Perspective: The High-Folate–Low-Vitamin B-12 Interaction Is a Novel Cause of Vitamin B-12 Depletion with a Specific Etiology—A Hypothesis

High folic acid or folate combined with low vitamin B-12 status: potential but inconsistent association with cognitive function in a nationally representative cross-sectional sample of US older adults participating in the NHANES

(2020) Regan L Bailey et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Knowledge gaps in understanding the metabolic and clinical effects of excess folates/folic acid: a summary, and perspectives, from an NIH workshop

(2020) Padma Maruvada et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Folate receptors and transporters: biological role and diagnostic/therapeutic targets in cancer and other diseases

(2019) Barbara Frigerio et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Age-specific reference ranges are needed to interpret serum methylmalonic acid concentrations in the US population

(2019) Ekaterina M Mineva et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Lack of historical evidence to support folic acid exacerbation of the neuropathy caused by vitamin B12 deficiency

(2019) Robert J Berry   AMERICAN JOURNAL OF CLINICAL NUTRITION

Folic acid, but not folate, regulates different stages of neurogenesis in the ventral hippocampus of adult female rats

(2019) Wansu Qiu et al.   JOURNAL OF NEUROENDOCRINOLOGY

Proton Pump Inhibitors, H2-Receptor Antagonists, Metformin, and Vitamin B-12 Deficiency: Clinical Implications

(2018) Joshua W Miller   Advances in Nutrition

Do the benefits of folic acid fortification outweigh the risk of masking vitamin B12deficiency?

(2018) James L Mills et al.   BMJ-British Medical Journal

Do the benefits of folic acid fortification outweigh the risk of masking vitamin B12deficiency?

(2018) James L Mills et al.   BMJ-British Medical Journal

Homocysteine, Vitamin B12, and Folic Acid Levels in Alzheimer's Disease, Mild Cognitive Impairment, and Healthy Elderly: Baseline Characteristics in Subjects of the Australian Imaging Biomarker Lifestyle Study

(2018) Noel G. Faux et al.   JOURNAL OF ALZHEIMERS DISEASE

Among Vitamin B12 Deficient Older People, High Folate Levels are Associated with Worse Cognitive Function: Combined Data from Three Cohorts

(2018) Eileen M. Moore et al.   JOURNAL OF ALZHEIMERS DISEASE

The risks of folic acid to the nervous system in vitamin B12deficiency: rediscovered in the era of folic acid fortification policies

(2017) Edward H Reynolds   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Vitamin B12 deficiency

(2017) Ralph Green et al.   Nature Reviews Disease Primers

Homocysteine, B Vitamins, and Cognitive Impairment

(2016) A. David Smith et al.   Annual Review of Nutrition

Absorption and blood/cellular transport of folate and cobalamin: Pharmacokinetic and physiological considerations

(2016) David H. Alpers   BIOCHIMIE

Bacterial Folates Provide an Exogenous Signal for C. elegans Germline Stem Cell Proliferation

(2016) Snehal N. Chaudhari et al.   DEVELOPMENTAL CELL

Safe use of high intakes of folic acid: research challenges and paths forward

(2016) Abee L. Boyles et al.   NUTRITION REVIEWS

Direct in vivo evidence of activated macrophages in human osteoarthritis

(2016) V.B. Kraus et al.   OSTEOARTHRITIS AND CARTILAGE

Vitamin B-12 treatment of asymptomatic, deficient, elderly Chileans improves conductivity in myelinated peripheral nerves, but high serum folate impairs vitamin B-12 status response assessed by the combined indicator of vitamin B-12 status

(2015) Alex Brito et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Folic acid mediates activation of the pro-oncogene STAT3 via the Folate Receptor alpha

(2015) Mariann F. Hansen et al.   CELLULAR SIGNALLING

Combined indicator of vitamin B12 status: modification for missing biomarkers and folate status and recommendations for revised cut-points

(2015) Sergey N. Fedosov et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

Serum folate, vitamin B12 and cognitive impairment in Chilean older adults

(2015) Cecilia Castillo-Lancellotti et al.   PUBLIC HEALTH NUTRITION

Folic acid inhibits COLO-205 colon cancer cell proliferation through activating the FRα/c-SRC/ERK1/2/NFκB/TP53 pathway: in vitro and in vivo studies

(2015) Chun-Ting Kuo et al.   Scientific Reports

The use of Blood Concentrations of Vitamins and their Respective Functional Indicators to Define Folate and Vitamin B12 Status

(2015) Jacob Selhub et al.   FOOD AND NUTRITION BULLETIN

Folic acid handling by the human gut: implications for food fortification and supplementation

(2014) Imran Patanwala et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Advanced Age as a Risk Factor for Folate-Associated Functional Cobalamin Deficiency

(2013) Lawrence R. Solomon   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Choroid plexus transcytosis and exosome shuttling deliver folate into brain parenchyma

(2013) Marcel Grapp et al.   Nature Communications

Vitamin B12 transport from food to the body's cells—a sophisticated, multistep pathway

(2012) Marianne J. Nielsen et al.   Nature Reviews Gastroenterology & Hepatology

Do high blood folate concentrations exacerbate metabolic abnormalities in people with low vitamin B-12 status?

(2011) James L Mills et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Circulating unmetabolized folic acid and 5-methyltetrahydrofolate in relation to anemia, macrocytosis, and cognitive test performance in American seniors

(2010) Martha Savaria Morris et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Positive newborn screen for methylmalonic aciduria identifies the first mutation in TCblR/CD320, the gene for cellular uptake of transcobalamin-bound vitamin B12

(2010) Edward V. Quadros et al.   HUMAN MUTATION

Metabolic evidence of vitamin B-12 deficiency, including high homocysteine and methylmalonic acid and low holotranscobalamin, is more pronounced in older adults with elevated plasma folate

(2009) Joshua W Miller et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Folate-targeted therapeutic and imaging agents for cancer

(2009) Philip Stewart Low et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Folate stimulates ERK1/2 phosphorylation and cell proliferation in fetal neural stem cells

(2009) Xu-Mei Zhang et al.   NUTRITIONAL NEUROSCIENCE

The extremely slow and variable activity of dihydrofolate reductase in human liver and its implications for high folic acid intake

(2009) S. W. Bailey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Folate and vitamin B12 status in relation to cognitive impairment and anaemia in the setting of voluntary fortification in the UK

(2008) Robert Clarke et al.   BRITISH JOURNAL OF NUTRITION

Discovery and Development of Folic-Acid-Based Receptor Targeting for Imaging and Therapy of Cancer and Inflammatory Diseases

(2007) Philip S. Low et al.   ACCOUNTS OF CHEMICAL RESEARCH