Downregulation of phosphoglycerate mutase 5 improves microglial inflammasome activation after traumatic brain injury

Phosphoglycerate Mutase 5 Knockdown Alleviates Neuronal Injury After Traumatic Brain Injury Through Drp1-Mediated Mitochondrial Dysfunction

(2020) Yuhua Chen et al.   ANTIOXIDANTS & REDOX SIGNALING

The NLRP3 inflammasome in traumatic brain injury: potential as a biomarker and therapeutic target

(2020) William T. O’Brien et al.   Journal of Neuroinflammation

Mitochondrial phosphatase PGAM5 modulates cellular senescence by regulating mitochondrial dynamics

(2020) Bo Yu et al.   Nature Communications

Estrogen Attenuates Traumatic Brain Injury by Inhibiting the Activation of Microglia and Astrocyte-Mediated Neuroinflammatory Responses

(2020) Jin Wang et al.   MOLECULAR NEUROBIOLOGY

SerpinA3N deficiency deteriorates impairments of learning and memory in mice following hippocampal stab injury

(2020) Zhi-Meng Wang et al.   Cell Death Discovery

Phosphoglycerate mutase 5 exacerbates cardiac ischemia-reperfusion injury through disrupting mitochondrial quality control

(2020) Hang Zhu et al.   Redox Biology

Rapamycin improves the neuroprotection effect of inhibition of NLRP3 inflammasome activation after TBI

(2019) Yuhua Chen et al.   BRAIN RESEARCH

STAT6 mediates the effect of ethanol on neuroinflammatory response in TBI

(2019) Florian olde Heuvel et al.   BRAIN BEHAVIOR AND IMMUNITY

Dynamic PGAM5 multimers dephosphorylate BCL-xL or FUNDC1 to regulate mitochondrial and cellular fate

(2019) Kaili Ma et al.   CELL DEATH AND DIFFERENTIATION

EK7 Regulates NLRP3 Inflammasome Activation and Neuroinflammation Post-traumatic Brain Injury

(2019) Yuhua Chen et al.   Frontiers in Molecular Neuroscience

Recent advances in traumatic brain injury

(2019) Abdelhakim Khellaf et al.   JOURNAL OF NEUROLOGY

Brain–Immune Interactions and Neuroinflammation After Traumatic Brain Injury

(2019) Virginie Dinet et al.   Frontiers in Neuroscience

Inflammasome: Its role in traumatic brain and spinal cord injury

(2018) Keywan Mortezaee et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Unconjugated bilirubin induces pyroptosis in cultured rat cortical astrocytes

(2018) Jie Feng et al.   Journal of Neuroinflammation

Ablation of caspase-1 protects against TBI-induced pyroptosis in vitro and in vivo

(2018) Wei Liu et al.   Journal of Neuroinflammation

Inhibitory effect of melatonin on necroptosis via repressing the Ripk3-PGAM5-CypD-mPTP pathway attenuates cardiac microvascular ischemia-reperfusion injury

(2018) Hao Zhou et al.   JOURNAL OF PINEAL RESEARCH

Secondary brain injury: Predicting and preventing insults

(2018) Christos Lazaridis et al.   NEUROPHARMACOLOGY

Caspase-1 inhibition prevents glial inflammasome activation and pyroptosis in models of multiple sclerosis

(2018) Brienne A. McKenzie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Uncoupled Endothelial Nitric Oxide Synthase Enhances p-Tau in Chronic Traumatic Encephalopathy Mouse Model

(2018) Nara Shin et al.   ANTIOXIDANTS & REDOX SIGNALING

Cleaved PGAM5 is released from mitochondria depending on proteasome-mediated rupture of the outer mitochondrial membrane during mitophagy

(2018) Ayane Yamaguchi et al.   JOURNAL OF BIOCHEMISTRY

The plasticity of primary microglia and their multifaceted effects on endogenous neural stem cells in vitro and in vivo

(2018) Sabine Ulrike Vay et al.   Journal of Neuroinflammation

Traumatic brain injury: integrated approaches to improve prevention, clinical care, and research

(2017) Andrew I R Maas et al.   LANCET NEUROLOGY

The far-reaching scope of neuroinflammation after traumatic brain injury

(2017) Dennis W. Simon et al.   Nature Reviews Neurology

PGAM5-mediated programmed necrosis of hepatocytes drives acute liver injury

(2016) Gui-Wei He et al.   GUT

Mitochondrial Protein PGAM5 Regulates Mitophagic Protection against Cell Necroptosis

(2016) Wei Lu et al.   PLoS One

Recombinant human interleukin-1 receptor antagonist promotes M1 microglia biased cytokines and chemokines following human traumatic brain injury

(2015) Adel Helmy et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The Mitochondrial Phosphatase PGAM5 Is Dispensable for Necroptosis but Promotes Inflammasome Activation in Macrophages

(2015) Kenta Moriwaki et al.   JOURNAL OF IMMUNOLOGY

Caspase-8 scaffolding function and MLKL regulate NLRP3 inflammasome activation downstream of TLR3

(2015) Seokwon Kang et al.   Nature Communications

Rapamycin and Interleukin-1β Impair Brain-derived Neurotrophic Factor-dependent Neuron Survival by Modulating Autophagy

(2014) Erica D. Smith et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Regulatory Signaling Loop Comprising the PGAM5 Phosphatase and CK2 Controls Receptor-Mediated Mitophagy

(2014) Guo Chen et al.   MOLECULAR CELL

The Mitochondrial Phosphatase PGAM5 Functions at the Convergence Point of Multiple Necrotic Death Pathways

(2012) Zhigao Wang et al.   CELL

Caspase-8 Blocks Kinase RIPK3-Mediated Activation of the NLRP3 Inflammasome

(2012) Tae-Bong Kang et al.   IMMUNITY

Interleukin-1β-induced brain injury and neurobehavioral dysfunctions in juvenile rats can be attenuated by α-phenyl-n-tert-butyl-nitrone

(2010) L.W. Fan et al.   NEUROSCIENCE