Article
Oncology
Rahim Ullah, Qing Yin, Aidan H. Snell, Lixin Wan
Summary: The RAF-MEK-ERK signaling cascade is a well-characterized MAPK pathway that plays a critical role in cell proliferation and survival. Genetic alterations in this pathway are highly prevalent in human cancers and can lead to uncontrolled cell growth and tumor formation. The crosstalk between the RAF-MEK-ERK axis and other signaling pathways further enhances its proliferative potential in human cancers.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Oncology
Da Wang, Fei Xiong, Guanhua Wu, Wenzheng Liu, Bing Wang, Yongjun Chen
Summary: The study found that in cholangiocarcinoma, miR-155-5p targets the 3' UTR of SOX1, activating the RAF/MEK/ERK pathway and promoting cancer progression.
CANCER CELL INTERNATIONAL
(2021)
Article
Oncology
Sara J. Hamis, Yury Kapelyukh, Aileen McLaren, Colin J. Henderson, C. Roland Wolf, Mark A. J. Chaplain
Summary: The study developed a mechanistic mathematical model to describe the synergistic action of dabrafenib and trametinib on ERK activity in BRAFV600E-mutant melanoma cells, elucidating the molecular mechanism underlying vertical inhibition of the BRAF-MEK-ERK cascade.
BRITISH JOURNAL OF CANCER
(2021)
Review
Biochemistry & Molecular Biology
Yanlin Song, Zhenfei Bi, Yu Liu, Furong Qin, Yuquan Wei, Xiawei Wei
Summary: Molecular target inhibitors have been approved for tumor treatment and mainly target cell proliferation and metabolism. The RAS-RAF-MEK-ERK pathway plays essential roles in cell functions and abnormal activation of this pathway leads to tumor development. In this review, the development and potential combinations of inhibitors targeting this pathway are discussed.
Article
Pharmacology & Pharmacy
Nuray Uremis, Yusuf Turkoz, Muhammed Mehdi Uremis, Yilmaz Cigremis, Emine Salva
Summary: In this study, the anticarcinogenic effects of sorafenib-cucurbitacin D and sorafenib-cucurbitacin I combination on HepG2 cell line were investigated. The results showed that the combination of cucurbitacin D and I with sorafenib had a synergistic effect, inhibiting cell proliferation, migration, and angiogenesis.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Article
Oncology
Ying Zhang, Qian Lu, Nan Li, Ming Xu, Tatsuo Miyamoto, Jing Liu
Summary: Sulforaphane (SFN), a natural compound derived from broccoli, has been found to significantly inhibit migration and invasion of breast cancer cells by affecting cytoskeleton formation. SFN can also directly bind to RAF family proteins and inhibit phosphorylation of the signaling pathway. These findings suggest that SFN has the potential to be used as a therapeutic drug to inhibit breast cancer cell metastasis.
Article
Pharmacology & Pharmacy
Zhaopeng Li, Ming-Zhong Sun, Xinxin Lv, Chunmei Guo, Shuqing Liu
Summary: In this study, we found that ETV6 inhibits erythroid differentiation of K562 cells in chronic myeloid leukemia (CML) by regulating the Raf/MEK/ERK pathway, suggesting that it could be a potential therapeutic target for dyserythropoiesis.
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2022)
Review
Pharmacology & Pharmacy
Yunli Huang, Yongqi Zhen, Yanmei Chen, Shaoguang Sui, Lan Zhang
Summary: This article provides a comprehensive review of the interplay between the RAS/RAF/MEK/ERK signaling pathway and autophagy, as well as their application in cancer therapy. The impact of small molecule inhibitors targeting this pathway on autophagy is discussed, and the advantages and limitations of combining these inhibitors with autophagy inhibitors are explored.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Plant Sciences
Danting Fu, Jiangfeng Zhou, Shanchun Xu, Jue Tu, Yueqin Cai, Jingyan Liu, Zhaowei Cai, Dejun Wang
Summary: TFLFs may protect against pathological cardiac hypertrophy via negative regulation of the Raf/MEK/ERK pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Qing Rao, Kaiqiang Xie, Krishnapriya M. Varier, Lei Huang, Jingrui Song, Jue Yang, Jianfei Qiu, Yubing Huang, Yan Li, Babu Gajendran, Yanmei Li, Sheng Liu
Summary: In this study, a mikanolide derivative, 3g, was found to exhibit potent antileukemic activity through the Ras/Raf/MEK/ERK pathway. It can arrest the cell cycle, induce apoptosis, and promote DNA and mitochondrial damage, suggesting its potential as a chemotherapeutic agent for leukemia.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Helen Hoffmann, Marina Ebensperger, Annika Schoensiegel, Hazem Hamza, Julia Koch-Heier, Andre Schreiber, Stephan Ludwig, Michael Schindler, Oliver Planz
Summary: The urgent need for broad-spectrum antivirals has been highlighted by the COVID-19 pandemic. In this study, the antiviral efficacy of zapnometinib was compared between influenza A virus (IAV) and SARS-CoV-2, revealing that IAV is more susceptible to treatment with zapnometinib compared to SARS-CoV-2.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Xiaoxia Yang, Pengfei Shang, Bingfang Yu, Qiuyang Jin, Jing Liao, Lei Wang, Jianbo Ji, Xiuli Guo
Summary: Resistance to breast cancer chemotherapy can be reversed by microRNA34a (miR34a). The combination of miR34a and Doxorubicin (Dox) significantly inhibits the proliferation, migration, invasion, and induces apoptosis of drug-resistant breast cancer cells. The mechanism involves the down-regulation of TOP2A and BCRP, as well as the inhibition of Snail through the Notch/NF-kappa B and RAS/RAF/MEK/ERK pathway.
ACTA PHARMACEUTICA SINICA B
(2021)
Article
Anatomy & Morphology
Yufang Wang, Mingfang Liu, Nan Huang, Tingting Wang
Summary: The study found that quercetin can promote the recovery of kidney function in kidney-injured mice. Histopathological results showed that kidney tissue damage and fibrosis were reduced under the action of quercetin. The mitochondrial swollen structure caused by doxorubicin was restored by quercetin. Quercetin regulated the levels of abnormal apoptotic proteins Bax and Bcl-2 to normal levels. The high expression of Ang II caused by doxorubicin was down-regulated by quercetin. Abnormal inflammatory factors caused by doxorubicin were reversed by quercetin. Western blot experiments showed that quercetin regulated the protein levels of AKT1 and Raf/MEK/ERK and inhibited the detrimental effects of doxorubicin.
Article
Pharmacology & Pharmacy
Bing Xiao, Fan Liu, Ye-Hui Jin, Ya-Qiong Jin, Li Wang, Jing-Chao Lu, Xiu-Chun Yang
Summary: In SHRs, RSD can effectively lower blood pressure, alleviate hypertension-induced left ventricular hypertrophy, and improve cardiac function by suppressing the Raf/MEK/ERK signaling pathway.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2021)
Article
Fisheries
Linlin Zhang, Lu Chen, Meng Qi, Fuchang Yu, Xiaotong Ni, Haozheng Hong, Haotian Xu, Shiwen Xu
Summary: Glyphosate exposure induces autophagy in hepatic L8824 cells by activating nitric oxide (NO), regulating energy metabolism, and activating the RAS/RAF/MEK/ERK signaling pathway. This study provides insight into the mechanism of glyphosate toxicity and its effects on cellular processes.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Review
Oncology
Xinru Zhou, Yin Jia, Chuanbin Mao, Shanrong Liu
Summary: Small extracellular vesicles (sEVs), such as exosomes, have emerged as crucial targets for liquid biopsy and promising drug delivery vehicles in tumor progression. They can serve as biomarkers for tumor diagnosis and as drug carriers for cancer treatment.
Article
Oncology
Ruochan Chen, Ju Zhu, Xiao Zhong, Jie Li, Rui Kang, Daolin Tang
Summary: The interplay between autophagy and apoptosis plays a crucial role in tumorigenesis and cancer therapy, with HMGB1 serving as a key regulator in these processes.
Article
Oncology
Zongfu Pan, Xixuan Lu, Tong Xu, Jinming Chen, Lisha Bao, Ying Li, Yingying Gong, Yulu Che, Xiaozhou Zou, Zhuo Tan, Ping Huang, Minghua Ge
Summary: This study uncovered the emerging role of HN1 in promoting dedifferentiation of anaplastic thyroid cancer (ATC) cells. HN1 negatively regulated the thyroid differentiation markers and had an inhibitory effect on the transcriptional activation of CTCF, thereby influencing the chromatin accessibility of thyroid differentiation genes.
Article
Oncology
Yi Qin, Shengjun Xiong, Jun Ren, Gautam Sethi
Summary: Autophagy plays an important regulatory role in glioblastoma, and its dysregulation can lead to drug resistance and radioresistance. It also affects stem cell characteristics, overall growth, and metastasis. Therefore, autophagy is a promising target for glioblastoma therapy.
Article
Oncology
Katsuya Nagaoka, Xuewei Bai, Dan Liu, Kevin Cao, Joud Mulla, Chengcheng Ji, Hongze Chen, Muhammad Azhar Nisar, Amalia Bay, William Mueller, Grace Hildebrand, Jin-Song Gao, Shaolei Lu, Hiroko Setoyama, Yasuhito Tanaka, Jack R. Wands, Chiung-Kuei Huang
Summary: This study found that serum 2-OG levels in cholangiocarcinoma patients are associated with the effectiveness of chemotherapy. Patients with progressive disease showed significantly higher levels of serum 2-OG compared to stable disease and partial response patients. The study also revealed that overexpression of ASPH mimics the effects of 2-OG, and knockdown of ASPH improves chemotherapy. Targeting ASPH enhances the effects of chemotherapy by modulating ATM and ATR, two key regulators of DDRs.
