FMRP-Driven Neuropathology in Autistic Spectrum Disorder and Alzheimer's disease: A Losing Game
出版年份 2021 全文链接
标题
FMRP-Driven Neuropathology in Autistic Spectrum Disorder and Alzheimer's disease: A Losing Game
作者
关键词
-
出版物
Frontiers in Molecular Biosciences
Volume 8, Issue -, Pages -
出版商
Frontiers Media SA
发表日期
2021-10-25
DOI
10.3389/fmolb.2021.699613
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- microRNAs as Early Biomarkers of Alzheimer’s Disease: A Synaptic Perspective
- (2021) Dolores Siedlecki-Wullich et al. Cells
- Missense mutation of Fmr1 results in impaired AMPAR-mediated plasticity and socio-cognitive deficits in mice
- (2021) Marta Prieto et al. Nature Communications
- Adenosine A2A receptor inhibition reduces synaptic and cognitive hippocampal alterations in Fmr1 KO mice
- (2021) Antonella Ferrante et al. Translational Psychiatry
- Presynaptic protein synthesis and brain plasticity: From physiology to neuropathology
- (2021) Carla Perrone-Capano et al. PROGRESS IN NEUROBIOLOGY
- Splicing of exon 9a in FMR1 transcripts results in a truncated FMRP with altered subcellular distribution
- (2020) Xian-guo Fu et al. GENE
- Transient upregulation of translational efficiency in prodromal and early symptomatic Tg2576 mice contributes to Aβ pathology
- (2020) Antonella Borreca et al. NEUROBIOLOGY OF DISEASE
- Basal forebrain volume reliably predicts the cortical spread of Alzheimer’s degeneration
- (2020) Sara Fernández-Cabello et al. BRAIN
- Elevated protein synthesis in microglia causes autism-like synaptic and behavioral aberrations
- (2020) Zhi-Xiang Xu et al. Nature Communications
- Elevated de novo protein synthesis in FMRP-deficient human neurons and its correction by metformin treatment
- (2020) Kagistia Hana Utami et al. Molecular Autism
- Alzheimer’s disease-related dysregulation of mRNA translation causes key pathological features with ageing
- (2020) Anshua Ghosh et al. Translational Psychiatry
- C1q/tumor necrosis factor-related protein-1 attenuates microglia autophagy and inflammatory response by regulating the Akt/mTOR pathway
- (2020) Huilin Wang et al. LIFE SCIENCES
- Association of Serum Complement C1q Concentration with Severity of Neurological Impairment and Infarct size in Patients with Acute Ischemic Stroke
- (2020) Dong-Dong Wang et al. Journal of Stroke & Cerebrovascular Diseases
- Identification of FMRP target mRNAs in the developmental brain: FMRP might coordinate Ras/MAPK, Wnt/β-catenin, and mTOR signaling during corticogenesis
- (2020) Cristine R. Casingal et al. Molecular Brain
- Activation of mGluR1 Mediates C1q-Dependent Microglial Phagocytosis of Glutamatergic Synapses in Alzheimer’s Rodent Models
- (2019) Bihua Bie et al. MOLECULAR NEUROBIOLOGY
- Deletion of the KH1 Domain of Fmr1 Leads to Transcriptional Alterations and Attentional Deficits in Rats
- (2019) Carla E M Golden et al. CEREBRAL CORTEX
- Cholinergic neurons of the medial septum are crucial for sensorimotor gating
- (2019) Junghee Jin et al. JOURNAL OF NEUROSCIENCE
- Local translation in neurons: visualization and function
- (2019) Christine E. Holt et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Altered cortical Cytoarchitecture in the Fmr1 knockout mouse
- (2019) Frankie H. F. Lee et al. Molecular Brain
- A de novo mutation in FMR1 in a patient with intellectual disability
- (2019) Sateesh Maddirevula et al. European Journal of Medical Genetics
- Deregulated Local Protein Synthesis in the Brain Synaptosomes of a Mouse Model for Alzheimer’s Disease
- (2019) Carolina Cefaliello et al. MOLECULAR NEUROBIOLOGY
- Fragile X-associated tremor ataxia syndrome with co-occurrent progressive supranuclear palsy-like neuropathology
- (2019) Amanda N. Sacino et al. Acta Neuropathologica Communications
- Microglia and Astrocytes in Alzheimer's Disease: Implications for Therapy
- (2018) Marc Fakhoury Current Neuropharmacology
- Protein synthesis levels are increased in a subset of individuals with fragile X syndrome
- (2018) Sébastien Jacquemont et al. HUMAN MOLECULAR GENETICS
- The Microglial Innate Immune Receptor TREM2 Is Required for Synapse Elimination and Normal Brain Connectivity
- (2018) Fabia Filipello et al. IMMUNITY
- STEP inhibition reverses behavioral, electrophysiologic, and synaptic abnormalities in Fmr1 KO mice
- (2018) Manavi Chatterjee et al. NEUROPHARMACOLOGY
- Handling FMRP and its molecular partners: Structural insights into Fragile X Syndrome
- (2018) Ilda D'Annessa et al. PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY
- Neuroligin 1, 2, and 3 Regulation at the Synapse: FMRP-Dependent Translation and Activity-Induced Proteolytic Cleavage
- (2018) Joanna J. Chmielewska et al. MOLECULAR NEUROBIOLOGY
- Fragile X and APP: a Decade in Review, a Vision for the Future
- (2018) Cara J. Westmark MOLECULAR NEUROBIOLOGY
- TREM2 — a key player in microglial biology and Alzheimer disease
- (2018) Tyler K. Ulland et al. Nature Reviews Neurology
- FMRP recruitment of β‐catenin to the translation pre‐initiation complex represses translation
- (2018) Saviz Ehyai et al. EMBO REPORTS
- Novel upregulation of amyloid-β precursor protein (APP) by microRNA-346 via targeting of APP mRNA 5′-untranslated region: Implications in Alzheimer’s disease
- (2018) Justin M. Long et al. MOLECULAR PSYCHIATRY
- Microglial cell activation and senescence are characteristic of the pathology FXTAS
- (2018) Verónica Martínez Cerdeño et al. MOVEMENT DISORDERS
- Intragenic FMR1 disease-causing variants: a significant mutational mechanism leading to Fragile-X syndrome
- (2017) Angélique Quartier et al. EUROPEAN JOURNAL OF HUMAN GENETICS
- Post-transcriptional regulation of mouse neurogenesis by Pumilio proteins
- (2017) Meng Zhang et al. GENES & DEVELOPMENT
- Expression of BC1 Impairs Spatial Learning and Memory in Alzheimer’s Disease Via APP Translation
- (2017) Tongmei Zhang et al. MOLECULAR NEUROBIOLOGY
- Cell-Type-Specific Translation Profiling Reveals a Novel Strategy for Treating Fragile X Syndrome
- (2017) Sophie R. Thomson et al. NEURON
- Adult Fmr1 knockout mice present with deficiencies in hippocampal interleukin-6 and tumor necrosis factor-α expression
- (2017) Samantha L. Hodges et al. NEUROREPORT
- MicroRNA-125b promotes neurons cell apoptosis and Tau phosphorylation in Alzheimer’s disease
- (2017) Xiaohui Ma et al. NEUROSCIENCE LETTERS
- Generation of a whole-brain atlas for the cholinergic system and mesoscopic projectome analysis of basal forebrain cholinergic neurons
- (2017) Xiangning Li et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Absence of the Fragile X Mental Retardation Protein results in defects of RNA editing of neuronal mRNAs in mouse
- (2017) Alice Filippini et al. RNA Biology
- Multifarious Functions of the Fragile X Mental Retardation Protein
- (2017) Jenna K. Davis et al. TRENDS IN GENETICS
- Fragile X mental retardation protein regulates skeletal muscle stem cell activity by regulating the stability of Myf5 mRNA
- (2017) Ryo Fujita et al. Skeletal Muscle
- The tandem Agenet domain of fragile X mental retardation protein interacts with FUS
- (2017) Qingzhong He et al. Scientific Reports
- MicroRNA-132 and early growth response-1 in nucleus basalis of Meynert during the course of Alzheimer’s disease
- (2016) Qiong-Bin Zhu et al. BRAIN
- Selective Deletion of Astroglial FMRP Dysregulates Glutamate Transporter GLT1 and Contributes to Fragile X Syndrome Phenotypes In Vivo
- (2016) H. Higashimori et al. JOURNAL OF NEUROSCIENCE
- Impairment of the nerve growth factor pathway driving amyloid accumulation in cholinergic neurons: the incipit of the Alzheimer′s disease story?
- (2016) Viviana Triaca et al. Neural Regeneration Research
- Basal Forebrain Cholinergic Circuits and Signaling in Cognition and Cognitive Decline
- (2016) Elizabeth C. Ballinger et al. NEURON
- FMRP regulates an ethanol-dependent shift in GABABR function and expression with rapid antidepressant properties
- (2016) Sarah A. Wolfe et al. Nature Communications
- Basal forebrain degeneration precedes and predicts the cortical spread of Alzheimer’s pathology
- (2016) Taylor W. Schmitz et al. Nature Communications
- The interaction between maternal immune activation and alpha 7 nicotinic acetylcholine receptor in regulating behaviors in the offspring
- (2015) Wei-Li Wu et al. BRAIN BEHAVIOR AND IMMUNITY
- Altered Machinery of Protein Synthesis in Alzheimer's: From the Nucleolus to the Ribosome
- (2015) Karina Hernández-Ortega et al. BRAIN PATHOLOGY
- A novel fragile X syndrome mutation reveals a conserved role for the carboxy-terminus in FMRP localization and function
- (2015) Z. Okray et al. EMBO Molecular Medicine
- Targeted Next-Generation Sequencing Analysis of 1,000 Individuals with Intellectual Disability
- (2015) Detelina Grozeva et al. HUMAN MUTATION
- Actinin-4 Governs Dendritic Spine Dynamics and Promotes Their Remodeling by Metabotropic Glutamate Receptors
- (2015) Magdalena Kalinowska et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Molecular docking based virtual screening of natural compounds as potential BACE1 inhibitors: 3D QSAR pharmacophore mapping and molecular dynamics analysis
- (2015) Akhil Kumar et al. JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
- Single-Molecule Imaging of PSD-95 mRNA Translation in Dendrites and Its Dysregulation in a Mouse Model of Fragile X Syndrome
- (2015) M. F. Ifrim et al. JOURNAL OF NEUROSCIENCE
- Genetic diagnosis of developmental disorders in the DDD study: a scalable analysis of genome-wide research data
- (2015) Caroline F Wright et al. LANCET
- Opposite Dysregulation of Fragile-X Mental Retardation Protein and Heteronuclear Ribonucleoprotein C Protein Associates with Enhanced APP Translation in Alzheimer Disease
- (2015) Antonella Borreca et al. MOLECULAR NEUROBIOLOGY
- X-exome sequencing of 405 unresolved families identifies seven novel intellectual disability genes
- (2015) H Hu et al. MOLECULAR PSYCHIATRY
- Parkinson’s Disease Genes VPS35 and EIF4G1 Interact Genetically and Converge on α-Synuclein
- (2015) Nripesh Dhungel et al. NEURON
- Dysregulated ADAM10-Mediated Processing of APP during a Critical Time Window Leads to Synaptic Deficits in Fragile X Syndrome
- (2015) Emanuela Pasciuto et al. NEURON
- The FMRP/GRK4mRNA interaction uncovers a new mode of binding of the Fragile X mental retardation protein in cerebellum
- (2015) Thomas Maurin et al. NUCLEIC ACIDS RESEARCH
- Independent role for presynaptic FMRP revealed by anFMR1missense mutation associated with intellectual disability and seizures
- (2015) Leila K. Myrick et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Modulation of social deficits and repetitive behaviors in a mouse model of autism: the role of the nicotinic cholinergic system
- (2015) Li Wang et al. PSYCHOPHARMACOLOGY
- The amino-terminal structure of human fragile X mental retardation protein obtained using precipitant-immobilized imprinted polymers
- (2015) Yufeng Hu et al. Nature Communications
- Novel RNA- and FMRP-binding protein TRF2-S regulates axonal mRNA transport and presynaptic plasticity
- (2015) Peisu Zhang et al. Nature Communications
- FMRP interacts with G-quadruplex structures in the 3’-UTR of its dendritic target Shank1 mRNA
- (2015) Yang Zhang et al. RNA Biology
- Impaired sensorimotor gating in Fmr1 knock out and Fragile X premutation model mice
- (2014) A.J. Renoux et al. BEHAVIOURAL BRAIN RESEARCH
- SnapShot: FMRP mRNA Targets and Diseases
- (2014) Emanuela Pasciuto et al. CELL
- Fragile X syndrome due to a missense mutation
- (2014) Leila K Myrick et al. EUROPEAN JOURNAL OF HUMAN GENETICS
- Plakophilins 1 and 3 Bind to FXR1 and Thereby Influence the mRNA Stability of Desmosomal Proteins
- (2014) R. Fischer-Ke o et al. MOLECULAR AND CELLULAR BIOLOGY
- Point mutation frequency in the FMR1 gene as revealed by fragile X syndrome screening
- (2014) Maximilian Handt et al. MOLECULAR AND CELLULAR PROBES
- FMRP S499 Is Phosphorylated Independent of mTORC1-S6K1 Activity
- (2014) Christopher M. Bartley et al. PLoS One
- 2-Methyl-6-(phenylethynyl) pyridine (MPEP) reverses maze learning and PSD-95 deficits in Fmr1 knock-out mice
- (2014) Réno M. Gandhi et al. Frontiers in Cellular Neuroscience
- Fragile X mental retardation protein expression in Alzheimer’s disease
- (2014) Abigail J. Renoux et al. Frontiers in Genetics
- Novel Approaches to Study the Involvement of α7-nAChR in Human Diseases
- (2013) Eleonora Palma et al. CURRENT DRUG TARGETS
- Astroglial FMRP-dependent translational down-regulation of mGluR5 underlies glutamate transporter GLT1 dysregulation in the fragile X mouse
- (2013) Haruki Higashimori et al. HUMAN MOLECULAR GENETICS
- Molecular dynamics simulations show how the FMRP Ile304Asn mutation destabilizes the KH2 domain structure and affects its function
- (2013) Daniele Di Marino et al. JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
- The Fragile X Mental Retardation Protein Regulates Matrix Metalloproteinase 9 mRNA at Synapses
- (2013) A. Janusz et al. JOURNAL OF NEUROSCIENCE
- FMRP and myelin protein expression in oligodendrocytes
- (2013) Anthony Giampetruzzi et al. MOLECULAR AND CELLULAR NEUROSCIENCE
- Phosphorylation of FMRP and alterations of FMRP complex underlie enhanced mLTD in adult rats triggered by early life seizures
- (2013) Paul B. Bernard et al. NEUROBIOLOGY OF DISEASE
- From FMRP Function to Potential Therapies for Fragile X Syndrome
- (2013) Ferzin Sethna et al. NEUROCHEMICAL RESEARCH
- CYFIP1 Coordinates mRNA Translation and Cytoskeleton Remodeling to Ensure Proper Dendritic Spine Formation
- (2013) Silvia De Rubeis et al. NEURON
- Multiple Autism-Linked Genes Mediate Synapse Elimination via Proteasomal Degradation of a Synaptic Scaffold PSD-95
- (2012) Nien-Pei Tsai et al. CELL
- Neurodegeneration-associated TDP-43 Interacts with Fragile X Mental Retardation Protein (FMRP)/Staufen (STAU1) and Regulates SIRT1 Expression in Neuronal Cells
- (2012) Zhipeng Yu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- What’s hAPPening at synapses? The role of amyloid β-protein precursor and β-amyloid in neurological disorders
- (2012) C J Westmark MOLECULAR PSYCHIATRY
- Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner
- (2012) Dorothy P. Schafer et al. NEURON
- BC1-FMRP interaction is modulated by 2′-O-methylation: RNA-binding activity of the tudor domain and translational regulation at synapses
- (2012) Caroline Lacoux et al. NUCLEIC ACIDS RESEARCH
- Basal Forebrain Involvement in Low-Functioning Autistic Children: A Voxel-Based Morphometry Study
- (2011) D. Riva et al. AMERICAN JOURNAL OF NEURORADIOLOGY
- Molecular Mechanisms of Fragile X Syndrome: A Twenty-Year Perspective
- (2011) Michael R. Santoro et al. Annual Review of Pathology-Mechanisms of Disease
- A nonsense mutation in FMR1 causing fragile X syndrome
- (2011) Karen Grønskov et al. EUROPEAN JOURNAL OF HUMAN GENETICS
- 15q11.2–13.3 chromatin analysis reveals epigenetic regulation of CHRNA7 with deficiencies in Rett and autism brain
- (2011) Dag H. Yasui et al. HUMAN MOLECULAR GENETICS
- Analysis of the Fragile X mental retardation protein isoforms 1, 2 and 3 interactions with the G-quadruplex forming semaphorin 3F mRNA
- (2011) Timothy L. Evans et al. Molecular BioSystems
- Autism, Alzheimer disease, and fragile X: APP, FMRP, and mGluR5 are molecular links
- (2011) D. K. Sokol et al. NEUROLOGY
- Group I metabotropic glutamate receptor antagonists alter select behaviors in a mouse model for fragile X syndrome
- (2011) Alexia M. Thomas et al. PSYCHOPHARMACOLOGY
- Developmental characteristics of dendritic spines in the dentate gyrus of Fmr1 knockout mice
- (2010) Aaron W. Grossman et al. BRAIN RESEARCH
- Cholinergic Abnormalities in Autism
- (2010) Stephen I. Deutsch et al. CLINICAL NEUROPHARMACOLOGY
- Fragile X syndrome: from gene discovery to therapy
- (2010) Inge Heulens Frontiers in Bioscience-Landmark
- MicroRNA-101 Regulates Amyloid Precursor Protein Expression in Hippocampal Neurons
- (2010) Elisa Vilardo et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Dysregulation of mTOR Signaling in Fragile X Syndrome
- (2010) A. Sharma et al. JOURNAL OF NEUROSCIENCE
- Fragile X Mental Retardation Protein Is Required for Rapid Experience-Dependent Regulation of the Potassium Channel Kv3.1b
- (2010) J. G. Strumbos et al. JOURNAL OF NEUROSCIENCE
- Fragile X mental retardation protein controls gating of the sodium-activated potassium channel Slack
- (2010) Maile R Brown et al. NATURE NEUROSCIENCE
- hnRNP C promotes APP translation by competing with FMRP for APP mRNA recruitment to P bodies
- (2010) Eun Kyung Lee et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Regulation of Synaptic Structure and Function by FMRP-Associated MicroRNAs miR-125b and miR-132
- (2010) Dieter Edbauer et al. NEURON
- Regulatory BC1 RNA and the Fragile X Mental Retardation Protein: Convergent Functionality in Brain
- (2010) Jun Zhong et al. PLoS One
- Region-specific alterations in brain development in one- to three-year-old boys with fragile X syndrome
- (2010) F. Hoeft et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Cholinergic dysfunction in fragile X syndrome and potential intervention: A preliminary1H MRS study
- (2009) Shelli R. Kesler et al. AMERICAN JOURNAL OF MEDICAL GENETICS PART A
- RhoA/ROCK1 signaling regulates stress granule formation and apoptosis
- (2009) Nien-Pei Tsai et al. CELLULAR SIGNALLING
- A Novel Function for Fragile X Mental Retardation Protein in Translational Activation
- (2009) Elias G Bechara et al. PLOS BIOLOGY
- The Fragile X Syndrome Protein Represses Activity-Dependent Translation through CYFIP1, a New 4E-BP
- (2008) Ilaria Napoli et al. CELL
- A Direct Role for FMRP in Activity-Dependent Dendritic mRNA Transport Links Filopodial-Spine Morphogenesis to Fragile X Syndrome
- (2008) Jason B. Dictenberg et al. DEVELOPMENTAL CELL
- Elongation Factor 2 and Fragile X Mental Retardation Protein Control the Dynamic Translation of Arc/Arg3.1 Essential for mGluR-LTD
- (2008) Sungjin Park et al. NEURON
- On BC1 RNA and the fragile X mental retardation protein
- (2008) A. Iacoangeli et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Fragile X mental retardation protein interactions with the microtubule associated protein 1B RNA
- (2008) L. Menon et al. RNA
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now