GalNAc-siRNA conjugates: Prospective tools on the frontier of anti-viral therapeutics

The outbreak of SARS-CoV-2 pneumonia calls for viral vaccines

(2020) Weilong Shang et al.   npj Vaccines

Delivery of Oligonucleotides to the Liver with GalNAc: From Research to Registered Therapeutic Drug

(2020) Alexandre J. Debacker et al.   MOLECULAR THERAPY

Recent advances in the development of HBV capsid assembly modulators

(2019) Bhavitavya Nijampatnam et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

New Phylogenetic Grouping of Positive-Sense RNA Viruses Is Concordant with Replication Complex Morphology

(2019) Tero Ahola   mBio

Non-alcoholic fatty liver disease in adults: Current concepts in etiology, outcomes and management

(2019) Thomas Marjot et al.   ENDOCRINE REVIEWS

RNA Interference Therapy with ARC‐520 Results in Prolonged HBsAg Response in Patients with Chronic Hepatitis B Infection

(2019) Man‐Fung Yuen et al.   HEPATOLOGY

Inhibition of dengue virus infection by small interfering RNAs that target highly conserved sequences in the NS4B or NS5 coding regions

(2018) Paula M. Villegas et al.   ARCHIVES OF VIROLOGY

Metazoan MicroRNAs

(2018) David P. Bartel   CELL

Towards HBV curative therapies

(2018) Raymond F. Schinazi et al.   LIVER INTERNATIONAL

Advanced siRNA Designs Further Improve In Vivo Performance of GalNAc-siRNA Conjugates

(2018) Donald J. Foster et al.   MOLECULAR THERAPY

The evolutionary history of vertebrate RNA viruses

(2018) Mang Shi et al.   NATURE

Post-exposure treatments for Ebola and Marburg virus infections

(2018) Robert W. Cross et al.   NATURE REVIEWS DRUG DISCOVERY

Comparison of partially and fully chemically-modified siRNA in conjugate-mediated delivery in vivo

(2018) Matthew R Hassler et al.   NUCLEIC ACIDS RESEARCH

GalNAc-siRNA Conjugates: Leading the Way for Delivery of RNAi Therapeutics

(2018) Aaron D. Springer et al.   Nucleic Acid Therapeutics

Liver-Targeted Anti-HBV Single-Stranded Oligonucleotides with Locked Nucleic Acid Potently Reduce HBV Gene Expression In Vivo

(2018) Hassan Javanbakht et al.   Molecular Therapy-Nucleic Acids

Serum HBV RNA: a New Potential Biomarker for Chronic Hepatitis B Virus Infection

(2018) Shi Liu et al.   HEPATOLOGY

Serum hepatitis B core-related antigen (HBcrAg) correlates with covalently closed circular DNA transcriptional activity in chronic hepatitis B patients

(2018) Barbara Testoni et al.   JOURNAL OF HEPATOLOGY

Virus found in a boreal lake links ssDNA and dsDNA viruses

(2017) Elina Laanto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNAi-based treatment of chronically infected patients and chimpanzees reveals that integrated hepatitis B virus DNA is a source of HBsAg

(2017) Christine I. Wooddell et al.   Science Translational Medicine

Preclinical and Clinical Advances of GalNAc-Decorated Nucleic Acid Therapeutics

(2017) Yuanyu Huang   Molecular Therapy-Nucleic Acids

Treatment of infantile-onset spinal muscular atrophy with nusinersen: a phase 2, open-label, dose-escalation study

(2016) Richard S Finkel et al.   LANCET

pH-Sensitive Nanomicelles for High-Efficiency siRNA Delivery in Vitro and in Vivo: An Insight into the Design of Polycations with Robust Cytosolic Release

(2016) Junhui Zhou et al.   NANO LETTERS

Hepatitis B virus X protein identifies the Smc5/6 complex as a host restriction factor

(2016) Adrien Decorsière et al.   NATURE

Pharmacokinetic and Pharmacodynamic Investigations of ION-353382, a Model Antisense Oligonucleotide: Using Alpha-2-Macroglobulin and Murinoglobulin Double-Knockout Mice

(2016) Colby S. Shemesh et al.   Nucleic Acid Therapeutics

Pharmacokinetic Behaviors of Intravenously Administered siRNA in Glandular Tissues

(2016) Yuanyu Huang et al.   Theranostics

Biomaterials in siRNA Delivery: A Comprehensive Review

(2016) William Ho et al.   Advanced Healthcare Materials

Experimental Treatment of Ebola Virus Disease with TKM-130803: A Single-Arm Phase 2 Clinical Trial

(2016) Jake Dunning et al.   PLOS MEDICINE

siRNA Conjugates Carrying Sequentially Assembled Trivalent N-Acetylgalactosamine Linked Through Nucleosides Elicit Robust Gene Silencing In Vivo in Hepatocytes

(2015) Shigeo Matsuda et al.   ACS Chemical Biology

Pharmacokinetics, biodistribution and cell uptake of antisense oligonucleotides

(2015) Richard S. Geary et al.   ADVANCED DRUG DELIVERY REVIEWS

Hepatocyte-Specific Delivery of siRNAs Conjugated to Novel Non-nucleosidic TrivalentN-Acetylgalactosamine Elicits Robust Gene Silencing in Vivo

(2015) Kallanthottathil G. Rajeev et al.   CHEMBIOCHEM

Clinical experiences with systemically administered siRNA-based therapeutics in cancer

(2015) Jonathan E. Zuckerman et al.   NATURE REVIEWS DRUG DISCOVERY

Knocking down disease: a progress report on siRNA therapeutics

(2015) Anders Wittrup et al.   NATURE REVIEWS GENETICS

Multivalent N-Acetylgalactosamine-Conjugated siRNA Localizes in Hepatocytes and Elicits Robust RNAi-Mediated Gene Silencing

(2014) Jayaprakash K. Nair et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Targeted delivery of antisense oligonucleotides to hepatocytes using triantennaryN-acetyl galactosamine improves potency 10-fold in mice

(2014) Thazha P. Prakash et al.   NUCLEIC ACIDS RESEARCH

Evolution of Tertiary Structure of Viral RNA Dependent Polymerases

(2014) Jiří Černý et al.   PLoS One

Molecular Mechanisms of RNA Interference

(2013) Ross C. Wilson et al.   Annual Review of Biophysics

Small-interfering RNAs (siRNAs) as a promising tool for ocular therapy

(2013) A Guzman-Aranguez et al.   BRITISH JOURNAL OF PHARMACOLOGY

Long Noncoding RNAs: Cellular Address Codes in Development and Disease

(2013) Pedro J. Batista et al.   CELL

Optimized siRNA-PEG Conjugates for Extended Blood Circulation and Reduced Urine Excretion in Mice

(2013) Frank Iversen et al.   Theranostics

Structure Unifies the Viral Universe

(2012) Nicola G.A. Abrescia et al.   Annual Review of Biochemistry

The entry inhibitor Myrcludex-B efficiently blocks intrahepatic virus spreading in humanized mice previously infected with hepatitis B virus

(2012) Tassilo Volz et al.   JOURNAL OF HEPATOLOGY

Non-coding RNAs as regulators of gene expression and epigenetics

(2011) M. U. Kaikkonen et al.   CARDIOVASCULAR RESEARCH

Engineering RNA for Targeted siRNA Delivery and Medical Application

(2010) Peixuan Guo et al.   ADVANCED DRUG DELIVERY REVIEWS

Infectious Diseases and the Liver

(2010) Rohit Talwani et al.   Clinics in Liver Disease

Postexposure protection of non-human primates against a lethal Ebola virus challenge with RNA interference: a proof-of-concept study

(2010) Thomas W Geisbert et al.   LANCET

Elimination Pathways of Systemically Delivered siRNA

(2010) Yuanyu Huang et al.   MOLECULAR THERAPY

siRNA delivery systems for cancer treatment

(2009) Yu-Kyoung Oh et al.   ADVANCED DRUG DELIVERY REVIEWS

History lessons: the Asian Flu pandemic

(2009) Claire Jackson   BRITISH JOURNAL OF GENERAL PRACTICE

Origins and Mechanisms of miRNAs and siRNAs

(2009) Richard W. Carthew et al.   CELL

Lipid-based nanotherapeutics for siRNA delivery

(2009) A. Schroeder et al.   JOURNAL OF INTERNAL MEDICINE

Knocking down barriers: advances in siRNA delivery

(2009) Kathryn A. Whitehead et al.   NATURE REVIEWS DRUG DISCOVERY

Chemically modified siRNA: tools and applications

(2008) J WATTS et al.   DRUG DISCOVERY TODAY

Targeted therapy of cancer: new roles for pathologists—prostate cancer

(2008) Mark A Rubin   MODERN PATHOLOGY