Therapeutic efficacy of antimalarial drugs targeting DosRS signaling in Mycobacterium abscessus

Unique Features of Mycobacterium abscessus Biofilms Formed in Synthetic Cystic Fibrosis Medium

(2021) Juan M. Belardinelli et al.   Frontiers in Microbiology

Inhibiting DosRST as a new approach to tuberculosis therapy

(2020) Huiqing Zheng et al.   Future Medicinal Chemistry

A mouse model of pulmonary Mycobacteroides abscessus infection

(2020) Emily C. Maggioncalda et al.   Scientific Reports

Extreme Drug Tolerance of Mycobacterium abscessus “Persisters”

(2020) Yee-Kuen Yam et al.   Frontiers in Microbiology

Cell Surface Remodeling of Mycobacterium abscessus under Cystic Fibrosis Airway Growth Conditions

(2020) Crystal J. Wiersma et al.   ACS Infectious Diseases

Preclinical Models of Nontuberculous Mycobacteria Infection for Early Drug Discovery and Vaccine Research

(2020) Elisa Rampacci et al.   Pathogens

Clofazimine inhalation suspension for the aerosol treatment of pulmonary nontuberculous mycobacterial infections

(2019) Brandon Banaschewski et al.   Journal of Cystic Fibrosis

Targeting autophagy enhances the anticancer effect of artemisinin and its derivatives

(2019) Xin Sun et al.   MEDICINAL RESEARCH REVIEWS

Role of M.tuberculosis protein Rv2005c in the aminoglycosides resistance

(2019) Divakar Sharma et al.   MICROBIAL PATHOGENESIS

Inhibiting Mycobacterium tuberculosis DosRST signaling by targeting response regulator DNA binding and sensor kinase heme

(2019) Huiqing Zheng et al.   ACS Chemical Biology

Mycobacterium tuberculosis DosR regulon gene Rv2004c contributes to streptomycin resistance and intracellular survival

(2019) Sankara Narayana Doddam et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Biofilms of Mycobacterium abscessus complex can be sensitized to antibiotics by disaggregation and oxygenation

(2019) Mette Kolpen et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Scalable and cost-effective ribonuclease-based rRNA depletion for transcriptomics

(2019) Yiming Huang et al.   NUCLEIC ACIDS RESEARCH

Mycobacterium abscessus Smooth and Rough Morphotypes Form Antimicrobial-Tolerant Biofilm Phenotypes but Are Killed by Acetic Acid

(2018) Gillian Clary et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

NTM drug discovery: status, gaps and the way forward

(2018) Mu-Lu Wu et al.   DRUG DISCOVERY TODAY

Nontuberculous Mycobacterial Infections in Cystic Fibrosis

(2018) Stacey L. Martiniano et al.   Thoracic Surgery Clinics

Structure–Activity Relationship of the Antimalarial Ozonide Artefenomel (OZ439)

(2017) Yuxiang Dong et al.   JOURNAL OF MEDICINAL CHEMISTRY

Controlling Extra- and Intramacrophagic Mycobacterium abscessus by Targeting Mycolic Acid Transport

(2017) Albertus Viljoen et al.   Frontiers in Cellular and Infection Microbiology

Biofilm Formation byMycobacterium abscessusin a Lung Cavity

(2016) Kevin P. Fennelly et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Stringent Response Factors PPX1 and PPK2 Play an Important Role in Mycobacterium tuberculosis Metabolism, Biofilm Formation, and Sensitivity to IsoniazidIn Vivo

(2016) Yu-Min Chuang et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Functional characterization of the Mycobacterium abscessus genome coupled with condition specific transcriptomics reveals conserved molecular strategies for host adaptation and persistence

(2016) Aleksandra A. Miranda-CasoLuengo et al.   BMC GENOMICS

Intrinsic rifamycin resistance ofMycobacterium abscessusis mediated by ADP-ribosyltransferase MAB_0591

(2016) Anna Rominski et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Inhibitors of Mycobacterium tuberculosis DosRST signaling and persistence

(2016) Huiqing Zheng et al.   Nature Chemical Biology

The DosR Regulon Modulates Adaptive Immunity and Is Essential forMycobacterium tuberculosisPersistence

(2015) Smriti Mehra et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

DosS Is Required for the Complete Virulence ofMycobacterium tuberculosisin Mice with Classical Granulomatous Lesions

(2015) Uma S. Gautam et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Susceptibility of Mycobacterium abscessus to Antimycobacterial Drugs in Preclinical Models

(2015) Andrés Obregón-Henao et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Chronic pulmonary disease withMycobacterium abscessuscomplex is a biofilm infection

(2015) Tavs Qvist et al.   EUROPEAN RESPIRATORY JOURNAL

The growing threat of nontuberculous mycobacteria in CF

(2015) R. Andres Floto et al.   Journal of Cystic Fibrosis

Malaria medicines: a glass half full?

(2015) Timothy N. C. Wells et al.   NATURE REVIEWS DRUG DISCOVERY

Essential genome ofPseudomonas aeruginosain cystic fibrosis sputum

(2015) Keith H. Turner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nontuberculous Mycobacteria in Cystic Fibrosis and Non–Cystic Fibrosis Bronchiectasis

(2015) In Park et al.   SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE

Microaggregate-associated protein involved in invasion of epithelial cells byMycobacterium aviumsubsp.hominissuis

(2015) Lmar Babrak et al.   Virulence

HTSeq--a Python framework to work with high-throughput sequencing data

(2014) S. Anders et al.   BIOINFORMATICS

Skewer: a fast and accurate adapter trimmer for next-generation sequencing paired-end reads

(2014) Hongshan Jiang et al.   BMC BIOINFORMATICS

The Environment of “Mycobacterium avium subsp. hominissuis” Microaggregates Induces Synthesis of Small Proteins Associated with Efficient Infection of Respiratory Epithelial Cells

(2014) Lmar Babrak et al.   INFECTION AND IMMUNITY

Biofilm-Related Infections: Bridging the Gap between Clinical Management and Fundamental Aspects of Recalcitrance toward Antibiotics

(2014) D. Lebeaux et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Mycobacterium avium Biofilm Attenuates Mononuclear Phagocyte Function by Triggering Hyperstimulation and Apoptosis during Early Infection

(2013) Sasha J. Rose et al.   INFECTION AND IMMUNITY

Identification and characterization of the genetic changes responsible for the characteristic smooth-to-rough morphotype alterations of clinically persistentMycobacterium abscessus

(2013) Alexandre Pawlik et al.   MOLECULAR MICROBIOLOGY

Mycobacterium abscessus Induces a Limited Pattern of Neutrophil Activation That Promotes Pathogen Survival

(2013) Kenneth C. Malcolm et al.   PLoS One

First-in-man safety and pharmacokinetics of synthetic ozonide OZ439 demonstrates an improved exposure profile relative to other peroxide antimalarials

(2012) Joerg J. Moehrle et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

In silico analysis of DosR regulon proteins of Mycobacterium tuberculosis

(2012) Suganya Selvaraj et al.   GENE

Fast gapped-read alignment with Bowtie 2

(2012) Ben Langmead et al.   NATURE METHODS

Adaptation of Pseudomonas aeruginosa to the cystic fibrosis airway: an evolutionary perspective

(2012) Anders Folkesson et al.   NATURE REVIEWS MICROBIOLOGY

Virulence of Mycobacterium tuberculosis Depends on Lipoamide Dehydrogenase, a Member of Three Multienzyme Complexes

(2011) Aditya Venugopal et al.   Cell Host & Microbe

Comparative Genomics of the Dormancy Regulons in Mycobacteria

(2011) A. Gerasimova et al.   JOURNAL OF BACTERIOLOGY

Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria

(2011) S. A. Charman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolic Regulation of Mycobacterial Growth and Antibiotic Sensitivity

(2011) Seung-Hun Baek et al.   PLOS BIOLOGY

Mycobacterium tuberculosis Uses Host Triacylglycerol to Accumulate Lipid Droplets and Acquires a Dormancy-Like Phenotype in Lipid-Loaded Macrophages

(2011) Jaiyanth Daniel et al.   PLoS Pathogens

Arterolane, a New Synthetic Trioxolane for Treatment of UncomplicatedPlasmodium falciparumMalaria: A Phase II, Multicenter, Randomized, Dose‐Finding Clinical Trial

(2010) Neena Valecha et al.   CLINICAL INFECTIOUS DISEASES

The Mycobacterium tuberculosis DosR Regulon Assists in Metabolic Homeostasis and Enables Rapid Recovery from Nonrespiring Dormancy

(2009) R. L. Leistikow et al.   JOURNAL OF BACTERIOLOGY

A Novel In Vitro Multiple-Stress Dormancy Model for Mycobacterium tuberculosis Generates a Lipid-Loaded, Drug-Tolerant, Dormant Pathogen

(2009) Chirajyoti Deb et al.   PLoS One

Differential Antibiotic Susceptibility of Mycobacterium abscessus Variants in Biofilms and Macrophages Compared to That of Planktonic Bacteria

(2008) R. Greendyke et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Acute Respiratory Failure Involving an R Variant of Mycobacterium abscessus

(2008) E. Catherinot et al.   JOURNAL OF CLINICAL MICROBIOLOGY