Bach1 derepression is neuroprotective in a mouse model of Parkinson’s disease

Parkinson's disease

(2021) Bastiaan R Bloem et al.   LANCET

Challenges and Limitations of Targeting the Keap1-Nrf2 Pathway for Neurotherapeutics: Bach1 De-Repression to the Rescue

(2021) Dmitry M. Hushpulian et al.   Frontiers in Aging Neuroscience

The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway

(2020) Liam Baird et al.   MOLECULAR AND CELLULAR BIOLOGY

Downregulation of BACH1 Protects AGAINST Cerebral Ischemia/Reperfusion Injury through the Functions of HO-1 and NQO1

(2020) Shan Yu et al.   NEUROSCIENCE

Succination inactivates gasdermin D and blocks pyroptosis

(2020) Fiachra Humphries et al.   SCIENCE

Isomeric O-methyl cannabidiolquinones with dual BACH1/NRF2 activity

(2020) Laura Casares et al.   Redox Biology

BTB and CNC homology 1 inhibition ameliorates fibrosis and inflammation via blocking ERK pathway in pulmonary fibrosis

(2020) Yuan Liu et al.   EXPERIMENTAL LUNG RESEARCH

Effective breast cancer combination therapy targeting BACH1 and mitochondrial metabolism

(2019) Jiyoung Lee et al.   NATURE

BACH1 Orchestrates Lung Cancer Metastasis

(2019) Nicole M. Anderson et al.   CELL

Parkinson Disease Epidemiology, Pathology, Genetics, and Pathophysiology

(2019) David K. Simon et al.   CLINICS IN GERIATRIC MEDICINE

Ferroptosis is controlled by the coordinated transcriptional regulation of glutathione and labile iron metabolism by the transcription factor BACH1

(2019) Hironari Nishizawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crosstalk between Nrf2 signaling and mitochondrial function in Parkinson's disease

(2019) Navneet Ammal Kaidery et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Dimethyl fumarate targets GAPDH and aerobic glycolysis to modulate immunity

(2018) Michael D. Kornberg et al.   SCIENCE

Aging-related decline in the induction of Nrf2-regulated antioxidant genes in human bronchial epithelial cells

(2018) Lulu Zhou et al.   Redox Biology

An immunoregulatory and tissue-residency program modulated by c-MAF in human TH17 cells

(2018) Dominik Aschenbrenner et al.   NATURE IMMUNOLOGY

Zinc-binding triggers a conformational-switch in the cullin-3 substrate adaptor protein KEAP1 that controls transcription factor NRF2

(2018) Michael McMahon et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Global, regional, and national burden of Parkinson's disease, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

(2018) E. Ray Dorsey et al.   LANCET NEUROLOGY

Bach1: Function, Regulation, and Involvement in Disease

(2018) Xinyue Zhang et al.   Oxidative Medicine and Cellular Longevity

The Emerging Evidence of the Parkinson Pandemic

(2018) E. Ray Dorsey et al.   Journal of Parkinsons Disease

Ferroptosis and cell death mechanisms in Parkinson's disease

(2017) Stephanie J. Guiney et al.   NEUROCHEMISTRY INTERNATIONAL

Silencing of BACH1 inhibits invasion and migration of prostate cancer cells by altering metastasis-related gene expression

(2017) Neda Shajari et al.   Artificial Cells Nanomedicine and Biotechnology

The Bach Family of Transcription Factors: A Comprehensive Review

(2016) Yin Zhou et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

BACH1, the master regulator gene: A novel candidate target for cancer therapy

(2016) Sadaf Davudian et al.   GENE

The double knockout of Bach1 and Bach2 in mice reveals shared compensatory mechanisms in regulating alveolar macrophage function and lung surfactant homeostasis

(2016) Risa Ebina-Shibuya et al.   JOURNAL OF BIOCHEMISTRY

Distinct Nrf2 Signaling Mechanisms of Fumaric Acid Esters and Their Role in Neuroprotection against 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Induced Experimental Parkinson's-Like Disease

(2016) M. Ahuja et al.   JOURNAL OF NEUROSCIENCE

The status of Nrf2-based therapeutics: current perspectives and future prospects

(2016) IrinaG Gazaryan et al.   Neural Regeneration Research

Nrf2—a therapeutic target for the treatment of neurodegenerative diseases

(2015) Delinda A. Johnson et al.   FREE RADICAL BIOLOGY AND MEDICINE

Dimethyl Fumarate and Monoethyl Fumarate Exhibit Differential Effects on KEAP1, NRF2 Activation, and Glutathione Depletion In Vitro

(2015) Melanie S. Brennan et al.   PLoS One

Induction of Heme Oxygenase I (HMOX1) by HPP-4382: A Novel Modulator of Bach1 Activity

(2014) Otis C. Attucks et al.   PLoS One

Heme in pathophysiology: a matter of scavenging, metabolism and trafficking across cell membranes

(2014) Deborah Chiabrando et al.   Frontiers in Pharmacology

Metalloporphyrins as Therapeutic Catalytic Oxidoreductants in Central Nervous System Disorders

(2013) Huaxin Sheng et al.   ANTIOXIDANTS & REDOX SIGNALING

Neuroinflammation and oxidative stress: Co-conspirators in the pathology of Parkinson’s disease

(2013) Juliet M. Taylor et al.   NEUROCHEMISTRY INTERNATIONAL

Regulation of APC development, immune response, and autoimmunity by Bach1/HO-1 pathway in mice

(2012) A. Y.-L. So et al.   BLOOD

Heme regulates B-cell differentiation, antibody class switch, and heme oxygenase-1 expression in B cells as a ligand of Bach2

(2011) M. Watanabe-Matsui et al.   BLOOD

Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway

(2011) Ralf A. Linker et al.   BRAIN

Ageing as a primary risk factor for Parkinson's disease: evidence from studies of non-human primates

(2011) Timothy J. Collier et al.   NATURE REVIEWS NEUROSCIENCE

Parkinson's Disease: From Molecular Pathways in Disease to Therapeutic Approaches

(2009) Bobby Thomas   ANTIOXIDANTS & REDOX SIGNALING

Genetic Ablation of Transcription Repressor Bach1 Reduces Neural Tissue Damage and Improves Locomotor Function after Spinal Cord Injury in Mice

(2009) Haruo Kanno et al.   JOURNAL OF NEUROTRAUMA

Hemin toxicity: a preventable source of brain damage following hemorrhagic stroke

(2009) Stephen R. Robinson et al.   REDOX REPORT

Ablation of the Bach1 Gene Leads to the Suppression of Atherosclerosis in Bach1 and Apolipoprotein E Double Knockout Mice

(2008) Yuichiro Watari et al.   HYPERTENSION RESEARCH

Modulation of the secondary injury process after spinal cord injury in Bach1-deficient mice by heme oxygenase–1

(2008) Kiyotaka Yamada et al.   JOURNAL OF NEUROSURGERY-SPINE