期刊
NEUROSCIENCE
卷 303, 期 -, 页码 160-165出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuroscience.2015.07.005
关键词
seizures; status epilepticus; reactive oxygen species; NADPH oxidase; cell death
资金
- Epilepsy Research UK
- Epilepsy Research UK [P1301] Funding Source: researchfish
- Medical Research Council [1203948] Funding Source: researchfish
Epilepsy and seizure activity result in the generation of reactive oxygen species (ROS), which contribute to seizure-induced neuronal damage. Recent in vitro evidence indicates that NADPH oxidase contributes significantly to seizure-induced ROS. We further tested this in rat glioneuronal cultures and in ex vivo chronic epileptic rat brain tissue using live cell-imaging techniques. Here, we show that ROS are upregulated in chronic epilepsy and that ROS production contributes to cell death, which is seen after status epilepticus (SE) and chronic seizures. Inhibition of ROS production by AEBSF, a NADPH oxidase inhibitor, markedly reduced seizure-induced cell death in the perforant path model of epilepsy. These findings demonstrate a critical role for ROS, generated by NADPH oxidase, contributing to seizure-induced cell death. These findings point to NADPH oxidase inhibition as a novel treatment strategy to prevent brain injury in SE and chronic epilepsy. (C) 2015 IBRO. Published by Elsevier Ltd. All rights reserved.
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