Human RIPK3 maintains MLKL in an inactive conformation prior to cell death by necroptosis

The regulation of necroptosis by post-translational modifications

(2021) Yanxiang Meng et al.   CELL DEATH AND DIFFERENTIATION

A class of viral inducer of degradation of the necroptosis adaptor RIPK3 regulates virus-induced inflammation

(2021) Zhijun Liu et al.   IMMUNITY

A toolbox for imaging RIPK1, RIPK3, and MLKL in mouse and human cells

(2021) André L. Samson et al.   CELL DEATH AND DIFFERENTIATION

Location, location, location: A compartmentalized view of TNF-induced necroptotic signaling

(2021) André L. Samson et al.   Science Signaling

A family harboring an MLKL loss of function variant implicates impaired necroptosis in diabetes

(2021) Joanne M. Hildebrand et al.   Cell Death & Disease

Conformational interconversion of MLKL and disengagement from RIPK3 precede cell death by necroptosis

(2021) Sarah E. Garnish et al.   Nature Communications

Necroptosis Signaling Promotes Inflammation, Airway Remodeling, and Emphysema in Chronic Obstructive Pulmonary Disease

(2021) Zhe Lu et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Evolutionary Profile for (Host and Viral) MLKL Indicates Its Activities as a Battlefront for Extensive Counteradaptation

(2021) Suzette N Palmer et al.   MOLECULAR BIOLOGY AND EVOLUTION

The Role of the Key Effector of Necroptotic Cell Death, MLKL, in Mouse Models of Disease

(2021) Emma C. Tovey Crutchfield et al.   Biomolecules

Identification of MLKL membrane translocation as a checkpoint in necroptotic cell death using Monobodies

(2020) Emma J. Petrie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Scaling diffraction data in the DIALS software package: algorithms and new approaches for multi-crystal scaling

(2020) James Beilsten-Edmands et al.   Acta Crystallographica Section D-Structural Biology

Human cytomegalovirus protein pUL36: A dual cell death pathway inhibitor

(2020) Alice Fletcher-Etherington et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MLKL trafficking and accumulation at the plasma membrane control the kinetics and threshold for necroptosis

(2020) Andre L. Samson et al.   Nature Communications

A missense mutation in the MLKL brace region promotes lethal neonatal inflammation and hematopoietic dysfunction

(2020) Joanne M. Hildebrand et al.   Nature Communications

Varicella zoster virus encodes a viral decoy RHIM to inhibit cell death

(2020) Megan Steain et al.   PLoS Pathogens

Potent Inhibition of Necroptosis by Simultaneously Targeting Multiple Effectors of the Pathway

(2020) Catia L. Pierotti et al.   ACS Chemical Biology

ATSAS 3.0: expanded functionality and new tools for small-angle scattering data analysis

(2020) Karen Manalastas-Cantos et al.   JOURNAL OF APPLIED CRYSTALLOGRAPHY

Regulated necrosis in kidney ischemia-reperfusion injury

(2019) Aspasia Pefanis et al.   KIDNEY INTERNATIONAL

Identification of RIPK3 Type II Inhibitors Using High-Throughput Mechanistic Studies in Hit Triage

(2019) Amy C. Hart et al.   ACS Medicinal Chemistry Letters

Viral MLKL Homologs Subvert Necroptotic Cell Death by Sequestering Cellular RIPK3

(2019) Emma J. Petrie et al.   Cell Reports

Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in Phenix

(2019) Dorothee Liebschner et al.   Acta Crystallographica Section D-Structural Biology

The Killer Pseudokinase Mixed Lineage Kinase Domain-Like Protein (MLKL)

(2019) James M. Murphy   Cold Spring Harbor Perspectives in Biology

The Structure of the Necrosome RIPK1-RIPK3 Core, a Human Hetero-Amyloid Signaling Complex

(2018) Miguel Mompeán et al.   CELL

The brace helices of MLKL mediate interdomain communication and oligomerisation to regulate cell death by necroptosis

(2018) Katherine A. Davies et al.   CELL DEATH AND DIFFERENTIATION

Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis

(2018) Emma J. Petrie et al.   Nature Communications

An optimized SEC-SAXS system enabling high X-ray dose for rapid SAXS assessment with correlated UV measurements for biomolecular structure analysis

(2018) Timothy M. Ryan et al.   JOURNAL OF APPLIED CRYSTALLOGRAPHY

MX2: a high-flux undulator microfocus beamline serving both the chemical and macromolecular crystallography communities at the Australian Synchrotron

(2018) David Aragão et al.   JOURNAL OF SYNCHROTRON RADIATION

The Structural Basis of Necroptotic Cell Death Signaling

(2018) Emma J. Petrie et al.   TRENDS IN BIOCHEMICAL SCIENCES

A FRET biosensor for necroptosis uncovers two different modes of the release of DAMPs

(2018) Shin Murai et al.   Nature Communications

Insane in the membrane: a structural perspective of MLKL function in necroptosis

(2017) Emma J Petrie et al.   IMMUNOLOGY AND CELL BIOLOGY

EspL is a bacterial cysteine protease effector that cleaves RHIM proteins to block necroptosis and inflammation

(2017) Jaclyn S. Pearson et al.   Nature Microbiology

Evolutionary divergence of the necroptosis effector MLKL

(2016) M C Tanzer et al.   CELL DEATH AND DIFFERENTIATION

Sequential Engagement of Distinct MLKL Phosphatidylinositol-Binding Sites Executes Necroptosis

(2016) Giovanni Quarato et al.   MOLECULAR CELL

HSP90 activity is required for MLKL oligomerisation and membrane translocation and the induction of necroptotic cell death

(2016) A V Jacobsen et al.   Cell Death & Disease

Necroptosis Promotes Staphylococcus aureus Clearance by Inhibiting Excessive Inflammatory Signaling

(2016) Kipyegon Kitur et al.   Cell Reports

Improved radiation dose efficiency in solution SAXS using a sheath flow sample environment

(2016) Nigel Kirby et al.   Acta Crystallographica Section D-Structural Biology

Suppression of RIP3-dependent Necroptosis by Human Cytomegalovirus

(2015) Shinya Omoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RIPK1 Regulates RIPK3-MLKL-Driven Systemic Inflammation and Emergency Hematopoiesis

(2014) James A. Rickard et al.   CELL

Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death

(2014) Joanne M. Hildebrand et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MLKL Compromises Plasma Membrane Integrity by Binding to Phosphatidylinositol Phosphates

(2014) Yves Dondelinger et al.   Cell Reports

TNFR1-dependent cell death drives inflammation in Sharpin-deficient mice

(2014) James A Rickard et al.   eLife

How good are my data and what is the resolution?

(2013) Philip R. Evans et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Necroptosis Is Active in Children With Inflammatory Bowel Disease and Contributes to Heighten Intestinal Inflammation

(2013) Maria Pierdomenico et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Insights into the evolution of divergent nucleotide-binding mechanisms among pseudokinases revealed by crystal structures of human and mouse MLKL

(2013) James M. Murphy et al.   BIOCHEMICAL JOURNAL

A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties

(2013) James M. Murphy et al.   BIOCHEMICAL JOURNAL

The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism

(2013) James M. Murphy et al.   IMMUNITY

Diverse Sequence Determinants Control Human and Mouse Receptor Interacting Protein 3 (RIP3) and Mixed Lineage Kinase domain-Like (MLKL) Interaction in Necroptotic Signaling

(2013) Wanze Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Toll-like Receptor 3-mediated Necrosis via TRIF, RIP3, and MLKL

(2013) William J. Kaiser et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis

(2013) Zhenyu Cai et al.   NATURE CELL BIOLOGY

Structural Insights into RIP3-Mediated Necroptotic Signaling

(2013) Tian Xie et al.   Cell Reports

Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase

(2012) Liming Sun et al.   CELL

Mixed lineage kinase domain-like is a key receptor interacting protein 3 downstream component of TNF-induced necrosis

(2012) J. Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Data processing and analysis with theautoPROCtoolbox

(2011) Clemens Vonrhein et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Joint X-ray and neutron refinement withphenix.refine

(2010) Pavel V. Afonine et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Integration, scaling, space-group assignment and post-refinement

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Phosphorylation-Driven Assembly of the RIP1-RIP3 Complex Regulates Programmed Necrosis and Virus-Induced Inflammation

(2009) YoungSik Cho et al.   CELL

Receptor Interacting Protein Kinase-3 Determines Cellular Necrotic Response to TNF-α

(2009) Sudan He et al.   CELL

Discovery of Pyrrolopyridine−Pyridone Based Inhibitors of Met Kinase: Synthesis, X-ray Crystallographic Analysis, and Biological Activities

(2008) Kyoung Soon Kim et al.   JOURNAL OF MEDICINAL CHEMISTRY

Kinase-Selective Enrichment Enables Quantitative Phosphoproteomics of the Kinome across the Cell Cycle

(2008) Henrik Daub et al.   MOLECULAR CELL

A quantitative atlas of mitotic phosphorylation

(2008) N. Dephoure et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA