Induction of the Nrf2 Pathway by Sulforaphane Is Neuroprotective in a Rat Temporal Lobe Epilepsy Model

Behavioral characteristics as potential biomarkers of the development and phenotype of epilepsy in a rat model of temporal lobe epilepsy

(2021) Karolina Nizinska et al.   Scientific Reports

Nrf2 activation through the inhibition of Keap1–Nrf2 protein–protein interaction

(2020) Sumi Lee et al.   MEDICINAL CHEMISTRY RESEARCH

Immunohistochemical Study of Antioxidant Enzymes Regulated by Nrf2 in the Models of Epileptic Seizures (KA and PTZ)

(2019) María Fernanda Munguía-Martínez et al.   Oxidative Medicine and Cellular Longevity

Targeting oxidative stress improves disease outcomes in a rat model of acquired epilepsy

(2019) Alberto Pauletti et al.   BRAIN

Advances in the Potential Biomarkers of Epilepsy

(2019) Dominik Kobylarek et al.   Frontiers in Neurology

Combination antioxidant therapy prevents epileptogenesis and modifies chronic epilepsy

(2019) Tawfeeq Shekh-Ahmad et al.   Redox Biology

The Epidemiology of Epilepsy

(2019) Ettore Beghi   NEUROEPIDEMIOLOGY

KEAP1 inhibition is neuroprotective and suppresses the development of epilepsy

(2018) Tawfeeq Shekh-Ahmad et al.   BRAIN

Increased seizure susceptibility and other toxicity symptoms following acute sulforaphane treatment in mice

(2017) Katarzyna Socała et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Sulforaphane reactivates cellular antioxidant defense by inducing Nrf2/ARE/Prdx6 activity during aging and oxidative stress

(2017) Eri Kubo et al.   Scientific Reports

Nrf2 activation in the treatment of neurodegenerative diseases: a focus on its role in mitochondrial bioenergetics and function

(2016) Noemí Esteras et al.   BIOLOGICAL CHEMISTRY

Sulforaphane is anticonvulsant and improves mitochondrial function

(2015) Catalina Carrasco-Pozo et al.   JOURNAL OF NEUROCHEMISTRY

Traumatic Brain Injury Increases the Expression of Nos1, Aβ Clearance, and Epileptogenesis in APP/PS1 Mouse Model of Alzheimer’s Disease

(2015) Diana Miszczuk et al.   MOLECULAR NEUROBIOLOGY

Status epilepticus results in persistent overproduction of reactive oxygen species, inhibition of which is neuroprotective

(2015) S. Williams et al.   NEUROSCIENCE

Seizure activity results in calcium- and mitochondria-independent ROS production via NADPH and xanthine oxidase activation

(2014) S Kovac et al.   Cell Death & Disease

Nrf2 defense pathway: Experimental evidence for its protective role in epilepsy

(2013) Manuela Mazzuferi et al.   ANNALS OF NEUROLOGY

Activation of Nrf2-ARE signal pathway protects the brain from damage induced by epileptic seizure

(2013) Wei Wang et al.   BRAIN RESEARCH

Nrf2/ARE pathway activation, HO-1 and NQO1 induction by polychlorinated biphenyl quinone is associated with reactive oxygen species and PI3K/AKT signaling

(2013) Lingrui Li et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Clinical and EEG risk factors for subsequent epilepsy in patients with complex febrile seizures

(2013) Hunmin Kim et al.   EPILEPSY RESEARCH

Mechanisms of epileptogenesis: a convergence on neural circuit dysfunction

(2013) Ethan M. Goldberg et al.   NATURE REVIEWS NEUROSCIENCE

Activation of Nrf2-ARE signal pathway in hippocampus of amygdala kindling rats

(2013) Wei Wang et al.   NEUROSCIENCE LETTERS

Identification of new epilepsy treatments: Issues in preclinical methodology

(2012) Aristea S. Galanopoulou et al.   EPILEPSIA

Sequel of spontaneous seizures after kainic acid-induced status epilepticus and associated neuropathological changes in the subiculum and entorhinal cortex

(2012) Meinrad Drexel et al.   NEUROPHARMACOLOGY

Metabolism and Tissue Distribution of Sulforaphane in Nrf2 Knockout and Wild-Type Mice

(2011) John D. Clarke et al.   PHARMACEUTICAL RESEARCH

Mitochondrial dysfunction and oxidative stress: a contributing link to acquired epilepsy?

(2010) Simon Waldbaum et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Prevention or Modification of Epileptogenesis after Brain Insults: Experimental Approaches and Translational Research

(2010) W. Loscher et al.   PHARMACOLOGICAL REVIEWS

Role of oxidative stress and intracellular glutathione in the sensitivity to apoptosis induced by proteasome inhibitor in thyroid cancer cells

(2009) Zhen-Xian Du et al.   BMC CANCER

Functional interference between glycogen synthase kinase-3 beta and the transcription factor Nrf2 in protection against kainate-induced hippocampal celldeath

(2008) Ana I. Rojo et al.   MOLECULAR AND CELLULAR NEUROSCIENCE