Review
Cell Biology
Yanlei Zhang, Quanbo Ji
Summary: Knee osteoarthritis (KOA) is a common degenerative disease in the elderly, causing chronic joint pain and physical impairment. There is currently a lack of effective interventions, making explorations of new treatments necessary. Photobiomodulation therapy (PBMT) is a drug-free, non-invasive, and safe intervention that enhances cellular activity and promotes tissue regeneration. This paper provides an overview of the effectiveness of PBMT in clinical settings, as well as the modulatory effects and potential mechanisms in addressing synovitis, cartilage degeneration, and pain resolution.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Medicine, General & Internal
Luca De Marziani, Angelo Boffa, Lucia Angelelli, Luca Andriolo, Alessandro Di Martino, Stefano Zaffagnini, Giuseppe Filardo
Summary: The aim of this study was to evaluate the relationship between infrared thermography and knee inflammation in osteoarthritis patients. The results showed that the skin temperature of the knee joint was influenced by demographic and clinical characteristics of patients, with higher temperatures in younger male patients with higher BMI and worse knee scores, and lower temperatures in patients affected by neuropathic pain.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Mauricio N. Ferrao Blanco, Yvonne M. Bastiaansen Jenniskens, Nicole Kops, Athina Chavli, Roberto Narcisi, Sander M. Botter, Pieter J. M. Leenen, Gerjo J. V. M. van Osch, Niamh Fahy
Summary: The study found that early intra-articular injection of TAA increases long-term synovial macrophage numbers and osteophytosis, exacerbating the progression of osteoarthritis.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Review
Orthopedics
P. Dainese, K. Wyngaert, S. De Mits, R. Wittoek, A. Van Ginckel, P. Calders
Summary: This article systematically reviews the relationship between markers of inflammation and pain in patients with knee osteoarthritis. The study found a moderate correlation between inflammation and pain, but the quality of evidence was conflicting.
OSTEOARTHRITIS AND CARTILAGE
(2022)
Article
Anesthesiology
Diana Amorim, Diana Fonseca-Rodrigues, Ana David-Pereira, Octavia Costa, Antonia Palhares Lima, Rosete Nogueira, Rute Cruz, Ana Sofia Martins, Liliana Sousa, Francisco Oliveira, Helder Pereira, Rogerio Pirraco, Antti Pertovaara, Armando Almeida, Filipa Pinto-Ribeiro
Summary: The injection of kaolin/carrageenan in the rat knee joint successfully models the physical and psychiatric features of human osteoarthritis. This experimental osteoarthritis allows for the study of disease mechanisms and evaluation of therapeutic strategies to halt disease progression at different stages.
Article
Radiology, Nuclear Medicine & Medical Imaging
Sara Ramezanpour, Thanat Kanthawang, John Lynch, Charles E. McCulloch, Michael C. Nevitt, Thomas M. Link, Gabby B. Joseph
Summary: This study investigates the impact of sustained synovitis on the progression of knee degenerative changes. The results suggest that sustained synovitis is associated with greater progression of structural degenerative disease.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Medicine, General & Internal
Dominika E. Nanus, Amel Badoume, Susanne N. Wijesinghe, Andrea M. Halsey, Patrick Hurley, Zubair Ahmed, Rajesh Botchu, Edward T. Davis, Mark A. Lindsay, Simon W. Jones
Summary: Research on patients with knee osteoarthritis has shown that synovial inflammation is associated with pain severity, and synovial tissue from areas associated with pain exhibits different features and subsets of synovial fibroblasts. Additionally, the secretions of synovial fibroblasts have an impact on neuronal growth.
Editorial Material
Orthopedics
Peter E. Mueller, Thomas R. Niethammer
Summary: Bone marrow lesions (BML) are often caused by stress-related bone marrow edema, associated with cartilage loss. Treatment of cartilage damage requires addressing the underlying bone marrow edema, and the critical point for successful treatment of larger defects is treating the cartilage defect effectively.
ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY
(2021)
Article
Food Science & Technology
Yves Henrotin, Christophe Antoine, Elodie Zwerts, Thibaut Neutelings, Elodie Bouvret
Summary: The study aimed to evaluate the effects of oral fish cartilage hydrolysate (FCH) on symptoms and joint tissue structure in rats with surgically induced osteoarthritis. FCH did not significantly affect cartilage lesion severity but tended to accelerate pain relief and joint function recovery. This positive trend may lead to further research on FCH as a potential treatment for joint discomfort associated with osteoarthritis.
FOOD SCIENCE & NUTRITION
(2021)
Article
Physiology
K. Warmink, J. L. Rios, D. R. van Valkengoed, P. Vinod, N. M. Korthagen, H. Weinans
Summary: Obesogenic diets exacerbate osteoarthritis by inducing joint damage and inflammation. High-fat and high-fat/high-sucrose diets result in increased metabolic dysregulation, synovial inflammation, and CD68 staining in bone marrow.
FRONTIERS IN PHYSIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Chun-De Liao, Yu-Yun Huang, Hung-Chou Chen, Tsan-Hon Liou, Che-Li Lin, Shih-Wei Huang
Summary: This network meta-analysis suggests that medium-energy ESWT combined with physical therapy or Chinese medicine is effective in treating pain and improving function in patients with knee osteoarthritis.
Article
Medicine, General & Internal
Linghui Qiao, Jun Gu, Yingjie Ni, Jianyue Wu, Dong Zhang, Yanglin Gu
Summary: Osteoarthritis (OA) is a chronic disease that commonly affects the elderly population and has significant health and economic implications. In this study, RNA-seq analysis of knee joint synovial tissue samples identified differentially expressed genes and non-coding RNAs associated with inflammation, providing new insights into the pathogenesis of OA and potential therapeutic targets.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Rheumatology
Jimin Zhu, Guangfeng Ruan, Han Cen, Tao Meng, Shuang Zheng, Yuanyuan Wang, Baikun Li, Zhaohua Zhu, Weiyu Han, Tania Winzenberg, Anita E. Wluka, Flavia Cicuttini, Binghui Wang, Changhai Ding
Summary: This study investigated the longitudinal associations of serum inflammatory markers and adipokines with joint symptoms and structures in participants with knee OA. The results showed that different inflammatory and metabolic components were associated differently with joint symptoms and structural changes in knee OA, suggesting a complex inflammatory and metabolic interrelationship in the pathogenesis of knee OA.
Article
Medicine, General & Internal
Luca De Marziani, Angelo Boffa, Simone Orazi, Luca Andriolo, Alessandro Di Martino, Stefano Zaffagnini, Giuseppe Filardo
Summary: Infrared thermography can be used to evaluate the inflammation in OA knees, but there is limited evidence on its response to physical exercise. Understanding the response to exercise and the influencing variables in OA knees can provide important information for profiling patients with different knee OA patterns.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Orthopedics
Pengwei Zhang, Bo Dong, Puwei Yuan, Xun Li
Summary: This article systematically summarizes the application of human umbilical cord-derived mesenchymal stem cells (HUC-MSCs) in the treatment of osteoarthritis (OA). HUC-MSCs can reduce inflammation, promote chondrocyte production, and synthesize cartilage, providing a theoretical basis for clinical treatment.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Oncology
Ashley L. Artese, Andrea Sitlinger, Grace MacDonald, Michael A. Deal, Erik D. Hanson, Carl F. Pieper, J. Brice Weinberg, Danielle M. Brander, David B. Bartlett
Summary: The study aimed to investigate the effects of a 12-week high-intensity interval training and resistance training intervention on health-related quality of life (HRQOL) in adults with treatment naive chronic lymphocytic leukemia (CLL). The results showed significant improvements in physical, emotional, social, and overall well-being in the group that participated in the intervention, compared to the control group who only had improvements in lymphoma-specific symptoms.
JOURNAL OF GERIATRIC ONCOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Amanda E. Paluch, Shivangi Bajpai, Marcel Ballin, David R. Bassett, Thomas W. Buford, Mercedes R. Carnethon, Ariel Chernofsky, Erin E. Dooley, Ulf Ekelund, Kelly R. Evenson, Deborah A. Galuska, Barbara J. Jefferis, Lingsong Kong, William E. Kraus, Martin G. Larson, I-Min Lee, Charles E. Matthews, Robert L. Newton, Anna Nordstrom, Peter Nordstrom, Priya Palta, Alpa V. Patel, Kelley Pettee Gabriel, Carl F. Pieper, Lisa Pompeii, Erika Rees-Punia, Nicole L. Spartano, Ramachandran S. Vasan, Peter H. Whincup, Shengping Yang, Janet E. Fulton
Summary: There is a significant difference in the association between steps per day and cardiovascular disease (CVD) risk between older and younger adults. For older adults, taking more steps per day was associated with a progressively decreased risk of CVD. However, no significant relationship was found between steps per day and CVD risk among younger adults.
Article
Neurosciences
Daniel C. Parker, William E. Kraus, Heather E. Whitson, Virginia B. Kraus, Patrick J. Smith, Harvey Jay Cohen, Carl F. Pieper, Richard A. Faldowski, Katherine S. Hall, Janet L. Huebner, Olga R. Ilkayeva, James R. Bain, L. Kristin Newby, Kim M. Huffman
Summary: This study found that an increasing KYN/TRP ratio is associated with greater concentrations of ADRD biomarkers (pTau181, GFAP, and NfL) in older adults, but not with cognitive performance (MoCA score) or the A beta(42)/ beta(40) ratio. There were no significant associations of KA/KYN with MoCA score or plasma ADRD biomarkers.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Health Care Sciences & Services
David A. Leiman, Harrison N. Jones, Rebecca North, Kathryn N. Porter Starr, Carl F. Pieper, Seth M. Cohen
Summary: This study assessed the associations between self-reported dysphagia and psychosocial health among older adults. The results showed a significant association between dysphagia and anxiety symptoms, as well as a decreased sense of well-being, but no association with social isolation.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Richard H. Lee, James Bain, Michael Muehlbauer, Olga Ilkayeva, Carl Pieper, Doug Wixted, Cathleen Colon-Emeric
Summary: Older adults with type 2 diabetes mellitus have an increased risk of fracture despite a paradoxically higher average bone mineral density. Additional markers of fracture risk, including non-esterified fatty acids and specific amino acids, were identified in this study.
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Multidisciplinary Sciences
Coralei E. Neighbors, Richard Sloane, Carl F. Pieper, Douglas Wixted, Christopher W. Woods, L. Kristin Newby
Summary: This study aimed to identify groups of individuals based on their self-reported compliance with COVID-19 mitigation behaviors and explored the associations between compliance classes and important study and public health outcomes. Through latent class analysis, the participants were categorized into three classes: most compliant, moderately compliant, and least compliant. These compliance classes had distinct characteristics, such as age, sex, medical history, and ethnicity, and were associated with important outcomes. Targeted public health policies and interventions based on compliance group characteristics may help increase compliance.
Article
Mathematical & Computational Biology
Megan L. Neely, Carl F. Pieper, Bida Gu, Natalia O. Dmitrieva, Jane F. Pendergast
Summary: Modeling longitudinal trajectories and identifying latent classes of trajectories is important in biomedical research. Different models can be used, such as latent class trajectory analysis (LCTA), growth mixture modeling (GMM), and covariance pattern mixture models (CPMM). The level of within-person correlation is non-negligible in biomedical applications, which can affect the model choice and interpretation. LCTA does not consider this correlation, while GMM incorporates random effects and CPMM specifies a model for within-class covariance matrix. This study highlights the importance of considering correlation in obtaining appropriate model interpretations and provides insights into model choice.
STATISTICS IN MEDICINE
(2023)
Article
Medicine, General & Internal
William U. Meyerson, Carl F. Pieper, Rick H. Hoyle
Summary: A secondary analysis of FDA clinical trial data showed that antidepressant therapy can effectively reduce depressive symptoms in patients with severe depression, but the response varies among individuals.
Article
Gerontology
Harrison N. Jones, David A. Leiman, Kathryn N. Porter Starr, Rebecca North, Carl F. Pieper, Raele D. Robison, Seth M. Cohen
Summary: This study examines the relationship between dysphagia and social determinants of health in older adults. It found that older adults with dysphagia had higher odds of experiencing food insecurity and being homebound.
JOURNAL OF APPLIED GERONTOLOGY
(2023)
Article
Clinical Neurology
Maria J. Marquine, Adam Parks, Jaime Perales-Puchalt, David A. Gonzalez, Monica Rosado-Bruno, Rebecca North, Carl Pieper, Amy E. Werry, Andrew Kiselica, Silvia Chapman, Hiroko Dodge, Kathryn Gauthreaux, Walter A. Kukull, Katya Rascovsky
Summary: Researchers developed normative data for the National Alzheimer's Coordinating Center Uniform Data Set Neuropsychological Battery (UDS3-NB) for Latino individuals in the US. Younger age and higher education were associated with better cognitive test scores, especially among Spanish-speakers. Sex effects varied across tests and language groups. These data can improve the diagnostic accuracy of the UDS3-NB among Latinos.
ALZHEIMERS & DEMENTIA
(2023)
Article
Endocrinology & Metabolism
R. H. Lee, J. Curtis, M. T. Drake, S. Bobo Tanner, L. Lenert, K. Schmader, C. Pieper, R. North, K. W. Lyles
Summary: In this retrospective longitudinal study, no benefit of nitrogen-containing bisphosphonates (N-BP) was found regarding ICU admission, ventilator use, and mortality among older adults with COVID-19 infection. Specifically, the intravenous bisphosphonate zoledronic acid (ZOL) was evaluated and no difference was found compared to oral bisphosphonates.
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Clinical Neurology
Thomas J. Farrer, Terri G. Monk, David L. McDonagh, Gavin Martin, Carl F. Pieper, Deborah Koltai
Summary: This study aimed to investigate the relationship between anesthesia type and the development of Post Operative Cognitive Decline (POCD) in older adults. The results showed that anesthesia type did not predict the development of POCD, while preoperative cognitive function was the only variable predictive of POCD development and activities of daily living (ADLs) were predictive of post-operative delirium.
APPLIED NEUROPSYCHOLOGY-ADULT
(2023)
Article
Immunology
Coralei E. Neighbors, Richard A. Faldowski, Carl F. Pieper, Joshua Taylor, Megan Gaines, Richard Sloane, Douglas Wixted, Christopher W. Woods, L. Kristin Newby
Summary: This study identified factors associated with COVID-19 vaccination promptness, including older age, lower education levels, lower household incomes, and vaccine hesitancy. The most common reasons for not being vaccinated were concerns about vaccine safety, side effects, and vaccine effectiveness.
Correction
Cell Biology
R. Waziry, C. P. Ryan, D. L. Corcoran, K. M. Huffman, M. S. Kobor, M. Kothari, G. H. Graf, V. B. Kraus, W. E. Kraus, D. T. S. Lin, C. F. Pieper, M. E. Ramaker, M. Bhapkar, S. K. Das, L. Ferrucci, W. J. Hastings, M. Kebbe, D. C. Parker, S. B. Racette, I. Shalev, B. Schilling, D. W. Belsky
Article
Anesthesiology
Corey B. Simon, Gregory E. Hicks, Carl F. Pieper, Virginia Byers Kraus, Francis J. Keefe, Cathleen Colon-Emeric
Summary: This study tested a new Movement-Evoked Provocation Test for Low Back Pain in Older Adults (MEPLO), and compared associations between movement-evoked pain and disability-associated outcomes. The results showed that MEPLO is a safe and feasible method in older adults with persistent LBP, and it is more strongly associated with self-reported physical function and usual gait speed compared to traditional pain measures.
CLINICAL JOURNAL OF PAIN
(2023)