A Dynamic Mass Redistribution Assay for the Human Sweet Taste Receptor Uncovers G-Protein Dependent Biased Ligands

Rapid throughput concentration-response analysis of human taste discrimination

(2021) R. Kyle Palmer et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Label-Free Investigations on the G Protein Dependent Signaling Pathways of Histamine Receptors

(2021) Ulla Seibel-Ehlert et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A single–cell type transcriptomics map of human tissues

(2021) Max Karlsson et al.   Science Advances

Biophysical and functional characterization of the human TAS1R2 sweet taste receptor overexpressed in a HEK293S inducible cell line

(2021) Christine Belloir et al.   Scientific Reports

Conformational Basis of G Protein-Coupled Receptor Signaling Versatility

(2020) Laura M. Wingler et al.   TRENDS IN CELL BIOLOGY

G Protein-Coupled Receptors in Taste Physiology and Pharmacology

(2020) Raise Ahmad et al.   Frontiers in Pharmacology

Biased Receptor Signaling in Drug Discovery

(2019) Terry Kenakin   PHARMACOLOGICAL REVIEWS

Lack of beta-arrestin signaling in the absence of active G proteins

(2018) Manuel Grundmann et al.   Nature Communications

NOP receptor pharmacological profile – A dynamic mass redistribution study

(2018) Davide Malfacini et al.   PLoS One

A Pharmacological Perspective on the Study of Taste

(2018) R. Kyle Palmer   PHARMACOLOGICAL REVIEWS

Practical guide for calculating and representing biased signaling by GPCR ligands: A stepwise approach

(2016) Karim Nagi et al.   METHODS

Molecular mechanism of sweetness sensation

(2016) Grant E. DuBois   PHYSIOLOGY & BEHAVIOR

Demonstration of the dynamic mass redistribution label-free technology as a useful cell-based pharmacological assay for endogenously expressed GABAA receptors

(2016) Anders B. Klein et al.   MedChemComm

Biased Agonism as a Novel Strategy To Harness the Proresolving Properties of Melanocortin Receptors without Eliciting Melanogenic Effects

(2015) Trinidad Montero-Melendez et al.   JOURNAL OF IMMUNOLOGY

Tissue-based map of the human proteome

(2015) M. Uhlen et al.   SCIENCE

A Comparison of Assay Performance Between the Calcium Mobilization and the Dynamic Mass Redistribution Technologies for the Human Urotensin Receptor

(2014) Mi Young Lee et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Divergent Label-free Cell Phenotypic Pharmacology of Ligands at the Overexpressed β2-Adrenergic Receptors

(2014) Ann M. Ferrie et al.   Scientific Reports

The taste of D- and L-amino acids: In vitro binding assays with cloned human bitter (TAS2Rs) and sweet (TAS1R2/TAS1R3) receptors

(2013) A. Bassoli et al.   FOOD CHEMISTRY

Agonists with supraphysiological efficacy at the muscarinic M2ACh receptor

(2012) R Schrage et al.   BRITISH JOURNAL OF PHARMACOLOGY

A Gβγ Effector, ElmoE, Transduces GPCR Signaling to the Actin Network during Chemotaxis

(2012) Jianshe Yan et al.   DEVELOPMENTAL CELL

A Simple Method for Quantifying Functional Selectivity and Agonist Bias

(2011) Terry Kenakin et al.   ACS Chemical Neuroscience

Dynamic Mass Redistribution as a Means to Measure and Differentiate Signaling via Opioid and Cannabinoid Receptors

(2011) Ellen E. Codd et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Biased agonism of the calcium-sensing receptor

(2011) Alex Rojas Bie Thomsen et al.   CELL CALCIUM

Ligand functional selectivity and quantitative pharmacology at G protein-coupled receptors

(2011) Wayne Stallaert et al.   Expert Opinion on Drug Discovery

Selective Orthosteric Free Fatty Acid Receptor 2 (FFA2) Agonists

(2011) Johannes Schmidt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional Selective Oxytocin-derived Agonists Discriminate between Individual G Protein Family Subtypes

(2011) Marta Busnelli et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal structure of the β2 adrenergic receptor–Gs protein complex

(2011) Søren G. F. Rasmussen et al.   NATURE

Applying label-free dynamic mass redistribution technology to frame signaling of G protein–coupled receptors noninvasively in living cells

(2011) Ralf Schröder et al.   Nature Protocols

Ligand-Directed Functional Selectivity at the Mu Opioid Receptor Revealed by Label-Free Integrative Pharmacology On-Target

(2011) Megan Morse et al.   PLoS One

The sweet taste of true synergy: positive allosteric modulation of the human sweet taste receptor

(2011) Guy Servant et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Identification of Orthosteric and Allosteric Site Mutations in M2Muscarinic Acetylcholine Receptors That Contribute to Ligand-selective Signaling Bias

(2010) Karen J. Gregory et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Prediction of Functionally Selective Allosteric Interactions at an M3 Muscarinic Acetylcholine Receptor Mutant Using Saccharomyces cerevisiae

(2010) G. D. Stewart et al.   MOLECULAR PHARMACOLOGY

A holistic view of GPCR signaling

(2010) Terry Kenakin   NATURE BIOTECHNOLOGY

Deconvolution of complex G protein–coupled receptor signaling in live cells using dynamic mass redistribution measurements

(2010) Ralf Schröder et al.   NATURE BIOTECHNOLOGY

International Union of Basic and Clinical Pharmacology. LXXVIII. Lysophospholipid Receptor Nomenclature

(2010) J. Chun et al.   PHARMACOLOGICAL REVIEWS

Positive allosteric modulators of the human sweet taste receptor enhance sweet taste

(2010) G. Servant et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular mechanism of the sweet taste enhancers

(2010) F. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Molecular Receptive Ranges of Human TAS2R Bitter Taste Receptors

(2009) Wolfgang Meyerhof et al.   CHEMICAL SENSES

Distinct growth factor-induced dynamic mass redistribution (DMR) profiles for monitoring oncogenic signaling pathways in various cancer cells

(2009) Yuhong Du et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

An optical dynamic mass redistribution assay reveals biased signaling of dualsteric GPCR activators

(2009) Anna Kebig et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

Label-free optical biosensor: A tool for G protein-coupled receptors pharmacology profiling and inverse agonists identification

(2009) Paul H. Lee   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

A 100K well screen for a muscarinic receptor using the Epic®label-free system – a reflection on the benefits of the label-free approach to screening seven-transmembrane receptors

(2009) K. Dodgson et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

Isovanillic Sweeteners: Sensory Evaluation and In Vitro Assays with Human Sweet Taste Receptor

(2008) Angela Bassoli et al.   Chemosensory Perception

Functional Selectivity in GPCR Modulator Screening

(2008) Terry Kenakin   COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING

Molecular mechanism for the umami taste synergism

(2008) F. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA