Folate receptors and transporters: biological role and diagnostic/therapeutic targets in cancer and other diseases

Methotrexate limits inflammation through an A20-dependent cross-tolerance mechanism

(2018) Cristina Municio et al.   ANNALS OF THE RHEUMATIC DISEASES

A review of mirvetuximab soravtansine in the treatment of platinum-resistant ovarian cancer

(2018) Kathleen N Moore et al.   Future Oncology

Development and evaluation of novel tumor-targeting paclitaxel-loaded nano-carriers for ovarian cancer treatment: in vitro and in vivo

(2018) Shu Yao et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Fate of Antibody-Drug Conjugates in Cancer Cells

(2018) Cécile Chalouni et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

The expansion of targetable biomarkers for CAR T cell therapy

(2018) Michelle H. Townsend et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Tumor Targeting with Novel Pyridyl 6-Substituted Pyrrolo[2,3-d]Pyrimidine Antifolates via Cellular Uptake by Folate Receptor α and the Proton-Coupled Folate Transporter and Inhibition of De Novo Purine Nucleotide Biosynthesis

(2018) Manasa Ravindra et al.   JOURNAL OF MEDICINAL CHEMISTRY

Selective targeting and degradation of doxorubicin-loaded folate-functionalized DNA nanocages

(2018) Sofia Raniolo et al.   Nanomedicine-Nanotechnology Biology and Medicine

Entry, fate and degradation of DNA nanocages in mammalian cells: a matter of receptors

(2018) Sofia Raniolo et al.   Nanoscale

Pre-clinical evaluation of EC1456, a folate-tubulysin anti-cancer therapeutic

(2018) Joseph A. Reddy et al.   Scientific Reports

Relationship between folate concentration and expression of folate-associated genes in tissue and plasma after intraoperative administration of leucovorin in patients with colorectal cancer

(2018) Helena Taflin et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Abstract 1656: First-in-class, fluorinated folate receptor specific agents that target tumor cells via inhibition of serine hydroxymethyltransferase 2 (SHMT2) and 5-aminoimidazole-4-carboxamide formyltransferase (AICARFTase)

(2018) Md Junayed Nayeen et al.   CANCER RESEARCH

Evaluation of Novel Tumor-Targeted Near-Infrared Probe for Fluorescence-Guided Surgery of Cancer

(2018) Sakkarapalayam M. Mahalingam et al.   JOURNAL OF MEDICINAL CHEMISTRY

Development and validation of a prognostic multivariable model to predict insufficient clinical response to methotrexate in rheumatoid arthritis

(2018) Maurits C. F. J. de Rotte et al.   PLoS One

The folate receptor β as a macrophage-mediated imaging and therapeutic target in rheumatoid arthritis

(2018) Durga M. S. H. Chandrupatla et al.   Drug Delivery and Translational Research

Dual Targeting of Epithelial Ovarian Cancer Via Folate Receptor α and the Proton-Coupled Folate Transporter with 6-Substituted Pyrrolo[2,3- d ]pyrimidine Antifolates

(2017) Zhanjun Hou et al.   MOLECULAR CANCER THERAPEUTICS

Regulation of Reduced Folate Carrier (RFC) by Vitamin D Receptor at the Blood-Brain Barrier

(2017) Camille Alam et al.   MOLECULAR PHARMACEUTICS

Expression in Sf9 insect cells, purification and functional reconstitution of the human proton-coupled folate transporter (PCFT, SLC46A1)

(2017) Swapneeta S. Date et al.   PLoS One

Structural and Enzymatic Analysis of Tumor-Targeted Antifolates That Inhibit Glycinamide Ribonucleotide Formyltransferase

(2016) Siobhan M. Deis et al.   BIOCHEMISTRY

Reversal of Cytosolic One-Carbon Flux Compensates for Loss of the Mitochondrial Folate Pathway

(2016) Gregory S. Ducker et al.   Cell Metabolism

High-affinity FRβ-specific CAR T cells eradicate AML and normal myeloid lineage without HSC toxicity

(2016) R C Lynn et al.   LEUKEMIA

MTHFD2- a new twist?

(2016) Philip M. Tedeschi et al.   Oncotarget

Mirvetuximab Soravtansine (IMGN853), a Folate Receptor Alpha–Targeting Antibody-Drug Conjugate, Potentiates the Activity of Standard of Care Therapeutics in Ovarian Cancer Models

(2016) Jose F. Ponte et al.   NEOPLASIA

Targeting the folate receptor: diagnostic and therapeutic approaches to personalize cancer treatments

(2015) J. A. Ledermann et al.   ANNALS OF ONCOLOGY

Targeting of folate receptor   on acute myeloid leukemia blasts with chimeric antigen receptor-expressing T cells

(2015) R. C. Lynn et al.   BLOOD

Transbilayer Lipid Interactions Mediate Nanoclustering of Lipid-Anchored Proteins

(2015) Riya Raghupathy et al.   CELL

Folic acid mediates activation of the pro-oncogene STAT3 via the Folate Receptor alpha

(2015) Mariann F. Hansen et al.   CELLULAR SIGNALLING

Increased synthesis of folate transporters regulates folate transport in conditions of ethanol exposure and folate deficiency

(2015) Shilpa Thakur et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Mitochondrial Methylenetetrahydrofolate Dehydrogenase (MTHFD2) Overexpression Is Associated with Tumor Cell Proliferation and Is a Novel Target for Drug Development

(2015) P. M. Tedeschi et al.   MOLECULAR CANCER RESEARCH

IMGN853, a Folate Receptor-  (FR )-Targeting Antibody-Drug Conjugate, Exhibits Potent Targeted Antitumor Activity against FR -Expressing Tumors

(2015) O. Ab et al.   MOLECULAR CANCER THERAPEUTICS

Targeting FR-expressing cells in ovarian cancer with Fab-functionalized nanoparticles: a full study to provide the proof of principle from in vitro to in vivo

(2015) Alessandra Quarta et al.   Nanoscale

Principles in the design of ligand-targeted cancer therapeutics and imaging agents

(2015) Madduri Srinivasarao et al.   NATURE REVIEWS DRUG DISCOVERY

Rigorous optimization and validation of potent RNA CAR T cell therapy for the treatment of common epithelial cancers expressing folate receptor

(2015) Keith Schutsky et al.   Oncotarget

The folate-coupled enzyme MTHFD2 is a nuclear protein and promotes cell proliferation

(2015) Nina Gustafsson Sheppard et al.   Scientific Reports

Efficient Nuclear DNA Cleavage in Human Cancer Cells by Synthetic Bleomycin Mimics

(2014) Qian Li et al.   ACS Chemical Biology

The folate receptor as a rational therapeutic target for personalized cancer treatment

(2014) Yehuda G. Assaraf et al.   DRUG RESISTANCE UPDATES

Mitochondrial MTHFD2L Is a Dual Redox Cofactor-specific Methylenetetrahydrofolate Dehydrogenase/Methenyltetrahydrofolate Cyclohydrolase Expressed in Both Adult and Embryonic Tissues

(2014) Minhye Shin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Liposomal Nitrooxy-Doxorubicin: One Step over Caelyx in Drug-Resistant Human Cancer Cells

(2014) Isabella Pedrini et al.   MOLECULAR PHARMACEUTICS

Clathrin-Independent Pathways of Endocytosis

(2014) S. Mayor et al.   Cold Spring Harbor Perspectives in Biology

Metabolic enzyme expression highlights a key role for MTHFD2 and the mitochondrial folate pathway in cancer

(2014) Roland Nilsson et al.   Nature Communications

Serine Catabolism Regulates Mitochondrial Redox Control during Hypoxia

(2014) J. Ye et al.   Cancer Discovery

PRECEDENT: A Randomized Phase II Trial Comparing Vintafolide (EC145) and Pegylated Liposomal Doxorubicin (PLD) in Combination Versus PLD Alone in Patients With Platinum-Resistant Ovarian Cancer

(2013) R. Wendel Naumann et al.   JOURNAL OF CLINICAL ONCOLOGY

Pemetrexed Induced Thymidylate Synthase Inhibition in Non-Small Cell Lung Cancer Patients: A Pilot Study with 3′-Deoxy-3′-[18F]fluorothymidine Positron Emission Tomography

(2013) Virginie Frings et al.   PLoS One

Choroid plexus transcytosis and exosome shuttling deliver folate into brain parenchyma

(2013) Marcel Grapp et al.   Nature Communications

Active Remodeling of Cortical Actin Regulates Spatiotemporal Organization of Cell Surface Molecules

(2012) Kripa Gowrishankar et al.   CELL

Mitochondrial-Targeting Nitrooxy-doxorubicin: A New Approach To Overcome Drug Resistance

(2012) Chiara Riganti et al.   MOLECULAR PHARMACEUTICS

Multifunctional Nanobeads Based on Quantum Dots and Magnetic Nanoparticles: Synthesis and Cancer Cell Targeting and Sorting

(2011) Riccardo Di Corato et al.   ACS Nano

CD27 costimulation augments the survival and antitumor activity of redirected human T cells in vivo

(2011) D.-G. Song et al.   BLOOD

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

[18F]FLT: An imaging biomarker of tumour proliferation for assessment of tumour response to treatment

(2011) Dmitry Soloviev et al.   EUROPEAN JOURNAL OF CANCER

In vivo suppressive function of myeloid-derived suppressor cells is limited to the inflammatory site

(2011) Jessica M. Haverkamp et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Update and new concepts in vitamin responsive disorders of folate transport and metabolism

(2011) David Watkins et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Folate receptor β as a potential delivery route for novel folate antagonists to macrophages in the synovial tissue of rheumatoid arthritis patients

(2009) Joost W. Van Der Heijden et al.   ARTHRITIS AND RHEUMATISM

Membrane transporters and folate homeostasis: intestinal absorption and transport into systemic compartments and tissues

(2009) Rongbao Zhao et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE