☆ 4.7 Article

Fragile X mental retardation protein controls gating of the sodium-activated potassium channel Slack

NATURE NEUROSCIENCE (2010)

期刊

NATURE NEUROSCIENCE

卷 13, 期 7, 页码 819-821

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NATURE PUBLISHING GROUP

DOI: 10.1038/nn.2563

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Neurosciences

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US National Institutes of Health [NS61479, DC008449, DC01919]
FRAXA Research Foundation

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摘要

In humans, the absence of Fragile X mental retardation protein (FMRP), an RNA-binding protein, results in Fragile X syndrome, the most common inherited form of intellectual disability. Using biochemical and electrophysiological studies, we found that FMRP binds to the C terminus of the Slack sodium-activated potassium channel to activate the channel in mice. Our findings suggest that Slack activity provides a link between patterns of neuronal firing and changes in protein translation.

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