Carbon Dot Therapeutic Platforms: Administration, Distribution, Metabolism, Excretion, Toxicity, and Therapeutic Potential

Density of surface charge is a more predictive factor of the toxicity of cationic carbon nanoparticles than zeta potential

(2021) Maud Weiss et al.   JOURNAL OF NANOBIOTECHNOLOGY

Key principles and methods for studying the endocytosis of biological and nanoparticle therapeutics

(2021) Joshua J. Rennick et al.   Nature Nanotechnology

Photodegradation of carbon dots cause cytotoxicity

(2021) Yue-Yue Liu et al.   Nature Communications

Multiscale and Multimodal Optical Imaging of the Ultrastructure of Human Liver Biopsies

(2021) Cihang Kong et al.   Frontiers in Physiology

Targeted drug delivery strategies for precision medicines

(2021) Mandana T. Manzari et al.   Nature Reviews Materials

Vascular normalisation as the stepping stone into tumour microenvironment transformation

(2021) Anette L. Magnussen et al.   BRITISH JOURNAL OF CANCER

Snapshots into carbon dots formation through a combined spectroscopic approach

(2021) Francesco Rigodanza et al.   Nature Communications

Selection of metastasis competent subclones in the tumour interior

(2021) Yue Zhao et al.   Nature Ecology & Evolution

Improvement of hydrophilicity and cell attachment of polycaprolactone scaffolds using green synthesized carbon dots

(2021) H. Ehtesabi et al.   Materials Today Sustainability

T-carbon: Experiments, properties, potential applications and derivatives

(2021) Xin-Wei Yi et al.   Nano Today

Iron doped carbon dots based nanohybrids as a tetramodal imaging agent for gene delivery promotion and photothermal-chemodynamic cancer synergistic theranostics

(2021) Tianying Luo et al.   MATERIALS & DESIGN

Red-Emissive Carbon Quantum Dots for Nuclear Drug Delivery in Cancer Stem Cells

(2020) Wen Su et al.   Journal of Physical Chemistry Letters

The entry of nanoparticles into solid tumours

(2020) Shrey Sindhwani et al.   NATURE MATERIALS

The effect of surface charge on cellular uptake and inflammatory behavior of carbon dots

(2020) Muhammad Usman et al.   Colloid and Interface Science Communications

Unraveling the Fluorescence Mechanism of Carbon Dots with Sub-Single-Particle Resolution

(2020) Huy A. Nguyen et al.   ACS Nano

Tumor extravasation and infiltration as barriers of nanomedicine for high efficacy: The current status and transcytosis strategy

(2020) Quan Zhou et al.   BIOMATERIALS

Active transcytosis and new opportunities for cancer nanomedicine

(2020) Subehndu Pandit et al.   NATURE MATERIALS

UV–Vis–NIR Full‐Range Responsive Carbon Dots with Large Multiphoton Absorption Cross Sections and Deep‐Red Fluorescence at Nucleoli and In Vivo

(2020) Lei Jiang et al.   Small

Selenium‐Doped Carbon Quantum Dots Act as Broad‐Spectrum Antioxidants for Acute Kidney Injury Management

(2020) Zachary T. Rosenkrans et al.   Advanced Science

Targeted tumour theranostics in mice via carbon quantum dots structurally mimicking large amino acids

(2020) Shuhua Li et al.   Nature Biomedical Engineering

Fluorescent Carbon Dots for Selective Labeling of Subcellular Organelles

(2020) Binesh Unnikrishnan et al.   ACS Omega

Rational Design of Far-Red to Near-Infrared Emitting Carbon Dots for Ultrafast Lysosomal Polarity Imaging

(2020) Yuanqiang Sun et al.   ACS Applied Materials & Interfaces

Monodisperse and Water-Soluble Quantum Dots for SWIR Imaging via Carboxylic Acid Copolymer Ligands

(2020) Daniel M. Montana et al.   ACS Applied Materials & Interfaces

Enriched graphitic N dopants of carbon dots as F cores mediate photothermal conversion in the NIR-II window with high efficiency

(2020) Bijiang Geng et al.   CARBON

Challenges and Opportunities in Cancer Drug Resistance

(2020) Richard A. Ward et al.   CHEMICAL REVIEWS

Quantitative comparison of three widely-used pulmonary administration methods in vivo with radiolabeled inhalable nanoparticles

(2020) Lan Wu et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Surface states of carbon dots and their influences on luminescence

(2020) Hui Ding et al.   JOURNAL OF APPLIED PHYSICS

Hetero-atom-doped carbon dots: Doping strategies, properties and applications

(2020) Shihai Miao et al.   Nano Today

Nucleolus‐Targeted Photodynamic Anticancer Therapy Using Renal‐Clearable Carbon Dots

(2020) Wen Pang et al.   Advanced Healthcare Materials

Membrane Heterogeneity Controls Cellular Endocytic Trafficking

(2020) Gregory M. I. Redpath et al.   Frontiers in Cell and Developmental Biology

Highly Efficient Antioxidant F- and Cl-Doped Carbon Quantum Dots for Bioimaging

(2020) Zoran M. Marković et al.   ACS Sustainable Chemistry & Engineering

Recent Developments of Carbon Dots in Biosensing: A Review

(2020) Chunyu Ji et al.   ACS Sensors

Advances in organelle-targeting carbon dots

(2020) Xin Zhang et al.   FULLERENES NANOTUBES AND CARBON NANOSTRUCTURES

Recent advances in the modification of carbon-based quantum dots for biomedical applications

(2020) Amirhossein Alaghmandfard et al.   Materials Science & Engineering C-Materials for Biological Applications

Insights into photoluminescence mechanisms of carbon dots: Advances and perspectives

(2020) Lin Ai et al.   Science Bulletin

Carbon Dots: A New Type of Carbon-Based Nanomaterial with Wide Applications

(2020) Junjun Liu et al.   ACS Central Science

Metal-doped and hybrid carbon dots: A comprehensive review on their synthesis and biomedical applications

(2020) Neeraj Tejwan et al.   JOURNAL OF CONTROLLED RELEASE

Colour-tunable ultralong-lifetime room temperature phosphorescence with external heavy-atom effect in boron-doped carbon dots

(2020) Qi Feng et al.   CHEMICAL ENGINEERING JOURNAL

Theranostic Carbon Dots with Innovative NIR-II Emission for in Vivo Renal Excreted Optical Imaging and Photothermal Therapy

(2019) Youbin Li et al.   ACS Applied Materials & Interfaces

Transcytosis to Cross the Blood Brain Barrier, New Advancements and Challenges

(2019) Victor M. Pulgar   Frontiers in Neuroscience

Shedding light on gene therapy: carbon dots for the minimally invasive image-guided delivery of plasmids and noncoding RNAs

(2019) Reza Mohammadinejad et al.   Journal of Advanced Research

Embracing the Diversity of Halogen Bonding Motifs in Fragment-Based Drug Discovery—Construction of a Diversity-Optimized Halogen-Enriched Fragment Library

(2019) Johannes Heidrich et al.   Frontiers in Chemistry

Carbon-dot-supported atomically dispersed gold as a mitochondrial oxidative stress amplifier for cancer treatment

(2019) Ningqiang Gong et al.   Nature Nanotechnology

Recent Advances in Carbon-Based Metal-Free Electrocatalysts

(2019) Rajib Paul et al.   ADVANCED MATERIALS

Fluorescence Based Platform to Discriminate Protein Using Carbon Quantum Dots

(2019) Antônio Alvernes Carneiro Cruz et al.   ChemistrySelect

Reactive oxygen species and cancer: A complex interaction

(2019) Sankaralingam Saikolappan et al.   CANCER LETTERS

Aptamer and nanomaterial based FRET biosensors: a review on recent advances (2014–2019)

(2019) Zeki Semih Pehlivan et al.   MICROCHIMICA ACTA

Enzyme-activatable polymer–drug conjugate augments tumour penetration and treatment efficacy

(2019) Quan Zhou et al.   Nature Nanotechnology

Activity-Based Sensing and Theranostic Probes Based on Photoinduced Electron Transfer

(2019) Wen Sun et al.   ACCOUNTS OF CHEMICAL RESEARCH

Evolution and Synthesis of Carbon Dots: From Carbon Dots to Carbonized Polymer Dots

(2019) Chunlei Xia et al.   Advanced Science

Incorporation of quantum carbon dots into a PVP/ZnO hydrogel for use as an effective hexavalent chromium sensing platform

(2019) Adam Truskewycz et al.   ANALYTICA CHIMICA ACTA

Specific targeting cancer cells with nanoparticles and drug delivery in cancer therapy

(2019) Sibi Raj et al.   SEMINARS IN CANCER BIOLOGY

Enzymatic Degradation of Graphene Quantum Dots by Human Peroxidases

(2019) Cristina Martín et al.   Small

Quantifying the photothermal conversion efficiency of plasmonic nanoparticles by means of terahertz radiation

(2019) H. Breitenborn et al.   APL Photonics

Electrochemiluminescence methods using CdS quantum dots in aptamer-based thrombin biosensors: a comparative study

(2019) Ibrahim Isildak et al.   MICROCHIMICA ACTA

Unexpected intracellular biodegradation and recrystallization of gold nanoparticles

(2019) Alice Balfourier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fluorescent Carbon Quantum Dots with Intrinsic Nucleolus-Targeting Capability for Nucleolus Imaging and Enhanced Cytosolic and Nuclear Drug Delivery

(2018) Xian-Wu Hua et al.   ACS Applied Materials & Interfaces

Highly Crystalline Multicolor Carbon Nanodots for Dual-Modal Imaging-Guided Photothermal Therapy of Glioma

(2018) Min Qian et al.   ACS Applied Materials & Interfaces

Cetuximab-conjugated iodine doped carbon dots as a dual fluorescent/CT probe for targeted imaging of lung cancer cells

(2018) Huifang Su et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

The effect of surface charge on the cytotoxicity and uptake of carbon quantum dots in human umbilical cord derived mesenchymal stem cells

(2018) Junyan Yan et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Synchronous and rapid preparation of lignin nanoparticles and carbon quantum dots from natural lignocellulose

(2018) Mengying Si et al.   GREEN CHEMISTRY

Amorphous solid dispersions and nanocrystal technologies for poorly water-soluble drug delivery – An update

(2018) Scott V. Jermain et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Ultrasmall noble metal nanoparticles: Breakthroughs and biomedical implications

(2018) Xingya Jiang et al.   Nano Today

Metal ions doped carbon quantum dots: Synthesis, physicochemical properties, and their applications

(2018) Liping Lin et al.   TRAC-TRENDS IN ANALYTICAL CHEMISTRY

Mechanisms of Carrier Formation during Clathrin-Independent Endocytosis

(2018) Antonio P.A. Ferreira et al.   TRENDS IN CELL BIOLOGY

Carbon Dots from Sugars and Ascorbic Acid: Role of the Precursors on Morphology, Properties, Toxicity, and Drug Uptake

(2018) Simone Cailotto et al.   ACS Medicinal Chemistry Letters

Homocysteine directly interacts and activates the angiotensin II type I receptor to aggravate vascular injury

(2018) Tuoyi Li et al.   Nature Communications

Germination heterochrony in annual plants of Salsola L.: an effective survival strategy in changing environments

(2018) Hua F. Liu et al.   Scientific Reports

Amorphous Carbon Dots and their Remarkable Ability to Detect 2,4,6-Trinitrophenol

(2018) Abu Bakar Siddique et al.   Scientific Reports

In vivo toxicology of carbon dots by 1H NMR-based metabolomics

(2018) Wei Hong et al.   Toxicology Research

Nonmetal Heteroatom Doped Carbon dots: Synthesis and Property

(2018) Feng Li et al.   CHEMISTRY-A EUROPEAN JOURNAL

Current status and prospects on chemical structure driven photoluminescence behaviour of carbon dots

(2018) Monoj Kumar Barman et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY C-PHOTOCHEMISTRY REVIEWS

Transport and interactions of nanoparticles in the kidneys

(2018) Bujie Du et al.   Nature Reviews Materials

Highly Biocompatible, Fluorescence, and Zwitterionic Carbon Dots as a Novel Approach for Bioimaging Applications in Cancerous Cells

(2018) Smriti Sri et al.   ACS Applied Materials & Interfaces

Cancer‐Targeting Graphene Quantum Dots: Fluorescence Quantum Yields, Stability, and Cell Selectivity

(2018) Qing Zhang et al.   ADVANCED FUNCTIONAL MATERIALS

Colorimetric and dark-field microscopic determination of cadmium(II) using unmodified gold nanoparticles and based on the formation of glutathione-cadmium(II) complexes

(2018) Li Li et al.   MICROCHIMICA ACTA

Graphene quantum dots in alveolar macrophage: uptake-exocytosis, accumulation in nuclei, nuclear responses and DNA cleavage

(2018) Lina Xu et al.   Particle and Fibre Toxicology

Biogreen Synthesis of Carbon Dots for Biotechnology and Nanomedicine Applications

(2018) Kok Ken Chan et al.   Nano-Micro Letters

In vivo theranostics with near-infrared-emitting carbon dots—highly efficient photothermal therapy based on passive targeting after intravenous administration

(2018) Xin Bao et al.   Light-Science & Applications

Near-infrared fluorescent carbon dots encapsulated liposomes as multifunctional nano-carrier and tracer of the anticancer agent cinobufagin in vivo and in vitro

(2018) Wei Ren et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Understanding the Capsanthin Tails in Regulating the Hydrophilic–Lipophilic Balance of Carbon Dots for a Rapid Crossing Cell Membrane

(2017) Jing Chen et al.   LANGMUIR

Preferential binding of positive nanoparticles on cell membranes is due to electrostatic interactions: A too simplistic explanation that does not take into account the nanoparticle protein corona

(2017) Valérie Forest et al.   Materials Science & Engineering C-Materials for Biological Applications

Methotrexate-loaded nitrogen-doped graphene quantum dots nanocarriers as an efficient anticancer drug delivery system

(2017) Fatemeh Khodadadei et al.   Materials Science & Engineering C-Materials for Biological Applications

The quenching of the fluorescence of carbon dots: A review on mechanisms and applications

(2017) Fanlin Zu et al.   MICROCHIMICA ACTA

Two-photon-excited near-infrared emissive carbon dots as multifunctional agents for fluorescence imaging and photothermal therapy

(2017) Minhuan Lan et al.   Nano Research

Mitochondria-targetable carbon quantum dots for differentiating cancerous cells from normal cells

(2017) Ge Gao et al.   Nanoscale

Fluorescent carbon dots and their sensing applications

(2017) Xiangcheng Sun et al.   TRAC-TRENDS IN ANALYTICAL CHEMISTRY

Carbon quantum dots: recent progresses on synthesis, surface modification and applications

(2017) Masoud Farshbaf et al.   Artificial Cells Nanomedicine and Biotechnology

Recent progress in carbon quantum dots: synthesis, properties and applications in photocatalysis

(2017) Ru Wang et al.   Journal of Materials Chemistry A

Targeting therapeutics to endothelium: are we there yet?

(2017) Raisa Yu. Kiseleva et al.   Drug Delivery and Translational Research

Aspirin-Based Carbon Dots, a Good Biocompatibility of Material Applied for Bioimaging and Anti-Inflammation

(2016) Xiaowei Xu et al.   ACS Applied Materials & Interfaces

Short- and Long-Term Tracking of Anionic Ultrasmall Nanoparticles in Kidney

(2016) Xiaowen Liang et al.   ACS Nano

Crossover between Anti- and Pro-oxidant Activities of Graphene Quantum Dots in the Absence or Presence of Light

(2016) Yu Chong et al.   ACS Nano

Cationic carbon quantum dots derived from alginate for gene delivery: One-step synthesis and cellular uptake

(2016) Jie Zhou et al.   Acta Biomaterialia

Tailoring Renal Clearance and Tumor Targeting of Ultrasmall Metal Nanoparticles with Particle Density

(2016) Shaoheng Tang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Toxicity of carbon dots – Effect of surface functionalization on the cell viability, reactive oxygen species generation and cell cycle

(2016) Marketa Havrdova et al.   CARBON

Nanoparticle–liver interactions: Cellular uptake and hepatobiliary elimination

(2016) Yi-Nan Zhang et al.   JOURNAL OF CONTROLLED RELEASE

The effect of nanoparticle size on in vivo pharmacokinetics and cellular interaction

(2016) Nazanin Hoshyar et al.   Nanomedicine

Mechanism of hard-nanomaterial clearance by the liver

(2016) Kim M. Tsoi et al.   NATURE MATERIALS

Toxicity of graphene-family nanoparticles: a general review of the origins and mechanisms

(2016) Lingling Ou et al.   Particle and Fibre Toxicology

Systematical investigation of in vitro molecular interaction between fluorescent carbon dots and human serum albumin

(2016) Shan Huang et al.   RSC Advances

Biodegradable Nitrogen-Doped Carbon Nanodots for Non-Invasive Photoacoustic Imaging and Photothermal Therapy

(2016) Changho Lee et al.   Theranostics

Heteroatom-doped carbon dots: synthesis, characterization, properties, photoluminescence mechanism and biological applications

(2016) Quan Xu et al.   Journal of Materials Chemistry B

Transport of Gold Nanoparticles by Vascular Endothelium from Different Human Tissues

(2016) Radka Gromnicova et al.   PLoS One

Self-Targeting Fluorescent Carbon Dots for Diagnosis of Brain Cancer Cells

(2015) Min Zheng et al.   ACS Nano

Fluorescent detection of Mucin 1 protein based on aptamer functionalized biocompatible carbon dots and graphene oxide

(2015) Yanjun Ding et al.   Analytical Methods

Efficient in vitro and in vivo pulmonary delivery of nucleic acid by carbon dot-based nanocarriers

(2015) Philippe Pierrat et al.   BIOMATERIALS

The photoluminescence mechanism in carbon dots (graphene quantum dots, carbon nanodots, and polymer dots): current state and future perspective

(2015) Shoujun Zhu et al.   Nano Research

Pharmacokinetics, pharmacodynamics and toxicology of theranostic nanoparticles

(2015) Homan Kang et al.   Nanoscale

Principles of nanoparticle design for overcoming biological barriers to drug delivery

(2015) Elvin Blanco et al.   NATURE BIOTECHNOLOGY

Mass spectrometry imaging reveals the sub-organ distribution of carbon nanomaterials

(2015) Suming Chen et al.   Nature Nanotechnology

Direct Solvent-Derived Polymer-Coated Nitrogen-Doped Carbon Nanodots with High Water Solubility for Targeted Fluorescence Imaging of Glioma

(2015) Yi Wang et al.   Small

Insoluble drug delivery strategies: review of recent advances and business prospects

(2015) Sandeep Kalepu et al.   Acta Pharmaceutica Sinica B

Radioactive 198Au-Doped Nanostructures with Different Shapes for In Vivo Analyses of Their Biodistribution, Tumor Uptake, and Intratumoral Distribution

(2014) Kvar C. L. Black et al.   ACS Nano

Binding of Human Serum Albumin to Single-Walled Carbon Nanotubes Activated Neutrophils to Increase Production of Hypochlorous Acid, the Oxidant Capable of Degrading Nanotubes

(2014) Naihao Lu et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Challenges associated with penetration of nanoparticles across cell and tissue barriers: A review of current status and future prospects

(2014) Sutapa Barua et al.   Nano Today

Endocytic Crosstalk: Cavins, Caveolins, and Caveolae Regulate Clathrin-Independent Endocytosis

(2014) Natasha Chaudhary et al.   PLOS BIOLOGY

Nanoparticle–protein corona complexes govern the biological fates and functions of nanoparticles

(2014) Cindy Gunawan et al.   Journal of Materials Chemistry B

Carbon quantum dots: synthesis, properties and applications

(2014) Youfu Wang et al.   Journal of Materials Chemistry C

Surface Coating of Graphene Quantum Dots Using Mussel-Inspired Polydopamine for Biomedical Optical Imaging

(2013) Md Nurunnabi et al.   ACS Applied Materials & Interfaces

In Vivo Biodistribution and Toxicology of Carboxylated Graphene Quantum Dots

(2013) Md Nurunnabi et al.   ACS Nano

Effect of Injection Routes on the Biodistribution, Clearance, and Tumor Uptake of Carbon Dots

(2013) Xinglu Huang et al.   ACS Nano

Renal clearable inorganic nanoparticles: a new frontier of bionanotechnology

(2013) Jinbin Liu et al.   Materials Today

Lighting up left-handed Z-DNA: photoluminescent carbon dots induce DNA B to Z transition and perform DNA logic operations

(2013) Lingyan Feng et al.   NUCLEIC ACIDS RESEARCH

Visualizing Dynamics of Sub-Hepatic Distribution of Nanoparticles Using Intravital Multiphoton Fluorescence Microscopy

(2012) Shih-Hsun Cheng et al.   ACS Nano

Cellular Uptake of Nanoparticles by Membrane Penetration: A Study Combining Confocal Microscopy with FTIR Spectroelectrochemistry

(2012) Tiantian Wang et al.   ACS Nano

Targeting receptor-mediated endocytotic pathways with nanoparticles: Rationale and advances

(2012) Shi Xu et al.   ADVANCED DRUG DELIVERY REVIEWS

COULOMB BLOCKADE IN GRAPHENE QUANTUM DOTS

(2012) QIONG MA et al.   MODERN PHYSICS LETTERS B

Delivery of nanoparticle-complexed drugs across the vascular endothelial barrier via caveolae

(2011) Zhenjia Wang et al.   IUBMB LIFE

Emerging nanomaterials for targeting subcellular organelles

(2011) Jasper G. Huang et al.   Nano Today

The effects of particle size, density and shape on margination of nanoparticles in microcirculation

(2011) Randall Toy et al.   NANOTECHNOLOGY

Molecular mechanism and physiological functions of clathrin-mediated endocytosis

(2011) Harvey T. McMahon et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Carbon nanotubes degraded by neutrophil myeloperoxidase induce less pulmonary inflammation

(2010) Valerian E. Kagan et al.   Nature Nanotechnology

Endocytosisviacaveolae: alternative pathway with distinct cellular compartments to avoid lysosomal degradation?

(2009) Anna L. Kiss et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE