Protease-activated receptor 2 deficiency mediates cardiac fibrosis and diastolic dysfunction

PAR2 (Protease-Activated Receptor 2) Deficiency Attenuates Atherosclerosis in MiceHighlights

(2018) Shannon M. Jones et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Modelling the complexity of heart failure with preserved ejection fraction

(2018) Kevin O’Gallagher et al.   CARDIOVASCULAR RESEARCH

Thrombin induces protease-activated receptor 1 signaling and activation of human atrial fibroblasts and dabigatran prevents these effects

(2018) Paola Altieri et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Possible role of rivaroxaban in attenuating pressure-overload-induced atrial fibrosis and fibrillation

(2018) Hidekazu Kondo et al.   Journal of Cardiology

Myocardial Interstitial Fibrosis in Heart Failure

(2018) Arantxa González et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Usefulness of Rivaroxaban for Secondary Prevention of Acute Coronary Syndrome Among Patients with History of Congestive Heart Failure (From the ATLAS-ACS-2 TIMI-51 Trial)

(2018) Serge Korjian et al.   AMERICAN JOURNAL OF CARDIOLOGY

Rivaroxaban in Patients with Heart Failure, Sinus Rhythm, and Coronary Disease

(2018) Faiez Zannad et al.   NEW ENGLAND JOURNAL OF MEDICINE

An integrative translational approach to study heart failure with preserved ejection fraction: a position paper from the Working Group on Myocardial Function of the European Society of Cardiology

(2017) Andre P. Lourenço et al.   EUROPEAN JOURNAL OF HEART FAILURE

Myocardial fibrosis: biomedical research from bench to bedside

(2017) Mariann Gyöngyösi et al.   EUROPEAN JOURNAL OF HEART FAILURE

Fibroblast-specific TGF-β–Smad2/3 signaling underlies cardiac fibrosis

(2017) Hadi Khalil et al.   JOURNAL OF CLINICAL INVESTIGATION

Biological Phenotypes of Heart Failure With Preserved Ejection Fraction

(2017) Gavin A. Lewis et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Heart Failure With Preserved, Borderline, and Reduced Ejection Fraction

(2017) Kevin S. Shah et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Mode of Death in Heart Failure With Preserved Ejection Fraction

(2017) Muthiah Vaduganathan et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Targeting coagulation factor receptors - protease-activated receptors in idiopathic pulmonary fibrosis

(2017) C. Lin et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Reversal of maladaptive fibrosis and compromised ventricular function in the pressure overloaded heart by a caveolin-1 surrogate peptide

(2017) Dorea Pleasant-Jenkins et al.   LABORATORY INVESTIGATION

Epidemiology of heart failure with preserved ejection fraction

(2017) Shannon M. Dunlay et al.   Nature Reviews Cardiology

Rivaroxaban with or without Aspirin in Stable Cardiovascular Disease

(2017) John W. Eikelboom et al.   NEW ENGLAND JOURNAL OF MEDICINE

Direct thrombin inhibition with dabigatran attenuates pressure overload-induced cardiac fibrosis and dysfunction in mice

(2017) Anping Dong et al.   THROMBOSIS RESEARCH

Precision Medicine for Heart Failure with Preserved Ejection Fraction: An Overview

(2017) Sanjiv J. Shah   Journal of Cardiovascular Translational Research

Temporal Relation Between Myocardial Fibrosis and Heart Failure With Preserved Ejection Fraction

(2017) Erik B. Schelbert et al.   JAMA Cardiology

Phenotype-Specific Treatment of Heart Failure With Preserved Ejection Fraction

(2016) Sanjiv J. Shah et al.   CIRCULATION

Interstitial Fibrosis, Functional Status, and Outcomes in Heart Failure With Preserved Ejection FractionCLINICAL PERSPECTIVE

(2016) Franz Duca et al.   Circulation-Cardiovascular Imaging

Hypercoagulability causes atrial fibrosis and promotes atrial fibrillation

(2016) Henri M.H. Spronk et al.   EUROPEAN HEART JOURNAL

2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure

(2016) Piotr Ponikowski et al.   EUROPEAN HEART JOURNAL

Myocardial Collagen Cross-Linking Is Associated With Heart Failure Hospitalization in Patients With Hypertensive Heart Failure

(2016) Begoña López et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Recommendations for the Evaluation of Left Ventricular Diastolic Function by Echocardiography: An Update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging

(2016) Sherif F. Nagueh et al.   JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY

Targeting LOXL2 for cardiac interstitial fibrosis and heart failure treatment

(2016) Jin Yang et al.   Nature Communications

PAR1 Scaffolds TGFβRII to Downregulate TGF-β Signaling and Activate ESC Differentiation to Endothelial Cells

(2016) Haixia Gong et al.   Stem Cell Reports

Myocardial Microvascular Inflammatory Endothelial Activation in Heart Failure With Preserved Ejection Fraction

(2016) Constantijn Franssen et al.   JACC-Heart Failure

Treating the Unstable Atherosclerotic Plaque by Targeting Activated Factor X　– Anticoagulation and Beyond –

(2015) Julian Friebel et al.   CIRCULATION JOURNAL

Quality of Anticoagulation Control in Preventing Adverse Events in Patients With Heart Failure in Sinus Rhythm: Warfarin Versus Aspirin in Reduced Cardiac Ejection Fraction Trial Substudy

(2015) S. Homma et al.   Circulation-Heart Failure

Protease-activated receptor (PAR)-2 is required for PAR-1 signalling in pulmonary fibrosis

(2015) Cong Lin et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Seven weeks of Western diet in apolipoprotein-E-deficient mice induce metabolic syndrome and non-alcoholic steatohepatitis with liver fibrosis

(2015) Robert Schierwagen et al.   Scientific Reports

Pleiotropic effects of factor Xa and thrombin: what to expect from novel anticoagulants

(2014) H. M. H. Spronk et al.   CARDIOVASCULAR RESEARCH

Cardiac Structure and Function and Prognosis in Heart Failure With Preserved Ejection Fraction

(2014) Amil M. Shah et al.   Circulation-Heart Failure

New strategies for heart failure with preserved ejection fraction: the importance of targeted therapies for heart failure phenotypes

(2014) M. Senni et al.   EUROPEAN HEART JOURNAL

Role of protease-activated receptors for the innate immune response of the heart

(2014) Alice Weithauser et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Coagulation and coagulation signalling in fibrosis

(2013) Paul F. Mercer et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Myocardial Titin Hypophosphorylation Importantly Contributes to Heart Failure With Preserved Ejection Fraction in a Rat Metabolic Risk Model

(2013) Nazha Hamdani et al.   Circulation-Heart Failure

Protease-Activated Receptor 1 Inhibition by SCH79797 Attenuates Left Ventricular Remodeling and Profibrotic Activities of Cardiac Fibroblasts

(2013) Dmitry L. Sonin et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS

Protease-Activated Receptor-2 Regulates the Innate Immune Response to Viral Infection in a Coxsackievirus B3–Induced Myocarditis

(2013) Alice Weithauser et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

A Novel Paradigm for Heart Failure With Preserved Ejection Fraction

(2013) Walter J. Paulus et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Protease Activated Receptor-2 Contributes to Heart Failure

(2013) Silvio Antoniak et al.   PLoS One

Matrix metalloproteases and PAR1 activation

(2012) K. M. Austin et al.   BLOOD

Defining the cellular repertoire of GPCRs identifies a profibrotic role for the most highly expressed receptor, protease-activated receptor 1, in cardiac fibroblasts

(2012) Aaron N. Snead et al.   FASEB JOURNAL

Collagen Cross-Linking But Not Collagen Amount Associates With Elevated Filling Pressures in Hypertensive Patients With Stage C Heart Failure

(2012) Begoña López et al.   HYPERTENSION

Targeting proteinase-activated receptors: therapeutic potential and challenges

(2012) Rithwik Ramachandran et al.   NATURE REVIEWS DRUG DISCOVERY

Platelet TGF- 1 contributions to plasma TGF- 1, cardiac fibrosis, and systolic dysfunction in a mouse model of pressure overload

(2011) A. Meyer et al.   BLOOD

Prevalence and Significance of Alterations in Cardiac Structure and Function in Patients With Heart Failure and a Preserved Ejection Fraction

(2011) Michael R. Zile et al.   CIRCULATION

Tryptase/Protease-Activated Receptor 2 Interactions Induce Selective Mitogen-Activated Protein Kinase Signaling and Collagen Synthesis by Cardiac Fibroblasts

(2011) Jennifer L. McLarty et al.   HYPERTENSION

Getting to the heart of cardiac remodeling; how collagen subtypes may contribute to phenotype

(2011) P. Collier et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Diastolic Tissue Doppler Indexes Correlate With the Degree of Collagen Expression and Cross-Linking in Heart Failure and Normal Ejection Fraction

(2011) Mario Kasner et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Activated protein C promotes protease-activated receptor-1 cytoprotective signaling through  -arrestin and dishevelled-2 scaffolds

(2011) U. J. K. Soh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protease-activated receptor 2 signaling in inflammation

(2011) Andrea S. Rothmeier et al.   Seminars in Immunopathology

Tryptase activates isolated adult cardiac fibroblasts via protease activated receptor-2 (PAR-2)

(2011) David B. Murray et al.   Journal of Cell Communication and Signaling

Role of lysyl oxidase in myocardial fibrosis: from basic science to clinical aspects

(2010) Begoña López et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Protease-Activated Receptor 2 Deficiency Reduces Cardiac Ischemia/Reperfusion Injury

(2010) Silvio Antoniak et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Cardiac Inflammation Contributes to Changes in the Extracellular Matrix in Patients With Heart Failure and Normal Ejection Fraction

(2010) Dirk Westermann et al.   Circulation-Heart Failure

Endocytic regulation of TGF-β signaling

(2008) Ye-Guang Chen   CELL RESEARCH

Role of Left Ventricular Stiffness in Heart Failure With Normal Ejection Fraction

(2008) Dirk Westermann et al.   CIRCULATION

Viral myocarditis and coagulopathy: Increased tissue factor expression and plasma thrombogenicity

(2008) Silvio Antoniak et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY