Engineered Ribosyl-1-Kinase Enables Concise Synthesis of Molnupiravir, an Antiviral for COVID-19

SARS-CoV-2 infection is effectively treated and prevented by EIDD-2801

(2021) Angela Wahl et al.   NATURE

Progress Toward a Large-Scale Synthesis of Molnupiravir (MK-4482, EIDD-2801) from Cytidine

(2021) Grace P. Ahlqvist et al.   ACS Omega

SARS-CoV-2 variants, spike mutations and immune escape

(2021) William T. Harvey et al.   NATURE REVIEWS MICROBIOLOGY

An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice

(2020) Timothy P. Sheahan et al.   Science Translational Medicine

A Concise Route to MK-4482 (EIDD-2801) from Cytidine: Part 2

(2020) Vijayagopal Gopalsamuthiram et al.   SYNLETT

Therapeutically administered ribonucleoside analogue MK-4482/EIDD-2801 blocks SARS-CoV-2 transmission in ferrets

(2020) Robert M. Cox et al.   Nature Microbiology

Design of an in vitro biocatalytic cascade for the manufacture of islatravir

(2019) Mark A. Huffman et al.   SCIENCE

Multienzymatic synthesis of nucleic acid derivatives: a general perspective

(2015) Jesús Fernández-Lucas   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Bioretrosynthetic construction of a didanosine biosynthetic pathway

(2014) William R Birmingham et al.   Nature Chemical Biology

Metabolic characteristics and importance of the universal methionine salvage pathway recycling methionine from 5′-methylthioadenosine

(2009) Eva Albers   IUBMB LIFE