3 Fatty Acid Supplements in Diabetes Mellitus

(2018)   NEW ENGLAND JOURNAL OF MEDICINE

MiR-21 Deficiency Alters the Survival of Ly-6C lo Monocytes in ApoE −/− Mice and Reduces Early-Stage Atherosclerosis

(2018) Anna Chipont et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The Forgotten Lipids: Triglycerides, Remnant Cholesterol, and Atherosclerotic Cardiovascular Disease Risk

(2018) Pratik B Sandesara et al.   ENDOCRINE REVIEWS

Marine n−3 Fatty Acids and Prevention of Cardiovascular Disease and Cancer

(2018) JoAnn E. Manson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cardiovascular Risk Reduction with Icosapent Ethyl for Hypertriglyceridemia

(2018) Deepak L. Bhatt et al.   NEW ENGLAND JOURNAL OF MEDICINE

PCSK9 monoclonal antibodies reverse the pro-inflammatory profile of monocytes in familial hypercholesterolaemia

(2017) Sophie J. Bernelot Moens et al.   EUROPEAN HEART JOURNAL

Effects of n-3 fatty acid treatment on monocyte phenotypes in humans with hypertriglyceridemia

(2017) Xiao-Yuan Dai Perrard et al.   Journal of Clinical Lipidology

Monocyte Subsets Coregulate Inflammatory Responses by Integrated Signaling through TNF and IL-6 at the Endothelial Cell Interface

(2017) Myriam Chimen et al.   JOURNAL OF IMMUNOLOGY

Very-Low-Density Lipoprotein–Associated Apolipoproteins Predict Cardiovascular Events and Are Lowered by Inhibition of APOC-III

(2017) Raimund Pechlaner et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Hypertriglyceridemia and atherosclerosis

(2017) Jia Peng et al.   Lipids in Health and Disease

Hypertriglyceridaemia and risk of coronary artery disease

(2017) Željko Reiner   Nature Reviews Cardiology

Cardiovascular and Metabolic Effects of ANGPTL3 Antisense Oligonucleotides

(2017) Mark J. Graham et al.   NEW ENGLAND JOURNAL OF MEDICINE

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

(2017) Paul M Ridker et al.   NEW ENGLAND JOURNAL OF MEDICINE

Donor pulmonary intravascular nonclassical monocytes recruit recipient neutrophils and mediate primary lung allograft dysfunction

(2017) Zhikun Zheng et al.   Science Translational Medicine

Triglyceride-Rich Lipoproteins and Atherosclerotic Cardiovascular Disease

(2016) Børge G. Nordestgaard   CIRCULATION RESEARCH

Elevated levels of triglycerides and vldl-cholesterol provoke activation of nlrp1 inflammasome in endothelial cells

(2016) Silvia Bleda et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Postprandial Monocyte Activation in Individuals With Metabolic Syndrome

(2016) Ilvira M. Khan et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Defective Association of the Platelet Glycoprotein Ib–IX Complex with the Glycosphingolipid-Enriched Membrane Domain Inhibits Murine Thrombus and Atheroma Formation

(2016) Hao Zhou et al.   JOURNAL OF IMMUNOLOGY

Genetic and Pharmacological Inhibition of TREM-1 Limits the Development of Experimental Atherosclerosis

(2016) Jeremie Joffre et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

CCN1/CYR61-mediated meticulous patrolling by Ly6Clowmonocytes fuels vascular inflammation

(2016) Beat A. Imhof et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Patrolling monocytes promote intravascular neutrophil activation and glomerular injury in the acutely inflamed glomerulus

(2016) Michaela Finsterbusch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Foamy Monocytes Form Early and Contribute to Nascent Atherosclerosis in Mice With HypercholesterolemiaSignificance

(2015) Lu Xu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Vascular risk factors, vascular disease, lipids and lipid targets in patients with familial dysbetalipoproteinemia: A European cross-sectional study

(2015) C. Koopal et al.   ATHEROSCLEROSIS

Aggravated restenosis and atherogenesis in ApoCIII transgenic mice but lack of protection in ApoCIII knockouts: the effect of authentic triglyceride-rich lipoproteins with and without ApoCIII

(2015) Haibo Li et al.   CARDIOVASCULAR RESEARCH

Association between hypertriglyceridemia and protein oxidation and proinflammatory markers in normocholesterolemic and hypercholesterolemic individuals

(2015) Jonatas Zeni Klafke et al.   CLINICA CHIMICA ACTA

CD11c/CD18 Signals Very Late Antigen-4 Activation To Initiate Foamy Monocyte Recruitment during the Onset of Hypercholesterolemia

(2015) G. A. Foster et al.   JOURNAL OF IMMUNOLOGY

Triglyceride-Rich Lipoproteins Modulate the Distribution and Extravasation of Ly6C/Gr1low Monocytes

(2015) Maha F. Saja et al.   Cell Reports

Postprandial hypertriglyceridemia as a coronary risk factor

(2014) Jan Borén et al.   CLINICA CHIMICA ACTA

The Role of Hypertriglyceridemia in the Development of Atherosclerosis and Endothelial Dysfunction

(2014) Saki Matsumoto et al.   Nutrients

Nonclassical Ly6C− Monocytes Drive the Development of Inflammatory Arthritis in Mice

(2014) Alexander V. Misharin et al.   Cell Reports

Antisense Oligonucleotide Inhibition of Apolipoprotein C-III Reduces Plasma Triglycerides in Rodents, Nonhuman Primates, and Humans

(2013) Mark J. Graham et al.   CIRCULATION RESEARCH

Macrophage lipoprotein lipase modulates the development of atherosclerosis but not adiposity

(2013) Manabu Takahashi et al.   JOURNAL OF LIPID RESEARCH

The effects of dietary fatty acids on the postprandial triglyceride-rich lipoprotein/apoB48 receptor axis in human monocyte/macrophage cells

(2013) Lourdes M. Varela et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Common variants associated with plasma triglycerides and risk for coronary artery disease

(2013) Ron Do et al.   NATURE GENETICS

Triglyceride-Rich Lipoprotein Modulates Endothelial Vascular Cell Adhesion Molecule (VCAM)-1 Expression via Differential Regulation of Endoplasmic Reticulum Stress

(2013) Ying I. Wang et al.   PLoS One

Triglyceride accumulation in macrophages upregulates paraoxonase 2 (PON2) expression via ROS-mediated JNK/c-Jun signaling pathway activation

(2012) Mira Rosenblat et al.   BIOFACTORS

Circulating CD14+CD16+ Monocyte Subsets as Biomarkers of the Severity of Coronary Artery Disease in Patients With Stable Angina Pectoris

(2012) Yuichi Ozaki et al.   CIRCULATION JOURNAL

Genetically elevated non-fasting triglycerides and calculated remnant cholesterol as causal risk factors for myocardial infarction

(2012) Anders Berg Jørgensen et al.   EUROPEAN HEART JOURNAL

CD14++CD16+ Monocytes Independently Predict Cardiovascular Events

(2012) Kyrill S. Rogacev et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Remnant Cholesterol as a Causal Risk Factor for Ischemic Heart Disease

(2012) Anette Varbo et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Large-scale association analysis identifies new risk loci for coronary artery disease

(2012) Panos Deloukas et al.   NATURE GENETICS

n–3 Fatty Acids and Cardiovascular Outcomes in Patients with Dysglycemia

(2012)   NEW ENGLAND JOURNAL OF MEDICINE

A high-fat meal promotes lipid-load and apolipoprotein B-48 receptor transcriptional activity in circulating monocytes

(2011) Lourdes M Varela et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

CD14 dim CD16 + and CD14 + CD16 + Monocytes in Obesity and During Weight Loss

(2011) Christine Poitou et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Gene expression profiling reveals the defining features of the classical, intermediate, and nonclassical human monocyte subsets

(2011) K. L. Wong et al.   BLOOD

Triglycerides and Cardiovascular Disease

(2011) Michael Miller et al.   CIRCULATION

Comparative analysis of genome-wide association studies signals for lipids, diabetes, and coronary heart disease: Cardiovascular Biomarker Genetics Collaboration

(2011) Aspasia Angelakopoulou et al.   EUROPEAN HEART JOURNAL

Suppressed monocyte recruitment drives macrophage removal from atherosclerotic plaques of Apoe–/– mice during disease regression

(2011) Stephane Potteaux et al.   JOURNAL OF CLINICAL INVESTIGATION

Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling

(2011) Haitao Wen et al.   NATURE IMMUNOLOGY

CD11c/CD18 Expression Is Upregulated on Blood Monocytes During Hypertriglyceridemia and Enhances Adhesion to Vascular Cell Adhesion Molecule-1

(2010) R. Michael Gower et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Human CD14dim Monocytes Patrol and Sense Nucleic Acids and Viruses via TLR7 and TLR8 Receptors

(2010) Jérôme Cros et al.   IMMUNITY

Toward a functional characterization of blood monocytes

(2010) Prakash Saha et al.   IMMUNOLOGY AND CELL BIOLOGY

Fatty Acids from Very Low-Density Lipoprotein Lipolysis Products Induce Lipid Droplet Accumulation in Human Monocytes

(2010) L. J. den Hartigh et al.   JOURNAL OF IMMUNOLOGY

Triglyceride-mediated pathways and coronary disease: collaborative analysis of 101 studies

(2010)   LANCET

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

(2010) Peter Duewell et al.   NATURE

CD11c Expression in Adipose Tissue and Blood and Its Role in Diet-Induced Obesity

(2009) Huaizhu Wu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Functional Role of CD11c + Monocytes in Atherogenesis Associated With Hypercholesterolemia

(2009) Huaizhu Wu et al.   CIRCULATION

Monocyte heterogeneity in obesity and subclinical atherosclerosis

(2009) K. S. Rogacev et al.   EUROPEAN HEART JOURNAL

Major Lipids, Apolipoproteins, and Risk of Vascular Disease

(2009) The Emerging Risk Factors Collaboration*   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Combined Inhibition of CCL2, CX3CR1, and CCR5 Abrogates Ly6C hi and Ly6C lo Monocytosis and Almost Abolishes Atherosclerosis in Hypercholesterolemic Mice

(2008) Christophe Combadière et al.   CIRCULATION

Triglyceride-rich lipoprotein lipolysis releases neutral and oxidized FFAs that induce endothelial cell inflammation

(2008) Limin Wang et al.   JOURNAL OF LIPID RESEARCH

Detection of apolipoproteins B-48 and B-100 carrying particles in lipoprotein fractions extracted from human aortic atherosclerotic plaques in sudden cardiac death cases

(2007) Takamitsu Nakano et al.   CLINICA CHIMICA ACTA