Mannose-6-phosphate glycan for lysosomal targeting: various applications from enzyme replacement therapy to lysosome-targeting chimeras

LYTACs that engage the asialoglycoprotein receptor for targeted protein degradation

(2021) Green Ahn et al.   Nature Chemical Biology

Dual-Functional Ti(IV)-IMAC Material Enables Simultaneous Enrichment and Separation of Diverse Glycopeptides and Phosphopeptides

(2021) Junfeng Huang et al.   ANALYTICAL CHEMISTRY

Harnessing the Power of Proteolysis for Targeted Protein Inactivation

(2020) Rati Verma et al.   MOLECULAR CELL

Crystal Structure of the Mannose-6-Phosphate Uncovering Enzyme

(2020) Alexei Gorelik et al.   STRUCTURE

FDA orphan drug designations for lysosomal storage disorders – a cross-sectional analysis

(2020) Sven F. Garbade et al.   PLoS One

Lysosome-targeting chimaeras for degradation of extracellular proteins

(2020) Steven M. Banik et al.   NATURE

The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K

(2020) Mikołaj Słabicki et al.   NATURE

Global view of human protein glycosylation pathways and functions

(2020) Katrine T. Schjoldager et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structure of the Human Cation-Independent Mannose 6-Phosphate/IGF2 Receptor Domains 7–11 Uncovers the Mannose 6-Phosphate Binding Site of Domain 9

(2020) Alice J. Bochel et al.   STRUCTURE

In Vitro N-Glycan Mannosyl-Phosphorylation of a Therapeutic Enzyme by Using Recombinant Mnn14 Produced from Pichia pastoris

(2020) Ji-Yeon Kang et al.   JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY

Glycosylation in health and disease

(2019) Colin Reily et al.   Nature Reviews Nephrology

Glycosylation of biosimilars: Recent advances in analytical characterization and clinical implications

(2019) Bastiaan L. Duivelshof et al.   ANALYTICA CHIMICA ACTA

Dual-Functional Titanium(IV) Immobilized Metal Affinity Chromatography Approach for Enabling Large-Scale Profiling of Protein Mannose-6-Phosphate Glycosylation and Revealing Its Predominant Substrates

(2019) Junfeng Huang et al.   ANALYTICAL CHEMISTRY

Lysosomes as a therapeutic target

(2019) Srinivasa Reddy Bonam et al.   NATURE REVIEWS DRUG DISCOVERY

ATTEC: a potential new approach to target proteinopathies

(2019) Zhaoyang Li et al.   Autophagy

AUTACs: Cargo-Specific Degraders Using Selective Autophagy

(2019) Daiki Takahashi et al.   MOLECULAR CELL

A Lifetime of Adventures in Glycobiology

(2018) Stuart Kornfeld   Annual Review of Biochemistry

Mannose-6-phosphate receptor: a novel regulator of T cell immunity

(2018) Anjuman Ara et al.   Cellular & Molecular Immunology

Mannose 6-phosphate-dependent lysosomal enzyme targeting in hydra: a biochemical, immunological and structural elucidation

(2018) Poorna Manasa Bhamidimarri et al.   FEBS LETTERS

Lysosomal Targeting Enhancement by Conjugation of Glycopeptides Containing Mannose-6-phosphate Glycans Derived from Glyco-engineered Yeast

(2018) Ji-Yeon Kang et al.   Scientific Reports

Mannose and Mannose-6-Phosphate Receptor-Targeted Drug Delivery Systems and Their Application in Cancer Therapy

(2018) Elena Dalle Vedove et al.   Advanced Healthcare Materials

Targeted analysis of lysosomal directed proteins and their sites of mannose-6-phosphate modification

(2018) Tomislav Caval et al.   MOLECULAR & CELLULAR PROTEOMICS

Customized protein glycosylation to improve biopharmaceutical function and targeting

(2018) Linde Van Landuyt et al.   CURRENT OPINION IN BIOTECHNOLOGY

Selective induction of apoptosis in MCF7 cancer-cell by targeted liposomes functionalised with mannose-6-phosphate

(2017) Cristina Minnelli et al.   JOURNAL OF DRUG TARGETING

Engineering of GlcNAc-1-Phosphotransferase for Production of Highly Phosphorylated Lysosomal Enzymes for Enzyme Replacement Therapy

(2017) Lin Liu et al.   Molecular Therapy-Methods & Clinical Development

Mannose-6-Phosphate Receptor: A Target for Theranostics of Prostate Cancer

(2015) Ophélie Vaillant et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Glyco-engineering strategies for the development of therapeutic enzymes with improved efficacy for the treatment of lysosomal storage diseases

(2015) Doo-Byoung Oh   BMB Reports

Identification of a fourth mannose 6-phosphate binding site in the cation-independent mannose 6-phosphate receptor

(2015) Linda J Olson et al.   GLYCOBIOLOGY

Increased mannosylphosphorylation of N-glycans by heterologous expression of YlMPO1 in glyco-engineered Saccharomyces cerevisiae for mannose-6-phosphate modification

(2015) Jin Young Gil et al.   JOURNAL OF BIOTECHNOLOGY

A Multivalent Ligand for the Mannose-6-Phosphate Receptor for Endolysosomal Targeting of an Activity-Based Probe

(2014) Sascha Hoogendoorn et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Comparative study on mannose 6-phosphate residue contents of recombinant lysosomal enzymes

(2014) Tadayasu Togawa et al.   MOLECULAR GENETICS AND METABOLISM

Liposomes containing mannose-6-phosphate-cholesteryl conjugates for lysosome-specific delivery

(2014) E. Crucianelli et al.   RSC Advances

The glycan-binding properties of the cation-independent mannose 6-phosphate receptor are evolutionary conserved in vertebrates

(2012) Alicia C Castonguay et al.   GLYCOBIOLOGY

A bacterial glycosidase enables mannose-6-phosphate modification and improved cellular uptake of yeast-produced recombinant human lysosomal enzymes

(2012) Petra Tiels et al.   NATURE BIOTECHNOLOGY

Extensive Mannose Phosphorylation on Leukemia Inhibitory Factor (LIF) Controls Its Extracellular Levels by Multiple Mechanisms

(2011) Jarrod Barnes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mannose-6-phosphate pathway: A review on its role in lysosomal function and dysfunction

(2011) Maria Francisca Coutinho et al.   MOLECULAR GENETICS AND METABOLISM

Tumor-targeted intracellular delivery of anticancer drugs through the mannose-6-phosphate/insulin-like growth factor II receptor

(2009) Jai Prakash et al.   INTERNATIONAL JOURNAL OF CANCER

Functions of the α, β, and γ Subunits of UDP-GlcNAc:Lysosomal EnzymeN-Acetylglucosamine-1-phosphotransferase

(2009) Yi Qian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glycoengineered Acid α-Glucosidase With Improved Efficacy at Correcting the Metabolic Aberrations and Motor Function Deficits in a Mouse Model of Pompe Disease

(2009) Yunxiang Zhu et al.   MOLECULAR THERAPY

Sorting of lysosomal proteins

(2008) Thomas Braulke et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Biochemical and pharmacological characterization of different recombinant acid α-glucosidase preparations evaluated for the treatment of Pompe disease

(2008) A.J. McVie-Wylie et al.   MOLECULAR GENETICS AND METABOLISM