Molecular evolution of PCSK family: Analysis of natural selection rate and gene loss

The motif EXEXXXL in the cytosolic tail of the secretory human proprotein convertase PC7 regulates its trafficking and cleavage activity

(2020) Loreleï Durand et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular evolution of autophagy rate-limiting factor LAMP2 in placental mammals

(2019) Zahra Jalali et al.   GENE

SWISS-MODEL: homology modelling of protein structures and complexes

(2018) Andrew Waterhouse et al.   NUCLEIC ACIDS RESEARCH

Quantification of GDF11 and Myostatin in Human Aging and Cardiovascular Disease

(2016) Marissa J. Schafer et al.   Cell Metabolism

PCSK1 Mutations and Human Endocrinopathies: From Obesity to Gastrointestinal Disorders

(2016) Pieter Stijnen et al.   ENDOCRINE REVIEWS

ETE 3: Reconstruction, Analysis, and Visualization of Phylogenomic Data

(2016) Jaime Huerta-Cepas et al.   MOLECULAR BIOLOGY AND EVOLUTION

Proprotein convertases in atherogenesis

(2015) Philipp Stawowy   CURRENT OPINION IN LIPIDOLOGY

Revisiting PC1/3 Mutants: Dominant-Negative Effect of Endoplasmic Reticulum-Retained Mutants

(2015) Elias H. Blanco et al.   ENDOCRINOLOGY

Population Genomics Reveal Recent Speciation and Rapid Evolutionary Adaptation in Polar Bears

(2014) Shiping Liu et al.   CELL

PCSK9

(2014) Nabil G. Seidah et al.   CIRCULATION RESEARCH

Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9): Lessons Learned from Patients with Hypercholesterolemia

(2014) Z. Awan et al.   CLINICAL CHEMISTRY

PCSK7Genotype Modifies Effect of a Weight-Loss Diet on 2-Year Changes of Insulin Resistance: The POUNDS LOST Trial

(2014) Tao Huang et al.   DIABETES CARE

Functional Consequences of a Novel Variant of PCSK1

(2013) Lindsay A. Pickett et al.   PLoS One

The M2 Module of the Cys-His-rich Domain (CHRD) of PCSK9 Protein Is Needed for the Extracellular Low-density Lipoprotein Receptor (LDLR) Degradation Pathway

(2012) Yascara Grisel Luna Saavedra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Internalization of Proprotein Convertase PC7 from Plasma Membrane Is Mediated by a Novel Motif

(2012) Jeroen Declercq et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The biology and therapeutic targeting of the proprotein convertases

(2012) Nabil G. Seidah et al.   NATURE REVIEWS DRUG DISCOVERY

Predicting the Functional Effect of Amino Acid Substitutions and Indels

(2012) Yongwook Choi et al.   PLoS One

Modulation of PC1/3 Activity by Self-Interaction and Substrate Binding

(2011) Akina Hoshino et al.   ENDOCRINOLOGY

An Improved Likelihood Ratio Test for Detecting Site-Specific Functional Divergence among Clades of Protein-Coding Genes

(2011) Cameron J. Weadick et al.   MOLECULAR BIOLOGY AND EVOLUTION

Association of obesity risk SNPs in PCSK1with insulin sensitivity and proinsulin conversion

(2010) Martin Heni et al.   BMC Medical Genetics

Update on the Role of Endothelial Lipase in High-Density Lipoprotein Metabolism, Reverse Cholesterol Transport, and Atherosclerosis

(2010) Tomoyuki Yasuda et al.   CIRCULATION JOURNAL

A Two-step Binding Model of PCSK9 Interaction with the Low Density Lipoprotein Receptor

(2010) Taichi Yamamoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

I-TASSER: a unified platform for automated protein structure and function prediction

(2010) Ambrish Roy et al.   Nature Protocols

Genetic Variation at the Proprotein Convertase Subtilisin/Kexin Type 5 Gene Modulates High-Density Lipoprotein Cholesterol Levels

(2009) Iulia Iatan et al.   Circulation-Cardiovascular Genetics

Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm

(2009) Prateek Kumar et al.   Nature Protocols

Functional and structural characterization of a dense core secretory granule sorting domain from the PC1/3 protease

(2009) J. D. Dikeakos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Investigations on the evolutionary conservation of PCSK9 reveal a functionally important protrusion

(2008) Jamie Cameron et al.   FEBS Journal

Structural requirements for PCSK9-mediated degradation of the low-density lipoprotein receptor

(2008) D.-W. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA