Article
Biochemistry & Molecular Biology
Xiang Gao, Lei Du, Edward Randell, Huijun Zhang, Kelei Li, Duo Li
Summary: The study showed that EPA/DHA-PC derived from Sthenototeuthis oualaniensis effectively reversed obesity, insulin resistance, and hyperglycemia induced by a high-fat diet in mice. The mechanism of action included modulating insulin signaling pathways, improving inflammatory pathways in adipose tissue, and altering gut microbiota composition.
Article
Nutrition & Dietetics
Daniel Antonio de Luis Roman, David Primo, Olatz IZaola, Emilia Gomez, Juan Jose Lopez
Summary: The ADIPOQ gene variant rs3774261 combined with a high polyunsaturated fat hypocaloric diet is associated with a significant increase in serum adiponectin levels and adiponectin/leptin ratio, as well as a decrease in lipid profile and C-reactive protein concentration.
Article
Food Science & Technology
Qian Su, Juan Huang, Xi Chen, Yijie Wang, Muqing Shao, Hongjia Yan, Caiyu Chen, Hongmei Ren, Fuwei Zhang, Yinxing Ni, Pedro A. Jose, Jian Zhong, Jian Yang
Summary: Long-term high-fat diet causes insulin resistance and impairs insulin clearance, with a decrease in renal IDE expression. The PPAR gamma pathway is involved in the inhibition of IDE expression by palmitic acid. Rosiglitazone improves insulin clearance and insulin resistance and increases renal IDE expression in HFD fed-mice.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Pharmacology & Pharmacy
D. A. De Luis, D. Primo, O. Izaola, J. Lopez-Gomez
Summary: This study examined the effects of rs3774261 of the ADIPOQ gene on metabolic response and adiposity parameters after a hypocaloric Mediterranean diet pattern. The results showed that carriers of the AA genotype had significant improvements in lipid levels, inflammatory markers, and adiponectin levels after the dietary intervention, while carriers of the G allele did not show improvement.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2023)
Article
Plant Sciences
Prabhakar Yellanur Konda, Vidyasagar Chennupati, Sreenivasulu Dasari, Nishesh Sharma, Muthukumaran Muthulingam, Ranjani Ramakrishnan, Ankanna Sade, Vigneshwari Jagadheeshkumar, Vijayakumar Natesan, Krishna Kumar Jaiswal
Summary: The study demonstrates that the supplementation of Syzygium paniculatum fruit extract can effectively improve hepatic insulin resistance induced by a high-fat diet, reducing body weight, blood sugar, insulin, lipid profiles, and liver enzymes in rats.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Endocrinology & Metabolism
Cheng Lin, YanYan Lin, Ji Luo, JunRu Yu, YaNi Cheng, XiaoYun Wu, Lin Lin, YuanShao Lin
Summary: The study demonstrated that maternal consumption of a high-fat diet during pregnancy and lactation had multigenerational effects on hippocampal synaptic plasticity and cognitive function in male offspring. Central insulin resistance may play a crucial role in the link between maternal diet and cognitive impairment across generations.
Article
Biochemistry & Molecular Biology
Jianfeng Du, Yu Tina Zhao, Hao Wang, Ling X. Zhang, Gangjian Qin, Shougang Zhuang, Marshall Kadin, Y. Eugene Chin, Paul Y. Liu, Ting C. Zhao
Summary: The study found that deletion of the PRAK gene exacerbates the effects of high-fat diet on cardiac function and insulin resistance in mice, resulting in decreased cardiac function, increased expression of hypertrophic genes, and metabolic disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Plant Sciences
Rasidat O. Tijani, Jose Alberto Molina-Tijeras, Teresa Vezza, Antonio Jesus Ruiz-Malagon, Maria de la Luz Cadiz-Gurrea, Antonio Segura-Carretero, Oyindamola O. Abiodun, Julio Galvez
Summary: The methanol extract of Myrianthus arboreus leaf showed significant therapeutic effects in a mice model of metabolic syndrome induced by a high-fat diet, including reducing weight gain, improving blood sugar and insulin resistance, and enhancing lipid profile. Additionally, the extract demonstrated potential in treating metabolic disorders through modulation of inflammatory status and gene expression related to obesity.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Nutrition & Dietetics
Nives Bogataj Jontez, Sasa Kenig, Karin Sik Novak, Ana Petelin, Zala Jenko Praznikar, Nina Mohorko
Summary: This study compared the dietary patterns of individuals following LCHF, vegan, vegetarian, and omnivorous diets. The results showed that compared to other groups, the LCHF group had higher intakes of saturated fats, cholesterol, and animal proteins, while the intakes of sugars and dietary fibers were lower. The levels of total and LDL cholesterol were significantly higher in the LCHF group. Thus, it is recommended to select healthy fat sources, increase dietary fiber intake, and partially replace animal sources with plant sources in the LCHF diet.
FRONTIERS IN NUTRITION
(2023)
Article
Biology
Valentina Murtaj, Silvia Penati, Sara Belloli, Maria Foti, Angela Coliva, Angela Papagna, Cecilia Gotti, Elisa Toninelli, Remy Chiaffarelli, Stefano Mantero, Susanna Pucci, Michela Matteoli, Maria Luisa Malosio, Rosa Maria Moresco
Summary: The study found that male mice exposed to a high fat diet are more susceptible to metabolic changes compared to female mice, showing faster and higher weight gain, elevated cholesterol and liver enzyme levels, and more prominent brain inflammation.
COMMUNICATIONS BIOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Guang Ren, Patrick Tae Joon Hwang, Reid Millican, Juhee Shin, Brigitta C. Brott, Thomas van Groen, Craig M. Powell, Sushant Bhatnagar, Martin E. Young, Ho-Wook Jun, Jeong-A Kim
Summary: This study demonstrates the effects of using PANO gel to inject exogenous NO on high-fat diet-induced obesity, insulin resistance, and cognitive functions. The use of PANO gel reduces body weight gain, improves glucose tolerance, decreases insulin and leptin levels, and enhances insulin signaling. Additionally, the PANO gel reduces inflammation, increases lipolysis, decreases serum lipids and liver triglycerides, stimulates the development of brown and beige fat tissues, increases cerebral blood flow, and improves learning and memory abilities.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Biochemistry & Molecular Biology
Jose Alberto Molina-Tijeras, Antonio Jesus Ruiz-Malagon, Laura Hidalgo-Garcia, Patricia Diez-Echave, Maria Jesus Rodriguez-Sojo, Maria de la Luz Cadiz-Gurrea, Antonio Segura-Carretero, Jose Perez del Palacio, Maria Reyes Gonzalez-Tejero, Maria Elena Rodriguez-Cabezas, Julio Galvez, Alba Rodriguez-Nogales, Teresa Vezza, Francesca Algieri
Summary: Obesity, a global public health problem, is increasing in prevalence rate. Plant-based treatments, such as Lavandula multifida extract (LME), have been gaining attention as a means to manage obesity and its comorbidities. In this study, LME was found to reduce weight gain, improve insulin sensitivity and glucose tolerance, decrease inflammation in the liver and adipose tissue, regulate gut permeability, and reduce oxidative stress. These findings suggest that LME may be a promising supplementary approach for managing obesity and its comorbidities.
Article
Medicine, Research & Experimental
Nibedita Nayak, Monalisa Mishra
Summary: The research found that a high-fat diet leads to obesity, insulin resistance, disruption of the clock, and other complications in the Drosophila model. These findings are significant for understanding and treating type-II diabetes and circadian anomalies.
Article
Pharmacology & Pharmacy
Nazia Begum, Kandavalli Manipriya, B. Veeresh
Summary: This study developed a new animal model by combining a high-fat diet with letrozole to better simulate polycystic ovary syndrome (PCOS). Compared to the letrozole-only model, this new model can better demonstrate metabolic anomalies observed in PCOS.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
Patricia Perez-Matute, Iciar P. Lopez, Maria iniguez, Emma Recio-Fernandez, Raquel Torrens, Sergio Pineiro-Hermida, Elvira Alfaro-Arnedo, Luong Chau, Christina Walz, Andreas Hoeflich, Jose A. Oteo, Jose G. Pichel
Summary: This study aims to investigate the short and long-term metabolic consequences of IGF1R systemic gene deficiency in mice. The results showed that young IGF1R-deficient mice were insulin-resistant and had altered circulating levels of IGF1, growth hormone (GH), and IGFBP3. Middle-aged IGF1R-deficient male mice were able to counteract the negative effects induced by aging and high-fat diet (HFD) in adiposity, inflammation, and glucose metabolism, demonstrating a metabolic sexual dimorphism dependent on IGF1R.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Nutrition & Dietetics
David Primo, Javier Garcia Rioja, Olatz Izaola, Carlos del Rio San Cristobal, Ruben Pinero Teno, Daniel de Luis Roman
Summary: Prescribing physical exercise through an online platform can improve anthropometric parameters, cardiovascular risk factors, and quality of life in sedentary obese patients.
NUTRICION HOSPITALARIA
(2022)
Review
Nutrition & Dietetics
Ricardo Usategui-Martin, Daniel-Antonio De Luis-Roman, Jose Maria Fernandez-Gomez, Marta Ruiz-Mambrilla, Jose-Luis Perez-Castrillon
Summary: This study evaluated the impact of polymorphisms in the vitamin D receptor gene on the response to vitamin D supplementation through a systematic review and meta-analysis. The results suggest that the TaqI and FokI polymorphisms may play a role in modulating the response to vitamin D supplementation.
Article
Endocrinology & Metabolism
Rebeca Jimenez-Sahagun, Emilia Gomez Hoyos, Gonzalo Diaz Soto, Maria de la O. Nieto de la Marca, Marta Sanchez Ibanez, Sofia del Amo Simon, Beatriz Torres Torres, Juan Jose Lopez Gomez, Esther Delgado Garcia, Ana Ortola Buigues, Daniel de Luis Roman
Summary: Flash glucose monitoring (FGM) combined with a structured educational program can improve the quality of life and patient satisfaction in patients with type 1 diabetes (DM1). However, there was no significant improvement in other glycemic control parameters, except for the improvement in HbA1c and reduction in the number of hypoglycemic events.
ENDOCRINOLOGIA DIABETES Y NUTRICION
(2022)
Article
Biotechnology & Applied Microbiology
Daniel de Luis, Olatz Izaola, David Primo, Rocio Aller
Summary: This study demonstrated a significant improvement in serum omentin-1 levels after weight loss with both high-fat hypocaloric diets, with Diet M showing a higher improvement compared to Diet P.
Article
Nutrition & Dietetics
Juan J. Lopez-Gomez, Katia Benito-Sendin Plaar, Olatz Izaola-Jauregui, David Primo-Martin, Emilia Gomez-Hoyos, Beatriz Torres-Torres, Daniel A. De Luis-Roman
Summary: This study compared the value of muscle ultrasonography with techniques such as anthropometry and impedanciometry in diagnosing malnutrition in patients with oncological pathology. The results showed that muscle ultrasonography correlates with body composition measurement techniques.
Article
Nutrition & Dietetics
Juan J. Lopez-Gomez, Jose L. Perez-Castrillon, Isabel Garcia de Santos, Maria Perez-Alonso, Olatz Izaola-Jauregui, David Primo-Martin, Daniel A. De Luis-Roman
Summary: This study examined the differences in bone metabolism between postmenopausal women with and without obesity, and compared the risk of fracture at five years between these groups.
Article
Nutrition & Dietetics
Daniel de Luis Roman, David Primo, Olatz Izaola, Rocio Aller
Summary: This study investigated the role of the genetic variant rs662799 of the APOA5 gene in metabolic changes after a 9-month consumption of a low-calorie Mediterranean pattern diet. The results showed that non-C allele carriers experienced a decrease in triglyceride, insulin, and HOMA-IR levels, while no such effect was observed in C allele carriers.
Article
Endocrinology & Metabolism
Carla Noemi Tafur Sanchez, Miguel Dura Gil, Andrea Aleman Dominguez del Rio, Celia Maria Hernandez Perez, Natalia Mora Cuadrado, Sara Gomez de la Cuesta, David Primo Martin, Daniel de Luis Roman, Rocio Aller de la Fuente
Summary: This study evaluated the diagnostic accuracy of non-invasive methods based on clinical and analytical data in the diagnosis of metabolic hepatic steatosis, compared to liver biopsy. The results showed that non-invasive steatosis indices were more sensitive, while fibrosis indices were more specific. HFS had the highest sensitivity and negative predictive value in diabetic patients.
ENDOCRINOLOGIA DIABETES Y NUTRICION
(2022)
Article
Food Science & Technology
Ivan Jesus Jimenez-Pulido, Rico Daniel, Jara Perez, Cristina Martinez-Villaluenga, Daniel De Luis, Ana Belen Martin Diana
Summary: Conventional wheat milling produces a significant amount of wheat bran, which is rich in polyphenols and insoluble fiber with potential health benefits. This study evaluated the impact of protein content on the antioxidant, anti-inflammatory, and glycemic properties of wheat bran. The findings demonstrated that protein content significantly influenced these properties, and segregation of wheat bran based on protein content could enhance the efficiency of valorization processes.
Article
Endocrinology & Metabolism
David Primo, Olatz Izaola, Daniel A. de Luis
Summary: This study found that the TyG index is more powerful for predicting metabolic syndrome than HOMA-IR in Caucasian obese subjects.
ANNALS OF NUTRITION AND METABOLISM
(2023)
Article
Surgery
Daniel Antonio de Luis, Olatz Izaola, David Primo, Juan Jose Lopez, David Pacheco
Summary: This study aimed to evaluate the effects of the rs9939609 genetic variant on weight loss and metabolic parameters after sleeve gastrectomy. The results showed that non-A allele carriers had better improvement in weight, waist circumference, and insulin levels after surgery, and had a lower percentage of participants with diabetes.
SURGERY FOR OBESITY AND RELATED DISEASES
(2023)
Article
Endocrinology & Metabolism
David Primo, Olatz Izaola, Daniel de Luis
Summary: This study found that the high resistin/uric acid index is associated with metabolic syndrome (MS) and is correlated with glucose levels, insulin levels, and insulin resistance (HOMA-IR) in a population of Caucasian females with obesity.
INTERNATIONAL JOURNAL OF OBESITY
(2023)
Article
Nutrition & Dietetics
Juan Jose Lopez-Gomez, David Garcia-Beneitez, Rebeca Jimenez-Sahagun, Olatz Izaola-Jauregui, David Primo-Martin, Beatriz Ramos-Bachiller, Emilia Gomez-Hoyos, Esther Delgado-Garcia, Paloma Perez-Lopez, Daniel A. De Luis-Roman
Summary: This study evaluated the relationship between nutritional ultrasound parameters and morphofunctional assessment in patients with disease-related malnutrition and found that the muscle mass and quality parameters determined by nutritional ultrasound were worse in patients with malnutrition and sarcopenia. In addition, there was a correlation between muscle quality parameters and electrical parameters and muscle strength.
Article
Nutrition & Dietetics
Daniel Antonio de Luis, Olatz Izaola, David Primo, Juan Jose Lopez Gomez
Summary: The objective of this study was to evaluate the role of the rs1042714 genetic variant of ADRB2 gene on weight loss, body composition, and metabolic changes in women with obesity. The study found that the G allele of rs1042714 predicts the magnitude of weight loss resulting from a pMR diet, and these adiposity improvements lead to a better improvement of insulin resistance and impaired glucose metabolism in G allele carriers.
Article
Nutrition & Dietetics
Cristina Serrano Valles, Emilia Gomez Hoyos, Ana Ortola Buigues, David Primo Martin, Rebeca Jimenez Sahagun, Susana Garcia Calvo, Juan Jose Lopez Gomez, Esther Delgado Garcia, Beatriz Torres Torres, Olatz Izaola Jauregui, Marta Sanchez Ibanez, Maria Angeles Castro, Daniel De Luis Roman
Summary: Hyponatremia is a common condition in patients receiving total enteral tube feeding, especially in malnourished patients. Patients with digestive system diseases and infectious diseases are more prone to developing hyponatremia.
NUTRICION HOSPITALARIA
(2022)
