标题
Insulin Resistance: From Mechanisms to Therapeutic Strategies
作者
关键词
-
出版物
Diabetes & Metabolism Journal
Volume 46, Issue 1, Pages 15-37
出版商
Korean Diabetes Association
发表日期
2021-12-30
DOI
10.4093/dmj.2021.0280
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Direct and indirect control of hepatic glucose production by insulin
- (2021) Gary F. Lewis et al. Cell Metabolism
- Insulin Signal Transduction Perturbations in Insulin Resistance
- (2021) Mariyam Khalid et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Multifactorial Basis and Therapeutic Strategies in Metabolism-Related Diseases
- (2021) João V. S. Guerra et al. Nutrients
- What lipodystrophies teach us about the metabolic syndrome
- (2019) Jake P. Mann et al. JOURNAL OF CLINICAL INVESTIGATION
- Understanding the glucoregulatory mechanisms of metformin in type 2 diabetes mellitus
- (2019) Marc Foretz et al. Nature Reviews Endocrinology
- Lack of O-GlcNAcylation enhances exercise-dependent glucose utilization potentially through AMP-activated protein kinase activation in skeletal muscle
- (2018) Koichiro Murata et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Mechanisms of Insulin Action and Insulin Resistance
- (2018) Max C. Petersen et al. PHYSIOLOGICAL REVIEWS
- Degradation of PHLPP2 by KCTD17, via a Glucagon-Dependent Pathway, Promotes Hepatic Steatosis
- (2017) KyeongJin Kim et al. GASTROENTEROLOGY
- Hepatic Diacylglycerol-Associated Protein Kinase Cε Translocation Links Hepatic Steatosis to Hepatic Insulin Resistance in Humans
- (2017) Kasper W. ter Horst et al. Cell Reports
- Inducible overexpression of adiponectin receptors highlight the roles of adiponectin-induced ceramidase signaling in lipid and glucose homeostasis
- (2017) William L. Holland et al. Molecular Metabolism
- Insulin receptor Thr1160 phosphorylation mediates lipid-induced hepatic insulin resistance
- (2016) Max C. Petersen et al. JOURNAL OF CLINICAL INVESTIGATION
- Hepatic ceramides dissociate steatosis and insulin resistance in patients with non-alcoholic fatty liver disease
- (2016) Panu K. Luukkonen et al. JOURNAL OF HEPATOLOGY
- mTORC1-independent Raptor prevents hepatic steatosis by stabilizing PHLPP2
- (2016) KyeongJin Kim et al. Nature Communications
- PP2A inhibition results in hepatic insulin resistance despite Akt2 activation
- (2016) Thomas Galbo et al. Aging-US
- Hepatic Acetyl CoA Links Adipose Tissue Inflammation to Hepatic Insulin Resistance and Type 2 Diabetes
- (2015) Rachel J. Perry et al. CELL
- Targeted Induction of Ceramide Degradation Leads to Improved Systemic Metabolism and Reduced Hepatic Steatosis
- (2015) Jonathan Y. Xia et al. Cell Metabolism
- Liver X receptor regulates hepatic nuclear O-GlcNAc signaling and carbohydrate responsive element-binding protein activity
- (2015) Christian Bindesbøll et al. JOURNAL OF LIPID RESEARCH
- Role of glycogen phosphorylase in liver glycogen metabolism
- (2015) Loranne Agius MOLECULAR ASPECTS OF MEDICINE
- Insulin resistance and white adipose tissue inflammation are uncoupled in energetically challenged Fsp27-deficient mice
- (2015) Linkang Zhou et al. Nature Communications
- Obesity-Induced CerS6-Dependent C16:0 Ceramide Production Promotes Weight Gain and Glucose Intolerance
- (2014) Sarah M. Turpin et al. Cell Metabolism
- Role of diacylglycerol activation of PKCθ in lipid-induced muscle insulin resistance in humans
- (2014) Julia Szendroedi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- An FGF21-Adiponectin-Ceramide Axis Controls Energy Expenditure and Insulin Action in Mice
- (2013) William L. Holland et al. Cell Metabolism
- Distinct patterns of tissue-specific lipid accumulation during the induction of insulin resistance in mice by high-fat feeding
- (2013) N. Turner et al. DIABETOLOGIA
- CGI-58 knockdown sequesters diacylglycerols in lipid droplets/ER-preventing diacylglycerol-mediated hepatic insulin resistance
- (2013) J. L. Cantley et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mechanisms for Insulin Resistance: Common Threads and Missing Links
- (2012) Varman T. Samuel et al. CELL
- A Ceramide-Centric View of Insulin Resistance
- (2012) Jose A. Chavez et al. Cell Metabolism
- The role of pathway-selective insulin resistance and responsiveness in diabetic dyslipoproteinemia
- (2012) Xiangdong Wu et al. CURRENT OPINION IN LIPIDOLOGY
- The Role of the Carbohydrate Response Element-Binding Protein in Male Fructose-Fed Rats
- (2012) Derek M. Erion et al. ENDOCRINOLOGY
- Intrahepatic Diacylglycerol Content Is Associated With Hepatic Insulin Resistance in Obese Subjects
- (2012) Faidon Magkos et al. GASTROENTEROLOGY
- Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine
- (2012) Kook Hwan Kim et al. NATURE MEDICINE
- Regulation of glucose transport by insulin: traffic control of GLUT4
- (2012) Dara Leto et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- FoxO transcription factors; Regulation by AKT and 14-3-3 proteins
- (2011) Guri Tzivion et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Rac1 signalling towards GLUT4/glucose uptake in skeletal muscle
- (2011) Tim T. Chiu et al. CELLULAR SIGNALLING
- Endoplasmic Reticulum Stress Promotes LIPIN2-Dependent Hepatic Insulin Resistance
- (2011) D. Ryu et al. DIABETES
- O-GlcNAcylation Increases ChREBP Protein Content and Transcriptional Activity in the Liver
- (2011) C. Guinez et al. DIABETES
- Time-dependent effects of Prkce deletion on glucose homeostasis and hepatic lipid metabolism on dietary lipid oversupply in mice
- (2011) K. Raddatz et al. DIABETOLOGIA
- Role of Sodium-Glucose Cotransporter 2 (SGLT 2) Inhibitors in the Treatment of Type 2 Diabetes
- (2011) Muhammad A. Abdul-Ghani et al. ENDOCRINE REVIEWS
- Apolipoprotein CIII overexpressing mice are predisposed to diet-induced hepatic steatosis and hepatic insulin resistance
- (2011) Hui-Young Lee et al. HEPATOLOGY
- The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance
- (2011) Bolormaa Vandanmagsar et al. NATURE MEDICINE
- FATP2 is a hepatic fatty acid transporter and peroxisomal very long-chain acyl-CoA synthetase
- (2010) Alaric Falcon et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Pathogenesis of Fasting and Postprandial Hyperglycemia in Type 2 Diabetes: Implications for Therapy
- (2010) R. A. Rizza DIABETES
- CGI-58 knockdown in mice causes hepatic steatosis but prevents diet-induced obesity and glucose intolerance
- (2010) J. Mark Brown et al. JOURNAL OF LIPID RESEARCH
- Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin
- (2010) William L Holland et al. NATURE MEDICINE
- Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis
- (2010) Shijie Li et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Akt–SREBP nexus: cell signaling meets lipid metabolism
- (2010) James R. Krycer et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- TORC2 Regulates Hepatic Insulin Signaling via a Mammalian Phosphatidic Acid Phosphatase, LIPIN1
- (2009) Dongryeol Ryu et al. Cell Metabolism
- Skeletal Muscle Insulin Resistance Is the Primary Defect in Type 2 Diabetes
- (2009) R. A. DeFronzo et al. DIABETES CARE
- Control of Liver Glycogen Synthase Activity and Intracellular Distribution by Phosphorylation
- (2009) Susana Ros et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Intrahepatic fat, not visceral fat, is linked with metabolic complications of obesity
- (2009) E. Fabbrini et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Cross-talk between GlcNAcylation and phosphorylation: roles in insulin resistance and glucose toxicity
- (2008) Ronald J. Copeland et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Alterations of insulin signaling in type 2 diabetes: A review of the current evidence from humans
- (2008) Sara Fröjdö et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Inactivation of Hepatic Foxo1 by Insulin Signaling Is Required for Adaptive Nutrient Homeostasis and Endocrine Growth Regulation
- (2008) Xiaocheng C. Dong et al. Cell Metabolism
- Skeletal Muscle-Specific Deletion of Lipoprotein Lipase Enhances Insulin Signaling in Skeletal Muscle but Causes Insulin Resistance in Liver and Other Tissues
- (2008) H. Wang et al. DIABETES
- O-GlcNAc Regulates FoxO Activation in Response to Glucose
- (2008) Michael P. Housley et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Elevation of GlobalO-GlcNAc Levels in 3T3-L1 Adipocytes by Selective Inhibition ofO-GlcNAcase Does Not Induce Insulin Resistance
- (2008) Matthew S. Macauley et al. JOURNAL OF BIOLOGICAL CHEMISTRY
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started