期刊
FEBS LETTERS
卷 589, 期 24, 页码 3714-3726出版社
WILEY
DOI: 10.1016/j.febslet.2015.10.022
关键词
Midbrain; Dopamine neuron subtypes; Molecular diversity; Selective vulnerability; Single cell expression profiling
资金
- NRSA, NIH [1F31 NS065670-01A2]
- FRSQ
- CIHR
- MJFF
- NARSAD [1R21NS072703-01]
- Paul Ruby Foundation
Since their discovery, midbrain dopamine (DA) neurons have been researched extensively, in part because of their diverse functions and involvement in various neuropsychiatric disorders. Over the last few decades, reports have emerged that midbrain DA neurons were not a homogeneous group, but that DA neurons located in distinct anatomical locations within the midbrain had distinctive properties in terms of physiology, function, and vulnerability. Accordingly, several studies focused on identifying heterogeneous gene expression across DA neuron clusters. Here we review the importance of understanding DA neuron heterogeneity at the molecular level, previous studies detailing heterogeneous gene expression in DA neurons, and finally recent work which brings together previous heterogeneous gene expression profiles in a coordinated manner, at single cell resolution. (C) 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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