Restoring normal islet mass and function in type 1 diabetes through regenerative medicine and tissue engineering

Longitudinal Assessment of 11C-5-Hydroxytryptophan Uptake in Pancreas After Debut of Type 1 Diabetes

(2021) Daniel Espes et al.   DIABETES

The promise of stem cell-derived islet replacement therapy

(2021) Douglas Melton   DIABETOLOGIA

The distribution of cellular turnover in the human body

(2021) Ron Sender et al.   NATURE MEDICINE

Pancreatic islet reserve in type 1 diabetes

(2021) Anneliese J. S. Flatt et al.   ANNALS OF THE NEW YORK ACADEMY OF SCIENCES

Hybrid closed‐loop glucose control with faster insulin aspart compared with standard insulin aspart in adults with type 1 diabetes: A double‐blind, multicentre, multinational, randomized, crossover study

(2021) Charlotte K. Boughton et al.   DIABETES OBESITY & METABOLISM

Pancreatic beta cell autophagy is impaired in type 1 diabetes

(2021) Charanya Muralidharan et al.   DIABETOLOGIA

Teplizumab improves and stabilizes beta cell function in antibody-positive high-risk individuals

(2021) Emily K. Sims et al.   Science Translational Medicine

Protecting islet functional viability using mesenchymal stromal cells

(2021) Ella L. Hubber et al.   Stem Cells Translational Medicine

Anti-interleukin-21 antibody and liraglutide for the preservation of β-cell function in adults with recent-onset type 1 diabetes: a randomised, double-blind, placebo-controlled, phase 2 trial

(2021) Matthias von Herrath et al.   Lancet Diabetes & Endocrinology

Human pluripotent stem cell-derived insulin-producing cells: A regenerative medicine perspective

(2021) Adriana Migliorini et al.   Cell Metabolism

TAK-101 Nanoparticles Induce Gluten-Specific Tolerance in Celiac Disease: A Randomized, Double-Blind, Placebo-Controlled Study

(2021) Ciarán P. Kelly et al.   GASTROENTEROLOGY

Paracrine signaling in islet function and survival

(2020) Sean M. Hartig et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Targeting the cytoskeleton to direct pancreatic differentiation of human pluripotent stem cells

(2020) Nathaniel J. Hogrebe et al.   NATURE BIOTECHNOLOGY

Human umbilical cord perivascular cells improve human pancreatic islet transplant function by increasing vascularization

(2020) Shareen Forbes et al.   Science Translational Medicine

GLP-1 receptor agonists synergize with DYRK1A inhibitors to potentiate functional human β cell regeneration

(2020) Courtney Ackeifi et al.   Science Translational Medicine

High residual C-peptide likely contributes to glycemic control in type 1 diabetes

(2020) Michael R. Rickels et al.   JOURNAL OF CLINICAL INVESTIGATION

Regulatory cell therapy in kidney transplantation (The ONE Study): a harmonised design and analysis of seven non-randomised, single-arm, phase 1/2A trials

(2020) Birgit Sawitzki et al.   LANCET

Reduced somatostatin signalling leads to hypersecretion of glucagon in mice fed a high fat diet

(2020) Joely A. Kellard et al.   Molecular Metabolism

Postexercise Glycemic Control in Type 1 Diabetes Is Associated With Residual β-Cell Function

(2020) Guy S. Taylor et al.   DIABETES CARE

Engineered immunological niches to monitor disease activity and treatment efficacy in relapsing multiple sclerosis

(2020) Aaron H. Morris et al.   Nature Communications

Multiplexing DNA methylation markers to detect circulating cell-free DNA derived from human pancreatic β cells

(2020) Daniel Neiman et al.   JCI Insight

Protective Effect of a Novel Clinical‐grade Small Molecule Necrosis Inhibitor Against Oxidative Stress and Inflammation During Islet Transplantation

(2020) Gyuri Kim et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Solving the Puzzle of Immune Tolerance for β-Cell Replacement Therapy for Type 1 Diabetes

(2020) Jeffrey A. Bluestone et al.   Cell Stem Cell

Comparing Beta Cell Preservation Across Clinical Trials in Recent-Onset Type 1 Diabetes

(2020) Laura M. Jacobsen et al.   Diabetes Technology & Therapeutics

Beta cell dysfunction in diabetes: the islet microenvironment as an unusual suspect

(2020) Joana Almaça et al.   DIABETOLOGIA

Functional effects of chimeric antigen receptor co-receptor signaling domains in human regulatory T cells

(2020) Nicholas A. J. Dawson et al.   Science Translational Medicine

Inhibition of NLRP3 inflammasome by MCC950 improves the metabolic outcome of islet transplantation by suppressing IL-1β and islet cellular death

(2020) Taisuke Matsuoka et al.   Scientific Reports

Immunotherapy via PD-L1–presenting biomaterials leads to long-term islet graft survival

(2020) María M. Coronel et al.   Science Advances

Pancreatic β-Cells Communicate With Vagal Sensory Neurons

(2020) Madina Makhmutova et al.   GASTROENTEROLOGY

Acquisition of Dynamic Function in Human Stem Cell-Derived β Cells

(2019) Leonardo Velazco-Cruz et al.   Stem Cell Reports

Recapitulating endocrine cell clustering in culture promotes maturation of human stem-cell-derived β cells

(2019) Gopika G. Nair et al.   NATURE CELL BIOLOGY

Beta cells in type 1 diabetes: mass and function; sleeping or dead?

(2019) Richard A. Oram et al.   DIABETOLOGIA

Operational immune tolerance towards transplanted allogeneic pancreatic islets in mice and a non-human primate

(2019) Midhat H. Abdulreda et al.   DIABETOLOGIA

Case Reports of Pre-clinical Replication Studies in Metabolism and Diabetes

(2019) Matthias von Herrath et al.   Cell Metabolism

A Map of Human Type 1 Diabetes Progression by Imaging Mass Cytometry

(2019) Nicolas Damond et al.   Cell Metabolism

Biofabrication of a vascularized islet organ for type 1 diabetes

(2019) Antonio Citro et al.   BIOMATERIALS

Oxygen generating biomaterial improves the function and efficacy of beta cells within a macroencapsulation device

(2019) M.M. Coronel et al.   BIOMATERIALS

Age Mosaicism across Multiple Scales in Adult Tissues

(2019) Rafael Arrojo e Drigo et al.   Cell Metabolism

A low-carbohydrate high-fat diet initiated promptly after diagnosis provides clinical remission in three patients with type 1 diabetes

(2019) B. Bouillet et al.   DIABETES & METABOLISM

Regulatory T cells engineered with a novel insulin-specific chimeric antigen receptor as a candidate immunotherapy for type 1 diabetes

(2019) Michel Tenspolde et al.   JOURNAL OF AUTOIMMUNITY

Residual β cell function and monogenic variants in long-duration type 1 diabetes patients

(2019) Marc Gregory Yu et al.   JOURNAL OF CLINICAL INVESTIGATION

Introducing the Endotype Concept to Address the Challenge of Disease Heterogeneity in Type 1 Diabetes

(2019) Manuela Battaglia et al.   DIABETES CARE

Long-term tolerance of islet allografts in nonhuman primates induced by apoptotic donor leukocytes

(2019) Amar Singh et al.   Nature Communications

Novel cell‐permeable p38‐MAPK inhibitor efficiently prevents porcine islet apoptosis and improves islet graft function

(2019) Hirofumi Noguchi et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Pancreatic islets engineered with a FasL protein induce systemic tolerance at the induction phase that evolves into long‐term graft‐localized immune privilege

(2019) Kyle B. Woodward et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Endothelialized collagen based pseudo-islets enables tuneable subcutaneous diabetes therapy

(2019) Alexander E. Vlahos et al.   BIOMATERIALS

Generation of highly potent DYRK1A-dependent inducers of human β-Cell replication via Multi-Dimensional compound optimization

(2019) Paul A. Allegretti et al.   BIOORGANIC & MEDICINAL CHEMISTRY

β‐Cell and renal transplantation options for diabetes

(2019) A. J. S. Flatt et al.   DIABETIC MEDICINE

Conformal Coating of Stem Cell-Derived Islets for β Cell Replacement in Type 1 Diabetes

(2019) Aaron A. Stock et al.   Stem Cell Reports

Improved outcomes of islet autotransplant after total pancreatectomy by combined blockade of IL-1β and TNFα

(2018) B. Naziruddin et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Stem Cell-Derived Pancreatic Progenitor Cells Have Now Been Transplanted into Patients: Report from IPITA 2018

(2018) Lara C. Pullen   AMERICAN JOURNAL OF TRANSPLANTATION

Transplantation of macroencapsulated human islets within the bioartificial pancreas βAir to patients with type 1 diabetes mellitus

(2018) Per-Ola Carlsson et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Artemether Does Not Turn α Cells into β Cells

(2018) Talitha van der Meulen et al.   Cell Metabolism

Paracrine Interactions within the Pancreatic Islet Determine the Glycemic Set Point

(2018) Rayner Rodriguez-Diaz et al.   Cell Metabolism

Pancreatic β Cell Regeneration as a Possible Therapy for Diabetes

(2018) Cristina Aguayo-Mazzucato et al.   Cell Metabolism

Bioengineering with Endothelial Progenitor Cells Improves the Vascular Engraftment of Transplanted Human Islets

(2018) Liza Grapensparr et al.   CELL TRANSPLANTATION

Initial Clinical Evaluation of VC-01TM Combination Product—A Stem Cell–Derived Islet Replacement for Type 1 Diabetes (T1D)

(2018) ROBERT R. HENRY et al.   DIABETES

Extracellular matrix molecules and their potential contribution to the function of transplanted pancreatic islets

(2018) L. Alberto Llacua et al.   DIABETOLOGIA

Vegf-A mRNA transfection as a novel approach to improve mouse and human islet graft revascularisation

(2018) Willem Staels et al.   DIABETOLOGIA

Type 1 diabetes

(2018) Linda A DiMeglio et al.   LANCET

Primary care-led weight management for remission of type 2 diabetes (DiRECT): an open-label, cluster-randomised trial

(2018) Michael EJ Lean et al.   LANCET

Local immunomodulation with Fas ligand-engineered biomaterials achieves allogeneic islet graft acceptance

(2018) Devon M. Headen et al.   NATURE MATERIALS

Verapamil and beta cell function in adults with recent-onset type 1 diabetes

(2018) Fernando Ovalle et al.   NATURE MEDICINE

(Re)generating Human Beta Cells: Status, Pitfalls, and Perspectives

(2018) Luc Baeyens et al.   PHYSIOLOGICAL REVIEWS

Evidence for a Neogenic Niche at the Periphery of Pancreatic Islets

(2018) Mark O. Huising et al.   BIOESSAYS

GABA and Artesunate Do Not Induce Pancreatic α-to-β Cell Transdifferentiation In Vivo

(2018) Amanda M. Ackermann et al.   Cell Metabolism

Endocrine lineage biases arise in temporally distinct endocrine progenitors during pancreatic morphogenesis

(2018) Marissa A. Scavuzzo et al.   Nature Communications

Lineage dynamics of murine pancreatic development at single-cell resolution

(2018) Lauren E. Byrnes et al.   Nature Communications

Absence of spontaneous regeneration of endogenous pancreatic β-cells after chemical-induced diabetes and no effect of GABA on α-to-β cell transdifferentiation in rhesus monkeys

(2018) Jun-Seop Shin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mesenchymal stem cells in combination with low-dose rapamycin significantly prolong islet allograft survival through induction of regulatory T cells

(2018) Wu Duan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Pancreas Pathology During the Natural History of Type 1 Diabetes

(2018) Teresa Rodriguez-Calvo et al.   Current Diabetes Reports

Improved islet recovery and efficacy through co-culture and co-transplantation of islets with human adipose-derived mesenchymal stem cells

(2018) Anissa Gamble et al.   PLoS One

Insulin Secretion Depends on Intra-islet Glucagon Signaling

(2018) Berit Svendsen et al.   Cell Reports

Single-Cell Transcriptome Profiling of Mouse and hESC-Derived Pancreatic Progenitors

(2018) Nicole A.J. Krentz et al.   Stem Cell Reports

Localized immune tolerance from FasL-functionalized PLG scaffolds

(2018) Michael Skoumal et al.   BIOMATERIALS

Measurement of Pro-Islet Amyloid Polypeptide (1–48) in Diabetes and Islet Transplants

(2017) Jaques A. Courtade et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

β Cells Persist in T1D Pancreata Without Evidence of Ongoing β-Cell Turnover or Neogenesis

(2017) Carol J Lam et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Bioengineering of an Intraabdominal Endocrine Pancreas

(2017) David A. Baidal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Incidence Trends of Type 1 and Type 2 Diabetes among Youths, 2002–2012

(2017) Elizabeth J. Mayer-Davis et al.   NEW ENGLAND JOURNAL OF MEDICINE

Single cell transcriptomic profiling of mouse pancreatic progenitors

(2017) Diana E. Stanescu et al.   PHYSIOLOGICAL GENOMICS

Immunological Balance Is Associated with Clinical Outcome after Autologous Hematopoietic Stem Cell Transplantation in Type 1 Diabetes

(2017) Kelen C. R. Malmegrim et al.   Frontiers in Immunology

Vasculogenic hydrogel enhances islet survival, engraftment, and function in leading extrahepatic sites

(2017) Jessica D. Weaver et al.   Science Advances

Unmethylated Insulin DNA Is Elevated After Total Pancreatectomy With Islet Autotransplantation: Assessment of a Novel Beta Cell Marker

(2016) M. D. Bellin et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Improvement of islet engrafts by enhanced angiogenesis and microparticle-mediated oxygenation

(2016) Leila Montazeri et al.   BIOMATERIALS

Transforming growth factor-beta 1 delivery from microporous scaffolds decreases inflammation post-implant and enhances function of transplanted islets

(2016) Jeffrey M.H. Liu et al.   BIOMATERIALS

Inhibition of DYRK1A Stimulates Human β-Cell Proliferation

(2016) Ercument Dirice et al.   DIABETES

Differential Insulitic Profiles Determine the Extent of β-Cell Destruction and the Age at Onset of Type 1 Diabetes

(2016) Pia Leete et al.   DIABETES

Biopatterned CTLA4/Fc Matrices Facilitate Local Immunomodulation, Engraftment, and Glucose Homeostasis After Pancreatic Islet Transplantation

(2016) Wensheng Zhang et al.   DIABETES

Elevations in the Fasting Serum Proinsulin–to–C-Peptide Ratio Precede the Onset of Type 1 Diabetes

(2016) Emily K. Sims et al.   DIABETES CARE

Phase 3 Trial of Transplantation of Human Islets in Type 1 Diabetes Complicated by Severe Hypoglycemia

(2016) Bernhard J. Hering et al.   DIABETES CARE

Extreme obesity induces massive beta cell expansion in mice through self-renewal and does not alter the beta cell lineage

(2016) Aaron R. Cox et al.   DIABETOLOGIA

Combinatorial hydrogel library enables identification of materials that mitigate the foreign body response in primates

(2016) Arturo J Vegas et al.   NATURE BIOTECHNOLOGY

Advances in islet encapsulation technologies

(2016) Tejal Desai et al.   NATURE REVIEWS DRUG DISCOVERY

Proinsulin and heat shock protein 90 as biomarkers of beta-cell stress in the early period after onset of type 1 diabetes

(2016) Renecia A. Watkins et al.   Translational Research

Progress in Clinical Encapsulated Islet Xenotransplantation

(2016) David K.C. Cooper et al.   TRANSPLANTATION

Type 1 diabetes vaccine candidates promote human Foxp3+Treg induction in humanized mice

(2016) Isabelle Serr et al.   Nature Communications

Fibrin gels engineered with pro-angiogenic growth factors promote engraftment of pancreatic islets in extrahepatic sites in mice

(2015) Mejdi Najjar et al.   BIOTECHNOLOGY AND BIOENGINEERING

Insulitis and β-Cell Mass in the Natural History of Type 1 Diabetes

(2015) Martha Campbell-Thompson et al.   DIABETES

Staging Presymptomatic Type 1 Diabetes: A Scientific Statement of JDRF, the Endocrine Society, and the American Diabetes Association

(2015) Richard A. Insel et al.   DIABETES CARE

Essential phospholipids prevent islet damage induced by proinflammatory cytokines and hypoxic conditions

(2015) Rauf Shahbazov et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Psychosocial aspects of closed- and open-loop insulin delivery: closing the loop in adults with Type 1 diabetes in the home setting

(2015) K. D. Barnard et al.   DIABETIC MEDICINE

Controlled induction of human pancreatic progenitors produces functional beta-like cells in vitro

(2015) H. A. Russ et al.   EMBO JOURNAL

β-Cell-targeted blockage of PD1 and CTLA4 pathways prevents development of autoimmune diabetes and acute allogeneic islets rejection

(2015) M M El Khatib et al.   GENE THERAPY

Estimated Life Expectancy in a Scottish Cohort With Type 1 Diabetes, 2008-2010

(2015) Shona J. Livingstone et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

β Cell death and dysfunction during type 1 diabetes development in at-risk individuals

(2015) Kevan C. Herold et al.   JOURNAL OF CLINICAL INVESTIGATION

Heterogeneity and Lobularity of Pancreatic Pathology in Type 1 Diabetes during the Prediabetic Phase

(2015) Teresa Rodriguez-Calvo et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Cellular Mechanisms of CCL22-Mediated Attenuation of Autoimmune Diabetes

(2015) Loraine Bischoff et al.   JOURNAL OF IMMUNOLOGY

Urocortin3 mediates somatostatin-dependent negative feedback control of insulin secretion

(2015) Talitha van der Meulen et al.   NATURE MEDICINE

A high-throughput chemical screen reveals that harmine-mediated inhibition of DYRK1A increases human pancreatic beta cell replication

(2015) Peng Wang et al.   NATURE MEDICINE

Inhibition of DYRK1A and GSK3B induces human β-cell proliferation

(2015) Weijun Shen et al.   Nature Communications

Enhancing Human Islet Transplantation by Localized Release of Trophic Factors From PLG Scaffolds

(2014) K. A. Hlavaty et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Neural control of the endocrine pancreas

(2014) Rayner Rodriguez-Diaz et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Nanoparticle delivery of donor antigens for transplant tolerance in allogeneic islet transplantation

(2014) Jane Bryant et al.   BIOMATERIALS

Generation of Functional Human Pancreatic β Cells In Vitro

(2014) Felicia W. Pagliuca et al.   CELL

Demonstration of an Intrinsic Relationship Between Endogenous C-Peptide Concentration and Determinants of Glycemic Control in Type 1 Diabetes Following Islet Transplantation

(2014) Augustin M. Brooks et al.   DIABETES CARE

Non-invasive quantification of the beta cell mass by SPECT with 111In-labelled exendin

(2014) Maarten Brom et al.   DIABETOLOGIA

Diabetes recovery by age-dependent conversion of pancreatic δ-cells into insulin producers

(2014) Simona Chera et al.   NATURE

Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells

(2014) Alireza Rezania et al.   NATURE BIOTECHNOLOGY

Cellular communication and heterogeneity in pancreatic islet insulin secretion dynamics

(2014) Richard K.P. Benninger et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Inflammatory Response in Islet Transplantation

(2014) Mazhar A. Kanak et al.   International Journal of Endocrinology

Attainment of Metabolic Goals in the Integrated UK Islet Transplant Program With Locally Isolated and Transported Preparations

(2013) A. M. Brooks et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Islet β cell mass in diabetes and how it relates to function, birth, and death

(2013) Gordon C. Weir et al.   Annals of the New York Academy of Sciences

Enhanced Oxygen Supply Improves Islet Viability in a New Bioartificial Pancreas

(2013) Uriel Barkai et al.   CELL TRANSPLANTATION

A Preexistent Hypoxic Gene Signature Predicts Impaired Islet Graft Function and Glucose Homeostasis

(2013) James Cantley et al.   CELL TRANSPLANTATION

Revascularization of Transplanted Pancreatic Islets and Role of the Transplantation Site

(2013) Andrew R. Pepper et al.   Clinical & Developmental Immunology

Amelioration of Hypoglycemia Via Somatostatin Receptor Type 2 Antagonism in Recurrently Hypoglycemic Diabetic Rats

(2013) J. T. Y. Yue et al.   DIABETES

Improvement in β-Cell Secretory Capacity After Human Islet Transplantation According to the CIT07 Protocol

(2013) Michael R. Rickels et al.   DIABETES

Impact of C-Peptide Preservation on Metabolic and Clinical Outcomes in the Diabetes Control and Complications Trial

(2013) J. M. Lachin et al.   DIABETES

The Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study at 30 Years: Overview

(2013) David M. Nathan et al.   DIABETES CARE

Safety of Nighttime 2-Hour Suspension of Basal Insulin in Pump-Treated Type 1 Diabetes Even in the Absence of Low Glucose

(2013) Jennifer L. Sherr et al.   DIABETES CARE

Maturation and function of human embryonic stem cell-derived pancreatic progenitors in macroencapsulation devices following transplant into mice

(2013) Jennifer E. Bruin et al.   DIABETOLOGIA

Antigen-Specific Tolerance by Autologous Myelin Peptide-Coupled Cells: A Phase 1 Trial in Multiple Sclerosis

(2013) A. Lutterotti et al.   Science Translational Medicine

PLG Scaffold Delivered Antigen-Specific Regulatory T Cells Induce Systemic Tolerance in Autoimmune Diabetes

(2013) John G. Graham et al.   TISSUE ENGINEERING PART A

Do MHCII-Presented Neoantigens Drive Type 1 Diabetes and Other Autoimmune Diseases?

(2013) P. Marrack et al.   Cold Spring Harbor Perspectives in Medicine

Potent Induction Immunotherapy Promotes Long-Term Insulin Independence After Islet Transplantation in Type 1 Diabetes

(2012) M. D. Bellin et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Preventing  -Cell Loss and Diabetes With Calcium Channel Blockers

(2012) G. Xu et al.   DIABETES

Maturation of Human Embryonic Stem Cell-Derived Pancreatic Progenitors Into Functional Islets Capable of Treating Pre-existing Diabetes in Mice

(2012) A. Rezania et al.   DIABETES

 -Cell Mass and Turnover in Humans: Effects of obesity and aging

(2012) Y. Saisho et al.   DIABETES CARE

Improvement in Outcomes of Clinical Islet Transplantation: 1999-2010

(2012) F. B. Barton et al.   DIABETES CARE

Incretin Effects on  -Cell Function, Replication, and Mass: The human perspective

(2011) A. J. Garber   DIABETES CARE

Unique Arrangement of  - and  -Cells in Human Islets of Langerhans

(2010) D. Bosco et al.   DIABETES

Residual Insulin Production and Pancreatic  -Cell Turnover After 50 Years of Diabetes: Joslin Medalist Study

(2010) H. A. Keenan et al.   DIABETES

Adaptive changes in pancreatic beta cell fractional area and beta cell turnover in human pregnancy

(2010) A. E. Butler et al.   DIABETOLOGIA

Epidemiology of Type 1 Diabetes

(2010) David M. Maahs et al.   ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA

Significant Human β-Cell Turnover Is Limited to the First Three Decades of Life as Determined byin VivoThymidine Analog Incorporation and Radiocarbon Dating

(2010) S. Perl et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Quantitative analysis of cell composition and purity of human pancreatic islet preparations

(2010) Anna Pisania et al.   LABORATORY INVESTIGATION

Conversion of adult pancreatic α-cells to β-cells after extreme β-cell loss

(2010) Fabrizio Thorel et al.   NATURE

Paracrinology of islets and the paracrinopathy of diabetes

(2010) R. H. Unger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pancreatic islet plasticity: Interspecies comparison of islet architecture and composition

(2010) Donald J. Steiner et al.   Islets

Positron Emission Tomography in Clinical Islet Transplantation

(2009) O. Eriksson et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Primary Graft Function, Metabolic Control, and Graft Survival After Islet Transplantation

(2009) M.-C. Vantyghem et al.   DIABETES CARE

The long lifespan and low turnover of human islet beta cells estimated by mathematical modelling of lipofuscin accumulation

(2009) M. Cnop et al.   DIABETOLOGIA

β-cell development and turnover during prenatal life in humans

(2009) Juris J Meier et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

C-Peptide Levels and Insulin Independence Following Autologous Nonmyeloablative Hematopoietic Stem Cell Transplantation in Newly Diagnosed Type 1 Diabetes Mellitus

(2009) Carlos E. B. Couri   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Transgenic Expression of Single-Chain Anti-CTLA-4 Fv on   Cells Protects Nonobese Diabetic Mice from Autoimmune Diabetes

(2009) S.-J. Shieh et al.   JOURNAL OF IMMUNOLOGY

Pancreas transplantation

(2009) Steve A White et al.   LANCET

 -Cell Replication Is the Primary Mechanism Subserving the Postnatal Expansion of  -Cell Mass in Humans

(2008) J. J. Meier et al.   DIABETES

Pancreatic β-cell mass in European subjects with type 2 diabetes

(2008) J. Rahier et al.   DIABETES OBESITY & METABOLISM

Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo

(2008) Evert Kroon et al.   NATURE BIOTECHNOLOGY

Noninvasive in vivo imaging of pancreatic islet cell biology

(2008) Stephan Speier et al.   NATURE MEDICINE