Astrocytic Kir4.1 regulates NMDAR/calpain signaling axis in lipopolysaccharide-induced depression-like behaviors in mice

Polygonatum sibiricum polysaccharide prevents depression-like behaviors by reducing oxidative stress, inflammation, and cellular and synaptic damage

(2021) Fengming Shen et al.   JOURNAL OF ETHNOPHARMACOLOGY

Dysregulation of BDNF/TrkB signaling mediated by NMDAR/Ca2+/calpain might contribute to postoperative cognitive dysfunction in aging mice

(2020) Li-Li Qiu et al.   Journal of Neuroinflammation

Dihydrolipoic acid protects against lipopolysaccharide-induced behavioral deficits and neuroinflammation via regulation of Nrf2/HO-1/NLRP3 signaling in rat

(2020) Hetao Bian et al.   Journal of Neuroinflammation

Calpain inhibition ameliorates depression-like behaviors by reducing inflammation and promoting synaptic protein expression in the hippocampus

(2020) Zhujin Song et al.   NEUROPHARMACOLOGY

Extrasynaptic CaMKIIα is involved in the antidepressant effects of ketamine by downregulating GluN2B receptors in an LPS-induced depression model

(2020) Xiao-Hui Tang et al.   Journal of Neuroinflammation

Ginsenoside Rg1 Prevents PTSD-Like Behaviors in Mice Through Promoting Synaptic Proteins, Reducing Kir4.1 and TNF-α in the Hippocampus

(2020) Zhengrong Zhang et al.   MOLECULAR NEUROBIOLOGY

Calpain-1 and calpain-2 in the brain: Dr. Jekill and Mr Hyde?

(2019) Michel Baudry   Current Neuropharmacology

TRPV1 mediates astrocyte activation and interleukin-1β release induced by hypoxic ischemia (HI)

(2019) Xing-Liang Yang et al.   Journal of Neuroinflammation

Changes in the global burden of depression from 1990 to 2017: Findings from the Global Burden of Disease study

(2019) Qingqing Liu et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Gut microbiota from NLRP3-deficient mice ameliorates depressive-like behaviors by regulating astrocyte dysfunction via circHIPK2

(2019) Yuan Zhang et al.   Microbiome

Peripheral and Central Effects of Memantine in a Mixed Preclinical Mice Model of Obesity and Familial Alzheimer’s Disease

(2018) Miren Ettcheto et al.   MOLECULAR NEUROBIOLOGY

Memantine ameliorates depressive-like behaviors by regulating hippocampal cell proliferation and neuroprotection in olfactory bulbectomized mice

(2018) Kohei Takahashi et al.   NEUROPHARMACOLOGY

Differentiating between bipolar and unipolar depression in functional and structural MRI studies

(2018) Kyu-Man Han et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Hippocampal ripples down-regulate synapses

(2018) Hiroaki Norimoto et al.   SCIENCE

Astroglial Kir4.1 in the lateral habenula drives neuronal bursts in depression

(2018) Yihui Cui et al.   NATURE

Ketamine blocks bursting in the lateral habenula to rapidly relieve depression

(2018) Yan Yang et al.   NATURE

A Membrane Potential- and Calpain-Dependent Reversal of Caspase-1 Inhibition Regulates Canonical NLRP3 Inflammasome

(2018) Yifei Zhang et al.   Cell Reports

Increased expression of inwardly rectifying Kir4.1 channel in the parietal cortex from patients with major depressive disorder

(2018) Zhongwei Xiong et al.   JOURNAL OF AFFECTIVE DISORDERS

Editorial: What is depression?

(2017) Argyris Stringaris   JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY

NLR members NLRC4 and NLRP3 mediate sterile inflammasome activation in microglia and astrocytes

(2017) Leslie Freeman et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Salvianolic acid B protects against lipopolysaccharide-induced behavioral deficits and neuroinflammatory response: involvement of autophagy and NLRP3 inflammasome

(2017) Pei Jiang et al.   Journal of Neuroinflammation

Activation of P2X7 receptor and NLRP3 inflammasome assembly in hippocampal glial cells mediates chronic stress-induced depressive-like behaviors

(2017) Na Yue et al.   Journal of Neuroinflammation

Lentivirus-mediated interleukin-1β (IL-1β) knock-down in the hippocampus alleviates lipopolysaccharide (LPS)-induced memory deficits and anxiety- and depression-like behaviors in mice

(2017) Mengmeng Li et al.   Journal of Neuroinflammation

Prefrontal–hippocampal interactions in episodic memory

(2017) Howard Eichenbaum   NATURE REVIEWS NEUROSCIENCE

NLRP3 inflammasome activation contributes to long-term behavioral alterations in mice injected with lipopolysaccharide

(2017) Wei Zhu et al.   NEUROSCIENCE

Calpain-1 deletion impairs mGluR-dependent LTD and fear memory extinction

(2017) Guoqi Zhu et al.   Scientific Reports

The role of glial-specific Kir4.1 in normal and pathological states of the CNS

(2016) Sinifunanya E. Nwaobi et al.   ACTA NEUROPATHOLOGICA

Effects of IL1B single nucleotide polymorphisms on depressive and anxiety symptoms are determined by severity and type of life stress

(2016) David Kovacs et al.   BRAIN BEHAVIOR AND IMMUNITY

Effect of memantine combination therapy on symptoms in patients with moderate-to-severe depressive disorder: randomized, double-blind, placebo-controlled study

(2016) M. Amidfar et al.   JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS

Nod-like receptor pyrin containing 3 (NLRP3) in the post-mortem frontal cortex from patients with bipolar disorder: A potential mediator between mitochondria and immune-activation

(2016) Helena Kyunghee Kim et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Defects in the CAPN1 Gene Result in Alterations in Cerebellar Development and Cerebellar Ataxia in Mice and Humans

(2016) Yubin Wang et al.   Cell Reports

MPTP-induced changes in hippocampal synaptic plasticity and memory are prevented by memantine through the BDNF-TrkB pathway

(2015) Guoqi Zhu et al.   BRITISH JOURNAL OF PHARMACOLOGY

Sequential activation of microglia and astrocyte cytokine expression precedes increased iba-1 or GFAP immunoreactivity following systemic immune challenge

(2015) Diana M. Norden et al.   GLIA

Lipopolysaccharide-induced blood-brain barrier disruption: roles of cyclooxygenase, oxidative stress, neuroinflammation, and elements of the neurovascular unit

(2015) William A. Banks et al.   Journal of Neuroinflammation

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

(2015) Rebecca C Coll et al.   NATURE MEDICINE

NLRP3 Inflammasome: A New Target in Major Depressive Disorder

(2014) Elísabet Alcocer-Gómez et al.   CNS Neuroscience & Therapeutics

Molecular and cellular neuroinflammatory status of mouse brain after systemic lipopolysaccharide challenge: importance of CCR2/CCL2 signaling

(2014) Julie Cazareth et al.   Journal of Neuroinflammation

Inflammasomes in the CNS

(2014) John G. Walsh et al.   NATURE REVIEWS NEUROSCIENCE

Calcium signaling and mitochondrial destabilization in the triggering of the NLRP3 inflammasome

(2014) Tiffany Horng   TRENDS IN IMMUNOLOGY

Ketamine as a new treatment for depression: A review of its efficacy and adverse effects

(2013) Natalie Katalinic et al.   AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY

K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter

(2013) Raúl Muñoz-Planillo et al.   IMMUNITY

The inflammasome: Pathways linking psychological stress, depression, and systemic illnesses

(2012) Masaaki Iwata et al.   BRAIN BEHAVIOR AND IMMUNITY

Obovatol attenuates LPS-induced memory impairments in mice via inhibition of NF-κB signaling pathway

(2011) Dong-Young Choi et al.   NEUROCHEMISTRY INTERNATIONAL

Are the Dorsal and Ventral Hippocampus Functionally Distinct Structures?

(2010) Michael S. Fanselow et al.   NEURON

Interleukin-6 Is Elevated in the Cerebrospinal Fluid of Suicide Attempters and Related to Symptom Severity

(2009) Daniel Lindqvist et al.   BIOLOGICAL PSYCHIATRY

A Meta-Analysis of Cytokines in Major Depression

(2009) Yekta Dowlati et al.   BIOLOGICAL PSYCHIATRY

Effects of Memantine on Neuronal Structure and Conditioned Fear in the Tg2576 Mouse Model of Alzheimer's Disease

(2008) Hongxin Dong et al.   NEUROPSYCHOPHARMACOLOGY

In vitromodulation of the glucocorticoid receptor by antidepressants

(2008) Livia A. Carvalho et al.   STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS

Neuroinflammation and synaptic plasticity: theoretical basis for a novel, immune-centred, therapeutic approach to neurological disorders

(2008) Massimiliano Di Filippo et al.   TRENDS IN PHARMACOLOGICAL SCIENCES