Disease modeling of pulmonary fibrosis using human pluripotent stem cell-derived alveolar organoids

Hydroxypropyl Cyclodextrin Improves Amiodarone-Induced Aberrant Lipid Homeostasis of Alveolar Cells

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Directed induction of alveolar type I cells derived from pluripotent stem cells via Wnt signaling inhibition

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Genomic, epigenomic, and biophysical cues controlling the emergence of the lung alveolus

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The Cellular and Physiological Basis for Lung Repair and Regeneration: Past, Present, and Future

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Inflammatory Signals Induce AT2 Cell-Derived Damage-Associated Transient Progenitors that Mediate Alveolar Regeneration

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Persistence of a regeneration-associated, transitional alveolar epithelial cell state in pulmonary fibrosis

(2020) Yoshihiko Kobayashi et al.   NATURE CELL BIOLOGY

Alveolar regeneration through a Krt8+ transitional stem cell state that persists in human lung fibrosis

(2020) Maximilian Strunz et al.   Nature Communications

The Idiopathic Pulmonary Fibrosis Cell Atlas

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Senescence of Alveolar Type 2 Cells Drives Progressive Pulmonary Fibrosis

(2020) Changfu Yao et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Human lung stem cell-based alveolospheres provide insights into SARS-CoV-2 mediated interferon responses and pneumocyte dysfunction

(2020) Hiroaki Katsura et al.   Cell Stem Cell

Three-dimensional human alveolar stem cell culture models reveal infection response to SARS-CoV-2

(2020) Jeonghwan Youk et al.   Cell Stem Cell

Contributions of alveolar epithelial cell quality control to pulmonary fibrosis

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STAT3–BDNF–TrkB signalling promotes alveolar epithelial regeneration after lung injury

(2020) Andrew J. Paris et al.   NATURE CELL BIOLOGY

Idiopathic pulmonary fibrosis: Disease mechanisms and drug development

(2020) Paolo Spagnolo et al.   PHARMACOLOGY & THERAPEUTICS

In Vitro Disease Modeling of Hermansky-Pudlak Syndrome Type 2 Using Human Induced Pluripotent Stem Cell-Derived Alveolar Organoids

(2019) Yohei Korogi et al.   Stem Cell Reports

An atlas of the aging lung mapped by single cell transcriptomics and deep tissue proteomics

(2019) Ilias Angelidis et al.   Nature Communications

Nascent Lung Organoids Reveal Epithelium- and BMP-Mediated Suppression of Fibroblast Activation

(2019) Qi Tan et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Targeting senescent cells in translational medicine

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Progressive Pulmonary Fibrosis Is Caused by Elevated Mechanical Tension on Alveolar Stem Cells

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Idiopathic Pulmonary Fibrosis

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Single-Cell Deconvolution of Fibroblast Heterogeneity in Mouse Pulmonary Fibrosis

(2018) Ting Xie et al.   Cell Reports

Single-Cell Transcriptomic Analysis of Human Lung Provides Insights into the Pathobiology of Pulmonary Fibrosis

(2018) Paul A Reyfman et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Long-term expansion of alveolar stem cells derived from human iPS cells in organoids

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The harmonizome: a collection of processed datasets gathered to serve and mine knowledge about genes and proteins

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Development of a Three-Dimensional Bioengineering Technology to Generate Lung Tissue for Personalized Disease Modeling

(2016) Dan C. Wilkinson et al.   Stem Cells Translational Medicine

IL1- and TGFβ-Nox4 signaling, oxidative stress and DNA damage response are shared features of replicative, oncogene-induced, and drug-induced paracrine ‘Bystander senescence’

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Alveolar progenitor and stem cells in lung development, renewal and cancer

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Generation of Alveolar Epithelial Spheroids via Isolated Progenitor Cells from Human Pluripotent Stem Cells

(2014) Shimpei Gotoh et al.   Stem Cell Reports

Type 2 alveolar cells are stem cells in adult lung

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An Efficient Nonviral Method to Generate Integration-Free Human-Induced Pluripotent Stem Cells from Cord Blood and Peripheral Blood Cells

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Cross Talk among TGF-  Signaling Pathways, Integrins, and the Extracellular Matrix

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Autocrine production of TGF-β1 promotes myofibroblastic differentiation of neonatal lung mesenchymal stem cells

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The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

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Multiple roles of the cell cycle inhibitor p21CDKN1A in the DNA damage response

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Targeted Injury of Type II Alveolar Epithelial Cells Induces Pulmonary Fibrosis

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Partial Inhibition of Integrin αvβ6 Prevents Pulmonary Fibrosis without Exacerbating Inflammation

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The bleomycin animal model: A useful tool to investigate treatment options for idiopathic pulmonary fibrosis?

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