Reducing ER stress with chaperone therapy reverses sleep fragmentation and cognitive decline in aged mice

Late-in-life neurodegeneration after chronic sleep loss in young adult mice

(2021) Jessica E Owen et al.   SLEEP

A role for the cortex in sleep–wake regulation

(2021) Lukas B. Krone et al.   NATURE NEUROSCIENCE

Evolutionarily Conserved Regulation of Sleep by the Protein Translational Regulator PERK

(2020) Sarah Ly et al.   CURRENT BIOLOGY

Mechanisms, regulation and functions of the unfolded protein response

(2020) Claudio Hetz et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Short-term sleep deprivation immediately after contextual conditioning inhibits BDNF signaling and disrupts memory consolidation in predator odor trauma mice model of PTSD

(2020) Rishi Sharma et al.   BRAIN RESEARCH

The leptin sensitizer celastrol reduces age-associated obesity and modulates behavioral rhythms

(2019) Karthikeyani Chellappa et al.   AGING CELL

On the Involvement of BDNF Signaling in Memory Reconsolidation

(2019) Maria Carolina Gonzalez et al.   Frontiers in Cellular Neuroscience

The unfolded protein response in neurodegenerative disorders - therapeutic modulation of the PERK pathway

(2018) Daniel Hughes et al.   FEBS Journal

Reduction of the molecular chaperone binding immunoglobulin protein (BiP) accentuates the effect of aging on sleep-wake behavior

(2018) Nirinjini Naidoo et al.   NEUROBIOLOGY OF AGING

Old Brains Come Uncoupled in Sleep: Slow Wave-Spindle Synchrony, Brain Atrophy, and Forgetting

(2018) Randolph F. Helfrich et al.   NEURON

Sleep disorders in the elderly: a growing challenge

(2018) Kamalesh K. Gulia et al.   Psychogeriatrics

Sleep disorders in the elderly: a growing challenge

(2018) Kamalesh K. Gulia et al.   Psychogeriatrics

The Discrimination Ratio derived from Novel Object Recognition tasks as a Measure of Recognition Memory Sensitivity, not Bias

(2018) Magali H. Sivakumaran et al.   Scientific Reports

4‐Phenylbutyric Acid Protects Ethanol‐Induced Damage in the Developing Mouse Brain

(2018) Hui Li et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Chronic Sleep Disruption Advances the Temporal Progression of Tauopathy in P301S Mutant Mice

(2018) Yan Zhu et al.   JOURNAL OF NEUROSCIENCE

ER Stress, CREB, and Memory: A Tangled Emerging Link in Disease

(2018) Nilkantha Sen   NEUROSCIENTIST

Local Inhibition of PERK Enhances Memory and Reverses Age-Related Deterioration of Cognitive and Neuronal Properties

(2017) Vijendra Sharma et al.   JOURNAL OF NEUROSCIENCE

Activation of PERK Elicits Memory Impairment through Inactivation of CREB and Downregulation of PSD95 After Traumatic Brain Injury

(2017) Tanusree Sen et al.   JOURNAL OF NEUROSCIENCE

Sleep and Human Aging

(2017) Bryce A. Mander et al.   NEURON

CREB overexpression in dorsal CA1 ameliorates long-term memory deficits in aged rats

(2017) Xiao-Wen Yu et al.   eLife

Ursodeoxycholic acid and 4-phenylbutyrate prevent endoplasmic reticulum stress-induced podocyte apoptosis in diabetic nephropathy

(2016) Ai-Li Cao et al.   LABORATORY INVESTIGATION

The aging population: demographics and the biology of aging

(2016) Eleni Kanasi et al.   PERIODONTOLOGY 2000

Sleep deprivation impairs memory by attenuating mTORC1-dependent protein synthesis

(2016) Jennifer C. Tudor et al.   Science Signaling

Age-Related Reduction of Recovery Sleep and Arousal Threshold in Drosophila

(2016) Julie Vienne et al.   SLEEP

Sodium Butyrate Reduces Colitogenic Immunoglobulin A-Coated Bacteria and Modifies the Composition of Microbiota in IL-10 Deficient Mice

(2016) Tenghui Zhang et al.   Nutrients

Sleep deprivation impairs memory by attenuating mTORC1-dependent protein synthesis

(2016) Jennifer C. Tudor et al.   Science Signaling

Age-Related Reduction of Recovery Sleep and Arousal Threshold in Drosophila

(2016) Julie Vienne et al.   SLEEP

PERK inhibition prevents tau-mediated neurodegeneration in a mouse model of frontotemporal dementia

(2015) Helois Radford et al.   ACTA NEUROPATHOLOGICA

Review: Modulating the unfolded protein response to prevent neurodegeneration and enhance memory

(2015) Mark Halliday et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Diet/Energy Balance Affect Sleep and Wakefulness Independent of Body Weight

(2015) Isaac J. Perron et al.   SLEEP

Partial restoration of protein synthesis rates by the small molecule ISRIB prevents neurodegeneration without pancreatic toxicity

(2015) M Halliday et al.   Cell Death & Disease

Diet/Energy Balance Affect Sleep and Wakefulness Independent of Body Weight

(2015) Isaac J. Perron et al.   SLEEP

Disturbance of endoplasmic reticulum proteostasis in neurodegenerative diseases

(2014) Claudio Hetz et al.   NATURE REVIEWS NEUROSCIENCE

XBP-1 Is a Cell-Nonautonomous Regulator of Stress Resistance and Longevity

(2013) Rebecca C. Taylor et al.   CELL

Control of arousal by the orexin neurons

(2013) Chloe Alexandre et al.   CURRENT OPINION IN NEUROBIOLOGY

Suppression of eIF2α kinases alleviates Alzheimer's disease–related plasticity and memory deficits

(2013) Tao Ma et al.   NATURE NEUROSCIENCE

Aging induced endoplasmic reticulum stress alters sleep and sleep homeostasis

(2013) Marishka K. Brown et al.   NEUROBIOLOGY OF AGING

Targeting the unfolded protein response in neurodegeneration: A new approach to therapy

(2013) Mark Halliday et al.   NEUROPHARMACOLOGY

BDNF mechanisms in late LTP formation: A synthesis and breakdown

(2013) Debabrata Panja et al.   NEUROPHARMACOLOGY

Impaired Spatial Learning and Memory after Sevoflurane–Nitrous Oxide Anesthesia in Aged Rats Is Associated with Down-Regulated cAMP/CREB Signaling

(2013) Wan-Xia Xiong et al.   PLoS One

Aging in Mice Reduces the Ability to Sustain Sleep/Wake States

(2013) Mathieu E. Wimmer et al.   PLoS One

Dietary Therapy Mitigates Persistent Wake Deficits Caused by Mild Traumatic Brain Injury

(2013) M. M. Lim et al.   Science Translational Medicine

GADD34 induces cell death through inactivation of Akt following traumatic brain injury

(2013) J M Farook et al.   Cell Death & Disease

The impact of sleep deprivation on neuronal and glial signaling pathways important for memory and synaptic plasticity

(2012) Robbert Havekes et al.   CELLULAR SIGNALLING

Protein Synthesis during Sleep Consolidates Cortical Plasticity In Vivo

(2012) Julie Seibt et al.   CURRENT BIOLOGY

Exploiting the selectivity of protein phosphatase 1 for pharmacological intervention

(2012) Pavel Tsaytler et al.   FEBS Journal

Sustained translational repression by eIF2α-P mediates prion neurodegeneration

(2012) Julie A. Moreno et al.   NATURE

The endoplasmic reticulum stress response in aging and age-related diseases

(2012) Marishka K. Brown et al.   Frontiers in Physiology

Endoplasmic reticulum stress in wake-active neurons progresses with aging

(2011) Nirinjini Naidoo et al.   AGING CELL

HDAC inhibition modulates hippocampus-dependent long-term memory for object location in a CBP-dependent manner

(2011) J. Haettig et al.   LEARNING & MEMORY

Aging impairs hippocampus-dependent long-term memory for object location in mice

(2011) Mathieu E. Wimmer et al.   NEUROBIOLOGY OF AGING

Long-Term Potentiation at CA3–CA1 Hippocampal Synapses with Special Emphasis on Aging, Disease, and Stress

(2011) Ashok Kumar   Frontiers in Aging Neuroscience

Protein homeostasis and aging: The importance of exquisite quality control

(2010) Hiroshi Koga et al.   AGEING RESEARCH REVIEWS

The memory function of sleep

(2010) Susanne Diekelmann et al.   NATURE REVIEWS NEUROSCIENCE

Self-Reported Sleep Quality Predicts Poor Cognitive Performance in Healthy Older Adults

(2009) R. D. Nebes et al.   JOURNALS OF GERONTOLOGY SERIES B-PSYCHOLOGICAL SCIENCES AND SOCIAL SCIENCES

Mechanisms of Sleep-Dependent Consolidation of Cortical Plasticity

(2009) Sara J. Aton et al.   NEURON

Phenylbutyrate Ameliorates Cognitive Deficit and Reduces Tau Pathology in an Alzheimer's Disease Mouse Model

(2009) Ana Ricobaraza et al.   NEUROPSYCHOPHARMACOLOGY

Salubrinal, an inhibitor of protein synthesis, promotes deep slow wave sleep

(2008) Melvi M. Methippara et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Aging Impairs the Unfolded Protein Response to Sleep Deprivation and Leads to Proapoptotic Signaling

(2008) N. Naidoo et al.   JOURNAL OF NEUROSCIENCE

BDNF is essential to promote persistence of long-term memory storage

(2008) P. Bekinschtein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of protein synthesis in memory consolidation: Progress amid decades of debate

(2007) Pepe J. Hernandez et al.   NEUROBIOLOGY OF LEARNING AND MEMORY