Antiproliferative, genotoxic activities and quantification of extracts and cucurbitacin B obtained from Luffa operculata (L.) Cogn

Structural Insights into JAK2 Inhibition by Ruxolitinib, Fedratinib, and Derivatives Thereof

(2021) Ryan R. Davis et al.   JOURNAL OF MEDICINAL CHEMISTRY

Evaluation of the genotoxicity and mutagenicity of isoeleutherin and eleutherin isolated from Eleutherine plicata herb. using bioassays and in silico approaches

(2021) Ana Laura Gadelha Castro et al.   Arabian Journal of Chemistry

Cucurbitacin B inhibits gastric cancer progression by suppressing STAT3 activity

(2020) Jiaxin Xu et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Cucurbitacin E Inhibits Huh7 Hepatoma Carcinoma Cell Proliferation and Metastasis via Suppressing MAPKs and JAK/STAT3 Pathways

(2020) Yang Liu et al.   MOLECULES

Novel Mechanistic Insight into the Anticancer Activity of Cucurbitacin D against Pancreatic Cancer (Cuc D Attenuates Pancreatic Cancer)

(2020) Mohammed Sikander et al.   Cells

Chemical Composition, Antimicrobial Properties of Siparuna guianensis Essential Oil and a Molecular Docking and Dynamics Molecular Study of its Major Chemical Constituent

(2020) Mozaniel Santana de Oliveira et al.   MOLECULES

Identification of Potential COX-2 Inhibitors for the Treatment of Inflammatory Diseases Using Molecular Modeling Approaches

(2020) Pedro H. F. Araújo et al.   MOLECULES

Chemometric methods in antimalarial drug design from 1,2,4,5-tetraoxanes analogues

(2020) E.B. Costa et al.   SAR AND QSAR IN ENVIRONMENTAL RESEARCH

Cytokinesis-Block Micronucleus Cytome Assay Evolution into a More Comprehensive Method to Measure Chromosomal Instability

(2020) Michael Fenech   Genes

Identification of New Rofecoxib-Based Cyclooxygenase-2 Inhibitors: A Bioinformatics Approach

(2020) Rozires P. Leão et al.   Pharmaceuticals

Cucurbitacin B Induces the Lysosomal Degradation of EGFR and Suppresses the CIP2A/PP2A/Akt Signaling Axis in Gefitinib-Resistant Non-Small Cell Lung Cancer

(2019) Pengfei Liu et al.   MOLECULES

Micronucleus study on breast cytology aspirate smears and its diagnostic utility

(2018) MaryT Sylvia et al.   Journal of Cytology

Luffa operculata fruit aqueous extract induces motor impairments, anxiety-like behavior, and testis damage in rats

(2018) Cinthia dos S. Alves et al.   JOURNAL OF ETHNOPHARMACOLOGY

Cucurbitacin D impedes gastric cancer cell survival via activation of the iNOS/NO and inhibition of the Akt signalling pathway

(2018) Yan Zhang et al.   ONCOLOGY REPORTS

Synthesis of Cucurbitacin B Derivatives as Potential Anti-Hepatocellular Carcinoma Agents

(2018) Weizhi Ge et al.   MOLECULES

Cucurbitacin B Induces Hypermethylation of Oncogenes in Breast Cancer Cells

(2018) Kanthanadon Dittharot et al.   PLANTA MEDICA

Gastric Cancer Cell Lines Have Different MYC-Regulated Expression Patterns but Share a Common Core of Altered Genes

(2018) Jersey Heitor da S. Maués et al.   Canadian Journal of Gastroenterology and Hepatology

Cucurbitacin B induces autophagy and apoptosis by suppressing CIP2A/PP2A/mTORC1 signaling axis in human cisplatin resistant gastric cancer cells

(2017) Xuewen Liu et al.   ONCOLOGY REPORTS

Cucurbitacin E induces apoptosis of human prostate cancer cells via cofilin-1 and mTORC1

(2017) Xiaolong He et al.   Oncology Letters

Cell Proliferation and Cytotoxicity Assays

(2016) Aysun Adan et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Cucurbitacin D exhibits potent anti-cancer activity in cervical cancer

(2016) Mohammed Sikander et al.   Scientific Reports

Cucurbitacins: A Systematic Review of the Phytochemistry and Anticancer Activity

(2015) Yuee Cai et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

DNA damage response – A double-edged sword in cancer prevention and cancer therapy

(2015) Hui Tian et al.   CANCER LETTERS

Treatment with cucurbitacin B alone and in combination with gefitinib induces cell cycle inhibition and apoptosis via EGFR and JAK/STAT pathway in human colorectal cancer cell lines

(2015) AS Yar Saglam et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Ponicidin Induces Apoptosis via JAK2 and STAT3 Signaling Pathways in Gastric Carcinoma

(2015) Yuan-Fei Liu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Transcriptional profiling of GBM invasion genes identifies effective inhibitors of the LIM kinase-Cofilin pathway

(2015) Jun-Bum Park et al.   Oncotarget

Cucurbitacin-E Inhibits Multiple Cancer Cells Proliferation Through Attenuation of Wnt/β-Catenin Signaling

(2014) Hui Feng et al.   CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS

Inhibition of STAT3 Promotes the Efficacy of Adoptive Transfer Therapy Using Type-1 CTLs by Modulation of the Immunological Microenvironment in a Murine Intracranial Glioma

(2014) M. Fujita et al.   JOURNAL OF IMMUNOLOGY

Effect of extraction solvent on total phenol content, total flavonoid content, and antioxidant activity of Limnophila aromatica

(2013) Quy Diem Do et al.   JOURNAL OF FOOD AND DRUG ANALYSIS

Biological activities and potential molecular targets of cucurbitacins

(2012) Xiuping Chen et al.   ANTI-CANCER DRUGS

Synthesis and cytotoxic activity evaluation of dihydrocucurbitacin B and cucurbitacin B derivatives

(2012) Karen Luise Lang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Whole plant extracts versus single compounds for the treatment of malaria: synergy and positive interactions

(2011) Philippe Rasoanaivo et al.   MALARIA JOURNAL

High performance liquid chromatography determination of cucurbitacins in the roots of Wilbrandia ebracteata Cogn.

(2010) Patricia Baier Krepsky et al.   Revista Brasileira de Farmacognosia-Brazilian Journal of Pharmacognosy

STAT-3 correlates with lymph node metastasis and cell survival in gastric cancer

(2010) Jing-Yu Deng   WORLD JOURNAL OF GASTROENTEROLOGY

Establishment and conventional cytogenetic characterization of three gastric cancer cell lines

(2009) Mariana Ferreira Leal et al.   CANCER GENETICS AND CYTOGENETICS

Cucurbitacin B inhibits STAT3 and the Raf/MEK/ERK pathway in leukemia cell line K562

(2009) Kin Tak Chan et al.   CANCER LETTERS

Dissecting Specificity in the Janus Kinases: The Structures of JAK-Specific Inhibitors Complexed to the JAK1 and JAK2 Protein Tyrosine Kinase Domains

(2009) Neal K. Williams et al.   JOURNAL OF MOLECULAR BIOLOGY