Structural and functional analysis of the promiscuous AcrB and AdeB efflux pumps suggests different drug binding mechanisms
出版年份 2021 全文链接
标题
Structural and functional analysis of the promiscuous AcrB and AdeB efflux pumps suggests different drug binding mechanisms
作者
关键词
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出版物
Nature Communications
Volume 12, Issue 1, Pages -
出版商
Springer Science and Business Media LLC
发表日期
2021-11-25
DOI
10.1038/s41467-021-27146-2
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Cryoelectron Microscopy Structures of AdeB Illuminate Mechanisms of Simultaneous Binding and Exporting of Substrates
- (2021) Christopher E. Morgan et al. mBio
- Structure, Assembly, and Function of Tripartite Efflux and Type 1 Secretion Systems in Gram-Negative Bacteria
- (2021) Ilyas Alav et al. CHEMICAL REVIEWS
- Ever-Adapting RND Efflux Pumps in Gram-Negative Multidrug-Resistant Pathogens: A Race against Time
- (2021) Martijn Zwama et al. Antibiotics-Basel
- Interactions of a Bacterial RND Transporter with a Transmembrane Small Protein in a Lipid Environment
- (2020) Dijun Du et al. STRUCTURE
- Acinetobacter baumannii Resistance: A Real Challenge for Clinicians
- (2020) Rosalino Vázquez-López et al. Antibiotics-Basel
- Antibiotic export by MexB multidrug efflux transporter is allosterically controlled by a MexA-OprM chaperone-like complex
- (2020) Marie Glavier et al. Nature Communications
- Holo-like and Druggable Protein Conformations from Enhanced Sampling of Binding Pocket Volume and Shape
- (2019) Andrea Basciu et al. Journal of Chemical Information and Modeling
- Cryo-Electron Microscopy Structure of an Acinetobacter baumannii Multidrug Efflux Pump
- (2019) Chih-Chia Su et al. mBio
- Structures of the wild-type MexAB–OprM tripartite pump reveal its complex formation and drug efflux mechanism
- (2019) Kenta Tsutsumi et al. Nature Communications
- AcrB: a mean, keen, drug efflux machine
- (2019) Jessica Kobylka et al. Annals of the New York Academy of Sciences
- Nosocomial outbreaks caused by Acinetobacter baumannii and Pseudomonas aeruginosa : Results of a systematic review
- (2018) Katja Wieland et al. AMERICAN JOURNAL OF INFECTION CONTROL
- CAVER Analyst 2.0: analysis and visualization of channels and tunnels in protein structures and molecular dynamics trajectories
- (2018) Adam Jurcik et al. BIOINFORMATICS
- Substrate Specificities and Efflux Efficiencies of RND Efflux Pumps of Acinetobacter baumannii
- (2018) Inga V. Leus et al. JOURNAL OF BACTERIOLOGY
- Discovery, research, and development of new antibiotics: the WHO priority list of antibiotic-resistant bacteria and tuberculosis
- (2018) Evelina Tacconelli et al. LANCET INFECTIOUS DISEASES
- Multidrug efflux pumps: structure, function and regulation
- (2018) Dijun Du et al. NATURE REVIEWS MICROBIOLOGY
- Multiple entry pathways within the efflux transporter AcrB contribute to multidrug recognition
- (2018) Martijn Zwama et al. Nature Communications
- New tools for automated high-resolution cryo-EM structure determination in RELION-3
- (2018) Jasenko Zivanov et al. eLife
- Protein–Ligand Scoring with Convolutional Neural Networks
- (2017) Matthew Ragoza et al. Journal of Chemical Information and Modeling
- MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy
- (2017) Shawn Q Zheng et al. NATURE METHODS
- The hydrophobic trap—the Achilles heel of RND efflux pumps
- (2017) Zachary Aron et al. RESEARCH IN MICROBIOLOGY
- Synergy between Active Efflux and Outer Membrane Diffusion Defines Rules of Antibiotic Permeation into Gram-Negative Bacteria
- (2017) Ganesh Krishnamoorthy et al. mBio
- An allosteric transport mechanism for the AcrAB-TolC multidrug efflux pump
- (2017) Zhao Wang et al. eLife
- Polder maps: improving OMIT maps by excluding bulk solvent
- (2017) Dorothee Liebschner et al. Acta Crystallographica Section D-Structural Biology
- Gctf: Real-time CTF determination and correction
- (2016) Kai Zhang JOURNAL OF STRUCTURAL BIOLOGY
- A saposin-lipoprotein nanoparticle system for membrane proteins
- (2016) Jens Frauenfeld et al. NATURE METHODS
- Molecular basis for inhibition of AcrB multidrug efflux pump by novel and powerful pyranopyridine derivatives
- (2016) Hanno Sjuts et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The assembly and disassembly of the AcrAB-TolC three-component multidrug efflux pump
- (2015) Reinke Tobias Müller et al. BIOLOGICAL CHEMISTRY
- A Database of Force-Field Parameters, Dynamics, and Properties of Antimicrobial Compounds
- (2015) Giuliano Malloci et al. MOLECULES
- The Phyre2 web portal for protein modeling, prediction and analysis
- (2015) Lawrence A Kelley et al. Nature Protocols
- Structural basis of RND-type multidrug exporters
- (2015) Akihito Yamaguchi et al. Frontiers in Microbiology
- Properties of AdeABC and AdeIJK Efflux Systems of Acinetobacter baumannii Compared with Those of the AcrAB-TolC System of Escherichia coli
- (2014) Etsuko Sugawara et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Crystal Structure of the Neisseria gonorrhoeae MtrD Inner Membrane Multidrug Efflux Pump
- (2014) Jani Reddy Bolla et al. PLoS One
- Coupling of remote alternating-access transport mechanisms for protons and substrates in the multidrug efflux pump AcrB
- (2014) Thomas Eicher et al. eLife
- How good are my data and what is the resolution?
- (2013) Philip R. Evans et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- RND-Type Efflux Pumps in Multidrug-Resistant Clinical Isolates of Acinetobacter baumannii: Major Role for AdeABC Overexpression and AdeRS Mutations
- (2013) Eun-Jeong Yoon et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Drug Uptake Pathways of Multidrug Transporter AcrB Studied by Molecular Simulations and Site-Directed Mutagenesis Experiments
- (2013) Xin-Qiu Yao et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- OmpA Is the Principal Nonspecific Slow Porin of Acinetobacter baumannii
- (2012) E. Sugawara et al. JOURNAL OF BACTERIOLOGY
- MMPBSA.py: An Efficient Program for End-State Free Energy Calculations
- (2012) Bill R. Miller et al. Journal of Chemical Theory and Computation
- Multidrug binding properties of the AcrB efflux pump characterized by molecular dynamics simulations
- (2012) A. V. Vargiu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Transport of drugs by the multidrug transporter AcrB involves an access and a deep binding pocket that are separated by a switch-loop
- (2012) T. Eicher et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- REFMAC5 for the refinement of macromolecular crystal structures
- (2011) Garib N. Murshudov et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- A Versatile and Efficient High-Throughput Cloning Tool for Structural Biology
- (2011) Eric R. Geertsma et al. BIOCHEMISTRY
- LigPlot+: Multiple Ligand–Protein Interaction Diagrams for Drug Discovery
- (2011) Roman A. Laskowski et al. Journal of Chemical Information and Modeling
- Effect of the F610A Mutation on Substrate Extrusion in the AcrB Transporter: Explanation and Rationale by Molecular Dynamics Simulations
- (2011) Attilio V. Vargiu et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Structures of the multidrug exporter AcrB reveal a proximal multisite drug-binding pocket
- (2011) Ryosuke Nakashima et al. NATURE
- XDS
- (2010) Wolfgang Kabsch ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Features and development ofCoot
- (2010) P. Emsley et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- PHENIX: a comprehensive Python-based system for macromolecular structure solution
- (2010) Paul D. Adams et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Overexpression of Resistance-Nodulation-Cell Division Pump AdeFGH Confers Multidrug Resistance in Acinetobacter baumannii
- (2010) S. Coyne et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Crystal structures of the CusA efflux pump suggest methionine-mediated metal transport
- (2010) Feng Long et al. NATURE
- MolProbity: all-atom structure validation for macromolecular crystallography
- (2009) Vincent B. Chen et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility
- (2009) Garrett M. Morris et al. JOURNAL OF COMPUTATIONAL CHEMISTRY
- Site-Directed Mutagenesis Reveals Putative Substrate Binding Residues in the Escherichia coli RND Efflux Pump AcrB
- (2008) J. A. Bohnert et al. JOURNAL OF BACTERIOLOGY
- Agar and broth dilution methods to determine the minimal inhibitory concentration (MIC) of antimicrobial substances
- (2008) Irith Wiegand et al. Nature Protocols
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