Review
Polymer Science
Alex Lopez Marquez, Ivan Emilio Gareis, Fernando Jose Dias, Christoph Gerhard, Maria Florencia Lezcano
Summary: Electrospun scaffolds are an important research direction in tissue engineering as they can imitate the hierarchical structures of the extracellular matrix. This article discusses the issues with commonly used methods for characterizing electrospun scaffolds and proposes more suitable imaging and physical measurement methods. The results show that imaging methods have the most benefits, with limitations only in terms of cost and expertise. By using more accurate characterization methods, researchers can gain a better understanding of the characteristics of electrospun scaffolds.
Review
Cell Biology
Chih-Ru Lin, Karim Bahmed, Beata Kosmider
Summary: Alveolar type II cells play a crucial role in repairing the alveolar epithelium and maintaining lung homeostasis. Various signaling pathways, including WNT/beta-catenin, YAP/TAZ, NOTCH, TGF-beta, and P53, are involved in the proliferation and differentiation of these cells. Imbalance in cell death and proliferation contributes to pathogenesis of pulmonary emphysema. Cigarette smoking induces oxidative stress, leading to inflammation and dysfunction of alveolar type II cells.
Letter
Respiratory System
Farbod N. Rahaghi, Joan F. Hilton, Ricardo A. Correa, Camila Loureiro, Jaquelina S. Ota-Arakaki, Carlos G. Y. Verrastro, Michael H. Lee, Claudia Mickael, Pietro Nardelli, David A. Systrom, Aaron B. Waxman, George R. Washko, Raul San Jose Estepar, Brian B. Graham, Rudolf K. F. Oliveira
Summary: Among the authors of this article, only F.N. Rahaghi and G.R. Washko have received funding or other payments from relevant institutions, while the other authors have reported no conflicts of interest.
EUROPEAN RESPIRATORY JOURNAL
(2021)
Article
Multidisciplinary Sciences
Ziyi Guo, Haoqi Yang, Jing-Ren Zhang, Wenwen Zeng, Xiaoyu Hu
Summary: Alveolar macrophages (AMs) play a crucial role in controlling pulmonary inflammation. They express Lepr, a receptor for the metabolic hormone leptin, which helps attenuate inflammation and protect against lung injury. However, this signaling also compromises the host defense against Streptococcus pneumoniae infection. Lepr signaling in AMs protects against necroptosis and limits excessive inflammation by regulating the release of proinflammatory cytokines.
Article
Nutrition & Dietetics
Xin Yan, Yujuan Gao, Qi Zhao, Xiaohua Qiu, Mi Tian, Jinghong Dai, Yi Zhuang
Summary: The lipid ratios, including TC-HDL-C and non-HDL-C, were found to be independent risk factors for the severity of PAP. TC/HDL-C showed promise as a biomarker for the severity of PAP.
FRONTIERS IN NUTRITION
(2021)
Article
Construction & Building Technology
Ahmet Akkaya, Ismail Hakki Cagatay
Summary: The study aimed to develop optimum pervious concrete mixtures for road paving on high volume roads, considering the Technical Specification for Concrete Road Pavements of General Directorate of Turkish Highways. Results showed that pervious concrete with appropriate aggregate size and (A/B) ratio can meet the strength requirements for concrete road pavements.
CONSTRUCTION AND BUILDING MATERIALS
(2021)
Article
Cell & Tissue Engineering
Takahiro Suezawa, Shuhei Kanagaki, Keita Moriguchi, Atsushi Masui, Kazuhisa Nakao, Masayasu Toyomoto, Koji Tamai, Ryuta Mikawa, Toyohiro Hirai, Koji Murakami, Masatoshi Hagiwara, Shimpei Gotoh
Summary: The study established a novel in vitro pulmonary fibrosis model using alveolar organoids made up of human pluripotent stem cell-derived alveolar epithelial cells and primary human lung fibroblasts. The findings suggest that blocking ALK5 or integrin alpha V beta 6 can ameliorate fibrogenic changes in the alveolar organoids, indicating the potential for targeting alveolar epithelial cells and epithelial-mesenchymal interactions to treat pulmonary fibrosis.
Article
Computer Science, Interdisciplinary Applications
Akindeji O. Fajana
Summary: The study analyzed the impact of different calculation methods on the volume of shale in reservoir petrophysical parameters, using MATLAB for modeling and evaluation, and developed PETRARCAL as a tool for calculating petrophysical parameters. The results showed that different calculation methods had certain correlations in the calculation of shale volume, and rigorous calculation methods could improve the accuracy of reservoir evaluation.
EARTH SCIENCE INFORMATICS
(2021)
Article
Veterinary Sciences
Richard Munn, Ted Whittem, Andrew P. Woodward
Summary: Pharmacokinetic and pharmacodynamic models are powerful tools for predicting outcomes. This study found that the surface area to volume ratio of tissue cages can affect the rate of drug movement and the concentration of prostaglandin metabolites over time.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Cardiac & Cardiovascular Systems
Anders Nelsson, Mikael Kanski, Henrik Engblom, Martin Ugander, Marcus Carlsson, Hakan Arheden
Summary: Increased pulmonary blood volume (PBV) is a measure of congestion and is associated with an increased risk of cardiovascular events. This study aimed to determine the accuracy and precision for different methods of quantifying PBV, finding that adjusting for left atrium volume (LAV) is crucial for more accurate results. Among the methods tested, CoG(FPP) had the best precision and lowest interobserver variability for measuring PBV.
JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE
(2021)
Article
Materials Science, Paper & Wood
Prakash Parajuli, Sanjit Acharya, Julia L. Shamshina, Noureddine Abidi
Summary: In this study, alkali and alkaline earth metal chlorides with different cationic radii were used to investigate the behavior of cellulose solutions in the presence of salts. The addition of salts had a significant impact on the sol-gel transition of cellulose solutions and their ability to form monoliths. By adding the appropriate salt, the properties of resulting aerocelluloses could be tailored for specific applications.
Article
Engineering, Multidisciplinary
Lukasz Sadowski, Jerzy Hola, Lech Czarnecki, Thomas G. Mathia
Summary: This article introduces a new paradigm of concrete surface morphology and discusses the fundamental definitions and various metrological methods used for characterizing concrete surfaces. It includes a critical analysis of these methods, classification of parameters, and applications of surface morphology methods in concrete over the past decades.
Article
Agriculture, Dairy & Animal Science
Paloma Helena Sanches da Silva, Carlos Eduardo Bastos Lopes, Larissa Bueno Stallmach, Lucas de Oliveira Ferreira, Pedro Antonio Bronhara Pimentel, Antonio Giuliano, Patricia Maria Coletto Freitas, Rodrigo dos Santos Horta
Summary: This study investigates the efficacy of different sealing methods after partial lobectomy in dogs and concludes that manual sutures and synthetic glue sealants are effective in preventing air leakage.
Article
Optics
Bowen Liu, Chunming Wang, Gaoyang Mi, Jun Wang, Wei Zhang, Xiong Zhang
Summary: The study investigated the effects of laser cleaning on the 5083 alloy, finding that changes in oxygen content and surface morphology evolution can affect welding quality. As energy density increased, morphological defects were gradually modified to form a striation morphology; the micromorphology after laser cleaning affects the stability of keyholes, thereby regulating process porosity.
OPTICS AND LASER TECHNOLOGY
(2021)
Article
Engineering, Chemical
Chenghao Ma, Changqi Zhu, Ru Qu, Haifeng Liu, Tianmin Wang
Summary: This study investigates the influence of particle morphology and internal pores on the limit void ratio of coral sand based on quantitative evaluation. Comparison tests reveal the impact of mineral composition on the limit void ratio of different aggregates. The findings indicate that particle roundness, internal porosity, and shape significantly affect the limit void ratio of coral sand.
Article
Mathematics
Carlos I. Andrade, Daniel E. Hurtado
Summary: This study aims to create a novel inelastic deformable image registration method that automatically detects sliding surfaces and handles discontinuous motion. Experimental results show that this method can provide accurate estimates of local lung strain on medical CT images, with significantly smaller errors compared to traditional elastic registration methods.
Article
Mathematics, Applied
Nicolas Barnafi, Gabriel N. Gatica, Daniel E. Hurtado, Willian Miranda, Ricardo Ruiz-Baier
Summary: This work presents new primal and dual-mixed finite element methods for deformable image registration, considering the continuity of the similarity measure and ellipticity of the regularizer. By modifying the original model to incorporate additional degrees of freedom from the regularizer's kernel, ellipticity is granted on the entire solution space. The well-posedness of extended formulations and error estimates with convergence rates are proven, with numerical examples demonstrating the efficiency of the methods in registration tasks, particularly for translations and rotations.
MATHEMATICAL MODELS & METHODS IN APPLIED SCIENCES
(2021)
Article
Engineering, Multidisciplinary
Daniel E. Hurtado, Patricio Zavala
Summary: A novel energy-transform variational formulation (ETVF) is proposed to accelerate the numerical simulation of hyperelastic biosolids. By introducing auxiliary fields and using Lagrange multiplier formulation to reduce non-linearity, the ETVF shows significant speed-ups in cardiovascular simulations and decreased wall-clock time in parallel computing.
COMPUTER METHODS IN APPLIED MECHANICS AND ENGINEERING
(2021)
Article
Engineering, Multidisciplinary
Felipe Alvarez-Barrientos, Daniel E. Hurtado, Martin Genet
Summary: In this study, a finite-deformation variational framework was developed for pressure-driven foams. The stress distribution in lung tissue was numerically simulated under different boundary conditions, revealing a strong dependence on kinematic constraints in the spherical alveolar model but not in the image-based alveolar model. Comparison of pressure-driven and deformation-driven models showed a significant shift in hydrostatic stresses but unaffected deviatoric stresses. These findings have implications for lung simulation related to mechanical ventilation and spontaneous breathing.
INTERNATIONAL JOURNAL OF ENGINEERING SCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Pamela Franco, Julio Sotelo, Cristian Montalba, Bram Ruijsink, Eric Kerfoot, David Nordsletten, Joaquin Mura, Daniel Hurtado, Sergio Uribe
Summary: This study applied a method to quantify multiple left intraventricular hemodynamic parameters, revealing significant differences in velocity, vorticity, energy loss, etc. between dilated cardiomyopathy patients and healthy volunteers. The hemodynamic parameters obtained showed high reproducibility.
APPLIED SCIENCES-BASEL
(2021)
Article
Veterinary Sciences
Joaquin Araos, Luca Lacitignola, Valentina de Monte, Marzia Stabile, Ian Porter, Daniel E. Hurtado, Agustin Perez, Antonio Crovace, Salvatore Grasso, Manuel Martin-Flores, Francesco Staffieri
Summary: This study found that body fat percentage affects lung function and the respiratory system in obese dogs, who often have extensive areas of hypo-aerated lungs. Ventilation protocols based on ideal body weight may be more beneficial for obese dogs in terms of lung deformation and airway pressure.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Engineering, Multidisciplinary
David Ortiz-Puerta, Agustin Cox, Daniel E. Hurtado
Summary: This study presents a novel framework for creating Non-Uniform Rational B-Splines surface models of the respiratory airways, enhancing the geometrical flexibility and accuracy of computational models of the respiratory system.
COMPUTER METHODS IN APPLIED MECHANICS AND ENGINEERING
(2022)
Article
Veterinary Sciences
Joaquin Araos, Pablo Cruces, Manuel Martin-Flores, Pablo Donati, Robin D. Gleed, Tomas Boullhesen-Williams, Agustin Perez, Francesco Staffieri, Jaime Retamal, Marcos Vidal F. Melo, Daniel E. Hurtado
Summary: This study describes the magnitude and spatial distribution of lung strain in healthy anesthetized, mechanically ventilated dogs with and without positive end-expiratory pressure (PEEP). It found that lung heterogeneity affects the accuracy of global lung strain in representing regional total tissue lung strain. PEEP reduced dynamic strain but induced a large static strain. Limiting dynamic strain may be an important clinical target in healthy and diseased lungs, but further research is needed.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Cardiac & Cardiovascular Systems
Julio Sotelo, Pamela Franco, Andrea Guala, Lydia Dux-Santoy, Aroa Ruiz-Munoz, Arturo Evangelista, Hernan Mella, Joaquin Mura, Daniel E. Hurtado, Jose F. Rodriguez-Palomares, Sergio Uribe
Summary: This study quantified and ranked several three-dimensional hemodynamic parameters in patients with bicuspid aortic valve (BAV), and found that flow eccentricity, velocity angle, and regurgitation fraction have the best relationships with aortic diameter, effectively differentiating patients with BAV from healthy volunteers.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Biology
Felipe Contreras-Briceno, Maximiliano Espinosa-Ramirez, Vicente Keim-Bagnara, Matias Carreno-Roman, Rafael Rodriguez-Villagra, Fernanda Villegas-Belmar, Gines Viscor, Luigi Gabrielli, Marcelo E. Andia, Oscar F. Araneda, Daniel E. Hurtado
Summary: The study aimed to evaluate if changes in oxygen saturation levels at intercostal muscles using NIRS could determine RCP during exercise in triathletes. The results showed a good agreement between NIRS and visual methods in determining RCP, indicating that changes in SmO2 m.intercostales measured by NIRS can effectively determine RCP in triathletes.
Article
Engineering, Multidisciplinary
Pablo Zurita, Daniel E. Hurtado
Summary: This study introduces a coupled three-dimensional computational model to simulate pulmonary capillary perfusion and gas exchange in alveolar structures. Numerical experiments validate the accuracy and applicability of the model, demonstrating blood pressure drops and gas partial pressure dynamics. This model contributes to a better understanding of lung physiology and pathology.
COMPUTER METHODS IN APPLIED MECHANICS AND ENGINEERING
(2022)
Article
Computer Science, Interdisciplinary Applications
Agustin Cox, David Ortiz-Puerta, Julio Sotelo, Sergio Uribe, Daniel E. Hurtado
Summary: This study presents a mechanics-informed snakes isogeometric analysis (MISIGA) method for estimating strain fields in the aortic wall from medical images. The method combines image segmentation with advanced curvilinear representations to capture the deformation mapping of irregular vessels, and constructs continuous strain fields in the full aorta. The MISIGA method performs well in strain estimation in both synthetic images and a normal aorta, demonstrating high accuracy and feasibility. It is envisioned that the MISIGA method can provide seamless high-fidelity analysis of 3D strain in the aorta and other vessels.
ENGINEERING WITH COMPUTERS
(2022)
Article
Physiology
Nibaldo Aviles-Rojas, Daniel E. Hurtado
Summary: This study aims to create anatomical computational models of the lungs to predict clinically-relevant respiratory variables. A continuum poromechanical framework is formulated to account for the air-tissue interaction in the lung parenchyma. The proposed lung model accurately predicts physiological variables in mechanical ventilation and the supersyringe method. The findings demonstrate the potential of finite-element poromechanical models in predicting clinically-relevant variables in respiratory medicine.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Geochemistry & Geophysics
Felipe Saez-Leiva, Daniel E. Hurtado, Muriel Gerbault, Javiera Ruz-Ginouves, Pablo Iturrieta, Jose Cembrano
Summary: In this study, a finite element method is used to simulate the control of crustal faults on nearby geothermal reservoirs. The results show that fault slip leads to changes in fluid pressure domains, which in turn affect the migration of reservoir fluids. These fluid pressure changes are achieved through variations in fault permeability and fluid viscosity. The study also finds that pressure-driven diffusion of fluids causes fluid flow to return to a stationary state over time. Therefore, solid-fluid coupling needs to be considered in numerical models for volcano-tectonic studies.
EARTH AND PLANETARY SCIENCE LETTERS
(2023)