Quantification of in vivo 31P NMR brain spectra using LCModel

Quantification of P-31 NMR spectra is commonly performed using line-fitting techniques with prior knowledge. Currently available time- and frequency-domain analysis software includes AMARES (in jMRUI) and CFIT respectively. Another popular frequency-domain approach is LCModel, which has been successfully used to fit both H-1 and C-13 in vivo NMR spectra. To the best of our knowledge LCModel has not been used to fit P-31 spectra. This study demonstrates the feasibility of using LCModel to quantify in vivo(31)P MR spectra, provided that adequate prior knowledge and LCModel control parameters are used. Both single-voxel and MRSI data are presented, and similar results are obtained with LCModel and with AMARES. This provides a new method for automated, operator-independent analysis of P-31 NMR spectra. Copyright (c) 2015 John Wiley & Sons, Ltd.