Catalytic atroposelective synthesis of axially chiral benzonitriles via chirality control during bond dissociation and CN group formation

Recent Advances in Catalytic Asymmetric Construction of Atropisomers

(2021) Jun Kee Cheng et al.   CHEMICAL REVIEWS

Expanding the Rare-Earth Metal BINOLate Catalytic Multitool beyond Enantioselective Organic Synthesis

(2021) Grace B. Panetti et al.   ACCOUNTS OF CHEMICAL RESEARCH

Design of an Electron-Withdrawing Benzonitrile Ligand for Ni-Catalyzed Cross-Coupling Involving Tertiary Nucleophiles

(2021) L. Reginald Mills et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Osilodrostat: First Approval

(2020) Sean Duggan   DRUGS

N ‐Heterocyclic carbene organocatalysis: activation modes and typical reactive intermediates

(2020) Xingkuan Chen et al.   CHINESE JOURNAL OF CHEMISTRY

Atropselective Dibrominations of a 1,1’-Disubstituted 2,2’-Biindolyl With Diverging Point-to-Axial Asymmetric Inductions. Deriving Diphosphane Ligands for Asymmetric Catalysis

(2019) Reinhard Brückner et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

NHC-Catalyzed Deamination of Primary Sulfonamides: A Platform for Late-Stage Functionalization

(2019) Patrick S. Fier et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Reductive Cleavage of Secondary Sulfonamides: Converting Terminal Functional Groups into Versatile Synthetic Handles

(2019) Patrick S. Fier et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective Indole N–H Functionalization Enabled by Addition of Carbene Catalyst to Indole Aldehyde at Remote Site

(2019) Xing Yang et al.   ACS Catalysis

A continuing challenge: N-heterocyclic carbene-catalyzed syntheses of γ-butyrolactones

(2018) Kathleen J. R. Murauski et al.   CHEMICAL SOCIETY REVIEWS

Enantioselective Halolactonization Reactions using BINOL-Derived Bifunctional Catalysts: Methodology, Diversification, and Applications

(2018) Daniel W. Klosowski et al.   JOURNAL OF ORGANIC CHEMISTRY

Ruthenium-Catalyzed Atropoenantioselective Synthesis of Axial Biaryls via Reductive Amination and Dynamic Kinetic Resolution

(2018) Donghui Guo et al.   ORGANIC LETTERS

Enantiodivergent Atroposelective Synthesis of Chiral Biaryls by Asymmetric Transfer Hydrogenation: Chiral Phosphoric Acid Catalyzed Dynamic Kinetic Resolution

(2016) Keiji Mori et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Dynamic Kinetic Resolution of Biaryl Lactones via a Chiral Bifunctional Amine Thiourea-Catalyzed Highly Atropo-enantioselective Transesterification

(2016) Chenguang Yu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

N-Heterocyclic Carbene Catalyzed Dynamic Kinetic Resolution of Pyranones

(2015) Changgui Zhao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Organocatalytic Reactions Enabled by N-Heterocyclic Carbenes

(2015) Darrin M. Flanigan et al.   CHEMICAL REVIEWS

Enantioselective and Enantiospecific Transition-Metal-Catalyzed Cross-Coupling Reactions of Organometallic Reagents To Construct C–C Bonds

(2015) Alan H. Cherney et al.   CHEMICAL REVIEWS

Recent advances in employing homoenolates generated by N-heterocyclic carbene (NHC) catalysis in carbon–carbon bond-forming reactions

(2015) Rajeev S. Menon et al.   CHEMICAL SOCIETY REVIEWS

Asymmetric Functional Organozinc Additions to Aldehydes Catalyzed by 1,1′-Bi-2-naphthols (BINOLs)

(2014) Lin Pu   ACCOUNTS OF CHEMICAL RESEARCH

On the Mechanism of N-Heterocyclic Carbene-Catalyzed Reactions Involving Acyl Azoliums

(2014) Jessada Mahatthananchai et al.   ACCOUNTS OF CHEMICAL RESEARCH

An overview of N-heterocyclic carbenes

(2014) Matthew N. Hopkinson et al.   NATURE

Enantioselective Sulfonation of Enones with Sulfonyl Imines by Cooperative N-Heterocyclic-Carbene/Thiourea/Tertiary-Amine Multicatalysis

(2013) Zhichao Jin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Acyl anion free N-heterocyclic carbene organocatalysis

(2013) Sarah J. Ryan et al.   CHEMICAL SOCIETY REVIEWS

Enhanced Rate and Selectivity by Carboxylate Salt as a Basic Cocatalyst in Chiral N-Heterocyclic Carbene-Catalyzed Asymmetric Acylation of Secondary Alcohols

(2013) Satoru Kuwano et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Discovery and in Vivo Evaluation of Potent Dual CYP11B2 (Aldosterone Synthase) and CYP11B1 Inhibitors

(2013) Erik L. Meredith et al.   ACS Medicinal Chemistry Letters

Bifunctional Catalyst Promotes Highly Enantioselective Bromolactonizations To Generate Stereogenic C–Br Bonds

(2012) Daniel H. Paull et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nickel-Catalyzed Asymmetric α-Arylation and Heteroarylation of Ketones with Chloroarenes: Effect of Halide on Selectivity, Oxidation State, and Room-Temperature Reactions

(2011) Shaozhong Ge et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Atroposelective Total Synthesis of Axially Chiral Biaryl Natural Products

(2010) Gerhard Bringmann et al.   CHEMICAL REVIEWS

Nitrile-Containing Pharmaceuticals: Efficacious Roles of the Nitrile Pharmacophore

(2010) Fraser F. Fleming et al.   JOURNAL OF MEDICINAL CHEMISTRY

CooperativeN-Heterocyclic Carbene/Lewis Acid Catalysis for Highly Stereoselective Annulation Reactions with Homoenolates

(2010) Benoit Cardinal-David et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Unexpected Transfer of Tosyl Group of ArCHNTs-Catalyzed byN-Heterocyclic Carbene

(2008) Dong-Dong Chen et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis of Novel Enantiopure BiphenylP,N-Ligands and Application in Palladium-Catalyzed Asymmetric Addition of Arylboronic Acids toN-Benzylisatin

(2008) Hongshan Lai et al.   JOURNAL OF ORGANIC CHEMISTRY