Review
Clinical Neurology
Stellina Y. H. Lee, Nathanael J. Yates, Susannah J. Tye
Summary: Inflammation plays a key role in the pathogenesis of Parkinson's disease, with microglia being activated early on and playing a role in triggering and propagating the disease process through immune mechanisms. Cytokines, gene regulators like miRNA, and inflammatory biomarkers are of interest in clinical settings for predicting, diagnosing, and monitoring PD. Understanding the contribution of inflammatory processes in PD can potentially lead to novel strategies for disease modification.
Review
Food Science & Technology
Wenli Ruan, Shuoheng Shen, Yang Xu, Na Ran, Heng Zhang
Summary: As the global population ages, more patients are diagnosed with neurodegenerative diseases, for which curative drugs or treatments are still lacking. Procyanidins, found in plants like grapes, blackberries, and hawthorn leaves, show potential protective roles in reducing oxidative stress, inhibiting neuroinflammation, and decreasing abnormal protein aggregation in Alzheimer's disease, highlighting a promising new therapeutic strategy for neurodegenerative diseases.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Review
Immunology
Shuo Sheng, Shuo Zhao, Feng Zhang
Summary: This article summarizes the role of bacterial infection in Parkinson's disease (PD) and introduces several antibiotics that have anti-PD effects.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Seulah Lee, Yeon Ji Suh, Yujeong Lee, Seonguk Yang, Dong Geun Hong, Dinakaran Thirumalai, Seung-Cheol Chang, Ki Wung Chung, Young-Suk Jung, Hyung Ryong Moon, Hae Young Chung, Jaewon Lee
Summary: This study investigated the neuroprotective effects of the barbiturate derivative, MHY2699, in a mouse model of Parkinson's disease. The results showed that MHY2699 ameliorated neuroinflammation, inhibited motor dysfunction, and prevented dopaminergic neuronal death in the MPTP-induced mouse model, suggesting its potential as a treatment for PD.
Article
Pharmacology & Pharmacy
Rana E. Kamal, Esther Menze, Amgad Albohy, Hebatalla I. Ahmed, Samar S. Azab
Summary: This study evaluated the potential of carvedilol as an anti-Parkinson's drug and anti-tau protein target through computational simulation and in vivo experiments. The results suggest that carvedilol has neuro-protective effects and may be a candidate for the management of Parkinson's disease.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Review
Immunology
Mohammed Alrouji, Hayder M. Al-Kuraishy, Ali I. Al-Gareeb, Hebatallah M. Saad, Gaber El-Saber Batiha
Summary: Parkinson's disease (PD) is a degenerative disorder caused by the damage to certain neurons in the brain. The use of non-steroidal anti-inflammatory drugs (NSAIDs) to treat musculoskeletal problems in PD patients can have both beneficial and harmful effects on the progression of the disease. NSAIDs can potentially prevent the development of PD by reducing neuroinflammation, but they may also inhibit neuroprotective mechanisms and worsen neuroinflammation. In conclusion, the effect of NSAIDs on PD neuropathology is still uncertain and further research is needed.
INFLAMMOPHARMACOLOGY
(2023)
Article
Food Science & Technology
Domenico Sergi, Alex Gelinas, Jimmy Beaulieu, Justine Renaud, Emilie Tardif-Pellerin, Jerome Guillard, Maria-Grazia Martinoli
Summary: The study evaluated the neuroprotective potential of viniferin in NGF-differentiated PC12 cells and its anti-inflammatory properties in a N9 microglia-neuronal PC12 cell co-culture system. Results showed that viniferin and a mixture of viniferin and resveratrol protect neuronal dopaminergic cells from 6-OHDA-induced cytotoxicity and apoptosis.
Review
Biochemistry & Molecular Biology
Hao Meng, Jia-Hang Wei, Peng-Zheng Yu, Jia-Xin Ren, Meng-Yao Tang, Jun-Yi Sun, Xiao-Yu Yan, Jing Su
Summary: Parkinson's disease is a severe neurodegenerative disorder. Deep brain electrical stimulation (DBS) is currently the primary surgical treatment, but it can cause serious neurological impairments. This review summarizes recent studies investigating the causes of neurological deficits after DBS and explores the role of neuroinflammation in these deficits. Existing drugs and treatments may help ameliorate the loss of neurological function in patients following DBS surgery.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Elena Vacchi, Jacopo Burrello, Alessio Burrello, Sara Bolis, Silvia Monticone, Lucio Barile, Alain Kaelin-Lang, Giorgia Melli
Summary: This study characterized and compared distinctive cerebrospinal fluid (CSF)-derived extracellular vesicles (EVs) in patients with Parkinson's Disease (PD) and atypical parkinsonisms (AP), and built a diagnostic model based on immune profiling of EV surface markers using artificial intelligence. The model, constructed using EV markers co-expressed in plasma and CSF, showed high sensitivity (96.6%) and accuracy (92.6%) in discriminating PD from non-PD patients. The research underscores the importance of EV surface markers in inflammation in PD and highlights the role of EVs as pathways/biomarkers for protein aggregation-related neurodegenerative diseases.
Article
Biochemistry & Molecular Biology
Ana Catarina Martins, Illyane Sofia Lima, Ana Catarina Pego, Ines Sa Pereira, Gracelino Martins, Antonino Kapitao, Raffaella Gozzelino
Summary: Parkinson's disease is a neurodegenerative disorder characterized by loss of dopaminergic neurons. Aging is a major risk factor for idiopathic PD, but immunity and inflammation also play a crucial role in its pathogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Linbin Dai, Yong Shen
Summary: Research suggests that dysfunctional T cells and neuroinflammation play critical roles in Alzheimer's disease pathology, with T cells contributing indirectly to neuroinflammation by secreting proinflammatory mediators. Risk factors and pathological hallmarks of AD are closely linked to immune responses, potentially influencing T cell function.
Article
Biochemistry & Molecular Biology
Seulah Lee, Yeon Ji Suh, Seonguk Yang, Dong Geun Hong, Akihito Ishigami, Hangun Kim, Jae-Seoun Hur, Seung-Cheol Chang, Jaewon Lee
Summary: The study demonstrates that evernic acid (EA) has neuroprotective and anti-inflammatory effects, protecting neurons against MPP+-induced cell death, mitochondrial dysfunction, and oxidative stress, and reducing astroglial activation. In mouse models, EA ameliorated MPTP-induced symptoms of PD, including motor dysfunction, dopaminergic neuronal loss, and neuroinflammation in the nigrostriatal pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Alexi Nott, Inge R. Holtman
Summary: Microglia, as the macrophages in the brain, play a vital role in brain homeostasis and are implicated in various brain disorders. Neuroinflammation has emerged as a potential therapeutic target for neurodegeneration, but the specific function of microglia in different neurodegenerative disorders is still being actively studied.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Rebecca Heinz, Ulf C. Schneider
Summary: Subarachnoid hemorrhage can lead to severe neurological deficits for survivors. Secondary brain injury, primarily caused by cerebral inflammation after bleeding, can result in additional brain damage. The toll-like receptor (TLR)4 signaling pathway plays a critical role in the pathophysiology of acute brain injuries like subarachnoid hemorrhage (SAH).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Sadegh Moradi Vastegani, Seyed Esmaeil Khoshnam, Esrafil Mansouri, Samireh Ghafouri, Nima Bakhtiari, Yaghoob Farbood, Alireza Sarkaki
Summary: This study found that anethole is a potential therapeutic agent for Parkinson's disease, improving both motor and non-motor symptoms through anti-inflammatory, anti-apoptotic, and antioxidant mechanisms.
METABOLIC BRAIN DISEASE
(2023)
Article
Neurosciences
Mariele Lino Silva, Lais Bhering Martins, Luana Caroline dos Santos, Gilberto Simeone Henriques, Antonio Lucio Teixeira, Ana Maria dos Santos Rodrigues, Adaliene Versiani Matos Ferreira
Summary: This study suggests that patients with migraine have lower plasma levels of minerals and lower dietary intake of minerals compared to individuals without migraine. It highlights the importance of dietary intervention to ensure adequate mineral intake as a therapeutic strategy for migraine.
NUTRITIONAL NEUROSCIENCE
(2023)
Article
Clinical Neurology
Mario A. Parra, Paulina Orellana, Tomas Leon, Cabello G. Victoria, Fernando Henriquez, Rodrigo Gomez, Constanza Avalos, Andres Damian, Andrea Slachevsky, Agustin Ibanez, Henrik Zetterberg, Betty M. Tijms, Jennifer S. Yokoyama, Stefanie D. Pina-Escudero, J. Nicholas Cochran, Diana L. Matallana, Daisy Acosta, Ricardo Allegri, Bianca P. Arias-Suarez, Bernardo Barra, Maria Isabel Behrens, SoniaM. D. Brucki, Geraldo Busatto, Paulo Caramelli, Sheila Castro-Suarez, Valeria Contreras, Nilton Custodio, Sergio Dansilio, Myriam De la Cruz-Puebla, Leonardo Cruz de Souza, Monica M. Diaz, Lissette Duque, Gonzalo A. Farias, Sergio T. Ferreira, Nahuel Magrath Guimet, Ana Kmaid, David Lira, Francisco Lopera, Beatriz Mar Meza, Eliane C. Miotto, Ricardo Nitrini, Alberto Nunez, Santiago O'Neill, John Ochoa, Maritza Pintado-Caipa, Elisa de Paula Franca Resende, Shannon Risacher, Luz Angela Rojas, Valentina Sabaj, Lucas Schilling, Allis F. Sellek, Ana Sosa, Leonel T. Takada, Antonio L. Teixeira, Martha Unaucho-Pilalumbo, Claudia Duran-Aniotz
Summary: Limited knowledge and funding, as well as inadequate infrastructure, present significant barriers to dementia biomarker research in Latin American and Caribbean countries. However, the region shows great potential for advancements in this field.
ALZHEIMERS & DEMENTIA
(2023)
Review
Neurosciences
Lais B. Martins, Ana L. M. Silveira, Antonio L. Teixeira
Summary: This study aims to provide a comprehensive overview of the involvement of the kynurenine pathway (KP) in the pathophysiology of Alzheimer's disease (AD) and Parkinson's disease (PD) and discuss potential therapeutic opportunities. The results showed altered levels of KP metabolites in the brains of AD and PD patients, and associations between peripheral levels of KP metabolites and cognitive function in these patients.
CURRENT NEUROPHARMACOLOGY
(2023)
Review
Dentistry, Oral Surgery & Medicine
Jose Alcides Almeida de Arruda, Fernanda Vieira Heimlich, Victor Zanetti Drumond, Lauren Frenzel Schuch, Manoela Domingues Martins, Lucas Guimaraes Abreu, Antonio Lucio Teixeira, Ricardo Alves Mesquita, Tarcilia Aparecida Silva
Summary: This systematic review examined the potential association between anxiety and depression and chemo/radiotherapy-induced oral mucositis. The results showed that there is a connection between anxiety and depression and the severity of oral mucositis in a significant number of participants. However, the limited number of cases and heterogeneity in the data hindered a conclusive conclusion about this association.
Article
Clinical Neurology
Kelly Santana, Eduardo Franca, Joao Sato, Ana Silva, Maria Queiroz, Julia de Farias, Danniely Rodrigues, Iara Souza, Vanessa Ribeiro, Egas Caparelli-Daquer, Antonio L. Teixeira, Leigh Charvet, Abhishek Datta, Marom Bikson, Suellen Andrade
Summary: This study investigated the potential therapeutic effects of High-Definition transcranial Direct Current Stimulation (HD-tDCs) combined with a rehabilitation program for the management of PASC-related fatigue. The results showed that active HD-tDCS significantly reduced fatigue, decreased anxiety, and improved quality of life compared to sham HD-tDCS.
Article
Neurosciences
Haitham Salem, Robert Suchting, Mitzi M. Gonzales, Sudha Seshadri, Antonio L. Teixeira
Summary: This study aimed to detect conversion rates from mild cognitive impairment (MCI) to Alzheimer's disease (AD) and determine the effect of apathy on the progression to AD in patients with MCI. The study found that 17.3% of individuals had conversion from MCI to AD over a period of 8.21 years. Patients with apathy had a higher conversion rate and shorter time-to-conversion. Age and cognitive performance were found to moderate the relationship between apathy and time-to-conversion.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Neurosciences
Eliana C. B. Toscano, Erica L. M. Vieira, Lea T. Grinberg, Natalia P. Rocha, Joseane A. S. Brant, Regina S. Paradela, Alexandre V. Giannetti, Claudia K. Suemoto, Renata E. P. Leite, Ricardo Nitrini, Milene A. Rachid, Antonio L. Teixeira
Summary: Temporal lobe epilepsy (TLE) is associated with cognitive deficits, and this study investigates the underlying neuronal basis. The researchers found that an increase in p-tau burden is potentially involved in cognitive deficits in mesial TLE, particularly attention impairment and seizure frequency.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Psychiatry
Izabela Guimaraes Barbosa, Flavia da Mata Chiacchio Leite, Maxime Bertoux, Henrique Cerqueira Guimaraes, Luciano Inacio Mariano, Leandro Boson Gambogi, Antonio Lucio Teixeira, Paulo Caramelli, Leonardo Cruz de Souza
Summary: This study found that bipolar disorder type 1 (BD1) and behavioral-variant frontotemporal dementia (bvFTD) have similar deficits in social cognition functions. The results of the Facial Emotion Recognition (FER) and Modified Faux-Pas (mFP) tests can be used to differentiate between the two disorders.
BRAZILIAN JOURNAL OF PSYCHIATRY
(2023)
Article
Neurosciences
Natalia Pessoa Rocha, Eduarda Xavier Carreira, Ana Carolina de Almeida Prado, Fabiola Tavares, Mayra Tavares, Francisco Cardoso, Antonio Jaeger, Leonardo Cruz de Souza, Antonio Lucio Teixeira
Summary: The International Parkinson's Disease and Movement Disorder Society (MDS) developed diagnostic criteria for mild cognitive impairment (MCI) and dementia in Parkinson disease (PD). However, the applicability of these criteria was limited for PD patients with low levels of formal education in Brazil. There is a need for revision of the guidelines to account for differences among populations, especially related to educational level.
ARQUIVOS DE NEURO-PSIQUIATRIA
(2023)
Review
Nutrition & Dietetics
Gabriela Barbosa Pires Fagundes, Jenneffer Rayane Braga Tibaes, Mariele Lino Silva, Marina Marcolino Braga, Ana Leticia Malheiros Silveira, Antonio Lucio Teixeira, Adaliene Versiani Matos Ferreira
Summary: The objective of this study was to evaluate the effects of 8 weeks of time-restricted eating (TRE) with a caloric restriction on metabolic profile, metabolic rate, symptoms of mood and eating disorders, and weight loss in women with overweight or obesity. The results showed that subjects in the TRE group experienced more pronounced weight loss, body fat mass loss, and fat-free mass loss compared to those in the non-TRE group. However, these losses were not associated with changes in resting metabolic rate, metabolic profile, or symptoms of eating or mood disorders. In conclusion, 8 weeks of TRE does not influence behavioral parameters in individuals with overweight or obesity, but may lead to weight loss.
Article
Multidisciplinary Sciences
Parnian Shobeiri, Sanam Alilou, Mehran Jaberinezhad, Farshad Zare, Nastaran Karimi, Saba Maleki, Antonio L. Teixeira, George Perry, Nima Rezaei
Summary: This systematic review evaluated the accuracy of long non-coding RNAs (lncRNAs) in identifying Alzheimer's disease (AD) through meta-analysis. The results showed that lncRNAs had high accuracy in identifying AD and could be considered a promising diagnostic biomarker for the disease.
Review
Medicine, General & Internal
Lijin Jose, Lais Bhering Martins, Thiago M. Cordeiro, Keya Lee, Alexandre Paim Diaz, Hyochol Ahn, Antonio L. Teixeira
Summary: This systematic review aims to investigate the effectiveness of noninvasive neuromodulation in HD-associated motor, cognitive, and behavioral symptoms. 19 studies were identified, exploring the use of ECT, TMS, and tDCS in the treatment of HD. The results showed improvement in HD symptoms, particularly depression and psychosis after ECT protocols, although the impact on cognitive and motor symptoms is more controversial.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Neurosciences
Karina Braga Gomes, Ramon Goncalves Pereira, Alexandre Alberto Braga, Henrique Cerqueira Guimaraes, Elisa de Paula Franca Resende, Antonio Lucio Teixeira, Maira Tonidandel Barbosa, Wagner Meira Junior, Maria das Gracas Carvalho, Paulo Caramelli
Summary: This study used machine learning algorithms to assess the ability of routine laboratory variables in predicting cognitive and functional decline in older adults. The random forest model was found to be the most accurate in predicting cognitive decline, including variables such as triglycerides, glucose, and hemoglobin. For functional decline, platelet count, hemoglobin, and cortisol were identified as important features. The findings suggest that routine laboratory variables can be used to predict cognitive and functional decline in older populations using machine learning algorithms.
Article
Medicine, Research & Experimental
Antonio L. Teixeira, Lais Bhering Martins, Thiago Macedo e Cordeiro, Lijin Jose, Robert Suchting, Holly M. Holmes, Ron Acierno, Hyochol Ahn
Summary: This study aims to evaluate the feasibility, safety, and efficacy of home-based transcranial direct current stimulation (tDCS) for the treatment of apathy in Alzheimer's disease (AD). A randomized, sham-controlled pilot clinical trial will be conducted involving 40 subjects with AD, with their caregivers administering tDCS at home under remote televideo supervision. The findings from this study will contribute to the development of non-pharmacological treatment strategies and have great potential for clinical translation.
PILOT AND FEASIBILITY STUDIES
(2023)
