Ligand-Directed Functional Selectivity at the Mu Opioid Receptor Revealed by Label-Free Integrative Pharmacology On-Target

Probing the links between in vitro potency, ADMET and physicochemical parameters

(2011) M. Paul Gleeson et al.   NATURE REVIEWS DRUG DISCOVERY

Agonist-Directed Desensitization of the β2-Adrenergic Receptor

(2011) Vasiliy Goral et al.   PLoS One

GPR55 ligands promote receptor coupling to multiple signalling pathways

(2010) Christopher M Henstridge et al.   BRITISH JOURNAL OF PHARMACOLOGY

The role of conformational ensembles of seven transmembrane receptors in functional selectivity

(2010) Nagarajan Vaidehi et al.   CURRENT OPINION IN PHARMACOLOGY

Probing cancer signaling with resonant waveguide grating biosensors

(2010) Ye Fang   Expert Opinion on Drug Discovery

Functional Selectivity and Biased Receptor Signaling

(2010) T. Kenakin   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Deconvolution of complex G protein–coupled receptor signaling in live cells using dynamic mass redistribution measurements

(2010) Ralf Schröder et al.   NATURE BIOTECHNOLOGY

Signal integration through blending, bolstering and bifurcating of intracellular information

(2010) Catherine T Pawson et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Seven Transmembrane Receptors as Shapeshifting Proteins: The Impact of Allosteric Modulation and Functional Selectivity on New Drug Discovery

(2010) T. Kenakin et al.   PHARMACOLOGICAL REVIEWS

Energy Landscapes as a Tool to Integrate GPCR Structure, Dynamics, and Function

(2010) Xavier Deupi et al.   PHYSIOLOGY

Neuroprotection by selective allosteric potentiators of the EP2 prostaglandin receptor

(2010) J. Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Label-free optical biosensor for probing integrative role of adenylyl cyclase in G protein-coupled receptor signaling

(2009) Elizabeth Tran et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

An optical dynamic mass redistribution assay reveals biased signaling of dualsteric GPCR activators

(2009) Anna Kebig et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

A 100K well screen for a muscarinic receptor using the Epic®label-free system – a reflection on the benefits of the label-free approach to screening seven-transmembrane receptors

(2009) K. Dodgson et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

Allosteric communication between protomers of dopamine class A GPCR dimers modulates activation

(2009) Yang Han et al.   Nature Chemical Biology

Novel highly potent μ-opioid receptor antagonist based on endomorphin-2 structure

(2008) Jakub Fichna et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

On the fitting of binding data when receptor dimerization is suspected

(2008) J Giraldo   BRITISH JOURNAL OF PHARMACOLOGY

Label-free optical biosensor for ligand-directed functional selectivity acting on β2adrenoceptor in living cells

(2008) Ye Fang et al.   FEBS LETTERS

Alternative Splicing Determines the Post-endocytic Sorting Fate of G-protein-coupled Receptors

(2008) Michael Tanowitz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY