OGA activated glycopeptide-based nano-activator to activate PKM2 tetramerization for switching catabolic pathways and sensitizing chemotherapy resistance

Targeting Pyruvate Kinase M2 Phosphorylation Reverses Aggressive Cancer Phenotypes

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An activated excretion-retarded tumor imaging strategy towards metabolic organs

(2021) Da-Yong Hou et al.   Bioactive Materials

A Near-Infrared Peptide Probe with Tumor-Specific Excretion-Retarded Effect for Image-Guided Surgery of Renal Cell Carcinoma

(2020) Hong-Wei An et al.   ACS Nano

PKM2 suppresses osteogenesis and facilitates adipogenesis by regulating β-catenin signaling and mitochondrial fusion and fission

(2020) Jiachao Guo et al.   Aging-US

Identification of Parthenolide Dimers as Activators of Pyruvate Kinase M2 in Xenografts of Glioblastoma Multiforme in Vivo

(2020) Yahui Ding et al.   JOURNAL OF MEDICINAL CHEMISTRY

Transformable peptide nanoparticles arrest HER2 signalling and cause cancer cell death in vivo

(2020) Lu Zhang et al.   Nature Nanotechnology

Pyruvate Kinase M2 and Cancer: The Role of PKM2 in Promoting Tumorigenesis

(2020) Kulsoom Zahra et al.   Frontiers in Oncology

Intervening Tumor Progression by Coupling Bacteria Respiration with Tumor Metabolism

(2020) Qi-Wen Chen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Warburg effect: essential part of metabolic reprogramming and central contributor to cancer progression

(2019) Peter Vaupel et al.   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Synthesis of novel 7-azaindole derivatives containing pyridin-3-ylmethyl dithiocarbamate moiety as potent PKM2 activators and PKM2 nucleus translocation inhibitors

(2019) Bin Liu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

An Overview of Structure, Function and Regulation of Pyruvate Kinases

(2019) Norbert Schormann et al.   PROTEIN SCIENCE

O-GlcNAcase targets pyruvate kinase M2 to regulate tumor growth

(2019) Jay Prakash Singh et al.   ONCOGENE

Intra/Extracellular Lactic Acid Exhaustion for Synergistic Metabolic Therapy and Immunotherapy of Tumors

(2019) Fan Gao et al.   ADVANCED MATERIALS

In vivo cancer targeting via glycopolyester nanoparticle mediated metabolic cell labeling followed by click reaction

(2019) Hua Wang et al.   BIOMATERIALS

A tumour-selective cascade activatable self-detained system for drug delivery and cancer imaging

(2019) Hong-Wei An et al.   Nature Communications

Targeting glucose metabolism to suppress cancer progression: prospective of anti-glycolytic cancer therapy

(2019) Ali F. Abdel-Wahab et al.   PHARMACOLOGICAL RESEARCH

Self-Assembled Peptide-Based Nanomaterials for Biomedical Imaging and Therapy

(2018) Guo-Bin Qi et al.   ADVANCED MATERIALS

Natural Product Micheliolide (MCL) Irreversibly Activates Pyruvate Kinase M2 and Suppresses Leukemia

(2018) Jing Li et al.   JOURNAL OF MEDICINAL CHEMISTRY

Protein O-GlcNAcylation: emerging mechanisms and functions

(2017) Xiaoyong Yang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

O-GlcNAcylation destabilizes the active tetrameric PKM2 to promote the Warburg effect

(2017) Yang Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evaluation of the binding of perfluorinated compound to pepsin: Spectroscopic analysis and molecular docking

(2016) Yuanyuan Yue et al.   CHEMOSPHERE

Targeting glucose uptake with siRNA-based nanomedicine for cancer therapy

(2015) Cong-Fei Xu et al.   BIOMATERIALS

The Role of Pyruvate Kinase M2 in Cancer Metabolism

(2015) Vivian M. Liu et al.   BRAIN PATHOLOGY

Study of interaction between human serum albumin and three phenanthridine derivatives: Fluorescence spectroscopy and computational approach

(2015) Jianming Liu et al.   SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY

Warburg Effect or Reverse Warburg Effect? A Review of Cancer Metabolism

(2015) Xiao Dong Xu et al.   Oncology Research and Treatment

Pyruvate Kinase M2: Regulatory Circuits and Potential for Therapeutic Intervention

(2015) Vibhor Gupta et al.   CURRENT PHARMACEUTICAL DESIGN

Serine is a natural ligand and allosteric activator of pyruvate kinase M2

(2012) Barbara Chaneton et al.   NATURE

Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis

(2012) Dimitrios Anastasiou et al.   Nature Chemical Biology

Brain Serotonin and Dopamine Transporter Bindings in Adults With High-Functioning Autism

(2010) Kazuhiko Nakamura et al.   ARCHIVES OF GENERAL PSYCHIATRY

Evaluation of thieno[3,2-b]pyrrole[3,2-d]pyridazinones as activators of the tumor cell specific M2 isoform of pyruvate kinase

(2010) Jian-kang Jiang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Pyruvate kinase type M2: A key regulator of the metabolic budget system in tumor cells

(2010) Sybille Mazurek   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Evaluation of SubstitutedN,N′-Diarylsulfonamides as Activators of the Tumor Cell Specific M2 Isoform of Pyruvate Kinase

(2009) Matthew B. Boxer et al.   JOURNAL OF MEDICINAL CHEMISTRY

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

(2008) Heather R. Christofk et al.   NATURE