期刊
出版社
ELSEVIER
DOI: 10.1016/j.msec.2020.111756
关键词
Carbon-based quantum dots; Surface modification; Biomedical application
This work reviewed the potential of carbon-based quantum dots in biomedical science and engineering applications, and investigated the efforts made to improve these zero-dimensional nano-materials through different surface modification techniques.
Carbon-based quantum dots (CDs) are mainly divided into two sub-groups; carbon quantum dots (CQDs) and graphene quantum dots (GQDs), which exhibit outstanding photoluminescence (PL) properties, low toxicity, superior biocompatibility and facile functionalization. Regarding these features, they have been promising candidates for biomedical science and engineering applications. In this work, we reviewed the efforts made to modify these zero dimensional nano-materials to obtain the best properties for bio-imaging, drug and gene delivery, cancer therapy, and bio-sensor applications. Five main surface modification techniques with outstanding results are investigated, including doping, surface functionalization, polymer capping, nano-composite and core-shell structures, and the drawbacks and challenges in each of these methods are discussed.
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