Trafficking of the glutamate transporter is impaired in LRRK2-related Parkinson’s disease
出版年份 2022 全文链接
标题
Trafficking of the glutamate transporter is impaired in LRRK2-related Parkinson’s disease
作者
关键词
-
出版物
ACTA NEUROPATHOLOGICA
Volume -, Issue -, Pages -
出版商
Springer Science and Business Media LLC
发表日期
2022-05-21
DOI
10.1007/s00401-022-02437-0
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Astrogliosis and sexually dimorphic neurodegeneration and microgliosis in the olfactory bulb in Parkinson’s disease
- (2021) Alicia Flores-Cuadrado et al. npj Parkinsons Disease
- Parkinson’s Disease–Associated LRRK2 Interferes with Astrocyte-Mediated Alpha-Synuclein Clearance
- (2021) Linn Streubel-Gallasch et al. MOLECULAR NEUROBIOLOGY
- Astrocytic atrophy as a pathological feature of Parkinson’s disease with LRRK2 mutation
- (2021) Paula Ramos-Gonzalez et al. npj Parkinsons Disease
- Microglia jointly degrade fibrillar alpha-synuclein cargo by distribution through tunneling nanotubes
- (2021) Hannah Scheiblich et al. CELL
- Understanding LRRK2 kinase activity in preclinical models and human subjects through quantitative analysis of LRRK2 and pT73 Rab10
- (2021) Xiang Wang et al. Scientific Reports
- Induction of Parkinsonian-Like Changes via Targeted Downregulation of Astrocytic Glutamate Transporter GLT-1 in the Striatum
- (2021) Chao Ren et al. Journal of Parkinsons Disease
- Generation of a Novel Mouse Model of Parkinson’s Disease via Targeted Knockdown of Glutamate Transporter GLT-1 in the Substantia Nigra
- (2020) Yunlong Zhang et al. ACS Chemical Neuroscience
- Diagnosis and Treatment of Parkinson Disease
- (2020) Melissa J. Armstrong et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- LRRK2 in Parkinson disease: challenges of clinical trials
- (2020) Eduardo Tolosa et al. Nature Reviews Neurology
- An Assessment of LRRK2 Serine 935 Phosphorylation in Human Peripheral Blood Mononuclear Cells in Idiopathic Parkinson’s Disease and G2019S LRRK2 Cohorts
- (2020) Shalini Padmanabhan et al. Journal of Parkinsons Disease
- Glutamate-induced excitotoxicity in Parkinson's disease: The role of glial cells
- (2020) L. Iovino et al. JOURNAL OF PHARMACOLOGICAL SCIENCES
- Distinct Roles for RAB10 and RAB29 in Pathogenic LRRK2-Mediated Endolysosomal Trafficking Alterations
- (2020) Pilar Rivero-Ríos et al. Cells
- Pathway-specific dysregulation of striatal excitatory synapses by LRRK2 mutations
- (2020) Chuyu Chen et al. eLife
- Divergent Effects of G2019S and R1441C LRRK2 Mutations on LRRK2 and Rab10 Phosphorylations in Mouse Tissues
- (2020) Lucia Iannotta et al. Cells
- Ubiquitination and the proteasome rather than caspase‐3‐mediated C‐terminal cleavage are involved in the EAAT2 degradation by staurosporine‐induced cellular stress
- (2020) Timo‐Daniel Voss et al. JOURNAL OF NEUROCHEMISTRY
- Multiplex imaging relates quantal glutamate release to presynaptic Ca2+ homeostasis at multiple synapses in situ
- (2019) Thomas P. Jensen et al. Nature Communications
- The G2019S variant of leucine-rich repeat kinase 2 (LRRK2) alters endolysosomal trafficking by impairing the function of the GTPase RAB8A
- (2019) Pilar Rivero-Ríos et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- α-Synuclein and astrocytes: tracing the pathways from homeostasis to neurodegeneration in Lewy body disease
- (2019) Zachary A. Sorrentino et al. ACTA NEUROPATHOLOGICA
- Basal and Evoked Neurotransmitter Levels in Parkin, DJ-1, PINK1 and LRRK2 Knockout Rat Striatum
- (2019) Rose B. Creed et al. NEUROSCIENCE
- RAB8, RAB10 and RILPL1 contribute to both LRRK2 kinase-mediated centrosomal cohesion and ciliogenesis deficits
- (2019) Antonio Jesús Lara Ordóñez et al. HUMAN MOLECULAR GENETICS
- Excitatory Amino Acid Transporters in Physiology and Disorders of the Central Nervous System
- (2019) Malik et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Divergent roles of astrocytic versus neuronal EAAT2 deficiency on cognition and overlap with aging and Alzheimer’s molecular signatures
- (2019) Abhijeet Sharma et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Parkinson disease-associated mutations in LRRK2 cause centrosomal defects via Rab8a phosphorylation
- (2018) Jesús Madero-Pérez et al. Molecular Neurodegeneration
- Physiology of Astroglia
- (2018) Alexei Verkhratsky et al. PHYSIOLOGICAL REVIEWS
- Serum amino acid profile in patients with Parkinson’s disease
- (2018) Monika Figura et al. PLoS One
- Robust kinase- and age-dependent dopaminergic and norepinephrine neurodegeneration in LRRK2 G2019S transgenic mice
- (2018) Yulan Xiong et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Single organelle dynamics linked to 3D structure by correlative live-cell imaging and 3D electron microscopy
- (2018) Job Fermie et al. TRAFFIC
- Dopamine D2 receptor-mediated neuroprotection in a G2019S Lrrk2 genetic model of Parkinson’s disease
- (2018) Alessandro Tozzi et al. Cell Death & Disease
- Novel interaction between Alzheimer’s disease-related protein presenilin 1 and glutamate transporter 1
- (2018) Katarzyna Marta Zoltowska et al. Scientific Reports
- Heterogeneity of Astrocytic and Neuronal GLT-1 at Cortical Excitatory Synapses, as Revealed by its Colocalization With Na+/K+-ATPase α Isoforms
- (2018) Marcello Melone et al. CEREBRAL CORTEX
- Parkinson's Disease-linked LRRK2-G2019S mutation alters synaptic plasticity and promotes resilience to chronic social stress in young adulthood
- (2018) Bridget A. Matikainen-Ankney et al. JOURNAL OF NEUROSCIENCE
- Beyond Dopamine: GABA, Glutamate, and the Axial Symptoms of Parkinson Disease
- (2018) Ruth L. O'Gorman Tuura et al. Frontiers in Neurology
- Astroglial glutamate transporters in the brain: Regulating neurotransmitter homeostasis and synaptic transmission
- (2017) Ciaran Murphy-Royal et al. JOURNAL OF NEUROSCIENCE RESEARCH
- Sonic hedgehog induces GLT-1 degradation via PKC delta to suppress its transporter activities
- (2017) Yuqing Wang et al. NEUROSCIENCE
- The Role of Astrocyte Dysfunction in Parkinson’s Disease Pathogenesis
- (2017) Heather D.E. Booth et al. TRENDS IN NEUROSCIENCES
- Regulation of glutamate transporter trafficking by Nedd4-2 in a Parkinson’s disease model
- (2017) Yunlong Zhang et al. Cell Death & Disease
- Initial elevations in glutamate and dopamine neurotransmission decline with age, as does exploratory behavior, in LRRK2 G2019S knock-in mice
- (2017) Mattia Volta et al. eLife
- Elevated LRRK2 autophosphorylation in brain-derived and peripheral exosomes in LRRK2 mutation carriers
- (2017) Shijie Wang et al. Acta Neuropathologica Communications
- Age-dependent dopamine transporter dysfunction and Serine129 phospho-α-synuclein overload in G2019S LRRK2 mice
- (2017) Francesco Longo et al. Acta Neuropathologica Communications
- Neuronal activity mediated regulation of glutamate transporter GLT-1 surface diffusion in rat astrocytes in dissociated and slice cultures
- (2016) Sana Al Awabdh et al. GLIA
- Pharmacologic inhibition of Hsp90 to prevent GLT-1 degradation as an effective therapy for epilepsy
- (2016) Longze Sha et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Parkinson’s: a syndrome rather than a disease?
- (2016) Nataliya Titova et al. JOURNAL OF NEURAL TRANSMISSION
- The astrocytic response to the dopaminergic denervation of the striatum
- (2016) Ingrid Morales et al. JOURNAL OF NEUROCHEMISTRY
- Altered Development of Synapse Structure and Function in Striatum Caused by Parkinson's Disease-Linked LRRK2-G2019S Mutation
- (2016) B. A. Matikainen-Ankney et al. JOURNAL OF NEUROSCIENCE
- Parkinson's disease: 4 big questions
- (2016) Sarah Deweerdt NATURE
- Neuronal vs glial glutamate uptake: Resolving the conundrum
- (2016) N.C. Danbolt et al. NEUROCHEMISTRY INTERNATIONAL
- Inflammation, Glutamate and Glia: A Trio of Trouble in Mood Disorders
- (2016) Ebrahim Haroon et al. NEUROPSYCHOPHARMACOLOGY
- DJ-1 deficiency impairs glutamate uptake into astrocytes via the regulation of flotillin-1 and caveolin-1 expression
- (2016) Jin-Mo Kim et al. Scientific Reports
- LRRK2 Regulates Voltage-Gated Calcium Channel Function
- (2016) Cade Bedford et al. Frontiers in Molecular Neuroscience
- Autophagy Constitutes a Protective Mechanism against Ethanol Toxicity in Mouse Astrocytes and Neurons
- (2016) Antoni Pla et al. PLoS One
- Surface diffusion of astrocytic glutamate transporters shapes synaptic transmission
- (2015) Ciaran Murphy-Royal et al. NATURE NEUROSCIENCE
- Low levels of astroglial markers in Parkinson’s disease: relationship to α-synuclein accumulation
- (2015) Junchao Tong et al. NEUROBIOLOGY OF DISEASE
- Progressive dopaminergic alterations and mitochondrial abnormalities in LRRK2 G2019S knock-in mice
- (2015) M. Yue et al. NEUROBIOLOGY OF DISEASE
- Neuroimaging of Parkinson's disease: Expanding views
- (2015) Carol P. Weingarten et al. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
- Proteomic Analysis of Gliosomes from Mouse Brain: Identification and Investigation of Glial Membrane Proteins
- (2014) Karen E. Carney et al. JOURNAL OF PROTEOME RESEARCH
- Genetic and pharmacological evidence that G2019S LRRK2 confers a hyperkinetic phenotype, resistant to motor decline associated with aging
- (2014) Francesco Longo et al. NEUROBIOLOGY OF DISEASE
- Localization of excitatory amino acid transporters EAAT1 and EAAT2 in human postmortem cortex: A light and electron microscopic study
- (2014) R.C. Roberts et al. NEUROSCIENCE
- Dopamine Reduction in the Substantia Nigra of Parkinson's Disease Patients Confirmed by In Vivo Magnetic Resonance Spectroscopic Imaging
- (2014) Adriane Gröger et al. PLoS One
- The Complex Ultrastructure of the Endolysosomal System
- (2014) J. Klumperman et al. Cold Spring Harbor Perspectives in Biology
- Ceftriaxone increases glutamate uptake and reduces striatal tyrosine hydroxylase loss in 6-OHDA Parkinson's model
- (2013) Tanya Chotibut et al. MOLECULAR NEUROBIOLOGY
- Divergent α-synuclein solubility and aggregation properties in G2019S LRRK2 Parkinson's disease brains with Lewy Body pathology compared to idiopathic cases
- (2013) Adamantios Mamais et al. NEUROBIOLOGY OF DISEASE
- Cell surface turnover of the glutamate transporter GLT-1 is mediated by ubiquitination/deubiquitination
- (2012) Jaime Martínez-Villarreal et al. GLIA
- Protein Kinase C (PKC)-promoted Endocytosis of Glutamate Transporter GLT-1 Requires Ubiquitin Ligase Nedd4-2-dependent Ubiquitination but Not Phosphorylation
- (2012) Noemí García-Tardón et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADP
- (2011) Patricia Gómez-Suaga et al. HUMAN MOLECULAR GENETICS
- Differential Expression of the Glutamate Transporter GLT-1 in Pancreas
- (2011) James S. Meabon et al. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
- Co-compartmentalization of the Astroglial Glutamate Transporter, GLT-1, with Glycolytic Enzymes and Mitochondria
- (2011) E. N. Genda et al. JOURNAL OF NEUROSCIENCE
- Neuroinflammation in Parkinson's disease
- (2011) Etienne C. Hirsch et al. PARKINSONISM & RELATED DISORDERS
- Structure−Activity Relationship Study of First Selective Inhibitor of Excitatory Amino Acid Transporter Subtype 1: 2-Amino-4-(4-methoxyphenyl)-7-(naphthalen-1-yl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile (UCPH-101)
- (2010) Mette N. Erichsen et al. JOURNAL OF MEDICINAL CHEMISTRY
- In vitroactivation of GAT1 transporters expressed in spinal cord gliosomes stimulates glutamate release that is abnormally elevated in the SOD1/G93A(+) mouse model of amyotrophic lateral sclerosis
- (2010) Marco Milanese et al. JOURNAL OF NEUROCHEMISTRY
- The Surface Density of the Glutamate Transporter EAAC1 is Controlled by Interactions with PDZK1 and AP2 Adaptor Complexes
- (2010) Anna D’ Amico et al. TRAFFIC
- Astrocytic expression of Parkinson's disease-related A53T α-synuclein causes neurodegeneration in mice
- (2010) Xing-Long Gu et al. Molecular Brain
- Glutamate Transporter Coupling to Na,K-ATPase
- (2009) E. M. Rose et al. JOURNAL OF NEUROSCIENCE
- PKC-dependent endocytosis of the GLT1 glutamate transporter depends on ubiquitylation of lysines located in a C-terminal cluster
- (2008) Inmaculada M. González-gonzález et al. GLIA
- Downregulation of glial glutamate transporters after dopamine denervation in the striatum of 6-hydroxydopamine-lesioned rats
- (2008) E.K.Y. Chung et al. JOURNAL OF COMPARATIVE NEUROLOGY
- A quantitative assessment of glutamate uptake into hippocampal synaptic terminals and astrocytes: New insights into a neuronal role for excitatory amino acid transporter 2 (EAAT2)
- (2008) D.N. Furness et al. NEUROSCIENCE
- Glial reactions in Parkinson's disease
- (2007) Patrick L. McGeer et al. MOVEMENT DISORDERS
- Internalization and degradation of the glutamate transporter GLT-1 in response to phorbol ester
- (2007) Bala T.S. Susarla et al. NEUROCHEMISTRY INTERNATIONAL
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